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Margaret A Vizzard - One of the best experts on this subject based on the ideXlab platform.
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expression and Function of transforming growth factor β isoforms and cognate receptors in the rat Urinary bladder following cyclophosphamide induced cystitis
American Journal of Physiology-renal Physiology, 2013Co-Authors: Eric J Gonzalez, Beatrice M Girard, Margaret A VizzardAbstract:Numerous proinflammatory cytokines have been implicated in the reorganization of lower Urinary Tract Function following cyclophosphamide (CYP)-induced cystitis. The present study investigated the f...
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changes in Urinary bladder neurotrophic factor mrna and ngf protein following Urinary bladder dysFunction
Experimental Neurology, 2000Co-Authors: Margaret A VizzardAbstract:AbsTract Spinal cord injury and cyclophosphamide-induced cystitis dramatically alter lower Urinary Tract Function and produce neurochemical, electrophysiological, and anatomical changes that may contribute to reorganization of the micturition reflex. Mechanisms underlying this neural plasticity may involve alterations in neurotrophic factors in the Urinary bladder. These studies have determined neurotrophic factors in the Urinary bladder that may contribute to reorganization of the micturition reflex following cystitis or spinal cord injury. A ribonuclease protection assay was used to measure changes in Urinary bladder neurotrophic factor mRNA (βNGF, BDNF, GDNF, CNTF, NT-3, and NT-4) following spinal cord injury (acute/chronic) or cyclophosphamide-induced cystitis (acute/chronic). The correlation between Urinary bladder nerve growth factor mRNA and nerve growth factor protein expression was also determined. Each experimental paradigm resulted in significant ( P ≤ 0.05–0.005) changes in Urinary bladder neurotrophic factor mRNA, although the magnitude of the changes differed between paradigms. Urinary bladders from rats with acute spinal cord injury (4 days) exhibited the largest increase in neurotrophic factor mRNA levels (βNGF, 21-fold increase; BDNF, 78-fold increase; GDNF, 11-fold increase; CNTF, 5.5-fold increase; NT-3, 10-fold increase; NT-4, 25-fold increase) relative to control Urinary bladders. More modest but significant increases were demonstrated for Urinary bladders from rats with chronic (4–6 weeks) spinal cord injury. Significant increases in Urinary bladder neurotrophic factor mRNA levels of comparable magnitude were demonstrated following either acute or chronic cyclophosphamide-induced cystitis. Increased abundance of Urinary bladder nerve growth factor mRNA was not always associated with increased total Urinary bladder nerve growth factor. Total Urinary bladder nerve growth factor decreased following acute or chronic cystitis despite increased abundance of nerve growth factor mRNA. Urinary bladder nerve growth factor mRNA correlates with protein measures 5–6 weeks following spinal cord injury but not earlier. The 5- to 6-week time point coincided with the reemergence of the spinal bladder-to-bladder reflex mechanisms following spinal cord injury. Discrepancies between two measures (mRNA and protein) may reflect retrograde axonal transport of nerve growth factor to the dorsal root ganglia (L6–S1). Retrogradely transported NGF may play a role in altered lower Urinary Tract Function following spinal cord injury or cyclophosphamide-induced cystitis.
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changes in Urinary bladder neurotrophic factor mrna and ngf protein following Urinary bladder dysFunction
Experimental Neurology, 2000Co-Authors: Margaret A VizzardAbstract:Spinal cord injury and cyclophosphamide-induced cystitis dramatically alter lower Urinary Tract Function and produce neurochemical, electrophysiological, and anatomical changes that may contribute to reorganization of the micturition reflex. Mechanisms underlying this neural plasticity may involve alterations in neurotrophic factors in the Urinary bladder. These studies have determined neurotrophic factors in the Urinary bladder that may contribute to reorganization of the micturition reflex following cystitis or spinal cord injury. A ribonuclease protection assay was used to measure changes in Urinary bladder neurotrophic factor mRNA (betaNGF, BDNF, GDNF, CNTF, NT-3, and NT-4) following spinal cord injury (acute/chronic) or cyclophosphamide-induced cystitis (acute/chronic). The correlation between Urinary bladder nerve growth factor mRNA and nerve growth factor protein expression was also determined. Each experimental paradigm resulted in significant (P Urinary bladder neurotrophic factor mRNA, although the magnitude of the changes differed between paradigms. Urinary bladders from rats with acute spinal cord injury (4 days) exhibited the largest increase in neurotrophic factor mRNA levels (betaNGF, 21-fold increase; BDNF, 78-fold increase; GDNF, 11-fold increase; CNTF, 5.5-fold increase; NT-3, 10-fold increase; NT-4, 25-fold increase) relative to control Urinary bladders. More modest but significant increases were demonstrated for Urinary bladders from rats with chronic (4-6 weeks) spinal cord injury. Significant increases in Urinary bladder neurotrophic factor mRNA levels of comparable magnitude were demonstrated following either acute or chronic cyclophosphamide-induced cystitis. Increased abundance of Urinary bladder nerve growth factor mRNA was not always associated with increased total Urinary bladder nerve growth factor. Total Urinary bladder nerve growth factor decreased following acute or chronic cystitis despite increased abundance of nerve growth factor mRNA. Urinary bladder nerve growth factor mRNA correlates with protein measures 5-6 weeks following spinal cord injury but not earlier. The 5- to 6-week time point coincided with the reemergence of the spinal bladder-to-bladder reflex mechanisms following spinal cord injury. Discrepancies between two measures (mRNA and protein) may reflect retrograde axonal transport of nerve growth factor to the dorsal root ganglia (L6-S1). Retrogradely transported NGF may play a role in altered lower Urinary Tract Function following spinal cord injury or cyclophosphamide-induced cystitis.
Karl B Thor - One of the best experts on this subject based on the ideXlab platform.
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effects of α1 adrenergic receptor subtype selective antagonists on lower Urinary Tract Function in rats with bladder outlet obstruction
The Journal of Urology, 2004Co-Authors: Baojun Gu, Jerome P Reiter, Debra A Schwinn, Michael P Smith, Cees Korstanje, Karl B Thor, Paul C DolberAbstract:PURPOSE: Antagonists of alpha 1-adrenergic receptors (alpha 1ARs) relieve obstructive and irritative symptoms in patients with bladder outlet obstruction. However, to our knowledge mechanisms underlying the relief of irritative symptoms remain unknown. Because bladder alpha 1dARs are up-regulated in some rats with bladder outlet obstruction, we investigated the effect of the alpha 1aAR antagonist 5-methyl urapidil (5MU) vs the alpha 1a/alpha 1dAR antagonist tamsulosin on Urinary frequency in obstructed rats. MATERIALS AND METHODS: Baseline frequency was measured using a chronic micturition recording system and then obstruction (40 rats) or sham obstruction surgery (11 rats) was performed. After 6 weeks frequency was reassessed, followed by subcutaneous implantation of osmotic pumps to deliver 5MU, tamsulosin or vehicle for 1 week. Upon the completion of drug treatment Urinary frequency was again measured and the pressor response to the alpha 1AR agonist phenylephrine was documented. RESULTS: Obstructed bladder mass was an average of 4.9 times greater than bladder mass in sham operated rats (p <0.001). Urinary frequency was elevated in obstructed rats with a bladder mass of greater than 500 mg vs all rats with a bladder mass of under 255 mg (p = 0.01). Of rats with a bladder mass of greater than 500 mg frequency was decreased in those treated with tamsulosin (p = 0.03) but not in those treated with 5MU. Tamsulosin and 5MU inhibited the pressor response to phenylephrine. CONCLUSIONS: Urinary frequency is increased in rats with a bladder mass of greater than 500 mg. The combined alpha 1a/alpha 1dAR antagonist tamsulosin decreases Urinary frequency more than the alpha 1aAR selective antagonist 5MU. This finding supports the hypothesis that the alpha 1dAR is important for mediating irritative symptoms.
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comparison of the effects of serotonin selective norepinephrine selective and dual serotonin and norepinephrine reuptake inhibitors on lower Urinary Tract Function in cats
Life Sciences, 2002Co-Authors: Mary A Katofiasc, Karl B Thor, Jeffrey S Nissen, James E AudiaAbstract:Previous studies showed that the dual serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake inhibitor, duloxetine, increases bladder capacity and urethral sphincter electromyographic (EMG) activity in a cat model of acetic acid-induced bladder irritation. The present study aimed to determine the relative importance of 5-HT versus NE reuptake inhibition for mediating these effects by examining drugs that are selective for either the 5-HT or NE system or both. Similar to duloxetine, venlafaxine (0.1 to 10 mg/kg), also a dual serotonin and norepinephrine reuptake inhibitor, produced marked increases in bladder capacity and EMG activity that were reversed by methiothepin (0.3 mg/kg). S-norfluoxetine (0.01 to 10 mg/kg), a serotonin selective reuptake inhibitor, produced small but significant increases in bladder capacity and EMG activity at doses of 3 and 10 mg/kg. Thionisoxetine (0.01 to 3.0 mg/kg), a NE selective reuptake inhibitor, produced no effects on bladder capacity or sphincter EMG activity. Surprisingly, co-administration of thionisoxetine and s-norfluoxetine up to doses of 1 mg/kg of each compound produced no effect on lower Urinary Tract Function. These doses were the maximum that could be administered in combination due to drug-induced emergence of skeletal muscle activity in chloralose-anesthetized animals. These results indicate that there are unexplained pharmacological differences between the effects of single compounds that exhibit dual NE and 5-HT reuptake inhibition and a combination of compounds that exhibit selective NE and 5-HT reuptake inhibition on lower Urinary Tract Function.
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effects of duloxetine a combined serotonin and norepinephrine reuptake inhibitor on central neural control of lower Urinary Tract Function in the chloralose anesthetized female cat
Journal of Pharmacology and Experimental Therapeutics, 1995Co-Authors: Karl B Thor, M A KatofiascAbstract:Because all three components of lower Urinary Tract control (parasympathetic, sympathetic and somatic) are intimately associated with serotonin (5-hydroxytryptamine [5HT])- and norepinephrine (NE)- containing terminals and receptors, in the present study, we examined the effects of increasing extracellular levels of 5HT and NE with duloxetine, a 5HT and NE reuptake inhibitor, on lower Urinary Tract Function under "normal" or nonirritated conditions (transvesical infusion of saline) and in a model of bladder irritation (i.e., transvesical infusion of 0.5% acetic acid) in chloralose-anesthetized cats. Irritation reduced bladder capacity (to 20% of control) and produced insignificant increases in periurethral electromyographic (EMG) activity compared with nonirritated control animals. Duloxetine produced insignificant increases in bladder capacity and sphincter EMG activity when administered under nonirritated bladder conditions. However, this duloxetine "pretreatment" did prevent the typical acetic acid-induced reductions in bladder capacity and unmasked a marked activation of sphincter EMG activity on acetic acid infusion (by 8-fold). Furthermore, when administered initially under irritated bladder conditions, duloxetine produced dose-dependent increases in bladder capacity (by 5-fold) and increased periurethral striated muscle EMG activity (by 8-fold). The effects on bladder activity were due to central mechanisms since bladder conTractions evoked by direct electrical stimulation of efferent fibers in the pelvic nerve were not effected by duloxetine. The effects of duloxetine on bladder capacity were antagonized by methiothepin, a non-selective 5HT receptor antagonist, but not by the other 5HT and NE receptor antagonists examined: LY53857, a 5HT2 antagonist; prazosin, an alpha-1-adrenergic receptor antagonist; idazoxan, an alpha-2-adrenergic receptor antagonist; or propranolol, a beta-adrenergic receptor antagonist. The facilitatory effects of duloxetine on periurethral sphincter EMG were significantly antagonized to various degrees by methiothepin, LY53857 and prazosin but not by idazoxan or propranolol. These results indicate that duloxetine, through inhibition of 5HT and NE reuptake, has weak effects under normal conditions. However, under conditions of bladder irritation, duloxetine suppresses bladder activity through 5HT receptor mechanisms and enhances external urethral sphincter activity through 5HT2 and alpha-1-adrenergic mechanisms.
W C De Groat - One of the best experts on this subject based on the ideXlab platform.
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effect of orchiectomy and testosterone replacement on lower Urinary Tract Function in anesthetized rats
American Journal of Physiology-renal Physiology, 2016Co-Authors: Chenli Cheng, W C De GroatAbstract:Lower Urinary Tract (LUT) symptoms (LUTS), including frequency, urgency, incomplete voiding, and slow stream, are common in both men and women with advancing age. The most common cause for LUTS in aging men is benign prostatic hyperplasia. Some studies have also revealed an inverse association of serum testosterone levels with LUTS; however, the underlying mechanisms by which gonadal hormones affect the LUT have not been clarified. In the present study, we examined the effect of orchiectomy and testosterone replacement on LUT Function in adult male Sprague-Dawley rats. Six weeks after bilateral orchiectomy or sham operations and 3 wk after injection of long-acting testosterone undecanoate (100 mg/kg im), transvesical cystometry and external urethral sphincter electromyogram (EUS EMG) recordings were performed under urethane anesthesia. The micturition reflex was elicited in both sham and orchiectomized animals. In orchiectomized rats, volume threshold for inducing micturition decreased by 47.6%; however, conTraction amplitude, duration, and voiding efficiency were similar in sham and orchiectomized rats. The active period during EUS EMG bursting was lengthened during micturition in orchiectomized animals. Testosterone treatment, which normalized plasma testosterone levels, reversed these changes but also increased the duration of EUS EMG bursting. Orchiectomy also reduced mean voiding flow rate estimated from the duration of EUS EMG bursting, an effect that was not reversed by testosterone. The results indicate that orchiectomy affects both the active and passive properties of the bladder and urethra, and that many, but not all, of the changes can be reversed by testosterone.
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serotonergic drugs and spinal cord transections indicate that different spinal circuits are involved in external urethral sphincter activity in rats
American Journal of Physiology-renal Physiology, 2007Co-Authors: Huiyi Chang, Chenli Cheng, Jia Jin Jason Chen, W C De GroatAbstract:Lower Urinary Tract Function is regulated by spinal and supraspinal reflexes that coordinate the activity of the Urinary bladder and external urethral sphincter (EUS). Two types of EUS activity (to...
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mechanisms underlying the recovery of lower Urinary Tract Function following spinal cord injury
Spinal Cord, 1995Co-Authors: W C De GroatAbstract:Mechanisms underlying the recovery of lower Urinary Tract Function following spinal cord injury
Thomas M. Kessler - One of the best experts on this subject based on the ideXlab platform.
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neuromodulation of Urinary Tract Function
The New England Journal of Medicine, 2019Co-Authors: Thomas M. Kessler, Lori A Birder, Pablo GomeryAbstract:Control of Urinary Tract Function Control of the lower Urinary Tract is complex and poorly understood. A preclinical study showed that precise control of neuronal innervation can be achieved by eng...
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International Spinal Cord Injury Lower Urinary Tract Function Basic Data Set (version 2.0)
Spinal Cord Series and Cases, 2018Co-Authors: Fin Biering-sørensen, Michael Kennelly, Todd Linsenmeyer, Lawrence Vogel, Jurgen Pannek, Thomas M. Kessler, Jean-jacques WyndaeleAbstract:Study designRevision, review, and presentation of the International Spinal Cord Injury (SCI) Lower Urinary Tract (LUT) Function Basic Data Set (version 2.0).ObjectivesDescribe the revision and review and present the data set.SettingInternational.MethodsThe first version of the data set was revised according to new knowledge and suggestions. The review included International SCI Data Sets Committee, American Spinal Injury Association (ASIA) board, International Spinal Cord Society (ISCoS) executive and scientific committees, major organizations, and interested individuals. The data set was also on ASIA and ISCoS websites. All replies were answered and appropriate adjustments made. Finally, the data set was endorsed by ASIA board, and ISCoS executive and scientific committees.ResultsAmong revisions are adoptions of new terminology by the International Continence Society. For most variables, advice for collection of information from pediatric patients stated. For the variable ‘Bladder emptying’, is in the data collection form to the response category ‘Normal voiding’ expanded. ‘Sacral Anterior Root Stimulator’ is deleted as response category. For the variable ‘Any involuntary urine leakage (incontinence) within the last 4 weeks’ ‘last 4 weeks’ has replaced ‘last 3 months’. The response categories have been adjusted to: ‘Daily’, ‘Once or more per week (but not daily)’, ‘Less than once per week’, ‘Never’, ‘Not applicable’ and ‘Unknown’. For the variable ‘Any drugs for the Urinary Tract within the last four weeks’ ‘last four weeks’ has replaced ‘last year’.ConclusionsThe International SCI LUT Function Basic Data Set (version 2.0) with its complete syllabus is available from http://www.iscos.org.uk/international-sci-data-sets .
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international spinal cord injury lower Urinary Tract Function basic data set version 2 0
Spinal cord series and cases, 2018Co-Authors: F Bieringsorensen, Todd Linsenmeyer, Jurgen Pannek, Thomas M. Kessler, Michael J Kennelly, Lawrence C Vogel, Jean-jacques WyndaeleAbstract:Revision, review, and presentation of the International Spinal Cord Injury (SCI) Lower Urinary Tract (LUT) Function Basic Data Set (version 2.0). Describe the revision and review and present the data set. International. The first version of the data set was revised according to new knowledge and suggestions. The review included International SCI Data Sets Committee, American Spinal Injury Association (ASIA) board, International Spinal Cord Society (ISCoS) executive and scientific committees, major organizations, and interested individuals. The data set was also on ASIA and ISCoS websites. All replies were answered and appropriate adjustments made. Finally, the data set was endorsed by ASIA board, and ISCoS executive and scientific committees. Among revisions are adoptions of new terminology by the International Continence Society. For most variables, advice for collection of information from pediatric patients stated. For the variable ‘Bladder emptying’, is in the data collection form to the response category ‘Normal voiding’ expanded. ‘Sacral Anterior Root Stimulator’ is deleted as response category. For the variable ‘Any involuntary urine leakage (incontinence) within the last 4 weeks’ ‘last 4 weeks’ has replaced ‘last 3 months’. The response categories have been adjusted to: ‘Daily’, ‘Once or more per week (but not daily)’, ‘Less than once per week’, ‘Never’, ‘Not applicable’ and ‘Unknown’. For the variable ‘Any drugs for the Urinary Tract within the last four weeks’ ‘last four weeks’ has replaced ‘last year’. The International SCI LUT Function Basic Data Set (version 2.0) with its complete syllabus is available from http://www.iscos.org.uk/international-sci-data-sets .
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Urodynamic Investigation: A Valid Tool to Define Normal Lower Urinary Tract Function?
2016Co-Authors: Lorenz Leitner, Matthias Walter, Ulla Sammer, Stephanie C. Knüpfer, Ulrich Mehnert, Thomas M. KesslerAbstract:ObjectivesTo evaluate whether urodynamic investigation (UDI), the gold standard to assess refractory lower Urinary Tract symptoms (LUTS), is appropriate to select healthy volunteers with apparent normal lower Urinary Tract Function as control subjects for comparative studies.Subjects and Methods42 healthy subjects (22 women, mean age 32±10 years; 20 men, mean age 37±12 years) without LUTS were included into this prospective single-centre cohort study. All subjects recorded a 3-day bladder diary, completed validated questionnaires regarding LUTS, and underwent neuro-urological assessment as well as free uroflowmetry. Same session repeat UDI was performed according to “Good Urodynamic Practice” recommended by the International Continence Society, but using an air-charged instead of a water-filled catheter, and evaluated by a blinded investigator.ResultsAll 3-day bladder diaries, LUTS questionnaires, neuro-urological assessments and free uroflowmetries were within normal limits. Overall (either during the first or second UDI), same session repeat UDI revealed pathological findings in 71% (30/42): Detrusor overactivity was detected in 14% (3/22) and 30% (6/20), post void residual >100mL in 14% (3/22) and 25% (5/20), bladder outlet obstruction in 9% (2/22) and 20% (4/20) and detrusor sphincter dyssynergia in 77% (17/22) and 65% (13/20) of our women and men, respectively.Repeatability of detrusor overactivity (κ = 0.78, 95% CI: 0.54–1.02) and detrusor sphincter dyssynergia (κ = 0.77, 95% CI: 0.55–0.98) showed substantial agreement between both UDIs. All other assessed urodynamic parameters had wide 95% limits of agreement for differences in the parameters indicating poor repeatability.ConclusionsMore than 70% of our healthy subjects showed pathological urodynamic findings. Although UDI is the gold standard to assess refractory LUTS, it seems not to be applicable in healthy subjects to define normal lower Urinary Tract Function. Therefore, we do not recommend using UDI to select healthy control subjects.
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protocol for a prospective magnetic resonance imaging study on supraspinal lower Urinary Tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxina injections for treating neurogenic detrusor overactivity
BMC Urology, 2014Co-Authors: Lorenz Leitner, Matthias Walter, Ulrich Mehnert, Lars Michels, Spyros Kollias, Patrick Freund, Thomas M. KesslerAbstract:The control of the lower Urinary Tract is a complex, multilevel process involving both the peripheral and central nervous system. Due to lesions of the neuraxis, most spinal cord injury patients suffer from neurogenic lower Urinary Tract dysFunction, which may jeopardise upper Urinary Tract Function and has a negative impact on health-related quality of life. However, the alterations to the nervous system following spinal cord injury causing neurogenic lower Urinary Tract dysFunction and potential effects of treatments such as intradetrusor onabotulinumtoxinA injections on lower Urinary Tract control are poorly understood. This is a prospective structural and Functional magnetic resonance imaging study investigating the supraspinal lower Urinary Tract control in healthy subjects and spinal cord injury patients undergoing intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity. Neuroimaging data will include structural magnetic resonance imaging (T1-weighted imaging and diffusion tensor imaging) as well as Functional, i.e. blood oxygen level-dependent sensitive magnetic resonance imaging using a 3 T magnetic resonance scanner. The Functional magnetic resonance imaging will be performed simultaneously to three different bladder stimulation paradigms using an automated magnetic resonance compatible and synchronised pump system. All subjects will undergo two consecutive and identical magnetic resonance imaging measurements. Healthy subjects will not undergo any intervention between measurements but spinal cord injury patients will receive intradetrusor onabotulinumtoxinA injections for treating neurogenic detrusor overactivity. Parameters of the clinical assessment including bladder diary, urinalysis, medical history, neuro-urological examination, urodynamic investigation as well as standardised questionnaires regarding lower Urinary Tract Function and quality of life will serve as co-variates in the magnetic resonance imaging analysis. This study will identify structural and Functional alterations in supraspinal networks of lower Urinary Tract control in spinal cord injury patients with neurogenic detrusor overactivity compared to healthy controls. Post-treatment magnetic resonance imaging measurements in spinal cord injury patients will provide further insights into the mechanism of action of treatments such as intradetrusor onabotulinumtoxinA injections and the effect on supraspinal lower Urinary Tract control. ClinicalTrials.gov NCT01768910 .
Jean-jacques Wyndaele - One of the best experts on this subject based on the ideXlab platform.
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International Spinal Cord Injury Lower Urinary Tract Function Basic Data Set (version 2.0)
Spinal Cord Series and Cases, 2018Co-Authors: Fin Biering-sørensen, Michael Kennelly, Todd Linsenmeyer, Lawrence Vogel, Jurgen Pannek, Thomas M. Kessler, Jean-jacques WyndaeleAbstract:Study designRevision, review, and presentation of the International Spinal Cord Injury (SCI) Lower Urinary Tract (LUT) Function Basic Data Set (version 2.0).ObjectivesDescribe the revision and review and present the data set.SettingInternational.MethodsThe first version of the data set was revised according to new knowledge and suggestions. The review included International SCI Data Sets Committee, American Spinal Injury Association (ASIA) board, International Spinal Cord Society (ISCoS) executive and scientific committees, major organizations, and interested individuals. The data set was also on ASIA and ISCoS websites. All replies were answered and appropriate adjustments made. Finally, the data set was endorsed by ASIA board, and ISCoS executive and scientific committees.ResultsAmong revisions are adoptions of new terminology by the International Continence Society. For most variables, advice for collection of information from pediatric patients stated. For the variable ‘Bladder emptying’, is in the data collection form to the response category ‘Normal voiding’ expanded. ‘Sacral Anterior Root Stimulator’ is deleted as response category. For the variable ‘Any involuntary urine leakage (incontinence) within the last 4 weeks’ ‘last 4 weeks’ has replaced ‘last 3 months’. The response categories have been adjusted to: ‘Daily’, ‘Once or more per week (but not daily)’, ‘Less than once per week’, ‘Never’, ‘Not applicable’ and ‘Unknown’. For the variable ‘Any drugs for the Urinary Tract within the last four weeks’ ‘last four weeks’ has replaced ‘last year’.ConclusionsThe International SCI LUT Function Basic Data Set (version 2.0) with its complete syllabus is available from http://www.iscos.org.uk/international-sci-data-sets .
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international spinal cord injury lower Urinary Tract Function basic data set version 2 0
Spinal cord series and cases, 2018Co-Authors: F Bieringsorensen, Todd Linsenmeyer, Jurgen Pannek, Thomas M. Kessler, Michael J Kennelly, Lawrence C Vogel, Jean-jacques WyndaeleAbstract:Revision, review, and presentation of the International Spinal Cord Injury (SCI) Lower Urinary Tract (LUT) Function Basic Data Set (version 2.0). Describe the revision and review and present the data set. International. The first version of the data set was revised according to new knowledge and suggestions. The review included International SCI Data Sets Committee, American Spinal Injury Association (ASIA) board, International Spinal Cord Society (ISCoS) executive and scientific committees, major organizations, and interested individuals. The data set was also on ASIA and ISCoS websites. All replies were answered and appropriate adjustments made. Finally, the data set was endorsed by ASIA board, and ISCoS executive and scientific committees. Among revisions are adoptions of new terminology by the International Continence Society. For most variables, advice for collection of information from pediatric patients stated. For the variable ‘Bladder emptying’, is in the data collection form to the response category ‘Normal voiding’ expanded. ‘Sacral Anterior Root Stimulator’ is deleted as response category. For the variable ‘Any involuntary urine leakage (incontinence) within the last 4 weeks’ ‘last 4 weeks’ has replaced ‘last 3 months’. The response categories have been adjusted to: ‘Daily’, ‘Once or more per week (but not daily)’, ‘Less than once per week’, ‘Never’, ‘Not applicable’ and ‘Unknown’. For the variable ‘Any drugs for the Urinary Tract within the last four weeks’ ‘last four weeks’ has replaced ‘last year’. The International SCI LUT Function Basic Data Set (version 2.0) with its complete syllabus is available from http://www.iscos.org.uk/international-sci-data-sets .
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international lower Urinary Tract Function basic spinal cord injury data set
Spinal Cord, 2008Co-Authors: F Bieringsorensen, M Craggs, Michael J Kennelly, E Schick, Jean-jacques WyndaeleAbstract:To create the International Lower Urinary Tract Function Basic Spinal Cord Injury (SCI) Data Set within the framework of the International SCI Data Sets. International working group. The draft of the Data Set was developed by a working group consisting of the members appointed by the International Continence Society, the European Association of Urology, the American Spinal Injury Association (ASIA), the International Spinal Cord Society (ISCoS) and a representative of the Executive Committee of the International SCI Standards and Data Sets. The final version of the Data Set was developed after review and comments by the members of the Executive Committee of the International SCI Standards and Data Sets, the ISCoS Scientific Committee, ASIA Board, relevant and interested (international) organizations and societies (around 40) and persons, and the ISCoS Council. Endorsement of the Data Set by relevant organizations and societies will be obtained. To make the Data Set uniform, each variable and each response category within each variable have been specifically defined in a way that is designed to promote the collection and reporting of comparable minimal data. Variables included in the International Lower Urinary Tract Function Basic SCI Data Set are as follows: date of data collection, Urinary Tract impairment unrelated to spinal cord lesion, awareness of the need to empty the bladder, bladder emptying, average number of voluntary bladder emptyings per day during the last week, incontinence within the last 3 months, collecting appliances for Urinary incontinence, any drugs for the Urinary Tract within the last year, surgical procedures on the Urinary Tract and any change in Urinary symptoms within the last year. Complete instruction for data collection, data sheet and training cases available at the website of ISCoS ( www.iscos.org.uk ) and ASIA ( www.asia-spinalinjury.org ).
