The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Joel L Friedman - One of the best experts on this subject based on the ideXlab platform.
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granular cell tumor of the testicular Tunica Albuginea a case report
Applied Immunohistochemistry & Molecular Morphology, 2014Co-Authors: Juan Guo, Joel L FriedmanAbstract:Granular cell tumor (GCT) is exceedingly rare in the genitourinary tract. We report a case of GCT arising in the Tunica Albuginea of the testis. A 42-year-old male presented with a painless left testicular mass. Scrotal ultrasound studies showed an intratesticular mass that was suspicious for a testicular malignancy; a left orchiectomy was subsequently performed. Grossly, there was a well-circumscribed tumor mass in the periphery of the testis abutting the Tunica Albuginea. Microscopically, the tumor was poorly delimited and located in the Tunica Albuginea with minimal infiltration to the underlying testicular parenchyma. The lesion consisted of clusters and sheets of large polygonal cells dissected by fibrous septa. The tumor cells had indistinct cellular borders, abundant granular eosinophilic cytoplasm, and small nuclei with indistinct nucleoli. No cytologic atypia or increased mitotic activity was seen. Immunohistochemically, the tumor cells were positive for S-100, inhibin-α, and CD68 and negative for calretinin, Melan-A, and WT-1. Ki-67 showed a low proliferation index (<1%). The morphology, in conjunction with immunohistochemical profile, led to a diagnosis of GCT of the Tunica Albuginea. Although GCT can occur in almost any location of the body, it has not been described to involve the human testis.
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Granular cell tumor of the testicular Tunica Albuginea: a case report
Applied immunohistochemistry & molecular morphology : AIMM, 2014Co-Authors: Juan Guo, Joel L FriedmanAbstract:Granular cell tumor (GCT) is exceedingly rare in the genitourinary tract. We report a case of GCT arising in the Tunica Albuginea of the testis. A 42-year-old male presented with a painless left testicular mass. Scrotal ultrasound studies showed an intratesticular mass that was suspicious for a testicular malignancy; a left orchiectomy was subsequently performed. Grossly, there was a well-circumscribed tumor mass in the periphery of the testis abutting the Tunica Albuginea. Microscopically, the tumor was poorly delimited and located in the Tunica Albuginea with minimal infiltration to the underlying testicular parenchyma. The lesion consisted of clusters and sheets of large polygonal cells dissected by fibrous septa. The tumor cells had indistinct cellular borders, abundant granular eosinophilic cytoplasm, and small nuclei with indistinct nucleoli. No cytologic atypia or increased mitotic activity was seen. Immunohistochemically, the tumor cells were positive for S-100, inhibin-α, and CD68 and negative for calretinin, Melan-A, and WT-1. Ki-67 showed a low proliferation index (
Juan Guo - One of the best experts on this subject based on the ideXlab platform.
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granular cell tumor of the testicular Tunica Albuginea a case report
Applied Immunohistochemistry & Molecular Morphology, 2014Co-Authors: Juan Guo, Joel L FriedmanAbstract:Granular cell tumor (GCT) is exceedingly rare in the genitourinary tract. We report a case of GCT arising in the Tunica Albuginea of the testis. A 42-year-old male presented with a painless left testicular mass. Scrotal ultrasound studies showed an intratesticular mass that was suspicious for a testicular malignancy; a left orchiectomy was subsequently performed. Grossly, there was a well-circumscribed tumor mass in the periphery of the testis abutting the Tunica Albuginea. Microscopically, the tumor was poorly delimited and located in the Tunica Albuginea with minimal infiltration to the underlying testicular parenchyma. The lesion consisted of clusters and sheets of large polygonal cells dissected by fibrous septa. The tumor cells had indistinct cellular borders, abundant granular eosinophilic cytoplasm, and small nuclei with indistinct nucleoli. No cytologic atypia or increased mitotic activity was seen. Immunohistochemically, the tumor cells were positive for S-100, inhibin-α, and CD68 and negative for calretinin, Melan-A, and WT-1. Ki-67 showed a low proliferation index (<1%). The morphology, in conjunction with immunohistochemical profile, led to a diagnosis of GCT of the Tunica Albuginea. Although GCT can occur in almost any location of the body, it has not been described to involve the human testis.
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Granular cell tumor of the testicular Tunica Albuginea: a case report
Applied immunohistochemistry & molecular morphology : AIMM, 2014Co-Authors: Juan Guo, Joel L FriedmanAbstract:Granular cell tumor (GCT) is exceedingly rare in the genitourinary tract. We report a case of GCT arising in the Tunica Albuginea of the testis. A 42-year-old male presented with a painless left testicular mass. Scrotal ultrasound studies showed an intratesticular mass that was suspicious for a testicular malignancy; a left orchiectomy was subsequently performed. Grossly, there was a well-circumscribed tumor mass in the periphery of the testis abutting the Tunica Albuginea. Microscopically, the tumor was poorly delimited and located in the Tunica Albuginea with minimal infiltration to the underlying testicular parenchyma. The lesion consisted of clusters and sheets of large polygonal cells dissected by fibrous septa. The tumor cells had indistinct cellular borders, abundant granular eosinophilic cytoplasm, and small nuclei with indistinct nucleoli. No cytologic atypia or increased mitotic activity was seen. Immunohistochemically, the tumor cells were positive for S-100, inhibin-α, and CD68 and negative for calretinin, Melan-A, and WT-1. Ki-67 showed a low proliferation index (
Wayne J.g. Hellstrom - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of corporal fibrosis in cadaveric pericardium and vein grafts for Tunica Albuginea substitution in rats.
Asian journal of andrology, 2003Co-Authors: Somboon Leungwattanakij, Vaewvadee Tiewthanom, Wayne J.g. HellstromAbstract:AIM To evaluate the degree of corporal fibrosis in rats with cadaveric pericardium or vein as grafting materials for Tunica Albuginea substitution. MATERIALS AND METHODS Thirty male Sprague-Dawley rats (300 g approximately 325 g) were divided at random into 3 groups of 10 animals each: group 1 was the sham-operated controls and groups 2 and 3 underwent wedge excision of Tunica Albuginea and replacement with cadaveric pericardium and vein grafts, respectively. Four months later, rats were sacrificed and the penis removed to assess the degree of fibrosis using RT-PCR technique for TGF-bgr1 mRNA expression. The tissues were fixed in 10% formalin, paraffin-embedded and stained with Masson's trichrome and Verhoff's van Giesen for collagen and elastic fibers. RESULTS Four months after grafting, there was minimal fibrosis surrounding the patch in the vein graft rats and moderate fibrosis in the pericardial graft rats. The degree of penile fibrosis in the pericardial graft rats was significantly higher than that in the controls (P 0.05). CONCLUSION The degree of penile fibrosis of cadaveric pericardial graft was significantly higher than that of the control group, while in the vein graft group it was comparable to the latter. The authors believe that the vein graft may be a more ideal substance to be used as the Tunica Albuginea substitute than the pericardial graft in the surgical treatment of Peyronie'S disease.
L. Ripa - One of the best experts on this subject based on the ideXlab platform.
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Cysts of the Tunica Albuginea: sonographic appearance.
AJR. American journal of roentgenology, 1998Co-Authors: M.t. Martinez-berganza, L. Sarria, R. Cozcolluela, T. Cabada, F Escolar, L. RipaAbstract:OBJECTIVE: Testicular cysts of the Tunica Albuginea are an uncommon phenomenon, important because of their possible confusion with testicular tumors. Accurate diagnosis may avoid aggressive and irreversible treatment such as testicular ablation. The purpose of this study is to report our experience in such diagnosis through sonographic detection of Albuginea cysts. CONCLUSION: Sonography is the technique of choice in the diagnosis of any testicular tumor formation, allowing the differentiation of cysts from neoplasia and avoiding unnecessary intervention in patients with cysts of the Tunica Albuginea.
Kevin T. Mcvary - One of the best experts on this subject based on the ideXlab platform.
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COMPARISON OF Tunica Albuginea SUBSTITUTES FOR THE TREATMENT OF PEYRONIE'S DISEASE
The Journal of urology, 1998Co-Authors: Robert E. Brannigan, Edward D. Kim, Ryoichi Oyasu, Kevin T. McvaryAbstract:AbstractPurpose: Peyronie's disease is a connective tissue disorder resulting in fibrotic plaque formation on the Tunica Albuginea of the penis. One approach to repair consists of plaque excision and patching with one of many potential patch materials. Because the optimal patch material for covering the resultant defect has not been determined, this study compares histological and cavernosometric changes in the penis as a result of the placement of three different types of patch grafts used in surgery for Peyronie's disease.Materials and Methods: Eleven mongrel dogs were divided into three groups, each receiving a different patch material (superficial dorsal penile vein, silicone fabric, and dermabraded preputial flap). Each dog had dynamic infusion cavernosometry (DIC) performed prior to placement of the patch over a 6 × 3 mm. defect surgically created in the Tunica Albuginea. Three months later, DIC was repeated prior to sacrifice. Histology of the penis was examined using Masson's trichrome, and hemato...
