The Experts below are selected from a list of 2017704 Experts worldwide ranked by ideXlab platform
Hubert Dyker - One of the best experts on this subject based on the ideXlab platform.
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Syntheses of depsipeptide analogues of the insect neuropeptide proctolin
Bioorganic & Medicinal Chemistry Letters, 2002Co-Authors: Jürgen Scherkenbeck, Andrew Plant, Peter Lösel, Frank Stieber, Hubert DykerAbstract:Abstract Four depsipeptide analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single ester linkage between Arg 1 and Tyr 2 , Tyr 2 and Leu 3 , and between Pro 4 and Thr 5 , respectively. A didepsipentapeptide containing an ester linkage between Tyr 2 and Leu 3 and between Pro 4 and Thr 5 , has also been prepared. The depsipeptide 4 is the first example of a backbone-modified proctolin analogue which shows full myotropic activity.
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syntheses of analogues of the insect neuropeptide proctolin containing an oxazole ring as an amide bond replacement
Organic Letters, 2001Co-Authors: Andrew Plant, Peter Lösel, Jürgen Scherkenbeck, Frank Stieber, Hubert DykerAbstract:Three oxazole analogues of the insect neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) have been prepared, containing a single oxazole between Tyr and Pro and between Pro and Thr, respectively. A compound containing an oxazole moiety between Tyr and Pro and between Pro and Thr has also been prepared. All compounds have been tested for myotropic activity.
Gerd Gade - One of the best experts on this subject based on the ideXlab platform.
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myotropic neuropeptides from the retrocerebral complex of the stick insect carausius morosus phasmatodea lonchodidae
European Journal of Entomology, 2013Co-Authors: Roland Kellner, Gerd GadeAbstract:Myotropic neuropeptides were isolated from the retrocerebral complex of the stick insect, Carausius morosus, by using three HPLC steps. Bioactivity during purification was measured by heterologous bioassays monitoring the contractions of the hyperneural muscle and hindgut of the American cockroach. Additionally, fractions not active in these bioassays were tested in a homologous bioassay evoking contractions of the hindgut of C. morosus. Peptide sequence analysis and mass spectrometry yielded the following structures: Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-NH2 (CCAP), pGlu-Thr-Phe-Gln-Tyr-Ser-His-Gly-Trp-Thr-Asn-NH2 (His7-corazonin) and Asp-Glu-Gly-Gly-Thr-Gln-Tyr-Thr-Pro-Arg-Leu-NH2 (Cam-PK-1). These neuropeptides are the first myotropins isolated from C. morosus. The most bioactive compound in the homologous bioassay, the C. morosus-hindgut assay, was CCAP.
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a tryptophan substituted member of the akh rpch family isolated from a stick insect corpus cardiacum
Biochemical and Biophysical Research Communications, 1992Co-Authors: Gerd Gade, Roland Kellner, Kenneth L Rinehart, Mark L ProefkeAbstract:Abstract A neuropeptide, Cam-HrTH-I, has been isolated from the corpus cardiacum of the Indian stick insect Carausius morosus. The peptide causes hyperlipaemia in Locusta migratoria and hypertrehalosaemia in Periplaneta americana and is related to the previously isolated Cam-HrTH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) by substitution, apparently by a hexose, on the Trp residue. This appears to be the first example of such substitution on a Trp residue.
J. Michael Conlon - One of the best experts on this subject based on the ideXlab platform.
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Isolation of [Pro2,Met13]somatostatin-14 and somatostatin-14 from the frog brain reveals the existence of a somatostatin gene family in a tetrapod.
Biochemical and biophysical research communications, 1992Co-Authors: Hubert Vaudry, Nicolas Chartrel, J. Michael ConlonAbstract:Two somatostatin-related peptides were isolated in pure form from an extract of the brain of the European green frog, Rana ridibunda. The primary structure of the most abundant component was identical to that of mammalian somatostatin-14. The primary structure of the second component, present in approximately 5% of the abundance of somatostatin-14, was established as Ala-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Met-Cys. This sequence shows two substitutions (Pro for Gly2 and Met for Ser13) compared with mammalian somatostatin-14. The data provide evidence for a somatostatin gene family in tetrapods as well as in teleost fish.
Mark L Proefke - One of the best experts on this subject based on the ideXlab platform.
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a tryptophan substituted member of the akh rpch family isolated from a stick insect corpus cardiacum
Biochemical and Biophysical Research Communications, 1992Co-Authors: Gerd Gade, Roland Kellner, Kenneth L Rinehart, Mark L ProefkeAbstract:Abstract A neuropeptide, Cam-HrTH-I, has been isolated from the corpus cardiacum of the Indian stick insect Carausius morosus. The peptide causes hyperlipaemia in Locusta migratoria and hypertrehalosaemia in Periplaneta americana and is related to the previously isolated Cam-HrTH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) by substitution, apparently by a hexose, on the Trp residue. This appears to be the first example of such substitution on a Trp residue.
Roland Kellner - One of the best experts on this subject based on the ideXlab platform.
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myotropic neuropeptides from the retrocerebral complex of the stick insect carausius morosus phasmatodea lonchodidae
European Journal of Entomology, 2013Co-Authors: Roland Kellner, Gerd GadeAbstract:Myotropic neuropeptides were isolated from the retrocerebral complex of the stick insect, Carausius morosus, by using three HPLC steps. Bioactivity during purification was measured by heterologous bioassays monitoring the contractions of the hyperneural muscle and hindgut of the American cockroach. Additionally, fractions not active in these bioassays were tested in a homologous bioassay evoking contractions of the hindgut of C. morosus. Peptide sequence analysis and mass spectrometry yielded the following structures: Pro-Phe-Cys-Asn-Ala-Phe-Thr-Gly-Cys-NH2 (CCAP), pGlu-Thr-Phe-Gln-Tyr-Ser-His-Gly-Trp-Thr-Asn-NH2 (His7-corazonin) and Asp-Glu-Gly-Gly-Thr-Gln-Tyr-Thr-Pro-Arg-Leu-NH2 (Cam-PK-1). These neuropeptides are the first myotropins isolated from C. morosus. The most bioactive compound in the homologous bioassay, the C. morosus-hindgut assay, was CCAP.
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a tryptophan substituted member of the akh rpch family isolated from a stick insect corpus cardiacum
Biochemical and Biophysical Research Communications, 1992Co-Authors: Gerd Gade, Roland Kellner, Kenneth L Rinehart, Mark L ProefkeAbstract:Abstract A neuropeptide, Cam-HrTH-I, has been isolated from the corpus cardiacum of the Indian stick insect Carausius morosus. The peptide causes hyperlipaemia in Locusta migratoria and hypertrehalosaemia in Periplaneta americana and is related to the previously isolated Cam-HrTH-II (pGlu-Leu-Thr-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) by substitution, apparently by a hexose, on the Trp residue. This appears to be the first example of such substitution on a Trp residue.
