The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
David Ezra - One of the best experts on this subject based on the ideXlab platform.
-
seizures after flumazenil administration in a case of combined benzodiazepine and Tricyclic Antidepressant Overdose
Critical Care Medicine, 1992Co-Authors: Amnon Mordel, Eyal Winkler, Moshe Tirosh, David EzraAbstract:Flumazenil (Anexate®, Roche, Basel, Switzerland) is a specific, high-affinity, competitive inhibitor of the central nervous system's benzodiazepine γ-aminobutyric acid receptor, with high clinical efficacy in reversing the effects of benzodiazepine Overdose (1, 2). Flumazenil is used in the emergenc
Damian Scullion - One of the best experts on this subject based on the ideXlab platform.
-
Tricyclic Antidepressant Overdose in a toddler treated with intravenous lipid emulsion
Pediatrics, 2011Co-Authors: David Hendron, Gareth Menagh, Euan A Sandilands, Damian ScullionAbstract:We report a case that involves the use of intravenous lipid emulsion as an antidote for a drug Overdose involving a 20-month-old girl who had ingested a potentially lethal amount of the Tricyclic Antidepressant (TCA) dothiepin. The patient's condition continued to deteriorate despite implementation of standard pediatric treatment recommendations for TCA toxicity. Administration of intravenous lipid emulsion in addition to standard therapy (including sodium bicarbonate) and direct-current cardioversion for ventricular arrhythmia led to a successful outcome. The case report is followed by a review of the current evidence underlying this novel therapy and the background on its use. TCA toxicity is addressed specifically.
Amnon Mordel - One of the best experts on this subject based on the ideXlab platform.
-
seizures after flumazenil administration in a case of combined benzodiazepine and Tricyclic Antidepressant Overdose
Critical Care Medicine, 1992Co-Authors: Amnon Mordel, Eyal Winkler, Moshe Tirosh, David EzraAbstract:Flumazenil (Anexate®, Roche, Basel, Switzerland) is a specific, high-affinity, competitive inhibitor of the central nervous system's benzodiazepine γ-aminobutyric acid receptor, with high clinical efficacy in reversing the effects of benzodiazepine Overdose (1, 2). Flumazenil is used in the emergenc
Devendra Amre - One of the best experts on this subject based on the ideXlab platform.
-
a meta analysis of prognostic indicators to predict seizures arrhythmias or death after Tricyclic Antidepressant Overdose
Clinical Toxicology, 2004Co-Authors: Barbara Bailey, Nicholas A Buckley, Devendra AmreAbstract:Objectives: To systematically review and summarize studies on the accuracy of ECG and Tricyclic Antidepressant (TCA) concentration as prognostic indicators of the risk of seizures, ventricular arrhythmia (VA) or death in patients with TCA Overdose. Methods: Articles were identified with MedLine and Cochrane register of controlled clinical trials searches and review of medical toxicology textbooks. Quality of the included studies was assessed. Pooled estimates of sensitivity, specificity, likelihood ratios and Summary Receiver Operating Characteristics (SROC) curves were generated. Results: A total of 18 studies were included in the analysis. The pooled sensitivity (Se) and specificity (Sp) of the QRS for predicting seizures were 0.69 [95% CI 0.57–0.78] and 0.69 [95% CI 0.58–0.78] as compared to 0.75 [95% CI 0.61–0.85] and 0.72 [95% CI 0.61–0.81] for the TCA concentration. The Se and Sp of the QRS to predict VA were 0.79 [95% CI 0.58–0.91] and 0.46 [95% CI 0.35–0.59] compared to 0.78 [95% CI 0.56–0.90] and...
David Hendron - One of the best experts on this subject based on the ideXlab platform.
-
Tricyclic Antidepressant Overdose in a toddler treated with intravenous lipid emulsion
Pediatrics, 2011Co-Authors: David Hendron, Gareth Menagh, Euan A Sandilands, Damian ScullionAbstract:We report a case that involves the use of intravenous lipid emulsion as an antidote for a drug Overdose involving a 20-month-old girl who had ingested a potentially lethal amount of the Tricyclic Antidepressant (TCA) dothiepin. The patient's condition continued to deteriorate despite implementation of standard pediatric treatment recommendations for TCA toxicity. Administration of intravenous lipid emulsion in addition to standard therapy (including sodium bicarbonate) and direct-current cardioversion for ventricular arrhythmia led to a successful outcome. The case report is followed by a review of the current evidence underlying this novel therapy and the background on its use. TCA toxicity is addressed specifically.
