The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Charles D. Ericsson - One of the best experts on this subject based on the ideXlab platform.
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Nonantimicrobial Agents in the Prevention and Treatment of Traveler' Diarrhea
Clinical Infectious Diseases, 2005Co-Authors: Charles D. EricssonAbstract:Among the nonantimicrobial agents that are available and useful for the prevention of Traveler’s Diarrhea are bismuth subsalicylate–containing preparations which can provide a rate of protection of up to 65% when taken 4 times daily. In one study the probiotic Lactobacillus GG was found to provide 49% protection against Traveler’s Diarrhea but results with this agent and other probiotics have been highly variable and geographically inconsistent. Tannin albuminate plus ethacridine lactate provided 36% protection but it is not widely available. Among the nonantimicrobial agents that are available and useful for the treatment of Traveler’s Diarrhea are bismuth subsalicylate–containing preparations which reduce the passage of loose stools by 16%–18%. The antisecretory and antimotility agent loperamide reduces the passage of loose stools by ~50% and has been especially useful in combination with antimicrobial agents in reducing the total duration of posttreatment Diarrhea to a matter of hours. (authors)
David N. Taylor - One of the best experts on this subject based on the ideXlab platform.
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Poorly Absorbed Antibiotics for the Treatment of Traveler' Diarrhea
Clinical Infectious Diseases, 2005Co-Authors: David N. TaylorAbstract:This article describes the use of poorly absorbed antibiotics for the treatment of Traveler’s Diarrhea. Poorly absorbed oral antibiotics can deliver high concentrations of drug to the site of enteric infection with minimal risk of systemic adverse effects toxicity and drug interactions. Compared with systemically absorbed oral antibiotics poorly absorbed oral antibiotics may be less associated with the pressure that leads to the development of bacterial resistance because they do not affect bacteria outside the gastrointestinal tract. In clinical studies poorly absorbed oral antibiotics including aztreonam bicozamycin and rifaximin were more effective than and as well tolerated as placebo; in particular rifaximin was as effective as oral ciprofloxacin in reducing the duration of illness in Traveler’s Diarrhea. More research is warranted to delineate the effects of poorly absorbed antibiotics in invasive infection and to assess the potential for the development of bacterial resistance. (authors)
Herbert L Dupont - One of the best experts on this subject based on the ideXlab platform.
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Pathogenesis of Traveler's Diarrhea.
Chemotherapy, 1995Co-Authors: Herbert L DupontAbstract:Diarrhea is the most common medical complication among persons venturing into tropical and semitropical regions of the developing world from industrialized regions. The illness is characteristically caused by one of a variety of bacterial agents, of which enterotoxigenic Escherichia coli is the most important. Intestinal electrolyte fluid movement explains the pathophysiology of most cases while in certain situations osmotic Diarrhea or altered intestinal motility may lead to passage of unformed stools. In 1-2% of Traveler, Diarrhea lasts more than 1 month. Most of the patients will have Diarrhea that is eventually self-limiting. The cause and mechanisms of Diarrhea in these settings are largely unknown although a focal intestinal inflammation lesion may be found.
