The Experts below are selected from a list of 6024 Experts worldwide ranked by ideXlab platform
Satchidananda Panda - One of the best experts on this subject based on the ideXlab platform.
-
Time-Restricted Feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption.
Nature communications, 2019Co-Authors: Jesús E Villanueva, Satchidananda Panda, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Uri Manor, Girish C. MelkaniAbstract:Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of body mass. Behavioral intervention that can counteract obesity arising from genetic, diet or circadian disruption and can improve muscle function holds untapped potential to combat the obesity epidemic. Here we show that Drosophila melanogaster (fruit fly) subject to obesogenic challenges exhibits metabolic disease phenotypes in skeletal muscle; sarcomere disorganization, mitochondrial deformation, upregulation of Phospho-AKT level, aberrant intramuscular lipid infiltration, and insulin resistance. Imposing Time-Restricted Feeding (TRF) paradigm in which flies were fed for 12 h during the day counteracts obesity-induced dysmetabolism and improves muscle performance by suppressing intramuscular fat deposits, Phospho-AKT level, mitochondrial aberrations, and markers of insulin resistance. Importantly, TRF was effective even in an irregular lighting schedule mimicking shiftwork. Hence, TRF is an effective dietary intervention for combating metabolic dysfunction arising from multiple causes.
-
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock.
Cell metabolism, 2018Co-Authors: Amandine Chaix, Terry Lin, Max W. Chang, Satchidananda PandaAbstract:Summary Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal Feeding-fasting cycle. We tested whether Time-Restricted Feeding (TRF) could prevent obesity and metabolic syndrome in whole-body Cry1;Cry2 and in liver-specific Bmal1 and Rev-erbα/β knockout mice. When provided access to food ad libitum , these mice rapidly gained weight and showed genotype-specific metabolic defects. However, when fed the same diet under TRF (food access Restricted to 10 hr during the dark phase) they were protected from excessive weight gain and metabolic diseases. Transcriptome and metabolome analyses showed that TRF reduced the accumulation of hepatic lipids and enhanced cellular defenses against metabolic stress. These results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in Feeding and fasting and by maintaining balance between nutrient and cellular stress responses.
-
Effects of 8-hour Time Restricted Feeding on body weight and metabolic disease risk factors in obese adults: A pilot study.
Nutrition and healthy aging, 2018Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A. VaradyAbstract:BACKGROUND Time Restricted Feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined. OBJECTIVE This study investigated the effects of 8-h Time Restricted Feeding on body weight and metabolic disease risk factors in obese adults. DESIGN Obese subjects (n = 23) participated in an 8-h Time Restricted Feeding intervention (ad libitum Feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (n = 23). RESULTS Body weight and energy intake decreased in the Time Restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (P
-
effects of 8 hour Time Restricted Feeding on body weight and metabolic disease risk factors in obese adults a pilot study
Nutrition and Healthy Aging, 2018Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Nicole Haggerty, Jeehee Song, Cynthia M Kroeger, John F Trepanowski, Satchidananda Panda, Krista A. VaradyAbstract:BACKGROUND Time Restricted Feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined. OBJECTIVE This study investigated the effects of 8-h Time Restricted Feeding on body weight and metabolic disease risk factors in obese adults. DESIGN Obese subjects (n = 23) participated in an 8-h Time Restricted Feeding intervention (ad libitum Feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Weight loss and other outcomes were compared to a matched historical control group (n = 23). RESULTS Body weight and energy intake decreased in the Time Restricted group (-2.6% ± 0.5; -341 ± 53 kcal/d) relative to controls over 12 weeks (P < 0.05). Systolic blood pressure decreased in the Time Restricted Feeding group (-7 ± 2 mm Hg) versus controls (P < 0.05). Fat mass, lean mass, visceral fat mass, diastolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, fasting glucose, fasting insulin, HOMA-IR, and homocysteine were not significantly different from controls after 12 weeks (no group×Time interaction). CONCLUSION These findings suggest that 8-h Time Restricted Feeding produces mild caloric restriction and weight loss, without calorie counting. It may also offer clinical benefits by reducing blood pressure.
-
Time Restricted Feeding for prevention and treatment of cardiometabolic disorders
The Journal of Physiology, 2017Co-Authors: Girish C. Melkani, Satchidananda PandaAbstract:The soaring prevalence of obesity and diabetes is associated with an increase in comorbidities, including elevated risk for cardiovascular diseases (CVDs). CVDs continue to be among the leading causes of death and disability in the United States. While increased nutritional intake from an energy-dense diet is known to disrupt metabolic homeostasis and contributes to the disease risk, circadian rhythm disruption is emerging as a new risk factor for CVD. Circadian rhythms coordinate cardiovascular health via temporal control of organismal metabolism and physiology. Thus, interventions that improve circadian rhythms are prospective entry points to mitigate cardiometabolic disease risk. Although light is a strong modulator of the neural circadian clock, Time of food intake is emerging as a dominant agent that affects circadian clocks in metabolic organs. We discovered that imposing a Time-Restricted Feeding (TRF) regimen in which all caloric intakes occur consistently within ≤ 12 h every day exerts many cardiometabolic benefits. TRF prevents excessive body weight gain, improves sleep, and attenuates age- and diet-induced deterioration in cardiac performance. Using an integrative approach that combines Drosophila melanogaster (fruit fly) genetics with transcriptome analyses it was found that the beneficial effects of TRF are mediated by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin and mitochondrial electron transport chain components. Parallel studies in rodents have shown TRF reduces metabolic disease risks by maintaining metabolic homeostasis. As modern humans continue to live under extended periods of wakefulness and ingestion events, daily eating pattern offers a new potential target for lifestyle intervention to reduce CVD risk.
Matthew J. Mcallister - One of the best experts on this subject based on the ideXlab platform.
-
Impact of Time Restricted Feeding on Fitness Variables in Professional Resistance Trained Firefighters
Journal of occupational and environmental medicine, 2021Co-Authors: Andrew E. Gonzalez, Hunter S. Waldman, Mark G. Abel, Kevin W. Mccurdy, Matthew J. McallisterAbstract:Firefighters are at an elevated risk for cardiometabolic disease and sudden cardiac death due to physiological and psychological stressors. Research suggests Time Restricted Feeding (TRF) may improve health and performance variables. This study investigated the effects of a 7-week TRF (14-hour fasting:10-hour eating window) on fitness variables related to physical health and performance among professional, resistance-trained firefighters. Several fitness variables were assessed pre- and post-TRF intervention. Relative and absolute ventilatory threshold (VT) increased (P < 0.05), relative and absolute , decreased (P < 0.05), and muscular strength, endurance, and power were not affected pre- versus post-intervention. Although , decreased, all other performance variables were not negatively impacted by TRF. Improvements in VT may be associated with improvements to markers of endurance exercise performance in firefighters, but more data are needed to confirm this hypothesis. Copyright © 2021 American College of Occupational and Environmental Medicine.
-
Impact of Time Restricted Feeding on Markers of Cardiometabolic Health and Oxidative Stress in Resistance-Trained Firefighters.
Journal of strength and conditioning research, 2020Co-Authors: Matthew J. Mcallister, Andrew E. Gonzalez, Hunter S. WaldmanAbstract:McAllister, MJ, Gonzalez, AE, and Waldman, HS. Impact of Time Restricted Feeding on markers of cardiometabolic health and oxidative stress in resistance-trained firefighters. J Strength Cond Res XX(X): 000-000, 2020-Firefighters are often exposed to numerous occupational stressors that cause inflammation, oxidative stress (OS), and elevated risk for developing cardiometabolic disease. Time-Restricted Feeding (TRF) has been shown to result in favorable changes in markers of inflammation and cardiometabolic health. This study investigated the impact of a 6-week TRF intervention (14:10; fasting:Feeding) in resistance-trained firefighters. Blood was analyzed for several markers of inflammation, OS, and cardiometabolic health: insulin, ghrelin, leptin, glucagon, adiponectin, resistin, advanced glycated end products (AGE), advanced oxidation protein products, total nitrite-nitrate levels, tumor necrosis factor-α, interleukin (IL)-6, IL-8, IL-10, as well as glucose and lipid levels. A graded exercise test was also conducted before and after the TRF intervention, and substrate oxidation rates were calculated and compared before and after the intervention. Comparisons pre and post TRF were determined with dependent t-tests. Time-Restricted Feeding resulted in significant reductions in advanced oxidation protein products (∼31%) and AGEs (∼25%); however, no other changes were found. These findings suggest that TRF may be a nutrition intervention aimed at improving some select markers of cardiometabolic health in firefighters, namely, by the reductions in advanced oxidation protein products and AGEs.
-
Time-Restricted Feeding improves markers of cardiometabolic health in physically active college-age men: a 4-week randomized pre-post pilot study
Nutrition research (New York N.Y.), 2019Co-Authors: Matthew J. Mcallister, Brandon L. Pigg, Liliana I Renteria, Hunter S. WaldmanAbstract:Abstract Time-Restricted Feeding (TRF) has been shown to improve body composition, blood lipids, and reduce markers of inflammation and oxidative stress. However, most of these studies come from rodent models and small human samples, and it is not clear if the benefits are dependent upon a caloric deficit, or the Time restriction nature of TRF. Based off of previous research, we hypothesized that humans following an ad libitum TRF protocol would reduce caloric intake and this caloric deficit would be associated with greater improvements in cardiometabolic health including blood pressure, body composition, blood lipids, and markers of inflammation and antioxidant status compared to an isocaloric TRF protocol. The purpose of this study was to: (1) examine the impact of TRF on markers of cardio-metabolic health and antioxidant status and (2) determine if the adaptations from TRF would differ under ad libitum compared to isocaloric conditions. Twenty-three healthy men were randomized to either an ad libitum or isocaloric 16:8 (fasting: Feeding) TRF protocol. A total of 22 men completed the 28-day TRF protocol (mean ± SD; age: 22 ± 2.5 yrs.; height: 178.4 ± 6.9 cm; weight: 90.3 ± 24 kg; BMI: 28.5 ± 8.3 kg/m2). Fasting blood samples were analyzed for glucose, lipids, as well as adiponectin, human growth hormone, insulin, cortisol, C-reactive protein, superoxide dismutase, total nitrate/nitrite, and glutathione. Time-Restricted Feeding in both groups was associated with significant (P
-
Time-Restricted Feeding for the prevention of cardiometabolic diseases in high-stress occupations: a mechanistic review.
Nutrition reviews, 2019Co-Authors: Hunter S. Waldman, Liliana I Renteria, Matthew J. McallisterAbstract:Factors such as shift work, poor diet, lack of physical activity, and irregular sleep patterns put men and women employed in high-stress occupations (e.g., firefighters, police officers) at risk for cardiometabolic diseases. Time-Restricted Feeding (TRF) is a new approach to combatting many of these diseases; it places an emphasis on when meals are consumed, rather than calorie content. By only manipulating the eating "window," and without changing the food composition of the diet, research in rodent models has shown promising results that have health implications in people, such as obesity prevention, improved insulin sensitivity, and decreased oxidative stress, inflammation, and cholesterol synthesis. Human trials remain limited and the current data are mixed with regard to TRF and improving health. Present findings suggest the timing of the Feeding-fasting window, with Feeding taking place in the waking hours and fasting in the evening hours, might offer the greatest benefit for improving cardiometabolic markers. Although additional human trials are needed, TRF might reset and synchronize metabolic "clocks" found throughout the body that are disturbed with obesity, shift work, and frequent eating. Therefore, TRF might offer an effective Feeding-fasting paradigm with significant clinical implications for the management and treatment of cardiometabolic diseases observed in individuals in high-stress occupations in the United States and in the US population in general. This review outlines the current rodent and human evidence in these areas and the efficacy of TRF for improving human health.
Hunter S. Waldman - One of the best experts on this subject based on the ideXlab platform.
-
Impact of Time Restricted Feeding on Fitness Variables in Professional Resistance Trained Firefighters
Journal of occupational and environmental medicine, 2021Co-Authors: Andrew E. Gonzalez, Hunter S. Waldman, Mark G. Abel, Kevin W. Mccurdy, Matthew J. McallisterAbstract:Firefighters are at an elevated risk for cardiometabolic disease and sudden cardiac death due to physiological and psychological stressors. Research suggests Time Restricted Feeding (TRF) may improve health and performance variables. This study investigated the effects of a 7-week TRF (14-hour fasting:10-hour eating window) on fitness variables related to physical health and performance among professional, resistance-trained firefighters. Several fitness variables were assessed pre- and post-TRF intervention. Relative and absolute ventilatory threshold (VT) increased (P < 0.05), relative and absolute , decreased (P < 0.05), and muscular strength, endurance, and power were not affected pre- versus post-intervention. Although , decreased, all other performance variables were not negatively impacted by TRF. Improvements in VT may be associated with improvements to markers of endurance exercise performance in firefighters, but more data are needed to confirm this hypothesis. Copyright © 2021 American College of Occupational and Environmental Medicine.
-
Impact of Time Restricted Feeding on Markers of Cardiometabolic Health and Oxidative Stress in Resistance-Trained Firefighters.
Journal of strength and conditioning research, 2020Co-Authors: Matthew J. Mcallister, Andrew E. Gonzalez, Hunter S. WaldmanAbstract:McAllister, MJ, Gonzalez, AE, and Waldman, HS. Impact of Time Restricted Feeding on markers of cardiometabolic health and oxidative stress in resistance-trained firefighters. J Strength Cond Res XX(X): 000-000, 2020-Firefighters are often exposed to numerous occupational stressors that cause inflammation, oxidative stress (OS), and elevated risk for developing cardiometabolic disease. Time-Restricted Feeding (TRF) has been shown to result in favorable changes in markers of inflammation and cardiometabolic health. This study investigated the impact of a 6-week TRF intervention (14:10; fasting:Feeding) in resistance-trained firefighters. Blood was analyzed for several markers of inflammation, OS, and cardiometabolic health: insulin, ghrelin, leptin, glucagon, adiponectin, resistin, advanced glycated end products (AGE), advanced oxidation protein products, total nitrite-nitrate levels, tumor necrosis factor-α, interleukin (IL)-6, IL-8, IL-10, as well as glucose and lipid levels. A graded exercise test was also conducted before and after the TRF intervention, and substrate oxidation rates were calculated and compared before and after the intervention. Comparisons pre and post TRF were determined with dependent t-tests. Time-Restricted Feeding resulted in significant reductions in advanced oxidation protein products (∼31%) and AGEs (∼25%); however, no other changes were found. These findings suggest that TRF may be a nutrition intervention aimed at improving some select markers of cardiometabolic health in firefighters, namely, by the reductions in advanced oxidation protein products and AGEs.
-
Time-Restricted Feeding improves markers of cardiometabolic health in physically active college-age men: a 4-week randomized pre-post pilot study
Nutrition research (New York N.Y.), 2019Co-Authors: Matthew J. Mcallister, Brandon L. Pigg, Liliana I Renteria, Hunter S. WaldmanAbstract:Abstract Time-Restricted Feeding (TRF) has been shown to improve body composition, blood lipids, and reduce markers of inflammation and oxidative stress. However, most of these studies come from rodent models and small human samples, and it is not clear if the benefits are dependent upon a caloric deficit, or the Time restriction nature of TRF. Based off of previous research, we hypothesized that humans following an ad libitum TRF protocol would reduce caloric intake and this caloric deficit would be associated with greater improvements in cardiometabolic health including blood pressure, body composition, blood lipids, and markers of inflammation and antioxidant status compared to an isocaloric TRF protocol. The purpose of this study was to: (1) examine the impact of TRF on markers of cardio-metabolic health and antioxidant status and (2) determine if the adaptations from TRF would differ under ad libitum compared to isocaloric conditions. Twenty-three healthy men were randomized to either an ad libitum or isocaloric 16:8 (fasting: Feeding) TRF protocol. A total of 22 men completed the 28-day TRF protocol (mean ± SD; age: 22 ± 2.5 yrs.; height: 178.4 ± 6.9 cm; weight: 90.3 ± 24 kg; BMI: 28.5 ± 8.3 kg/m2). Fasting blood samples were analyzed for glucose, lipids, as well as adiponectin, human growth hormone, insulin, cortisol, C-reactive protein, superoxide dismutase, total nitrate/nitrite, and glutathione. Time-Restricted Feeding in both groups was associated with significant (P
-
Time-Restricted Feeding for the prevention of cardiometabolic diseases in high-stress occupations: a mechanistic review.
Nutrition reviews, 2019Co-Authors: Hunter S. Waldman, Liliana I Renteria, Matthew J. McallisterAbstract:Factors such as shift work, poor diet, lack of physical activity, and irregular sleep patterns put men and women employed in high-stress occupations (e.g., firefighters, police officers) at risk for cardiometabolic diseases. Time-Restricted Feeding (TRF) is a new approach to combatting many of these diseases; it places an emphasis on when meals are consumed, rather than calorie content. By only manipulating the eating "window," and without changing the food composition of the diet, research in rodent models has shown promising results that have health implications in people, such as obesity prevention, improved insulin sensitivity, and decreased oxidative stress, inflammation, and cholesterol synthesis. Human trials remain limited and the current data are mixed with regard to TRF and improving health. Present findings suggest the timing of the Feeding-fasting window, with Feeding taking place in the waking hours and fasting in the evening hours, might offer the greatest benefit for improving cardiometabolic markers. Although additional human trials are needed, TRF might reset and synchronize metabolic "clocks" found throughout the body that are disturbed with obesity, shift work, and frequent eating. Therefore, TRF might offer an effective Feeding-fasting paradigm with significant clinical implications for the management and treatment of cardiometabolic diseases observed in individuals in high-stress occupations in the United States and in the US population in general. This review outlines the current rodent and human evidence in these areas and the efficacy of TRF for improving human health.
Yi Liu - One of the best experts on this subject based on the ideXlab platform.
-
impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by Time Restricted Feeding
Chinese Science Bulletin, 2020Co-Authors: Zhihui Zhang, Qiaocheng Zhai, Tao Zhang, Zhengyun Huang, Zhiwei Liu, Yi LiuAbstract:The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-Restricted Feeding (TRF) has potential as a preventative or therapeutic approach against many diseases. The potential side effects of TRF remain unknown. Here we show that daily 4-h TRF treatment in mice can severely impair body temperature homeostasis and can result in lethality. Nearly half of the mice died at 21 °C, and all mice died at 18 °C during 4-h TRF. This effect was modulated by the circadian clock and was associated with severe hypothermia due to loss of body temperature homeostasis. Remarkably, disrupting the circadian clock by SCN lesions or constant light rescued lethality during TRF. Analysis of circadian gene expression in the dorsomedial hypothalamus (DMH) demonstrated that TRF reprograms rhythmic transcriptome in DMH and suppresses expression of genes, such as Ccr5 and Calcrl, which are involved in thermoregulation. Together, our results demonstrated a potent effect of TRF on body temperature homeostasis and the role of SCN function in this process. Our results further suggested that circadian arrhythmicity can have potential beneficial effects under certain stress conditions.
-
Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by Time-Restricted Feeding.
Science bulletin, 2020Co-Authors: Zhihui Zhang, Qiaocheng Zhai, Tao Zhang, Zhengyun Huang, Zhiwei Liu, Yi LiuAbstract:The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-Restricted Feeding (TRF) has potential as a preventative or therapeutic approach against many diseases. The potential side effects of TRF remain unknown. Here we show that a 4-hour TRF stimulus in mice can severely impair body temperature homeostasis and can result in lethality. Nearly half of the mice died at 21 °C, and all mice died at 18 °C during 4-hour TRF. Moreover, this effect was modulated by the circadian clock and was associated with severe hypothermia due to loss of body temperature homeostasis, which is different from "torpor", an adaptive response under food deprivation. Disrupting the circadian clock by the SCN lesions or a non-invasive method (constant light) which disrupts circadian clock rescued lethality during TRF. Analysis of circadian gene expression in the dorsomedial hypothalamus (DMH) demonstrated that TRF reprograms rhythmic transcriptome in DMH and suppresses expression of genes, such as Ccr5 and Calcrl, which are involved in thermoregulation. We demonstrate a side effect of 4-hour TRF on the homeostasis of body temperature and a rescue function by impairing the SCN function. Altogether, our results suggested that constructing a circadian arrhythmicity may have a beneficial effect on the host response to an acute stress.
Krista A. Varady - One of the best experts on this subject based on the ideXlab platform.
-
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Cell metabolism, 2020Co-Authors: Sofia Cienfuegos, Kelsey Gabel, Faiza Kalam, Mark Ezpeleta, Eric Wiseman, Vasiliki Pavlou, Shuhao Lin, Manoela Lima Oliveira, Krista A. VaradyAbstract:Summary Time-Restricted Feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (∼3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by ∼550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health.
-
The Effect of 6- h and 8-h Time Restricted Feeding on Body Weight, Glucoregulatory Factors, IGF-1 and IGFBP-3 in Adults with Obesity
Current Developments in Nutrition, 2020Co-Authors: Kelsey Gabel, Sofia Cienfuegos, Faiza Kalam, Mark Ezpeleta, Krista A. VaradyAbstract:Abstract Objectives Time Restricted Feeding is a novel approach to intermittent fasting which includes a 6–10 hour Feeding window and a 14–18 hour fasting window daily. Some forms of intermittent fasting have resulted in improvement in IGF-1 and IGFBP-3 in mice. These factors may affect cancer risk and cancer progression after diagnosis. However, effect in humans remains unknown. This exploratory analysis examined the effect of 12 weeks of 8-hour Time-Restricted Feeding (10:00–18:00) and 8 weeks of 6-hour Time-Restricted Feeding (12:00–18:00) versus a control in adults with obesity. Methods Participants with obesity (n = 24) participated in either an 8-h Time Restricted Feeding intervention (ad libitum Feeding between 10:00–6:00 pm) for 12 weeks or a 6-h Time Restricted Feeding intervention (ad libitum Feeding between 1:00–700 pm) for 8 weeks. Data for two Time-Restricted Feeding trials were combined for this exploratory analysis and compared to a no intervention control group with obesity (n = 8). Weight loss, glucose regulatory factors, IGF-1 and IGFBP3 were measured. Results Body weight decreased significantly more in the 6-h (−2.82 ± 0.05 kg) and the 8-h (−2.77 ± 0.50 kg) groups than the controls (p < 0.001). Fat mass decreased significantly more in the 6-h (−1.5 ± 0.2 kg) and the 8-h (−1.5 ± 0.4 kg) groups than the controls (p = 0.016). Lean mass decreased significantly more in the 6-h group (−1.8 ± 0.2 kg) than the 8-h (p = .005) and the controls (p = .004). HOMA-IR decreased significantly more in the 8-h group (−0.3 ± 0.1 units) than the control group (p = 0.38). There was no difference in HOMA-IR (measure of insulin resistance) between the 6-h group (−.01 ± 0.3 units) and either the 8-h or the control groups (p = 0.91 and p = 0.86). Fasting insulin decreased significantly more in the 8-h group (−1.2 ± 0.6 uIU/ml) than control group (p = .033). There was no difference in change in insulin between the 8-h and 6-h groups (p = .952). No changes were seen in glucose, IGF-1 (8-h: −3.04 ± 13.49 ng/mL, 6-h: −0.42 ± 16.96 ng/mL) or IGFBP-3 (8-h: 0.17 ± 0.15 ng/mL, 6-h: 0.18 ± 0.07 ng/mL). Conclusions These findings suggest that 6-h and 8-h Time-Restricted Feeding produce mild weight and fat loss as well as glucoregulatory improvement. It is unclear if Time Restricted Feeding effects the cancer promoting biomarkers, IGF-1 and IGFBP3. Funding Sources University of Illinois at Chicago.
-
Safety of 8-h Time Restricted Feeding in Adults with Obesity (FS18-05-19)
Current Developments in Nutrition, 2019Co-Authors: Kelsey Gabel, Krista A. VaradyAbstract:Abstract Objectives Time Restricted Feeding (TRF) is a novel approach to intermittent fasting which includes a 4–10 hour Feeding window and a 14–20 hour fasting window daily. However, the safety of TRF has yet to be determined. This study was undertaken to determine the effects of TRF on certain safety parameters, including: eating disorder symptoms, body image perception, complete blood count, resting metabolic rate, and frequency of adverse events, in adults with obesity. Methods Adults with obesity (n = 23) participated in an 8-h TRF intervention (ad libitum Feeding between 10:00 to 18:00 h, water fasting between 18:00 to 10:00 h) for 12 weeks. Results Body weight significantly (P < 0.001) decreased by 2.6 ± 0.5% after 12 weeks of TRF. Resting metabolic rate did not change over Time (baseline: 1431 ± 62 kcal/d; week 1: 1393 ± 82 kcal/d; week 12: 1318 ± 61 kcal/d). Self-reported adverse events (gastrointestinal or neurological) did not change over Time. Eating disorder symptoms including depression, binge eating, purgative behavior, fear of fatness, restrictive eating, and avoidance of forbidden foods, did not change from baseline to week 12. Concerns about body size and shape remained unchanged. Cognitive restraint, uncontrolled eating and emotional eating did not change over Time. There were no significant changes in any of the complete blood count parameters from baseline to week 12. Conclusions This study is the first to show that TRF is a safe diet therapy for weight loss as it does not negatively impact eating disorder symptoms, eating behaviors, resting metabolic rate, or measures of overall health, such as complete blood count. Funding Sources University of Illinois Chicago Campus Research Board Pilot Grant; NIH T32HL007909.
-
Effect of 8-h Time-Restricted Feeding on sleep quality and duration in adults with obesity.
Applied physiology nutrition and metabolism = Physiologie appliquee nutrition et metabolisme, 2019Co-Authors: Kelsey Gabel, Kristin K. Hoddy, Helen J. Burgess, Krista A. VaradyAbstract:This study examined the effects of Time-Restricted Feeding (TRF; 8-h Feeding window/16-h fasting window daily) on sleep. Obese adults (n = 23) followed 8-h TRF for 12 weeks. Pittsburgh Sleep Quality Index (PSQI) total score was below 5 at week 1 (4.7 ± 0.5) and week 12 (4.8 ± 0.7), indicating good sleep quality throughout the trial. Subjective measures of wake Time, bedTime, and sleep duration remained unchanged. Findings from this secondary analysis indicate that TRF does not alter sleep quality or duration in subjects with obesity. Novelty This study is the first to show that TRF (8-h Feeding window/16-h fasting window daily) does not alter sleep quality or duration in subjects with obesity.
-
Time Restricted Feeding and risk of metabolic disease a review of human and animal studies
Nutrition Reviews, 2014Co-Authors: Jeffrey M. Rothschild, Kristin K. Hoddy, Pera Jambazian, Krista A. VaradyAbstract:Time-Restricted Feeding (TRF), a key component of intermittent fasting regimens, has gained considerable attention in recent years. TRF allows ad libitum energy intake within controlled Time frames, generally a 3–12 hour range each day. The impact of various TRF regimens on indicators of metabolic disease risk has yet to be investigated. Accordingly, the objective of this review was to summarize the current literature on the effects of TRF on body weight and markers of metabolic disease risk (i.e., lipid, glucoregulatory, and inflammatory factors) in animals and humans. Results from animal studies show TRF to be associated with reductions in body weight, total cholesterol, and concentrations of triglycerides, glucose, insulin, interleukin 6, and tumor necrosis factor-α as well as with improvements in insulin sensitivity. Human data support the findings of animal studies and demonstrate decreased body weight (though not consistently), lower concentrations of triglycerides, glucose, and low-density lipoprotein cholesterol, and increased concentrations of high-density lipoprotein cholesterol. These preliminary findings show promise for the use of TRF in modulating a variety of metabolic disease risk factors.