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Xiao Chen - One of the best experts on this subject based on the ideXlab platform.
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A nomogram to predict cadmium-induced renal Tubular Dysfunction.
Scientific reports, 2020Co-Authors: Xinru Wang, Taiyi Jin, Guoying Zhu, Xin Chen, Xiao ChenAbstract:Cadmium-induced renal Dysfunction varies between individuals. It would be valuable to figure out those susceptible individuals or predict the risk of cadmium induced renal Dysfunction. In the present study, we used a nomogram model to identify high-risk of cadmium-induced renal Tubular Dysfunction. 342 subjects living in low and moderately cadmium polluted areas were included in this study. The daily cadmium intake from food (FCd) was estimated using food survey. The cadmium in blood (BCd) and urine (UCd) were detected by using flame atomic absorption spectrometry. Urinary β2Microglobulin (UBMG) was chosen as indicator of renal Dysfunction. Logistic regression was used to select the independent risk factors for renal Dysfunction. Bootstrap self-sampling and calibration curves were performed to quantify our modeling strategy. Age, sex, BCd and TCd were used to construct the nomogam in total population; age, BCd and TCd were adopted in women; age and BCd were used in men. The internal validation showed the C-index was 0.76 (95% 47 confidence interval (CI): 0.71-0.82) in total population, 0.74 (95% CI: 0.69-0.79) in men and 0.78 (95% CI: 0.72-0.84) in women. The area under the curve of the nomogram was 0.77 (95% CI: 0.71-0.83) in total population, 0.82(95% CI: 0.74-0.90) in women and 0.74(95% CI: 0.66-0.82) in men. Nomogram may be a rapid and simple risk assessment tool for predicting high-risk of renal Tubular Dysfunction in subjects exposed cadmium.
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The Association Between Alcohol Consumption and Renal Tubular Dysfunction Induced by Cadmium Exposure.
Biological trace element research, 2019Co-Authors: Xiao Chen, Wenjing Cui, Na Duan, Guoying Zhu, Taiyi Jin, Zhongqiu WangAbstract:Alcohol consumption is inversely associated with the risk of chronic kidney diseases. However, this association has not been reported in populations exposed to cadmium. In the present study, we examined the association between alcohol consumption and renal Tubular Dysfunction in populations living in cadmium-polluted areas. A total of 446 subjects (170 men and 276 women) were finally included in our analysis. The urinary cadmium (UCd) and cadmium in blood (BCd) were determined as the exposure biomarkers. Urinary N-acetyl-β-D-glucosaminidase (UNAG) and β2-microgloblin (UBMG) were measured as renal indicators. Alcohol drinking patterns were obtained from a questionnaire and divided into four categories: non-drinking, light drinking ( 7 drinks /week). If UNAG was the indicator of renal Dysfunction, the prevalence of renal Tubular Dysfunction was decreased in subjects with alcohol consumption both in men (χ2 = 8.5, p 3.0 μg/L) or UCd (> 5.0 μg/g creatinine). Our data show that alcohol consumption is inversely associated with cadmium-induced renal Tubular Dysfunction.
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The association between serum vitamin D levels and renal Tubular Dysfunction in a general population exposed to cadmium in China.
PloS one, 2018Co-Authors: Xiao Chen, Guoying Zhu, Zhongqiu Wang, Yan Dai, Xiaoqiang Ding, Taiyi JinAbstract:Cadmium exposure can cause renal Tubular Dysfunction. Recent studies show that vitamin D can play multiple roles in the body. However, the association between serum vitamin D levels and renal Tubular Dysfunction in a general population exposed to cadmium has not been clarified. We performed study to assess the effects of cadmium on serum 25(OH) D levels and the association between serum 25(OH) D levels and renal Tubular Dysfunction in a population environmentally exposed to cadmium. A total of 133 subjects living in control area and two cadmium polluted areas were included in the present study. Cadmium in urine (UCd) and blood (BCd), urinary β2Microglobulin (UBMG), urinary retinol binding protein (URBP) and serum 25 (OH) D were determined. Logistic regression was used to estimate the association between 25 (OH) D and prevalence of renal Tubular Dysfunction. No significant differences were observed in serum 25(OH) D levels among the four quartile of UCd and BCd after adjusting with cofounders. After adjusted with the confounders, the odds ratio (OR) of subjects with 25(OH) D ≥ 40 ng/ml were 0.20 (95%CI: 0.1-0.8) if UBMG was chosen as indicators of renal Dysfunction and 0.28 (95%CI: 0.1-1.1) if URBP was chosen as indicators of renal Dysfunction, compared with those with 25(OH) D < 30 ng/ml, respectively. Similar results were observed in those subjects living in cadmium polluted areas or with high level of UCd or BCd. Our data indicated that cadmium exposure did not affect serum 25(OH) D level and high 25 (OH) D levels were associated with a decreased risk of renal Tubular Dysfunction induced by cadmium.
Taiyi Jin - One of the best experts on this subject based on the ideXlab platform.
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A nomogram to predict cadmium-induced renal Tubular Dysfunction.
Scientific reports, 2020Co-Authors: Xinru Wang, Taiyi Jin, Guoying Zhu, Xin Chen, Xiao ChenAbstract:Cadmium-induced renal Dysfunction varies between individuals. It would be valuable to figure out those susceptible individuals or predict the risk of cadmium induced renal Dysfunction. In the present study, we used a nomogram model to identify high-risk of cadmium-induced renal Tubular Dysfunction. 342 subjects living in low and moderately cadmium polluted areas were included in this study. The daily cadmium intake from food (FCd) was estimated using food survey. The cadmium in blood (BCd) and urine (UCd) were detected by using flame atomic absorption spectrometry. Urinary β2Microglobulin (UBMG) was chosen as indicator of renal Dysfunction. Logistic regression was used to select the independent risk factors for renal Dysfunction. Bootstrap self-sampling and calibration curves were performed to quantify our modeling strategy. Age, sex, BCd and TCd were used to construct the nomogam in total population; age, BCd and TCd were adopted in women; age and BCd were used in men. The internal validation showed the C-index was 0.76 (95% 47 confidence interval (CI): 0.71-0.82) in total population, 0.74 (95% CI: 0.69-0.79) in men and 0.78 (95% CI: 0.72-0.84) in women. The area under the curve of the nomogram was 0.77 (95% CI: 0.71-0.83) in total population, 0.82(95% CI: 0.74-0.90) in women and 0.74(95% CI: 0.66-0.82) in men. Nomogram may be a rapid and simple risk assessment tool for predicting high-risk of renal Tubular Dysfunction in subjects exposed cadmium.
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The Association Between Alcohol Consumption and Renal Tubular Dysfunction Induced by Cadmium Exposure.
Biological trace element research, 2019Co-Authors: Xiao Chen, Wenjing Cui, Na Duan, Guoying Zhu, Taiyi Jin, Zhongqiu WangAbstract:Alcohol consumption is inversely associated with the risk of chronic kidney diseases. However, this association has not been reported in populations exposed to cadmium. In the present study, we examined the association between alcohol consumption and renal Tubular Dysfunction in populations living in cadmium-polluted areas. A total of 446 subjects (170 men and 276 women) were finally included in our analysis. The urinary cadmium (UCd) and cadmium in blood (BCd) were determined as the exposure biomarkers. Urinary N-acetyl-β-D-glucosaminidase (UNAG) and β2-microgloblin (UBMG) were measured as renal indicators. Alcohol drinking patterns were obtained from a questionnaire and divided into four categories: non-drinking, light drinking ( 7 drinks /week). If UNAG was the indicator of renal Dysfunction, the prevalence of renal Tubular Dysfunction was decreased in subjects with alcohol consumption both in men (χ2 = 8.5, p 3.0 μg/L) or UCd (> 5.0 μg/g creatinine). Our data show that alcohol consumption is inversely associated with cadmium-induced renal Tubular Dysfunction.
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The association between serum vitamin D levels and renal Tubular Dysfunction in a general population exposed to cadmium in China.
PloS one, 2018Co-Authors: Xiao Chen, Guoying Zhu, Zhongqiu Wang, Yan Dai, Xiaoqiang Ding, Taiyi JinAbstract:Cadmium exposure can cause renal Tubular Dysfunction. Recent studies show that vitamin D can play multiple roles in the body. However, the association between serum vitamin D levels and renal Tubular Dysfunction in a general population exposed to cadmium has not been clarified. We performed study to assess the effects of cadmium on serum 25(OH) D levels and the association between serum 25(OH) D levels and renal Tubular Dysfunction in a population environmentally exposed to cadmium. A total of 133 subjects living in control area and two cadmium polluted areas were included in the present study. Cadmium in urine (UCd) and blood (BCd), urinary β2Microglobulin (UBMG), urinary retinol binding protein (URBP) and serum 25 (OH) D were determined. Logistic regression was used to estimate the association between 25 (OH) D and prevalence of renal Tubular Dysfunction. No significant differences were observed in serum 25(OH) D levels among the four quartile of UCd and BCd after adjusting with cofounders. After adjusted with the confounders, the odds ratio (OR) of subjects with 25(OH) D ≥ 40 ng/ml were 0.20 (95%CI: 0.1-0.8) if UBMG was chosen as indicators of renal Dysfunction and 0.28 (95%CI: 0.1-1.1) if URBP was chosen as indicators of renal Dysfunction, compared with those with 25(OH) D < 30 ng/ml, respectively. Similar results were observed in those subjects living in cadmium polluted areas or with high level of UCd or BCd. Our data indicated that cadmium exposure did not affect serum 25(OH) D level and high 25 (OH) D levels were associated with a decreased risk of renal Tubular Dysfunction induced by cadmium.
Fatih Bulucu - One of the best experts on this subject based on the ideXlab platform.
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Renal Tubular Dysfunction in -Thalassemia Minor
2003Co-Authors: Türker Çetin, Cagatay Oktenli, Taner Ozgurtas, Mujdat Yenicesu, S. Yavuz Sanisoglu, Yusuf Oguz, Oguzhan Yildiz, Ismail Kurt, Ugur Musabak, Fatih BulucuAbstract:● Background: Persons with -thalassemia minor usually are symptomless. However, we previously reported renal Tubular Dysfunction in a patient with -thalassemia minor. The aim of this study is to investigate renal function in patients with -thalassemia minor. Methods: Forty-one subjects with -thalassemia minor and 20 sex- and age-matched healthy subjects were enrolled in the study. For analysis, patients were divided into 2 groups: group A, all patients with anemia (n 19), and group B, patients without anemia (n 22). Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis. Results: Anemic patients had increased urinary zinc excretion (Uzinc) and fractional excretion of sodium (FENa) and uric acid (FEUA) compared with both controls and patients without anemia. Hemoglobin levels correlated significantly in a negative manner with Uzinc ,F E Na, and FEUA in patients with -thalassemia minor. However, serum lactate dehydrogenase levels correlated significantly in a positive manner with the same parameters. In addition, 6 of 41 patients (14.6%) with -thalassemia minor showed significant signs of renal tubulopathy, such as hypercalciuria, decreased Tubular reabsorption of phosphorus with hypophosphatemia, hypomagnesemia with renal magnesium wasting, hypouricemia with renal uric acid wasting, and Tubular proteinuria. Conclusion: Proximal renal Tubular Dysfunction is not rare in patients with -thalassemia minor. Am J Kidney Dis 42:1164-1168. © 2003 by the National Kidney Foundation, Inc.
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Renal Tubular Dysfunction in β-thalassemia minor
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003Co-Authors: Türker Çetin, Cagatay Oktenli, Taner Ozgurtas, Mujdat Yenicesu, S. Yavuz Sanisoglu, Yusuf Oguz, Oguzhan Yildiz, Ismail Kurt, Ugur Musabak, Fatih BulucuAbstract:Abstract Background: Persons with β-thalassemia minor usually are symptomless. However, we previously reported renal Tubular Dysfunction in a patient with β-thalassemia minor. The aim of this study is to investigate renal function in patients with β-thalassemia minor. Methods: Forty-one subjects with β-thalassemia minor and 20 sex- and age-matched healthy subjects were enrolled in the study. For analysis, patients were divided into 2 groups: group A, all patients with anemia (n = 19), and group B, patients without anemia (n = 22). Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis. Results: Anemic patients had increased urinary zinc excretion (U zinc ) and fractional excretion of sodium (FE Na ) and uric acid (FE UA ) compared with both controls and patients without anemia. Hemoglobin levels correlated significantly in a negative manner with U zinc , FE Na , and FE UA in patients with β-thalassemia minor. However, serum lactate dehydrogenase levels correlated significantly in a positive manner with the same parameters. In addition, 6 of 41 patients (14.6%) with β-thalassemia minor showed significant signs of renal tubulopathy, such as hypercalciuria, decreased Tubular reabsorption of phosphorus with hypophosphatemia, hypomagnesemia with renal magnesium wasting, hypouricemia with renal uric acid wasting, and Tubular proteinuria. Conclusion: Proximal renal Tubular Dysfunction is not rare in patients with β-thalassemia minor.
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Renal Tubular Dysfunction in a patient with beta-thalassemia minor.
Nephron, 2002Co-Authors: Cagatay Oktenli, Fatih BulucuAbstract:β-Thalassemia minor is a hemoglobinopathy which has been known as a symptomless carrier state. Although there are many causes leading to renal Tubular Dysfunction, β-thalassemia minor has not been rep
Teruhiko Kido - One of the best experts on this subject based on the ideXlab platform.
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Renal Tubular Dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas.
Journal of exposure science & environmental epidemiology, 2014Co-Authors: Yasushi Suwazono, Kazuhiro Nogawa, Yuko Morikawa, Muneko Nishijo, Etsuko Kobayashi, Teruhiko Kido, Hideaki Nakagawa, Koji NogawaAbstract:Renal Tubular Dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas
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influence of consumption of cadmium polluted rice or jinzu river water on occurrence of renal Tubular Dysfunction and or itai itai disease
Biological Trace Element Research, 2009Co-Authors: Etsuko Kobayashi, Yasushi Suwazono, Mirei Dochi, Ryumon Honda, Teruhiko KidoAbstract:The aim of this study was to clarify whether consumption of cadmium (Cd)-polluted rice or Jinzu River water exerted any influence on the occurrence of renal Tubular Dysfunction and/or Itai-itai disease. From the participants of health examinations conducted in 1967 and 1968, 3,078 subjects who had resided for >30 years in the present hamlet and were aged >50 years were selected as the target population and were divided according to their residence in 55 hamlets. In a multiple regression analysis, the regression coefficients between rice-Cd concentration and prevalence of abnormal urinary findings (proteinuria, glucosuria, or proteinuria with glucosuria) or patients with Itai-itai disease were statistically significant between both sexes. The correlation between the prevalence of users of Jinzu River water and the occurrence of glucosuria in men as well as abnormal urinary findings in women was not statistically significant. We surmise that eating Cd-polluted rice and drinking and/or cooking with Jinzu River water influenced the occurrence of Itai-itai disease. The occurrence of renal Tubular Dysfunction is likely to have also been influenced by both factors, with eating Cd-polluted rice having a greater impact on the occurrence of renal Tubular Dysfunction as compared to drinking and/or cooking with Jinzu River water.
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Influence of consumption of cadmium-polluted rice or Jinzu River water on occurrence of renal Tubular Dysfunction and/or Itai-itai disease.
Biological trace element research, 2008Co-Authors: Etsuko Kobayashi, Yasushi Suwazono, Mirei Dochi, Ryumon Honda, Teruhiko KidoAbstract:The aim of this study was to clarify whether consumption of cadmium (Cd)-polluted rice or Jinzu River water exerted any influence on the occurrence of renal Tubular Dysfunction and/or Itai-itai disease. From the participants of health examinations conducted in 1967 and 1968, 3,078 subjects who had resided for >30 years in the present hamlet and were aged >50 years were selected as the target population and were divided according to their residence in 55 hamlets. In a multiple regression analysis, the regression coefficients between rice-Cd concentration and prevalence of abnormal urinary findings (proteinuria, glucosuria, or proteinuria with glucosuria) or patients with Itai-itai disease were statistically significant between both sexes. The correlation between the prevalence of users of Jinzu River water and the occurrence of glucosuria in men as well as abnormal urinary findings in women was not statistically significant. We surmise that eating Cd-polluted rice and drinking and/or cooking with Jinzu River water influenced the occurrence of Itai-itai disease. The occurrence of renal Tubular Dysfunction is likely to have also been influenced by both factors, with eating Cd-polluted rice having a greater impact on the occurrence of renal Tubular Dysfunction as compared to drinking and/or cooking with Jinzu River water.
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Causes of death and renal Tubular Dysfunction in residents exposed to cadmium in the environment.
Occupational and environmental medicine, 2006Co-Authors: Muneko Nishijo, Yuko Morikawa, Etsuko Kobayashi, Teruhiko Kido, Hideaki Nakagawa, Kenji Tawara, Katsuyuki Miura, Akemi Ikawa, Koji NogawaAbstract:Objectives: To clarify the causes of death of residents with renal Tubular Dysfunction induced by cadmium (Cd) in the environment. Methods: A 15 year follow up study was performed with the inhabitants living in the Cd polluted Kakehashi River basin in Japan. Standardised mortality ratios (SMRs) for causes of death, classified by ICD-9, were computed using the person-years method to investigate the excess mortality of subjects with urinary β2-MG (microglobulin) ⩾1000 μg/gCr. Mortality risk analysis was performed using Cox’s proportional model to compare mortality between subjects with urinary β2-MG ⩾1000 and Results: Excess mortality due to heart failure and cerebral infarction in both sexes, and nephritis and nephrosis in men, was observed among subjects with urinary β2-MG ⩾1000 μg/gCr. Significant increases in mortality risk for cerebral infarction in men and for malignant neoplasms in women with urinary β2-MG ⩾1000 μg/gCr were observed during the first five year observation period. For nephritis and nephrosis, the mortality risks for men and women with urinary β2-MG ⩾1000 μg/gCr significantly increased over the 15 year observation period. The mortality risks for heart failure and cerebral infarction increased in proportion to the increased urinary β2-MG in both sexes. Increased mortality risks for nephritis and nephrosis were identified in the subjects with urinary β2-MG ⩾10000 μg/gCr in both sexes. Conclusion: Renal Tubular Dysfunction induced by Cd affected the causes of death, and mortality for heart failure, cerebral infarction, and nephritis and nephrosis was increased among inhabitants living in a Cd polluted area in Japan. In women, cancer mortality may have been increased while Cd pollution was ongoing.
Kazunari Kaneko - One of the best experts on this subject based on the ideXlab platform.
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Risk factors for sodium valproate-induced renal Tubular Dysfunction
Clinical and experimental nephrology, 2017Co-Authors: Satoko Koga, Takahisa Kimata, Sohsaku Yamanouchi, Shoji Tsuji, Ken Yoshimura, Atsushi Araki, Kazunari KanekoAbstract:Objective To explore the risk factors for the development of sodium valproate (VPA)-induced renal Tubular Dysfunction for early diagnosis and treatment. Study design The subjects were selected from patients who were diagnosed with epilepsy and administered VPA. Blood and spot urine samples were collected and measured the concentration of VPA, the level of serum phosphorus, serum uric acid, serum free carnitine, serum cystatin-c, and urine β2-microglobulin (BMG). Patients with urine BMG/creatinine levels above 219.2 were treated as renal proximal Tubular Dysfunction (RTD), with all others treated as non-RTD. Results Eighty-seven patients, 4-48 years, 53 men and 34 women, were studied. RTD group is 17 patients and non-RTD group is 70 patients. Univariate analyses revealed that the RTD patients were more likely to be bedridden, receiving enteral tube feeding, taking more anticonvulsants, and demonstrating significantly lower serum levels of free carnitine, uric acid, and phosphorus. Among them, bedridden, free serum carnitine, and phosphorus levels were associated with the development of RTD by multivariate analysis. Conclusions Bedridden patients receiving VPA are susceptible to hypocarnitinemia, which can cause RTD and may lead to FS. Therefore, urinary BMG should be measured regularly in all patients receiving VPA to assess renal Tubular function. An additional measurement of serum free carnitine level should be considered in patients who developed RTD. Supplementation of carnitine for those patients to prevent such complication deserves for further study.
