The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Wesley C. Voorhis - One of the best experts on this subject based on the ideXlab platform.
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Therapy and Prophylaxis of Systemic Protozoan Infections
Drugs, 1990Co-Authors: Wesley C. VoorhisAbstract:This article summarises current therapy and prophylaxis for Pneumocystis carinii , Toxoplasma gondii, Leishmania species, African trypanosomes (Trypanosoma brucei gambiense and T. b. rhodesiense) , and American trypanosome (Trypanosoma cruzi) infections. Each agent and the disease it causes is briefly reviewed, and current data on the structure, mode of action, indications for treatment, dosage, administration, duration of therapy, efficacy, toxicity, and necessary monitoring during therapy are discussed for each drug. Drugs considered include cotrimoxazole (trimethoprim + sulfamethoxazole), pentamidine, dapsone (diaphenylsulfone), trimetrexate, eflornithine (DFMO), and primaquine/clindamycin and pyrimethamine/sulphonamide combinations for Pneumocystis pneumonia; pyrimethamine/sulfadiazine, spiramycin, and clindamycin for toxoplasmosis; pentavalent antimonials (‘Pentostam’ and ‘Glucantime’), pentamidine, amphotericin B, allopurinol, ketoconazole, and itraconazole for leishmaniasis; suramin, pentamidine, melarsoprol, Tryparsamide, Mel W, berenil, and eflornithine (DFMO) for African trypanosomiasis; and nifurtimox, benznidazole and gentian violet for American trypanosomiasis.
P. Dukes - One of the best experts on this subject based on the ideXlab platform.
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Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei☆
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2004Co-Authors: P. DukesAbstract:Abstract Resistance to the trypanocidal drugs atoxyl and Tryparsamide was traditionally considered to be a diagnostic feature of rhodesian sleeping sickness and, consequently, of Trypanosoma rhodesiense. In examining the Tryparsamide sensitivity of 13 isoenzymically defined stocks of the subgenus Trypanozoon , typical West African stocks showed no greater drug sensitivity than did those of East and Central Africa. The greatest resistance to Tryparsamide was shown by two stocks isolated in the Ivory Coast. There was no evidence of strain differences in drug sensitivity to melarsoprol (Mel B) among 26 tested populations; none the less, differential melarsoprol sensitivity was evident in clones from a single mixed population. By contrast, isoenzymically defined West African stocks appeared to be less sensitive to pentamidine and diminazene aceturate (Berenil) than were typical East African stocks. Drug sensitivity was measured in a novel in vivo test designed to minimize the influence of host-parasite interactions, in particular trypanosome penetration of drug-inaccessible sites and host-antibody induced remission of parasitaemia. Drug effect was expressed as the DS 0·1 , the dose required to suppress parasitaemia to 0·1% of that in untreated control mice.
T. M. Davie - One of the best experts on this subject based on the ideXlab platform.
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Tryparsamide Therapy in General Paralysis of the Insane
British Journal of Psychiatry, 2020Co-Authors: T. M. DavieAbstract:Tryparsamide, the sodium salt of N-phenylglycineanmid-p-arsonic acid, was first prepared by Jacobs and Heidelberger in 1915 in the laboratories of the Rockefeller Institute. Following on the excellent reports of its efficacy in the treatment of neuro-syphilis in America, it was distributed to various research centres in this country through the agency of the Medical Research Council prior to its liberation for general use.
A. R. Martin - One of the best experts on this subject based on the ideXlab platform.
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The Treatment of General Paralysis by Tryparsamide
British Journal of Psychiatry, 2020Co-Authors: M. Brown, A. R. MartinAbstract:In spite of the inability of organic arsenical compounds to stem the course of general paralysis, nevertheless, as each new member of this group appears it is given a trial in the hope that it may do good. This has been done in many cases in the, absence of evidence supporting the use of the drug, and where the only justification for its use appears to have been its relation to salvarsan. The results have always proved discouraging, and indeed in many cases the dissolution process has actually been hastened.
Arthur J. Keevill - One of the best experts on this subject based on the ideXlab platform.
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The treatment of sleeping sickness (Trypanosoma rhodesiense)—A study of fifty cases
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2005Co-Authors: Arthur J. KeevillAbstract:Summary 1. In Trypanosoma rhodesiense infections Tryparsamide fails to sterilize either the peripheral blood or the spinal fluid, and produces very little immediate physical improvement. 2. Immediate physical improvement usually follows treatment with “Bayer 205”, with sterilisation of the peripheral blood and disappearance of trypanosomes from the spinal fluid. 3. The place of Tryparsamide is in the treatment of those cases which have relapsed after treatment with “Bayer 205”; or, ideally, in the subsequent treatment of all cases in which the spinal fluid fails to return to normal. 4. Previous treatment with “Bayer 205” greatly increases the risk of visual disturbance and blindness, and subsequent treatment with Tryparsamide should be postponed for at least ten weeks, even if the urine gives no indication of renal changes being still present. 5. The immediate results obtained with the drug which Fourneau, Thefouel and Vallee have designated “309” are at least as good as those obtained with “Bayer 205”.
