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Walter Goessler - One of the best experts on this subject based on the ideXlab platform.
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Arsenic speciation in aerosols of a respiratory therapeutic cave: A first approach to study arsenicals in ultrafine particles.
The Science of the total environment, 2018Co-Authors: Stefan Tanda, Roman Ličbinský, Jitka Hegrová, Jiří Faimon, Walter GoesslerAbstract:Arsenic is ubiquitous in the environment and of special concern due to its varying toxicity depending on the chemical form present. Less is known about arsenic in air, especially about organoarsenicals, their sources and fate. There is also a lack of knowledge regarding arsenic in airborne nanoparticles that are critical for understanding with respect to human health effects due to their size. Here we show results from an arsenic speciation analysis in size-resolved airborne particles with aerodynamic diameters down to 15 nm. Analysis of aerosols from a respiratory therapeutic cave showed temporarily higher concentrations of Trimethylarsine Oxide than inorganic arsenic and substantial amounts of organoarsenicals, especially in smaller particles. Our method provides guidance for future studies investigating arsenicals in ultrafine particles and their health implications. Furthermore, the method developed can be used to widely monitor particle-bound organoarsenicals to fully understand the importance of As biovolatilization in the environment.
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A unique arsenic speciation profile in Elaphomyces spp. (“deer truffles”)—Trimethylarsine Oxide and methylarsonous acid as significant arsenic compounds
Analytical and Bioanalytical Chemistry, 2018Co-Authors: Simone Braeuer, Jan Borovicka, Walter GoesslerAbstract:Arsenic and its species were investigated for the first time in nine collections of Elaphomyces spp. (“deer truffles”) from the Czech Republic with inductively coupled plasma mass spectrometry (ICPMS) and high-performance liquid chromatography coupled to ICPMS. The total arsenic concentrations ranged from 12 to 42 mg kg^−1 dry mass in samples of E. asperulus and from 120 to 660 mg kg^−1 dry mass in E. granulatus and E. muricatus . These concentrations are remarkably high for terrestrial organisms and demonstrate the arsenic-accumulating ability of these fungi. The dominating arsenic species in all samples was methylarsonic acid which accounted for more than 30% of the extractable arsenic. Arsenobetaine, dimethylarsinic acid, and inorganic arsenic were present as well, but only at trace concentrations. Surprisingly, we found high amounts of Trimethylarsine Oxide in all samples (0.32–28% of the extractable arsenic). Even more remarkable was that all but two samples contained significant amounts of the highly toxic trivalent arsenic compound methylarsonous acid (0.08–0.73% of the extractable arsenic). This is the first report of the occurrence of Trimethylarsine Oxide and methylarsonous acid at significant concentrations in a terrestrial organism. Our findings point out that there is still a lot to be understood about the biotransformation pathways of arsenic in the terrestrial environment. Graphical abstract Trimethylarsine Oxide and methylarsonous acid in “deer truffles”
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a unique arsenic speciation profile in elaphomyces spp deer truffles Trimethylarsine Oxide and methylarsonous acid as significant arsenic compounds
Analytical and Bioanalytical Chemistry, 2018Co-Authors: Simone Braeuer, Jan Borovicka, Walter GoesslerAbstract:Arsenic and its species were investigated for the first time in nine collections of Elaphomyces spp. (“deer truffles”) from the Czech Republic with inductively coupled plasma mass spectrometry (ICPMS) and high-performance liquid chromatography coupled to ICPMS. The total arsenic concentrations ranged from 12 to 42 mg kg−1 dry mass in samples of E. asperulus and from 120 to 660 mg kg−1 dry mass in E. granulatus and E. muricatus. These concentrations are remarkably high for terrestrial organisms and demonstrate the arsenic-accumulating ability of these fungi. The dominating arsenic species in all samples was methylarsonic acid which accounted for more than 30% of the extractable arsenic. Arsenobetaine, dimethylarsinic acid, and inorganic arsenic were present as well, but only at trace concentrations. Surprisingly, we found high amounts of Trimethylarsine Oxide in all samples (0.32–28% of the extractable arsenic). Even more remarkable was that all but two samples contained significant amounts of the highly toxic trivalent arsenic compound methylarsonous acid (0.08–0.73% of the extractable arsenic). This is the first report of the occurrence of Trimethylarsine Oxide and methylarsonous acid at significant concentrations in a terrestrial organism. Our findings point out that there is still a lot to be understood about the biotransformation pathways of arsenic in the terrestrial environment.
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Arsenic speciation in fish sauce samples determined by HPLC coupled to inductively coupled plasma mass spectrometry.
Food Chemistry, 2009Co-Authors: Irene B. Rodriguez, Georg Raber, Walter GoesslerAbstract:Abstract Fish sauce is a condiment typically used in most East Asian cooking and has recently been considered as an effective route to iron fortification in countries where iron deficiency anaemia is widespread. Current consumption and the increasing awareness of the uniqueness of fish sauce as a condiment necessitate assessment of the health risk that it poses. This study focuses on the analysis of arsenic in fish sauce samples with special emphasis on identification of the species present as a consequence of the fermentation process. Total arsenic concentrations of six different fish sauces from Thailand and Vietnam were in the range of 0.69–2.75 mg l −1 . Speciation analyses done on the fish sauce samples showed that most of the arsenic present in the fish sauces were arsenobetaine (82–94%), arsenocholine (4.9–7.7%), Trimethylarsine Oxide (0.7–7.8%), and trimethylarsenopropionate (0.5–2.1%). Highly toxic arsenic compounds, such as arsenite, arsenate, methylarsonic acid (MA) and dimethylarsinic acid (DMA), were below the detection limit of 0.01 mg l −1 .
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Novel Thioarsenic Metabolites in Human Urine after Ingestion of an Arsenosugar, 2‘,3‘-Dihydroxypropyl 5-Deoxy-5-dimethylarsinoyl-β-d-riboside
Chemical research in toxicology, 2005Co-Authors: Reingard Raml, Walter Goessler, Pedro Traar, Takafumi Ochi, Kevin A. FrancesconiAbstract:The presence of arsenic-containing carbohydrates, arsenosugars, in many seafoods raises questions of human health concerning the ingestion and metabolism of these compounds. A previous study investigating the metabolites in human urine after the ingestion of a common arsenosugar 2‘,3‘-dihydroxypropyl 5-deoxy-5-dimethylarsinoyl-β-d-riboside (oxo-arsenosugar) showed that the arsenic was rapidly excreted in the urine and was present as at least 12 metabolites, only three of which could be identified. In this repeat study with oxo-arsenosugar and using high-performance liquid chromatography/inductively coupled plasma mass spectrometry, we report the identification of seven arsenic metabolites, which together accounted for 88% of the total urinary arsenic collected over 61 h. The metabolites included previously reported human urinary arsenicals dimethylarsinate (DMA), oxo-dimethylarsenoethanol (oxo-DMAE), and Trimethylarsine Oxide, in addition to new human metabolites oxo-dimethylarsenoacetate (oxo-DMAA), thio...
Toshikazu Kaise - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxicological aspects of organic arsenic compounds contained in marine products using the mammalian cell culture technique
Applied Organometallic Chemistry, 1998Co-Authors: Toshikazu Kaise, Ken'ichi Hanaoka, Teruaki Sakurai, Y Oya-ohta, T Ochi, Tohru Saitoh, Chiyo MatsubaraAbstract:Arsenobetaine, arsenocholine, Trimethylarsine Oxide and tetramethylarsonium iodide, which are contained in marine fishery products, were examined for their potencies on cell growth inhibition, chromosomal aberration and sister chromatid exchange (SCE). Arsenobetaine, the major water-soluble organic arsenic compound in marine animals, exhibited very low cytotoxicity towards mammalian cells. This compound showed no cell growth inhibition at a concentration of 10 mg cm -3 and the cytotoxicity was lower than 1/14 000th of that of sodium arsenite and 1/1600th of that of sodium arsenate towards BALB/c 3T3 cells. The chromosomal aberrations caused by arsenobetaine at a concentration of 10 mg cm -3 consisted mainly of chromatid gaps and chromatid breaks, but in this concentration chromosomal breakage owing to its osmotic pressure is likely to be considerable. No SCE was observed at a concentration of 1 mg cm -3 . Arsenocholine and Trimethylarsine Oxide also showed no cell growth inhibited at a concentration of 10 mg cm -3 . However, tetramethylarsonium iodide inhibition the growth of BALBIc 3T3 at a concentration of 8 mg cm -3 . These compounds exhibited a low ability to induce chromosomal aberrations at a concentration range of 2-10 mg cm -3 and no SCE was observed at a concentration of 1.0 mg cm -3 . These results suggested that the major and minor organic arsenic compounds contained in marine fishery products are much less cytotoxic inorganic arsenic, methylarsonic acid and dimethylarsinic acid.
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Biotransformation of arsenobetaine to Trimethylarsine Oxide by marine microorganisms in a gill of clam Meretrix lusoria
Chemosphere, 1998Co-Authors: Toshikazu Kaise, Teruaki Sakurai, Tohru Saitoh, Chiyo Matsubara, Naoko Takada-oikawa, Ken'ichi HanaokaAbstract:The tetramethylarsonium ion has been found in the gill of the clam Meretrix lusoria. We attempted to confirm the conversion of arsenobetaine to the tetramethylarsonium ion in a culture with marine microorganisms occurring in the gill of the clam Meretrix lusoria. Arsenobetaine was aerobically incubated with microorganisms. A garlic-like odor was faintly detected after 5 to 8 days incubation. The mass spectrum of the odorous substance was essentially identical with that of synthetic Trimethylarsine. Trimethylarsine Oxide (TMAO) was also detected in the culture medium after 3 weeks incubation. Arsenobetaine was biotransformed to TMAO during the incubation in the culture growth by the marine microorganisms. Tetramethylarsonium ion was not detected in the culture medium even after 72 days incubation.
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Arsenic Compounds Accumulated in Sedimentary Microorganisms Cultivated in Media Containing Several Arsenicals
Applied Organometallic Chemistry, 1996Co-Authors: Ken'ichi Hanaoka, Toshikazu Kaise, Yosio Dote, Kenta Yosida, Takayosi Kuroiwa, Sigeru MaedaAbstract:Sediments, as sources of microorganisms, were added to two kinds of media, 1/5 ZoBell 2216E and a solution of inorganic salts, which contained inorganic arsenic(III), inorganic arsenic(V), methanearsonic acid, dimethyl- arsinic acid, Trimethylarsine Oxide, tetramethylarsonium salt or arsenocholine. After 17 days of incubation at 20 °C, the arsenicals that had accumulated in the microorganisms were analysed by high-performance liquid chromatography (HPLC). While the more toxic arsenicals [inorganic arsenic(III), inorganic arsenic(V), methanearsonic acid, dimethylarsinic acid] were not converted in the microorganisms, Trimethylarsine Oxide and tetramethylarsonium salt were considerably degraded to inorganic arsenic(V), and arsenocholine to arsenobetaine. Arsenobetaine that had accumulated in the microorganisms was extracted and confirmed by thin-layer chromatography (TLC) and fast atom bombardment (FAB) mass spectrometry.
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Degradation of arsenobetaine to inorganic arsenic by bacteria in seawater
Hydrobiologia, 1995Co-Authors: Ken'ichi Hanaoka, Shoji Tagawa, Osamu Nakamura, Hiroshi Ohno, Toshikazu KaiseAbstract:The substances suspended in seawater were fractionated by membrane filtration into three fractions. Fraction 1 was collected on a membrane filter of 0.22 µm pore-size, fraction 2 on a 5 µm pore-size and fraction 3 on 0.22 µm pore-size from the filtrate passed through the 5 µm membrane filter. Arsenobetaine was incubated with each of these fractions in two media (ZoBell 2216E and a solution of inorganic salts) at 25 °C in the dark under aerobic conditions. The mixture added with fraction 3 was considered to contain only bacteria. In every case, in the inorganic salt medium, inorganic arsenic(V) was derived from arsenobetaine via Trimethylarsine Oxide. In the ZoBell medium, arsenobetaine was not degraded to inorganic arsenic, although Trimethylarsine Oxide was derived in every case. We conclude that the degradation of arsenobetaine to Trimethylarsine Oxide or inorganic arsenic can be accomplished in seawater by bacteria alone.
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Degradation of a tetramethylarsonium salt by microorganisms occurring in sediments and suspended substances under both aerobic and anaerobic conditions
Applied Organometallic Chemistry, 1994Co-Authors: Ken'ichi Hanaoka, Shoji Tagawa, Noriyuki Araki, Toshikazu KaiseAbstract:Microbial degradation of a tetramethylarsonium salt during incubation at 25°C was investigated under both aerobic and anaerobic conditions. Two media (1/5 ZoBell 2216E and inorganic salt medium), added with the sediments or suspended substances as the sources of the microorganisms, were used. Degradation of the tetramethylarsonium salt occurred only in the ZoBell medium: under anaerobic conditions, Trimethylarsine Oxide and dimethylarsinic acid were derived with the sediments, and dimethylarsinic acid with the suspended substances, the salt degrading more rapidly with the former than with the latter. Small amounts of two metabolites, Trimethylarsine Oxide and inorganic arsenic(V), was also derived in the aerobically incubated ZoBell medium added with the suspended substances. This result means that the tetramethylarsonium salt is degraded to inorganic arsenic, which is the starting material for arsenic circulation in marine ecosystems, via Trimethylarsine Oxide and dimethylarsinic acid.
Ken'ichi Hanaoka - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxicological aspects of organic arsenic compounds contained in marine products using the mammalian cell culture technique
Applied Organometallic Chemistry, 1998Co-Authors: Toshikazu Kaise, Ken'ichi Hanaoka, Teruaki Sakurai, Y Oya-ohta, T Ochi, Tohru Saitoh, Chiyo MatsubaraAbstract:Arsenobetaine, arsenocholine, Trimethylarsine Oxide and tetramethylarsonium iodide, which are contained in marine fishery products, were examined for their potencies on cell growth inhibition, chromosomal aberration and sister chromatid exchange (SCE). Arsenobetaine, the major water-soluble organic arsenic compound in marine animals, exhibited very low cytotoxicity towards mammalian cells. This compound showed no cell growth inhibition at a concentration of 10 mg cm -3 and the cytotoxicity was lower than 1/14 000th of that of sodium arsenite and 1/1600th of that of sodium arsenate towards BALB/c 3T3 cells. The chromosomal aberrations caused by arsenobetaine at a concentration of 10 mg cm -3 consisted mainly of chromatid gaps and chromatid breaks, but in this concentration chromosomal breakage owing to its osmotic pressure is likely to be considerable. No SCE was observed at a concentration of 1 mg cm -3 . Arsenocholine and Trimethylarsine Oxide also showed no cell growth inhibited at a concentration of 10 mg cm -3 . However, tetramethylarsonium iodide inhibition the growth of BALBIc 3T3 at a concentration of 8 mg cm -3 . These compounds exhibited a low ability to induce chromosomal aberrations at a concentration range of 2-10 mg cm -3 and no SCE was observed at a concentration of 1.0 mg cm -3 . These results suggested that the major and minor organic arsenic compounds contained in marine fishery products are much less cytotoxic inorganic arsenic, methylarsonic acid and dimethylarsinic acid.
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Biotransformation of arsenobetaine to Trimethylarsine Oxide by marine microorganisms in a gill of clam Meretrix lusoria
Chemosphere, 1998Co-Authors: Toshikazu Kaise, Teruaki Sakurai, Tohru Saitoh, Chiyo Matsubara, Naoko Takada-oikawa, Ken'ichi HanaokaAbstract:The tetramethylarsonium ion has been found in the gill of the clam Meretrix lusoria. We attempted to confirm the conversion of arsenobetaine to the tetramethylarsonium ion in a culture with marine microorganisms occurring in the gill of the clam Meretrix lusoria. Arsenobetaine was aerobically incubated with microorganisms. A garlic-like odor was faintly detected after 5 to 8 days incubation. The mass spectrum of the odorous substance was essentially identical with that of synthetic Trimethylarsine. Trimethylarsine Oxide (TMAO) was also detected in the culture medium after 3 weeks incubation. Arsenobetaine was biotransformed to TMAO during the incubation in the culture growth by the marine microorganisms. Tetramethylarsonium ion was not detected in the culture medium even after 72 days incubation.
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Arsenic Compounds Accumulated in Sedimentary Microorganisms Cultivated in Media Containing Several Arsenicals
Applied Organometallic Chemistry, 1996Co-Authors: Ken'ichi Hanaoka, Toshikazu Kaise, Yosio Dote, Kenta Yosida, Takayosi Kuroiwa, Sigeru MaedaAbstract:Sediments, as sources of microorganisms, were added to two kinds of media, 1/5 ZoBell 2216E and a solution of inorganic salts, which contained inorganic arsenic(III), inorganic arsenic(V), methanearsonic acid, dimethyl- arsinic acid, Trimethylarsine Oxide, tetramethylarsonium salt or arsenocholine. After 17 days of incubation at 20 °C, the arsenicals that had accumulated in the microorganisms were analysed by high-performance liquid chromatography (HPLC). While the more toxic arsenicals [inorganic arsenic(III), inorganic arsenic(V), methanearsonic acid, dimethylarsinic acid] were not converted in the microorganisms, Trimethylarsine Oxide and tetramethylarsonium salt were considerably degraded to inorganic arsenic(V), and arsenocholine to arsenobetaine. Arsenobetaine that had accumulated in the microorganisms was extracted and confirmed by thin-layer chromatography (TLC) and fast atom bombardment (FAB) mass spectrometry.
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Degradation of arsenobetaine to inorganic arsenic by bacteria in seawater
Hydrobiologia, 1995Co-Authors: Ken'ichi Hanaoka, Shoji Tagawa, Osamu Nakamura, Hiroshi Ohno, Toshikazu KaiseAbstract:The substances suspended in seawater were fractionated by membrane filtration into three fractions. Fraction 1 was collected on a membrane filter of 0.22 µm pore-size, fraction 2 on a 5 µm pore-size and fraction 3 on 0.22 µm pore-size from the filtrate passed through the 5 µm membrane filter. Arsenobetaine was incubated with each of these fractions in two media (ZoBell 2216E and a solution of inorganic salts) at 25 °C in the dark under aerobic conditions. The mixture added with fraction 3 was considered to contain only bacteria. In every case, in the inorganic salt medium, inorganic arsenic(V) was derived from arsenobetaine via Trimethylarsine Oxide. In the ZoBell medium, arsenobetaine was not degraded to inorganic arsenic, although Trimethylarsine Oxide was derived in every case. We conclude that the degradation of arsenobetaine to Trimethylarsine Oxide or inorganic arsenic can be accomplished in seawater by bacteria alone.
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Degradation of a tetramethylarsonium salt by microorganisms occurring in sediments and suspended substances under both aerobic and anaerobic conditions
Applied Organometallic Chemistry, 1994Co-Authors: Ken'ichi Hanaoka, Shoji Tagawa, Noriyuki Araki, Toshikazu KaiseAbstract:Microbial degradation of a tetramethylarsonium salt during incubation at 25°C was investigated under both aerobic and anaerobic conditions. Two media (1/5 ZoBell 2216E and inorganic salt medium), added with the sediments or suspended substances as the sources of the microorganisms, were used. Degradation of the tetramethylarsonium salt occurred only in the ZoBell medium: under anaerobic conditions, Trimethylarsine Oxide and dimethylarsinic acid were derived with the sediments, and dimethylarsinic acid with the suspended substances, the salt degrading more rapidly with the former than with the latter. Small amounts of two metabolites, Trimethylarsine Oxide and inorganic arsenic(V), was also derived in the aerobically incubated ZoBell medium added with the suspended substances. This result means that the tetramethylarsonium salt is degraded to inorganic arsenic, which is the starting material for arsenic circulation in marine ecosystems, via Trimethylarsine Oxide and dimethylarsinic acid.
Kurt J. Irgolic - One of the best experts on this subject based on the ideXlab platform.
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Arsenic Compounds in Terrestrial Biota
Arsenic Exposure and Health Effects III, 1999Co-Authors: Kurt J. Irgolic, Walter Goessler, Doris KuehneltAbstract:Publisher Summary During the past two decades Trimethylarsine Oxide, the tetramethylarsonium cation, arsenobetaine, arsenocholine, arsenic-containing riboses, and arsenic-containing lipids were identified in marine organisms. Terrestrial biota appeared to be restricted to the simpler organic compounds of arsenic (As), such as methylarsonic acid, dimethylarsinic acid, and perhaps Trimethylarsine. The development of an analytical method for the identification and quantification of inorganic and organic As compounds with very low detection limits (extraction, evaporation of extract, dissolution of the residue, chromatography, nebulization in a hydraulic high-pressure nebulizer, detection of As in the column effluent with an inductively coupled argon plasma mass spectrometer) proved that almost all of the As compounds thus far found in marine organisms are also present in terrestrial biota. The detection limits of the analytical system are so low, that As compounds can be quantified in human food derived from terrestrial biota. The knowledge of As compounds in food should improve the assessment of risk posed by ingested arsenic.
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Retention behavior of arsenobetaine, arsenocholine, Trimethylarsine Oxide and tetramethylarsonium iodide on a styrene-divinylbenzene column with benzenesulfonates as ion-pairing reagents
Journal of Chromatography A, 1996Co-Authors: Jürgen Gailer, Kurt J. IrgolicAbstract:Abstract The pH-dependent retention behavior of arsenobetaine, arsenocholine, Trimethylarsine Oxide, tetramethylarsonium iodide (cationic arsenic compounds), arsenite, arsenate, methylarsonic acid, and dimethylarsinic acid (anionic arsenic compounds) was studied on a Hamilton PRP-1 reversed-phase column (250×4.1 mm I.D.) with 10 m M aqueous solutions of benzensulfonic acids (X-C 6 H 4 SO 3 − ; X=H, 4-HO, 3-CO 2 H; 4-HO-3-HO 2 C-C 6 H 3 SO 3 − ) as ion-pairing reagents in the pH range 2–5 using flame atomic absorption spectrometry as the arsenic-specific detector. The dependencies of the k ′-values of the ‘cationic’ arsenic compounds was rationalized on the basis of the protonation/deprotonation behavior of the arsenic compounds and of the four benzenesulfonates. The results provided evidence for the formation of a cationic species from Trimethylarsine Oxide below pH 3. Benzenesulfonate is the most hydrophobic ion-pairing reagent causing strong retention of the cationic arsenic compounds and consequently impeding their rapid separation. With the less hydrophobic, substituted benzenesulfonates the cationic arsenic compounds had retention times not exceeding 6 min. At a flow-rate of 1.5 cm 3 min −1 10 m M aqueous 3-carboxy-4-hydroxybenzenesulfonate solution adjusted to pH 3.5 allowed the separation of arsenate, methylarsonic acid, arsenobetaine, Trimethylarsine Oxide, the tetramethylarsonium ion, and arsenocholine within 3 min. Dimethylarsinic acid coelutes with arsenobetaine at pH 3.5, but can be separated from arsenobetaine with the same mobile phase at pH 2.5. At pH 2.5 the signals for Trimethylarsine Oxide, the tetramethylarsonium ion, and arsenocholine are too broad to be useful for quantification. Arsenite and methylarsonic acid cannot be separated under these conditions.
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In‐vitro prenatal toxicity of Trimethylarsine, Trimethylarsine Oxide and Trimethylarsine sulfide
Applied Organometallic Chemistry, 1995Co-Authors: T. Rick Irvin, Kurt J. IrgolicAbstract:The embryolethality and the embryotoxicity of Trimethylarsine, Trimethylarsine Oxide and Trimethylarsine sulfide were investigated employing Sprague–Dawley rat embryos with intact yolk sacs. The embryos were removed on day 11 of gestation and grown in a culture medium (Way-mouth's 725/1) spiked with the arsenic compounds to concentrations in the range 4–100 mM in the presence or absence of rat liver (S-9) homogenate. After 24 h the yolk-sac circulation and heart beat were monitored (indicator of embryolethality), the crown-to-rump lengths were measured, the neural structures (somites) counted, and the development of the limb buds evaluated (indicators of embryotoxicity). At a Trimethylarsine concentration of 18.7 mM 78% of the embryos were dead when no S-9 was present. In the presence of S-9 all embryos survived but were necrotic and malformed. Signs of embryotoxicity were observed at concentrations of 18.7 and 9.3 mM. At the 4.7 mM concentration the embryos grew as well as the control embryos. Trimethylarsine Oxide v as lethal at 100 mM and severely embryotoxic at 50 and 25 mM. At all but the lowest concentration (4.5 mM) the embryos looked sick, and were frequently necrotic, deformed and underdeveloped. Trimethylarsine sulfide exhibited severe embryotoxicity at 50 mM concentration in the absence and in the presence of S-9. Signs of acute toxicity were observable at 9 mM concentrations of Trimethylarsine and Trimethylarsine Oxide. Compared with other environmental toxicants that show effects at concentrations orders of magnitude smaller, these arsenic compounds cannot be classified as very toxic.
Ivy Shiue - One of the best experts on this subject based on the ideXlab platform.
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IgE antibodies and urinary Trimethylarsine Oxide accounted for 1–7 % population attributable risks for eczema in adults: USA NHANES 2005–2006
Environmental Science and Pollution Research, 2015Co-Authors: Ivy ShiueAbstract:Population attributable risks from serum IgE and dust miteallergen concentrations and environmental chemicals for eczema are unclear. Therefore, it was aimed to examine serum IgE and allergen concentrations and environmental chemicals for eczema in adults and to calculate population attributable risks in a national and population-based setting. Data retrieved from the National Health and Nutrition Examination Survey, 2005–2006, was analyzed. Information on demographics and self-reported ever eczema was obtained by household interview. Bloods and urines (sub-sample) were also collected during the interview. Adults aged 20–85 were included. Statistical analyses were using chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of all the included American adults ( n = 4979), 310 (6.2 %) reported ever eczema. Moreover, more eczema cases were observed in female adults but fewer cases in people born in Mexico. There were no significant associations observed between commonly known biomarkers (including vitamin D) and eczema or between dust mite allergens and eczema. Serum D. Farinae (PAR 1.0 %), D. Pteronyssinus (PAR 1.1 %), cat (PAR 1.8 %), dog (PAR 1.6 %), and muse (PAR 3.2 %) IgE antibodies were associated with eczema. Adults with ever eczema were found to have higher levels of urinary Trimethylarsine Oxide concentrations (PAR 7.0 %) but not other speciated arsenic concentrations. There were no clear associations between other environmental chemicals including heavy metals, phthalates, phenols, parabens, pesticides, nitrate, perchlorate, polycyclic hydrocarbons and eczema as well. Elimination of environmental risks might help delay or stop eczema up to 7 % in the adult population.
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IgE antibodies and urinary Trimethylarsine Oxide accounted for 1-7% population attributable risks for eczema in adults: USA NHANES 2005-2006.
Environmental science and pollution research international, 2015Co-Authors: Ivy ShiueAbstract:Population attributable risks from serum IgE and dust miteallergen concentrations and environmental chemicals for eczema are unclear. Therefore, it was aimed to examine serum IgE and allergen concentrations and environmental chemicals for eczema in adults and to calculate population attributable risks in a national and population-based setting. Data retrieved from the National Health and Nutrition Examination Survey, 2005–2006, was analyzed. Information on demographics and self-reported ever eczema was obtained by household interview. Bloods and urines (sub-sample) were also collected during the interview. Adults aged 20–85 were included. Statistical analyses were using chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of all the included American adults (n = 4979), 310 (6.2 %) reported ever eczema. Moreover, more eczema cases were observed in female adults but fewer cases in people born in Mexico. There were no significant associations observed between commonly known biomarkers (including vitamin D) and eczema or between dust mite allergens and eczema. Serum D. Farinae (PAR 1.0 %), D. Pteronyssinus (PAR 1.1 %), cat (PAR 1.8 %), dog (PAR 1.6 %), and muse (PAR 3.2 %) IgE antibodies were associated with eczema. Adults with ever eczema were found to have higher levels of urinary Trimethylarsine Oxide concentrations (PAR 7.0 %) but not other speciated arsenic concentrations. There were no clear associations between other environmental chemicals including heavy metals, phthalates, phenols, parabens, pesticides, nitrate, perchlorate, polycyclic hydrocarbons and eczema as well. Elimination of environmental risks might help delay or stop eczema up to 7 % in the adult population.
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Relationship of environmental exposures and ankylosing spondylitis and spinal mobility: US NHAENS, 2009-2010
International journal of environmental health research, 2014Co-Authors: Ivy ShiueAbstract:It was aimed to study the relationships of different sets of urinary environmental chemical concentrations and ankylosing spondylitis in a national and population-based setting. Data were extracted from United States National Health and Nutrition Examination Surveys, 2009–2010. Information on demographics was obtained by household interview and ankylosing spondylitis clinical measures and urines were taken at examination. People with abnormal occiput-to-wall distance were found to have higher urinary cadmium (OR 2.17, 95 % CI 1.34–3.52, p = 0.004), antimony (OR 1.74, 95 % CI 1.15–2.62, p = 0.012), tungsten (OR 1.91, 95 % CI 1.39–2.64, p = 0.001), uranium (OR 1.49, 95 % CI 1.03–2.15, p = 0.036), and Trimethylarsine Oxide (OR 5.01, 95 % CI 2.34–10.71, p
