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Lesley E. Rhodes - One of the best experts on this subject based on the ideXlab platform.
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Tomato Paste rich in lycopene protects against cutaneous photodamage in humans in vivo a randomized controlled trial
British Journal of Dermatology, 2011Co-Authors: M Rizwan, Andrew Harbottle, I Rodriguezblanco, Mark A Birchmachin, Rachel E B Watson, Lesley E. RhodesAbstract:Summary Background Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. Objectives We examined whether Tomato Paste – rich in lycopene, a powerful antioxidant – can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. Methods In a randomized controlled study, 20 healthy women (median age 33 years, range 21–47; phototype I/II) ingested 55 g Tomato Paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 × MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. Results Mean ± SD erythemal D30 was significantly higher following Tomato Paste vs. control (baseline, 26·5 ± 7·5 mJ cm−2; control, 23 ± 6·6 mJ cm−2; Tomato Paste, 36·6 ± 14·7 mJ cm−2; P = 0·03), while the MED was not significantly different between groups (baseline, 35·1 ± 9·9 mJ cm−2; control, 32·6 ± 9·6 mJ cm−2; Tomato Paste, 42·2 ± 11·3 mJ cm−2). Presupplementation, UVR induced an increase in MMP-1 (P = 0·01) and a reduction in fibrillin-1 (P = 0·03). Postsupplementation, UVR-induced MMP-1 was reduced in the Tomato Paste vs. control group (P = 0·04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following Tomato Paste (P = 0·05). mtDNA 3895-bp deletion following 3 × MED UVR was significantly reduced postsupplementation with Tomato Paste (P = 0·01). Conclusions Tomato Paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.
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Tomato Paste rich in lycopene protects against cutaneous photodamage in humans in vivo.
British Journal of Dermatology, 2010Co-Authors: M Rizwan, I Rodriguez-blanco, Andrew Harbottle, Mark A. Birch-machin, Watson Reb., Lesley E. RhodesAbstract:Summary Background Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. Objectives We examined whether Tomato Paste – rich in lycopene, a powerful antioxidant – can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. Methods In a randomized controlled study, 20 healthy women (median age 33 years, range 21–47; phototype I/II) ingested 55 g Tomato Paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 × MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. Results Mean ± SD erythemal D30 was significantly higher following Tomato Paste vs. control (baseline, 26·5 ± 7·5 mJ cm−2; control, 23 ± 6·6 mJ cm−2; Tomato Paste, 36·6 ± 14·7 mJ cm−2; P = 0·03), while the MED was not significantly different between groups (baseline, 35·1 ± 9·9 mJ cm−2; control, 32·6 ± 9·6 mJ cm−2; Tomato Paste, 42·2 ± 11·3 mJ cm−2). Presupplementation, UVR induced an increase in MMP-1 (P = 0·01) and a reduction in fibrillin-1 (P = 0·03). Postsupplementation, UVR-induced MMP-1 was reduced in the Tomato Paste vs. control group (P = 0·04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following Tomato Paste (P = 0·05). mtDNA 3895-bp deletion following 3 × MED UVR was significantly reduced postsupplementation with Tomato Paste (P = 0·01). Conclusions Tomato Paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.
Ingvild Paur - One of the best experts on this subject based on the ideXlab platform.
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Tomato Paste alters nf κb and cancer related mrna expression in prostate cancer cells xenografts and xenograft microenvironment
Nutrition and Cancer, 2015Co-Authors: Marit Kolberg, Sigrid Pedersen, Nasser E Bastani, Harald Carlsen, Rune Blomhoff, Ingvild PaurAbstract:Tomatoes may protect against prostate cancer development, possibly through targeting signaling pathways such as nuclear factor-κB (NF-κB). We investigated whether Tomato Paste could modulate NF-κB activity and cancer-related gene expression in human derived prostate cancer cells (PC3) and PC3 xenografts. PC3-cells were stably transduced with an NF-κB-luciferase construct, and treated with Tomato extracts or vehicle control. Nude mice bearing PC3 xenografts were fed a Western-like diet with or without 10% Tomato Paste for 6.5 wk. The Tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultured PC3 cells, and modulated the expression of genes associated with inflammation, apoptosis, and cancer progression. Accumulation of lycopene occurred in liver, xenografts, and serum of mice fed Tomato diet. Tomato Paste in the diet did not affect tumor size in mice; however, there was a trend toward inhibition of NF-κB activity in the xenografts. The effect of Tomato on gene expression was most prominent in the xenograft microenvironment, where among others NFKB2, STAT3, and STAT6 showed higher expression levels after Tomato treatment. Our findings support biological activity of Tomatoes in cancer-related inflammation.
M Rizwan - One of the best experts on this subject based on the ideXlab platform.
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Tomato Paste rich in lycopene protects against cutaneous photodamage in humans in vivo a randomized controlled trial
British Journal of Dermatology, 2011Co-Authors: M Rizwan, Andrew Harbottle, I Rodriguezblanco, Mark A Birchmachin, Rachel E B Watson, Lesley E. RhodesAbstract:Summary Background Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. Objectives We examined whether Tomato Paste – rich in lycopene, a powerful antioxidant – can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. Methods In a randomized controlled study, 20 healthy women (median age 33 years, range 21–47; phototype I/II) ingested 55 g Tomato Paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 × MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. Results Mean ± SD erythemal D30 was significantly higher following Tomato Paste vs. control (baseline, 26·5 ± 7·5 mJ cm−2; control, 23 ± 6·6 mJ cm−2; Tomato Paste, 36·6 ± 14·7 mJ cm−2; P = 0·03), while the MED was not significantly different between groups (baseline, 35·1 ± 9·9 mJ cm−2; control, 32·6 ± 9·6 mJ cm−2; Tomato Paste, 42·2 ± 11·3 mJ cm−2). Presupplementation, UVR induced an increase in MMP-1 (P = 0·01) and a reduction in fibrillin-1 (P = 0·03). Postsupplementation, UVR-induced MMP-1 was reduced in the Tomato Paste vs. control group (P = 0·04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following Tomato Paste (P = 0·05). mtDNA 3895-bp deletion following 3 × MED UVR was significantly reduced postsupplementation with Tomato Paste (P = 0·01). Conclusions Tomato Paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.
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Tomato Paste rich in lycopene protects against cutaneous photodamage in humans in vivo.
British Journal of Dermatology, 2010Co-Authors: M Rizwan, I Rodriguez-blanco, Andrew Harbottle, Mark A. Birch-machin, Watson Reb., Lesley E. RhodesAbstract:Summary Background Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. Objectives We examined whether Tomato Paste – rich in lycopene, a powerful antioxidant – can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. Methods In a randomized controlled study, 20 healthy women (median age 33 years, range 21–47; phototype I/II) ingested 55 g Tomato Paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 × MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. Results Mean ± SD erythemal D30 was significantly higher following Tomato Paste vs. control (baseline, 26·5 ± 7·5 mJ cm−2; control, 23 ± 6·6 mJ cm−2; Tomato Paste, 36·6 ± 14·7 mJ cm−2; P = 0·03), while the MED was not significantly different between groups (baseline, 35·1 ± 9·9 mJ cm−2; control, 32·6 ± 9·6 mJ cm−2; Tomato Paste, 42·2 ± 11·3 mJ cm−2). Presupplementation, UVR induced an increase in MMP-1 (P = 0·01) and a reduction in fibrillin-1 (P = 0·03). Postsupplementation, UVR-induced MMP-1 was reduced in the Tomato Paste vs. control group (P = 0·04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following Tomato Paste (P = 0·05). mtDNA 3895-bp deletion following 3 × MED UVR was significantly reduced postsupplementation with Tomato Paste (P = 0·01). Conclusions Tomato Paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.
Suradeep Basak - One of the best experts on this subject based on the ideXlab platform.
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shelf life extension of Tomato Paste through organoleptically acceptable concentration of betel leaf essential oil under accelerated storage environment
Journal of Food Science, 2018Co-Authors: Suradeep BasakAbstract:This study was attempted with two objectives: (1) to find an acceptable concentration of betel leaf essential oil (BLEO) based on sensory evaluation that can be employed in Tomato Paste; (2) to evaluate the effect of the acceptable concentration of BLEO in the Paste during accelerated storage under 89 ± 1.2% RH at 39 ± 1 °C. Linguistic data obtained from sensory evaluation of Tomato Paste treated with 4 different concentrations of BLEO were analyzed using fuzzy logic approach. The organoleptically acceptable concentration was determined to be 0.25 mg/g of BLEO in Tomato Paste. The effect of the selected concentration of BLEO on different physicochemical and microbial attributes of Tomato Paste during accelerated storage was studied. Untreated Tomato Paste was found to have 12% less total antioxidant capacity than treated Paste at the end of storage. Based on a*/b*value in CIELAB color space, the BLEO treated Paste efficiently extended the shelf life by 14 days with respect to untreated Paste samples under accelerated storage conditions. BLEO comes with a tag contributing to green consumerism, and its application as food preservative is no less than a value addition to the product. Essential oil is considered to have promising potential as an alternative food preservative, and its use is practically possible if they could overcome the sensory barrier, while retaining the preservative potency. The importance of identifying the sensory attributes for commercial success of essential oil treated food product was considered in this study. It contributes to the potency of organoleptically acceptable concentration of BLEO in shelf life extension of Tomato Paste under accelerated storage conditions. At industrial level, the estimated shelf life of treated Tomato Paste can be increased by incorporating more hurdles alongside BLEO.
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betel leaf piper betle l essential oil microemulsion characterization and antifungal activity on growth and apparent lag time of aspergillus flavus in Tomato Paste
Lwt - Food Science and Technology, 2017Co-Authors: Suradeep Basak, Proshanta GuhaAbstract:Abstract The present study aimed at characterization of betel leaf ( Piper betle L.) essential oil based microemulsion (BLEO-ME) and modelling its effect on growth of Aspergillus flavus in Tomato Paste. The microemulsion was formulated using betel leaf essential oil, Tween 20 and water by low energy emulsification method. The average droplet size of formulated emulsions having different concentration of surfactant (5%, 10% and 15%) and BLEO (2.5%, 5% and 10%) was evaluated. The formulated BLEO-ME was observed to be kinetically and thermodynamically stable for at least 90 days at 4 °C. Primary modelling estimated maximum growth rate ( μ max ) and apparent lag time ( λ ) of the selected mould in Tomato Paste. Secondary modelling was performed to evaluate the effect of different concentration of BLEO on estimated growth parameters. Estimated E max (minimum concentration of oil at which mould growth was inhibited) and MIC (minimum inhibitory concentration of BLEO at which lag time is infinite) value against A. flavus was estimated to be 2.01 ppm and 3.55 ppm in Tomato Paste, respectively. Accuracy and bias factor of the fitted secondary models suggested good similarity between observed and estimated values of μ max and λ . The formulated BLEO-ME exhibited antifungal efficacy in Tomato Paste, which suggests its potential as natural preservative.
Marit Kolberg - One of the best experts on this subject based on the ideXlab platform.
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Tomato Paste alters nf κb and cancer related mrna expression in prostate cancer cells xenografts and xenograft microenvironment
Nutrition and Cancer, 2015Co-Authors: Marit Kolberg, Sigrid Pedersen, Nasser E Bastani, Harald Carlsen, Rune Blomhoff, Ingvild PaurAbstract:Tomatoes may protect against prostate cancer development, possibly through targeting signaling pathways such as nuclear factor-κB (NF-κB). We investigated whether Tomato Paste could modulate NF-κB activity and cancer-related gene expression in human derived prostate cancer cells (PC3) and PC3 xenografts. PC3-cells were stably transduced with an NF-κB-luciferase construct, and treated with Tomato extracts or vehicle control. Nude mice bearing PC3 xenografts were fed a Western-like diet with or without 10% Tomato Paste for 6.5 wk. The Tomato diet significantly inhibited TNFα stimulated NF-κB activity in cultured PC3 cells, and modulated the expression of genes associated with inflammation, apoptosis, and cancer progression. Accumulation of lycopene occurred in liver, xenografts, and serum of mice fed Tomato diet. Tomato Paste in the diet did not affect tumor size in mice; however, there was a trend toward inhibition of NF-κB activity in the xenografts. The effect of Tomato on gene expression was most prominent in the xenograft microenvironment, where among others NFKB2, STAT3, and STAT6 showed higher expression levels after Tomato treatment. Our findings support biological activity of Tomatoes in cancer-related inflammation.