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Pierre J. Meunier - One of the best experts on this subject based on the ideXlab platform.
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An Economic Evaluation of Tiludronic Acid Treatment in Paget’s Disease of Bone
PharmacoEconomics, 1997Co-Authors: Antoine Lafuma, Francis Fagnani, Pierre J. MeunierAbstract:The objective of this study was to evaluate the long term comparative outcome of intermittent courses of therapy with low-dosage Tiludronic Acid (400 mg/day) versus etidronic Acid in patients with Paget’s disease of bone. The long term outcome was evaluated by means of a model, as the number of complications avoided during a 5-year period. Only major complications were considered (fractures of long bones, spinal cord dysfunction, osteoarthritis of the hip), which can be cured by adequate medical intervention, and may thus be valued in terms of direct costs. Deafness was not considered and was not valued. The various additional direct costs incurred (treatment and follow-up) and avoided (complications avoided) were assessed using an extrapolation model, based on the results of a clinical study. A standard costing methodology was used, according to the patterns of care currently in use in France. Costs were calculated from a societal perspective, including social security and private insurance fund reimbursements, and outof- pocket expenses. These were estimated in French francs (F; 1994 values). The estimated mean treatment cost per patient for the treatment of Paget’s disease and its complications over a 5-year period was F34 198 with etidronic Acid, and F30754 to F36422 w;th Tiludronic Acid, depending on whether an optimistic or a conservative view of the efficacy of Tiludronic Acid was assumed. Despite its higher acquisition cost, the use ofTiludronic Acid was less expensive in the treatment of Paget’s disease and its complications, compared with the use of etidronic Acid, when an optimistic view of the efficacy of Tiludronic Acid was assumed.
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An economic evaluation of Tiludronic Acid treatment in Paget's disease of bone.
PharmacoEconomics, 1997Co-Authors: Antoine Lafuma, Francis Fagnani, Pierre J. MeunierAbstract:The objective of this study was to evaluate the long term comparative outcome of intermittent courses of therapy with low-dosage Tiludronic Acid (400 mg/day) versus etidronic Acid in patients with Paget’s disease of bone.
Jan H.g. Jonkman - One of the best experts on this subject based on the ideXlab platform.
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Multiple dose pharmacokinetics of tiludronate in healthy volunteers
European journal of clinical pharmacology, 1996Co-Authors: H. R. Schwietert, P. A. M. Peeters, J. Dingemanse, J. F. Thiercelin, J. Necciari, H. De Bruin, Jan H.g. JonkmanAbstract:Objectives: A double-blind, placebo-controlled study was conducted to assess the pharmacokinetics and pharmacodynamics of the bisphosphonate Tiludronic Acid, administered once daily as sodium tiludronate 200, 400, 600 and 800 mg for 12 days. Four groups of ten subjects participated in the study, with a drug to placebo ratio of 4:1.
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Multiple dose pharmacokinetics of tiludronate in healthy volunteers
European Journal of Clinical Pharmacology, 1996Co-Authors: H. R. Schwietert, P. A. M. Peeters, J. Dingemanse, J. F. Thiercelin, J. Necciari, H. De Bruin, Jan H.g. JonkmanAbstract:Objectives : A double-blind, placebo-controlled study was conducted to assess the pharmacokinetics and pharmacodynamics of the bisphosphonate Tiludronic Acid, administered once daily as sodium tiludronate 200, 400, 600 and 800 mg for 12 days. Four groups of ten subjects participated in the study, with a drug to placebo ratio of 4:1. Methods: Pre-dose blood samples were taken on alternate days, starting on Day 1 and additional samples were collected over 144 h following the final dose on Day 12. Urine was collected over 24 h after the final dose. Indices of calcium homeostasis and biochemical markers of bone turnover were assessed during the study as pharmacodynamic parameters. Tolerability was evaluated with special emphasis on renal function and gastrointestinal irritation. Adverse experiences were assessed at regular time intervals. Results and conclusions: Steady state was attained from Day 4 (200 mg) or from Day 6 (400, 600 and 800 mg). Following the final dose on Day 12, minimal plasma concentrations (C_min) ranged between 0.19 and 1.5 mg ⋅ l^−1, and maximal plasma concentrations (C_max) between 1.1 and 7.8 mg⋅l^−1 for the lowest and highest doses, respectively. A supra-proportional increase in C_max, AUC_24 and A^e _24 with dose was observed. There was a linear relationship between the plasma Tiludronic Acid and its urinary excretion rate, so, the disproportional rise in C_max and AUC_24 with increasing dose could not be attributed to saturation of renal excretion. Certain indices of calcium homeostasis changed significantly during the study, but generally, became only prominent at the highest dose level of 800 mg. Total serum calcium and the urinary calcium/creatinine clearance ratio fell, indicating depression of osteoclastic bone resorption, which was not revealed by serum osteocalcin levels probably because of the brevity of the treatment (12 days). In response to the decline in serum calcium, serum 1,25-dihydroxyvitamin D_3 and intact PTH (1–84) levels increased. None of the safety parameters raised any concerns about the safety of sodium tiludronate administered in this way.
Flávia A.c. Furlaneto - One of the best experts on this subject based on the ideXlab platform.
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Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats.
Archives of oral biology, 2018Co-Authors: Flávia A.c. Furlaneto, Ivan Lima Oliveira Filho, Nicolly Parente Ribeiro Frota, Kely O. Yamamoto, Mario Roberto Pontes Lisboa, Mário Taba, Nara L.t. Nunes, Ricardo Basto Souza, Hellíada Vasconcelos Chaves, Edilson ErvolinoAbstract:Abstract Objective The purpose of this study was to evaluate whether local administration of TIL could influence the expression of the inflammatory mediators IL-1β, TNF-α, MMP-8 and COX-2 in rats with experimental periodontitis (EP). Methods Twenty-four adult male rats (Rattus norvegicus, albinus, Wistar) were assigned to groups C, EP, EP-TIL (C Control group, EP–Periodontitis groups). On EP groups, a ligature was placed around maxillary 2nd molars on day 1. On group EP-TIL, 20 μL of TIL solution (1 mg/kg body weight) was injected into the subperiosteal palatal area adjacent to the maxillary 2nd molar every other day until euthanasia (day 11). Alveolar bone loss was morphometrically analyzed. mRNA expressions of IL-1β, TNF-α, MMP-8 and COX-2 were assessed by qPCR. IL-1β, TNF-α, MMP-8 and COX-2 were immunohistochemically analyzed. Data were analyzed statistically. Results Group EP-TIL presented reduced alveolar bone loss when compared with group EP (p 0.05). Conclusion Within the limits of this study, it can be concluded that local administration of TIL downregulates important mediators involved in periodontal tissue destruction in ligature-induced periodontitis in rats.
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Effects of local administration of Tiludronic Acid on experimental periodontitis in diabetic rats.
Journal of periodontology, 2017Co-Authors: Nara L.t. Nunes, Mario Roberto Pontes Lisboa, Edilson Ervolino, Rodrigo Otavio Rego, Michel Reis Messora, Luiz F.f. Oliveira, Marina Costa Barcellos Garcia, Arthur B. Novaes, Sérgio Luis Scombatti De Souza, Flávia A.c. FurlanetoAbstract:Abstract Background Tiludronic Acid (TIL) presents antiresorptive and anti‐inflammatory properties and has not been evaluated in the periodontitis–diabetes mellitus (DM) association to date, to the best knowledge of the authors. This study evaluates effects of local administration of TIL on experimental periodontitis (EP) in rats with streptozotocin‐induced DM. Methods Thirty‐two animals (Rattus norvegicus albinus, Wistar) were divided into groups DM/C (Control), DM/EP, DM/EP/TIL1, and DM/EP/TIL3. In EP groups, a ligature was placed around mandibular first molars. In groups DM/EP/TIL1 and DM/EP/TIL3, TIL solutions (1 and 3 mg/kg, respectively) were injected into the gingival tissue of mandibular molars every other day for 10 days, until euthanasia. Periodontal tissues were analyzed by microcomputed tomography (micro‐CT), histomorphometry, immunohistochemistry (tartrate‐resistant Acid phosphatase [TRAP], receptor activator of nuclear factor‐κB ligand [RANKL], osteoprotegerin, cleaved caspase 3), and quanti...
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Effects of Locally Administered Tiludronic Acid on Experimental Periodontitis in Rats
Journal of periodontology, 2014Co-Authors: Flávia A.c. Furlaneto, Nara L.t. Nunes, Ivan Lima Oliveira Filho, Nicolly Parente Ribeiro Frota, Kely O. Yamamoto, Mario Roberto Pontes Lisboa, Edilson Ervolino, Mário Taba, Rodrigo Otavio Rego, Michel Reis MessoraAbstract:Background: It appears there are no studies evaluating the influence of the bisphosphonate Tiludronic Acid (TIL) on periodontitis. The purpose of this study is to evaluate via microtomographic, histopathologic, histometric, and immunohistochemical analyses the effects of local administration of TIL on ligature-induced periodontitis in rats.Methods: Forty-eight rats were divided into six groups: C (control), EP (experimental periodontitis), EP-Saline, EP-TIL0.1, EP-TIL0.3, and EP-TIL1. In EP, a ligature was placed around maxillary second molars. In EP-TIL0.1, EP-TIL0.3, and EP-TIL1, TIL solutions of 0.1, 0.3, and 1 mg/kg body weight, respectively, were injected into the subperiosteal palatal area adjacent to maxillary second molars every other day. EP-Saline received 0.9% NaCl solution instead. Animals were euthanized at day 11. Bone changes were evaluated by microtomographic and histometric analyses. Histopathologic analysis and immunohistochemical detection of tartrate-resistant Acid phosphatase (TRAP) w...
Antoine Lafuma - One of the best experts on this subject based on the ideXlab platform.
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An Economic Evaluation of Tiludronic Acid Treatment in Paget’s Disease of Bone
PharmacoEconomics, 1997Co-Authors: Antoine Lafuma, Francis Fagnani, Pierre J. MeunierAbstract:The objective of this study was to evaluate the long term comparative outcome of intermittent courses of therapy with low-dosage Tiludronic Acid (400 mg/day) versus etidronic Acid in patients with Paget’s disease of bone. The long term outcome was evaluated by means of a model, as the number of complications avoided during a 5-year period. Only major complications were considered (fractures of long bones, spinal cord dysfunction, osteoarthritis of the hip), which can be cured by adequate medical intervention, and may thus be valued in terms of direct costs. Deafness was not considered and was not valued. The various additional direct costs incurred (treatment and follow-up) and avoided (complications avoided) were assessed using an extrapolation model, based on the results of a clinical study. A standard costing methodology was used, according to the patterns of care currently in use in France. Costs were calculated from a societal perspective, including social security and private insurance fund reimbursements, and outof- pocket expenses. These were estimated in French francs (F; 1994 values). The estimated mean treatment cost per patient for the treatment of Paget’s disease and its complications over a 5-year period was F34 198 with etidronic Acid, and F30754 to F36422 w;th Tiludronic Acid, depending on whether an optimistic or a conservative view of the efficacy of Tiludronic Acid was assumed. Despite its higher acquisition cost, the use ofTiludronic Acid was less expensive in the treatment of Paget’s disease and its complications, compared with the use of etidronic Acid, when an optimistic view of the efficacy of Tiludronic Acid was assumed.
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An economic evaluation of Tiludronic Acid treatment in Paget's disease of bone.
PharmacoEconomics, 1997Co-Authors: Antoine Lafuma, Francis Fagnani, Pierre J. MeunierAbstract:The objective of this study was to evaluate the long term comparative outcome of intermittent courses of therapy with low-dosage Tiludronic Acid (400 mg/day) versus etidronic Acid in patients with Paget’s disease of bone.
Michel Reis Messora - One of the best experts on this subject based on the ideXlab platform.
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Effects of local administration of Tiludronic Acid on experimental periodontitis in diabetic rats.
Journal of periodontology, 2017Co-Authors: Nara L.t. Nunes, Mario Roberto Pontes Lisboa, Edilson Ervolino, Rodrigo Otavio Rego, Michel Reis Messora, Luiz F.f. Oliveira, Marina Costa Barcellos Garcia, Arthur B. Novaes, Sérgio Luis Scombatti De Souza, Flávia A.c. FurlanetoAbstract:Abstract Background Tiludronic Acid (TIL) presents antiresorptive and anti‐inflammatory properties and has not been evaluated in the periodontitis–diabetes mellitus (DM) association to date, to the best knowledge of the authors. This study evaluates effects of local administration of TIL on experimental periodontitis (EP) in rats with streptozotocin‐induced DM. Methods Thirty‐two animals (Rattus norvegicus albinus, Wistar) were divided into groups DM/C (Control), DM/EP, DM/EP/TIL1, and DM/EP/TIL3. In EP groups, a ligature was placed around mandibular first molars. In groups DM/EP/TIL1 and DM/EP/TIL3, TIL solutions (1 and 3 mg/kg, respectively) were injected into the gingival tissue of mandibular molars every other day for 10 days, until euthanasia. Periodontal tissues were analyzed by microcomputed tomography (micro‐CT), histomorphometry, immunohistochemistry (tartrate‐resistant Acid phosphatase [TRAP], receptor activator of nuclear factor‐κB ligand [RANKL], osteoprotegerin, cleaved caspase 3), and quanti...
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Effects of Locally Administered Tiludronic Acid on Experimental Periodontitis in Rats
Journal of periodontology, 2014Co-Authors: Flávia A.c. Furlaneto, Nara L.t. Nunes, Ivan Lima Oliveira Filho, Nicolly Parente Ribeiro Frota, Kely O. Yamamoto, Mario Roberto Pontes Lisboa, Edilson Ervolino, Mário Taba, Rodrigo Otavio Rego, Michel Reis MessoraAbstract:Background: It appears there are no studies evaluating the influence of the bisphosphonate Tiludronic Acid (TIL) on periodontitis. The purpose of this study is to evaluate via microtomographic, histopathologic, histometric, and immunohistochemical analyses the effects of local administration of TIL on ligature-induced periodontitis in rats.Methods: Forty-eight rats were divided into six groups: C (control), EP (experimental periodontitis), EP-Saline, EP-TIL0.1, EP-TIL0.3, and EP-TIL1. In EP, a ligature was placed around maxillary second molars. In EP-TIL0.1, EP-TIL0.3, and EP-TIL1, TIL solutions of 0.1, 0.3, and 1 mg/kg body weight, respectively, were injected into the subperiosteal palatal area adjacent to maxillary second molars every other day. EP-Saline received 0.9% NaCl solution instead. Animals were euthanized at day 11. Bone changes were evaluated by microtomographic and histometric analyses. Histopathologic analysis and immunohistochemical detection of tartrate-resistant Acid phosphatase (TRAP) w...