The Experts below are selected from a list of 4980 Experts worldwide ranked by ideXlab platform
Maged Younes - One of the best experts on this subject based on the ideXlab platform.
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Dioxins: WHO’s Tolerable Daily Intake (TDI) revisited
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
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Dioxins: WHO's Tolerable Daily Intake (TDI) revisited.
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
F.x.rolaf Van Leeuwen - One of the best experts on this subject based on the ideXlab platform.
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Dioxins: WHO’s Tolerable Daily Intake (TDI) revisited
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
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Dioxins: WHO's Tolerable Daily Intake (TDI) revisited.
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
A G Renwick - One of the best experts on this subject based on the ideXlab platform.
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The Use of an Additional Safety or Uncertainty Factor for Nature of Toxicity in the Estimation of Acceptable Daily Intake and Tolerable Daily Intake Values
Regulatory toxicology and pharmacology : RTP, 1995Co-Authors: A G RenwickAbstract:Abstract The use of a safety factor specifically for nature of toxicity by different advisory and regulatory bodies has been reviewed. The main reasons for the application of such a factor were the detection of carcinogenicity for nongenotoxic chemicals and teratogenicity. Inconsistencies and discrepancies were found between different advisory bodies and by the same body when considering the databases for different chemicals. In some cases the extra safety factor for nature of toxicity was applied specifically to the no-observed-adverse-effect-level (NOAEL) for the toxicity endpoint which triggered the use of the extra factor. However, in many cases the extra factor was applied when the NOAEL used to calculate the Tolerable Daily Intake (TDI) was for an unrelated toxicity, sometimes in a different species. If a safety factor for nature of toxicity is to be used, then logically it should be applied to the NOAEL for the toxicity which resulted in its use; the TDI should be calculated for different toxicity endpoints using the total safety/uncertainty factor appropriate for each endpoint. The TDI adopted would then be the lowest of those calculated for different endpoints.
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an analysis of the risk of exceeding the acceptable or Tolerable Daily Intake
Regulatory Toxicology and Pharmacology, 1993Co-Authors: A G Renwick, R WalkerAbstract:The acceptable or Tolerable Daily Intake (ADI or TDI) for food additives and contaminants is usually derived from chronic animal toxicity studies. The basis for the ADI or TDI is the determination of the no-observed effect level (NOEL) for the most sensitive toxicological effect in the most sensitive laboratory species. This "safe Intake" for animals is then divided by a safety or uncertainty factor to allow for possible differences between the test species and humans and for possible differences within the human population. Therefore, the ADI or TDI is related to a toxic effect in the test species which is considered to be of relevance to humans. Any risk to humans who exceeded the ADI or TDI can only be assessed by reference to the dose-response for the toxicity giving rise to the NOEL. The duration of a human Intake in excess of the ADI should also be considered in relation to the protocol used in such animal studies.
Mark Feeley - One of the best experts on this subject based on the ideXlab platform.
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Methylmercury blood guidance values for Canada.
Canadian journal of public health = Revue canadienne de sante publique, 2010Co-Authors: Melissa Legrand, Mark Feeley, Constantine Tikhonov, Deborah Schoen, Angela Li-mullerAbstract:Exposure to methylmercury (MeHg) from fish and marine mammal consumption continues to present a public health concern. To date, developmental neurotoxicity is the most sensitive health outcome, forming the basis for health-risk assessments and the derivation of biomonitoring guidance values. This article summarizes existing Health Canada MeHg blood guidance values for general population and expands them to include a harmonized provisional interim blood guidance value of 8 µg/L based on the existing provisional Tolerable Daily Intake for children, pregnant women and women of childbearing age. Associated public health actions, according to age, sex, and level of exposure are recommended.
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Dioxins: WHO’s Tolerable Daily Intake (TDI) revisited
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
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Dioxins: WHO's Tolerable Daily Intake (TDI) revisited.
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
Dieter Schrenk - One of the best experts on this subject based on the ideXlab platform.
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Dioxins: WHO’s Tolerable Daily Intake (TDI) revisited
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
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Dioxins: WHO's Tolerable Daily Intake (TDI) revisited.
Chemosphere, 2000Co-Authors: F.x.rolaf Van Leeuwen, Mark Feeley, Dieter Schrenk, John Christian Larsen, William H. Farland, Maged YounesAbstract:In December 1990, the World Health Organization (WHO) established a Tolerable Daily Intake (TDI) of 10 pg/kg b.w. (body weight) for TCDD, based on liver toxicity, reproductive effects and immunotoxicity in experimental animals, and making use of kinetic data in humans and experimental animals. Since then new epidemiological and toxicological data have emerged, in particular with respect to neurodevelopmental and endocrine effects of dioxin. Therefore, the European Centre for Environment and Health of the World Health Organization (WHO-ECEH) and the International Programme on Chemical Safety (IPCS) jointly organized a consultation on the "Assessment of the health risk of dioxins: re-evaluation of the TDI", May 1998, Geneva, Switzerland. The participants discussed the health risks for infants, cancer and non-cancer endpoints in humans and animals, mechanistic aspects, kinetic behaviour, modelling, exposure, and the applicability of the toxic equivalency (TEQ) concept. For the health risk assessment of dioxin-like compounds, the WHO Consultation focused on the most sensitive effects that are considered adverse (hormonal, reproductive and developmental effects) seen at low doses in animal studies (rats and monkeys). Human Daily Intakes corresponding with body burdens similar to those associated with adverse effects in animals could be estimated to be in the range of 14-37 pg/kg b.w./day. To arrive at a TDI expressed as TEQ, a composite uncertainty factor of 10 was recommended. By applying this uncertainty factor a TDI range of 1-4 pg TEQs/kg body weight was established. An extensive executive summary of the results of this WHO Consultation with all the underlying background documents will be published in Food Additives and Contaminants (in press).
