The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Keiichi Sasaki - One of the best experts on this subject based on the ideXlab platform.
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Root development of rat Tooth germs implanted in the Tooth Socket and in the subcutaneous tissue.
Oral diseases, 2008Co-Authors: Y Ina, Yasuyuki Sasano, N. Akiba, Kouki Hatori, Takahiro Honma, Keiichi SasakiAbstract:Objective: This study was designed to investigate root development of a rat Tooth germ implanted in a Tooth Socket or in a subcutaneous region. Materials and methods: Tooth germs of the upper left first molars in 2-week-old rats were extracted and implanted in the original Tooth Socket or in the subcutaneous region of the back. The upper right first molar was used as a control. The rats were fixed in weeks 1, 2, 4, 8 and 12. The root development was examined quantitatively with X-ray radiographic morphometry. The cellular activity of producing matrix proteins was assessed using in situ hybridization for type I collagen. Results: Root development was observed in the implanted teeth in the Tooth Socket as also in the control teeth. In contrast, roots hardly developed in subcutaneously implanted teeth. Histology showed that periodontal ligaments were arranged around roots of implanted teeth in the Tooth Socket as around control teeth, but few periodontal ligaments were identified in the subcutaneous implantation. Dentin and cementum formed in both the implanted teeth as also in the control teeth and odontoblasts, cementoblasts and cementocytes expressed type I collagen. Conclusion: Tooth Sockets may possess specific environments that allow root development of a Tooth germ.
Ljubomir Todorovic - One of the best experts on this subject based on the ideXlab platform.
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preimplantation filling of Tooth Socket with β tricalcium phosphate polylactic polyglycolic acid β tcp plga root analogue clinical and histological analysis in a patient
Vojnosanitetski Pregled, 2011Co-Authors: Vladimir Kokovic, Ljubomir TodorovicAbstract:Introduction. Bone resorption is a physiological process after Tooth extraction. The use of bone substitutes to fill the Tooth Socket is suggested to prevent bone resorption and establish good bone architecture for implant placement. A pure s-tricalcium phosphate coated with copolymer (polylactic-polyglycolic acid) as a root analogue, is suitable for filling Tooth Sockets. Case report. We presented a patient successfully treated with root analogue after extraction of the right second lower premolar. Three months later, the patient was planned for the placement of six TE® ITI dental implants into the mandible. During the surgery, the biopsy of bone-like tissue from the previously treated Socket was taken. All the implants were immediately loaded due to good primary stability. Histological analysis of the specimen revealed fibrous healing in the area treated with root analogue. Conclusion. The use of s-tricalcium phosphate coated with copolymers after Tooth extraction enables satisfactory bone architecture for consequent implant treatment.
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Preimplantation filling of Tooth Socket with β-tricalcium phosphate/polylactic-polyglycolic acid (β-TCP/PLGA) root analogue: clinical and histological analysis in a patient
Vojnosanitetski pregled, 2011Co-Authors: Vladimir Kokovic, Ljubomir TodorovicAbstract:Introduction. Bone resorption is a physiological process after Tooth extraction. The use of bone substitutes to fill the Tooth Socket is suggested to prevent bone resorption and establish good bone architecture for implant placement. A pure s-tricalcium phosphate coated with copolymer (polylactic-polyglycolic acid) as a root analogue, is suitable for filling Tooth Sockets. Case report. We presented a patient successfully treated with root analogue after extraction of the right second lower premolar. Three months later, the patient was planned for the placement of six TE® ITI dental implants into the mandible. During the surgery, the biopsy of bone-like tissue from the previously treated Socket was taken. All the implants were immediately loaded due to good primary stability. Histological analysis of the specimen revealed fibrous healing in the area treated with root analogue. Conclusion. The use of s-tricalcium phosphate coated with copolymers after Tooth extraction enables satisfactory bone architecture for consequent implant treatment.
Y Ina - One of the best experts on this subject based on the ideXlab platform.
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Root development of rat Tooth germs implanted in the Tooth Socket and in the subcutaneous tissue.
Oral diseases, 2008Co-Authors: Y Ina, Yasuyuki Sasano, N. Akiba, Kouki Hatori, Takahiro Honma, Keiichi SasakiAbstract:Objective: This study was designed to investigate root development of a rat Tooth germ implanted in a Tooth Socket or in a subcutaneous region. Materials and methods: Tooth germs of the upper left first molars in 2-week-old rats were extracted and implanted in the original Tooth Socket or in the subcutaneous region of the back. The upper right first molar was used as a control. The rats were fixed in weeks 1, 2, 4, 8 and 12. The root development was examined quantitatively with X-ray radiographic morphometry. The cellular activity of producing matrix proteins was assessed using in situ hybridization for type I collagen. Results: Root development was observed in the implanted teeth in the Tooth Socket as also in the control teeth. In contrast, roots hardly developed in subcutaneously implanted teeth. Histology showed that periodontal ligaments were arranged around roots of implanted teeth in the Tooth Socket as around control teeth, but few periodontal ligaments were identified in the subcutaneous implantation. Dentin and cementum formed in both the implanted teeth as also in the control teeth and odontoblasts, cementoblasts and cementocytes expressed type I collagen. Conclusion: Tooth Sockets may possess specific environments that allow root development of a Tooth germ.
J L Saffar - One of the best experts on this subject based on the ideXlab platform.
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estrogen withdrawal transiently increased bone turnover without affecting the bone balance along the Tooth Socket in rats
Journal of Periodontology, 2009Co-Authors: S Gallina, S Barrancopiedra, Daniel Torreslagares, Brigitte Baroukh, Annie Llorens, Joseluis Gutierrezperez, J L Saffar, M CherruauAbstract:Background: Estrogen withdrawal causes marked bone loss in the appendicular skeleton but slightly affects mandibular cancellous bone; in contrast, little is known of its effects on alveolar wall turnover associated with Tooth drift. In this study, we assessed short-term changes in alveolar wall turnover after an ovariectomy and compared it to other bone sites exhibiting different levels of turnover. Methods: Forty Sprague-Dawley rats were ovariectomized or sham operated. Right mandibles and femurs were processed without demineralization for bone histomorphometry in three different sites: the alveolar wall around the first molar buccal root, apical interradicular bone, and femoral metaphysis. Bone changes were assessed 14 and 28 days after the ovariectomy. Data were compared using non-parametric statistics. Results: At 14 days, on the resorption side of the alveolar wall, resorption parameters were higher in the ovariectomized rats (P <0.01), whereas the formation was lower (P <0.05); on the formation side, the daily mineral apposition rate increased (P <0.01). The root resorption was higher in ovariectomized rats (P <0.05). In the periodontal ligament, the numbers of osteoclast precursors were significantly higher. At 28 days, the drift slowed down in both the sham and ovariectomized groups. The ovariectomy had no effect on interradicular bone turnover, whereas bone loss and numbers of osteoclasts were strongly increased in the femur as soon as 14 days after the ovariectomy. Conclusions: Estrogen withdrawal had transient repercussions on alveolar wall turnover. The different reactivities of the three envelopes studied suggest that a response to an ovariectomy in the short term is related to initial basal turnover. J Periodontol 2009;80:2035-2044.
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Effects of Essential Fatty Acid Deficiency on Periodontal Tissue Adaptation to Spontaneous Tooth Migration
Calcified Tissue International, 2005Co-Authors: L. Vermelin, B. Baroukh, A. Llorens, J L SaffarAbstract:Essential fatty acids (EFAs) play a significant role in bone metabolism. Herein we studied the adaptation of alveolar bone to physiologic Tooth drift in young rats deprived of essential fatty acids from birth. Reductions in femur size and trabecular bone volume reflected body growth impairment. Along the alveolar wall, osteoclastic resorption and bone formation were depressed, disrupting the adaptive deformation of the Tooth Socket to ongoing migration. As a result, the periodontal ligament narrowed considerably, and further adaptation was achieved through root resorption. Essential fatty acid deficiency (EFAD), did not affect precursor recruitment or differentiation in the periodontal ligament (PDL), but caused redistribution of nonspecific-esterase (NSE)–positive osteoclast precursors and tartrate-resistant acid phosphatase (TRAP)–positive preosteoclasts between the bone compartment (which was depleted) and the root compartment (which was enriched). EFAD had also a marked effect on the PDL vasculature; the number of vessels was reduced, whereas their size was markedly increased. As a whole, our results show that EFAD disturbs alveolar bone adaptation to drift, but that a reaction (detrimental to root integrity) prevents root collision with the bone surface, thereby preserving the PDL as a source of precursor cells for bone and cementum homeostasis. Moreover, our results confirm that although alveolar bone resorption is arachidonic acid–dependent, the factors activating root resorption are different.
Ali Bagherian - One of the best experts on this subject based on the ideXlab platform.
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Can tert-butylhydroquinone improve the healing of extracted Tooth Socket in rats?
Dental research journal, 2017Co-Authors: Somayeh Khoramian Tusi, T. Manesh, Mahmood Sheikh Fathollahi, Ali BagherianAbstract:Background: Tooth extraction causes an open wound in the soft and hard tissues. During the inflammatory phase of the healing process, a large amount of free radicals are produced and cause oxidative stress, which leads to tissue damage and delayed wound healing. Thus, in this study, we evaluated the effect of tert‑butylhydroquinone (TBHQ), as an antioxidant, on the healing process of Tooth Sockets in rats. Materials and Methods: To conduct this experimental study, male Wistar rats (n = 42) were divided into two groups. In each case, one upper second molar was extracted under general anesthesia. After the extraction, the Tooth Sockets of the experimental group were treated with a 0.02% TBHQ solution (0.1 ml) while the same volume of distilled water placed in the Sockets of the control group. On days 3, 7, and 21 postoperatively, 7 rats from each group were euthanized, and histological slides were prepared from their Tooth Sockets. The prepared slides were examined histopathologically using a light microscope and compared using an independent two‑sample t‑test. The significance level was set at 0.05. Results: In the experimental group, a statistically significant (P = 0.003) increase in granulation tissue was observed on day 3, in comparison to the control group. The extent of bony trabeculation was also significantly higher in the TBHQ‑treated group than in the control group on day 21 (P < 0.001). Conclusion: Considering the limitations of an experimental study, it can be concluded that TBHQ may enhance the healing of the hard tissue in the Tooth Sockets. Key Words: Antioxidants, rats, Tooth extraction, wound healing
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Can tert-butylhydroquinone improve the healing of extracted Tooth Socket in rats?
Wolters Kluwer Medknow Publications, 2017Co-Authors: Somayeh Khoramian Tusi, T. Manesh, Mahmood Sheikh Fathollahi, Ali BagherianAbstract:Background: Tooth extraction causes an open wound in the soft and hard tissues. During the inflammatory phase of the healing process, a large amount of free radicals are produced and cause oxidative stress, which leads to tissue damage and delayed wound healing. Thus, in this study, we evaluated the effect of tert-butylhydroquinone (TBHQ), as an antioxidant, on the healing process of Tooth Sockets in rats. Materials and Methods: To conduct this experimental study, male Wistar rats (n = 42) were divided into two groups. In each case, one upper second molar was extracted under general anesthesia. After the extraction, the Tooth Sockets of the experimental group were treated with a 0.02% TBHQ solution (0.1 ml) while the same volume of distilled water placed in the Sockets of the control group. On days 3, 7, and 21 postoperatively, 7 rats from each group were euthanized, and histological slides were prepared from their Tooth Sockets. The prepared slides were examined histopathologically using a light microscope and compared using an independent two-sample t-test. The significance level was set at 0.05. Results: In the experimental group, a statistically significant (P = 0.003) increase in granulation tissue was observed on day 3, in comparison to the control group. The extent of bony trabeculation was also significantly higher in the TBHQ-treated group than in the control group on day 21 (P < 0.001). Conclusion: Considering the limitations of an experimental study, it can be concluded that TBHQ may enhance the healing of the hard tissue in the Tooth Sockets
