The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform

Alexandra Kozyreff - One of the best experts on this subject based on the ideXlab platform.

Stefano De Cillà - One of the best experts on this subject based on the ideXlab platform.

  • Swept-source optical coherence tomography and optical coherence tomography angiography in acquired Toxoplasmic Chorioretinitis: a case report
    Journal of medical case reports, 2018
    Co-Authors: Diego Vezzola, Davide Allegrini, Alfredo Borgia, Paolo Fogagnolo, Luca Rossetti, Mario R. Romano, Stefano De Cillà
    Abstract:

    To describe swept-source optical coherence tomography and optical coherence tomography angiography retinal changes in a case of acute Toxoplasmic Chorioretinitis both at the time of diagnosis and after healing. A 57-year-old white woman suffering from acquired Toxoplasmic Chorioretinitis underwent swept-source optical coherence tomography and optical coherence tomography angiography both at the time of diagnosis and after healing. In the acute phase of the disease, swept-source optical coherence tomography clearly showed retinal and choroidal involvement in the superficial retina and in the choroidal swelling. Optical coherence tomography angiography showed a complete loss of deep and superficial capillary networks and of choroidal vessels in the area of the inflammation. After healing, swept-source optical coherence tomography showed a retinal thinning of the area involved, with a subversion of retinal layers and no visible change at the choroid level. On the other hand, optical coherence tomography angiography showed the persistence of a vascular occlusion at the retina and choroid level. This is the first case in the optical coherence tomography angiography literature that shows the imaging of Toxoplasmic chorioretinal lesions. This case confirms the involvement of the retina and choroid in Toxoplasmic uveitis and the disruptive potential of such inflammation. The optical coherence tomography angiography performed after healing showed a persistent ablation of the retina, choriocapillaris, and choroidal vessels. The non-invasive optical coherence tomography angiography imaging technique may have diagnostic and prognostic value in regard to Toxoplasmic uveitis.

  • Swept-source optical coherence tomography and optical coherence tomography angiography in acquired Toxoplasmic Chorioretinitis : a case report 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1113 Ophthalmology and Optometry 02 Physical Sciences 0299 Other Physical Sciences
    'Springer Science and Business Media LLC', 2018
    Co-Authors: Diego Vezzola, Davide Allegrini, Paolo Fogagnolo, M.a.m. Borgia, L.m. Rossetti, Stefano De Cillà
    Abstract:

    Purpose: To describe swept-source optical coherence tomography and optical coherence tomography angiography retinal changes in a case of acute Toxoplasmic Chorioretinitis both at the time of diagnosis and after healing. Case presentation: A 57-year-old white woman suffering from acquired Toxoplasmic Chorioretinitis underwent swept-source optical coherence tomography and optical coherence tomography angiography both at the time of diagnosis and after healing. In the acute phase of the disease, swept-source optical coherence tomography clearly showed retinal and choroidal involvement in the superficial retina and in the choroidal swelling. Optical coherence tomography angiography showed a complete loss of deep and superficial capillary networks and of choroidal vessels in the area of the inflammation. After healing, swept-source optical coherence tomography showed a retinal thinning of the area involved, with a subversion of retinal layers and no visible change at the choroid level. On the other hand, optical coherence tomography angiography showed the persistence of a vascular occlusion at the retina and choroid level. Conclusion: This is the first case in the optical coherence tomography angiography literature that shows the imaging of Toxoplasmic chorioretinal lesions. This case confirms the involvement of the retina and choroid in Toxoplasmic uveitis and the disruptive potential of such inflammation. The optical coherence tomography angiography performed after healing showed a persistent ablation of the retina, choriocapillaris, and choroidal vessels. The non-invasive optical coherence tomography angiography imaging technique may have diagnostic and prognostic value in regard to Toxoplasmic uveitis

A P Guagnini - One of the best experts on this subject based on the ideXlab platform.

Ermanno Candolfi - One of the best experts on this subject based on the ideXlab platform.

  • comparison of enzyme linked immunosorbent assay immunoblotting and pcr for diagnosis of Toxoplasmic Chorioretinitis
    Journal of Clinical Microbiology, 2003
    Co-Authors: Odile Villard, Denis Filisetti, Florence Rochderies, Justus G Garweg, Jacques Flament, Ermanno Candolfi
    Abstract:

    Ocular toxoplasmosis is the major cause of posterior uvetis in European populations. The clinical diagnosis of Toxoplasmic Chorioretinitis is based upon ophthalmoscopic findings, which are often but not always typical. Laboratory testing is therefore important to confirm the etiology of the disease. In the present 2-year prospective study, the relative diagnostic sensitivities of the three analytical techniques (enzyme-linked immunosorbent assay [ELISA], immunoblotting, and PCR) were compared by using a group of patients (n = 19) with suspected ocular toxoplasmosis. The relative specificities of the three techniques were assessed by including two control groups of patients: one with nonToxoplasmic and noninflammatory ocular disease (n = 48) and the other with nonToxoplasmic and inflammatory ocular disease (n = 20). All 19 of the clinically suspect patients had serological evidence of exposure to Toxoplasma gondii: 17 had been previously infected, and 2 had current infection. The analysis of paired aqueous humor and serum samples by ELISA and immunoblotting revealed the local production of specific antibodies of the immunoglobulin G type in 63% (12 of 19) and 53% (10 of 19) of patients, respectively. PCR analysis of aqueous humor samples confirmed the presence of T. gondii DNA in 28% (5 of 18) of cases. When combined, ELISA, immunoblotting, and PCR findings confirmed the Toxoplasmic origin of retinal lesions in 83% (15 of 18) of patients. The relative specificities of the three techniques were 89% for ELISA and immunoblotting and 100% for PCR.

Gwendolyn A Noble - One of the best experts on this subject based on the ideXlab platform.

  • Chorioretinal lesions in mothers of children with congenital toxoplasmosis in the National Collaborative Chicago-based, Congenital Toxoplasmosis Study
    Editora da Pontifícia Universidade Católica do Rio Grande do Sul (EDIPUCRS), 2010
    Co-Authors: Gwendolyn A Noble, Paul Latkany, Jessica Jalbrzikowski, Jaroslaw Kusmierczyk, Marilyn Mets, Peter Rabiah, Kenneth Boyer, Kristen Wroblewski, Theodore Karrison, Charles N. Swisher
    Abstract:

    Aims: To determine whether mothers of children with congenital toxoplasmosis have chorioretinal lesions consistent with toxoplasmosis.Methods: Prospective cohort study. Ophthalmologists in our study have examined 173 children with congenital toxoplasmosis in a hospital outpatient setting. These children were referred to us by their primary care physicians. One hundred and thirty mothers of these children had retina examinations of both eyes at least once. Main outcome measure was lesion(s) consistent with ocular toxoplasmosis.Results: Of 130 mothers examined between 1991-2005, 10 (7.7%, 95% Confidence Interval 3.8%, 13.7%) had chorioretinal lesions which likely represent resolved Toxoplasmic Chorioretinitis. Most of these were small peripheral chorioretinal lesions. None reactivated between 1991-2005.Conclusions: Chorioretinal lesions consistent with quiescent ocular toxoplasmosis occur in mothers of children with congenital toxoplasmosis in the United States

  • severe sulfadiazine hypersensitivity in a child with reactivated congenital Toxoplasmic Chorioretinitis
    Pediatric Infectious Disease Journal, 2006
    Co-Authors: Rima Mcleod, Asif Rashid Khan, Gwendolyn A Noble, Paul Latkany, Jessica Jalbrzikowski, Kenneth M Boyer
    Abstract:

    A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated Chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines. Symptoms resolved when systemic corticosteroids were administered. This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of Toxoplasmic Chorioretinitis.