The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Joris R Delanghe - One of the best experts on this subject based on the ideXlab platform.
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renal tubular epithelial cells add value in the diagnosis of upper Urinary Tract Pathology
Clinical Chemistry and Laboratory Medicine, 2020Co-Authors: Matthijs Oyaert, Marijn M Speeckaert, Jerina Boelens, Joris R DelangheAbstract:Background Diagnosis of upper Urinary Tract infections (UTI) is challenging. We evaluated the analytical and diagnostic performance characteristics of renal tubular epithelial cells (RTECs) and transitional epithelial cells (TECs) on the Sysmex UF-5000 urine sediment analyzer. Methods Urinary samples from 506 patients presenting with symptoms of a UTI were collected. Only samples for which a Urinary culture was available were included. Analytical (imprecision, accuracy, stability and correlation with manual microscopy) and diagnostic performance (sensitivity and specificity) were evaluated. Results The Sysmex UF-5000 demonstrated a good analytical performance. Depending on the storage time, storage conditions (2-8 °C or 20-25 °C) and Urinary pH, RTECs and TECs were stable in urine for at least 4 h. Using Passing-Bablok and Bland-Altman analysis, an acceptable agreement was observed between the manual and automated methods. Compared to TECs, RTECs demonstrated an acceptable diagnostic performance for the diagnosis of upper UTI. Conclusions While TECs do not seem to serve as a helpful marker, increased Urinary levels of RTECs add value in the diagnosis of upper UTI and may be helpful in the discrimination between upper and lower UTIs.
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diagnostic performance of combined specific Urinary proteins and Urinary flow cytometry in Urinary Tract Pathology
Clinical Chemistry and Laboratory Medicine, 2007Co-Authors: Joris Penders, Tom Fiers, Karel Everaert, Joeri Barth, Annemieke Dhondt, Joris R DelangheAbstract:Background: Urinalysis comprises three techniques: Urinary flow cytometry, test strip analysis and determination of specific Urinary proteins. We investigated the diagnostic possibilities of combining these methods for a cohort of patients with a variety of well-documented urological and nephrological Pathology. Methods: Urinary samples from 407 in- and outpatients with nephrological or urological Pathology were retrospectively included in our study. Test strip analysis (URISYS 2400), Urinary flow cytometry (UF-100) and Urinary protein analysis [albumin, total protein, α 1 -microglobulin (A1M), α 2 -macroglobulin (A2M)] were performed. Results: In discriminating upper and lower Urinary Tract infections, A1M and A1M/log(white blood cells) can be used, whereas pathological casts only give poor discrimination. The ratio A2M/log(red blood cells; RBC) allows differentiation between cystitis and pyelonephritis, while glomerular diseases can be recognised by the log(RBC × Urinary total protein). Combining A2M and Urinary albumin allows the determination of acute prostatitis. Conclusions: Using combined parameters provided by various urinalysis techniques, ratios can be proposed with diagnostic value for classifying renal and urological conditions. Possible integration in computer-based knowledge systems may offer valuable information for clinicians dealing with these pathologies.
Petrisor Geavlete - One of the best experts on this subject based on the ideXlab platform.
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retrograde flexible ureteroscopic approach of upper Urinary Tract Pathology what is the status in 2014
International Journal of Urology, 2014Co-Authors: Petrisor Geavlete, Razvan Multescu, Bogdan GeavleteAbstract:Flexible uretero-renoscopy witnessed dramatic technological improvements, ultimately translating in more diverse indications, better instrument durability, procedural efficacy and safety. Diagnostic exploration of the upper Urinary Tract, treatment of selected cases of ureteral and especially pyelocaliceal stones, caliceal diverticulum and infundibular stenosis, treatment, and follow-up of upper Urinary Tract tumors are the main indications for this approach. We review the technique, results and complications of retrograde flexible ureteroscopy, with an emphasis on the latest developments of the method.
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Conventional Fiberoptic Flexible Ureteroscope Versus Fourth Generation Digital Flexible Ureteroscope: A Critical Comparison
Journal of endourology, 2010Co-Authors: Razvan Multescu, Bogdan Geavlete, Dragoş Georgescu, Petrisor GeavleteAbstract:AbsTract Background and Purpose: Development of flexible renoureteroscopy had a significant impact on the diagnosis and management of upper Urinary Tract Pathology. The aim of our study was to compare the performances of a fiberoptic flexible ureteroscope (FFU) with those of a digital flexible ureteroscope (DFU). Material and Methods: We compared the maneuverability, visibility, and fragility of a Storz 11274AA FFU and of an Olympus URF-Vo DFU. In 44 diagnostic retrograde procedures (22 with FFU and 22 with DFU), the maneuverability and visibility were evaluated with a score ranging from 1 to 5. The success of the inferior calix approach, maximal deflection, irrigation flow, and the endoscopes' fatigability were also compared. Results: FFU and DFU received mean scores of 3.64 vs 4.27 for maneuverability and 3.27 vs 4.68 for visibility. In four cases, acute infundibulopelvic angle and long infundibulum prevented the inferior calix approach with FFU. In two cases, the approach of the narrow infundibulum was...
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flexible nephroscopy for upper Urinary Tract Pathology
Chirurgia (Bucharest Romania), 2007Co-Authors: Petrisor Geavlete, Răzvan Mulţescu, D. GeorgescuAbstract:: Flexible nephroscopy was introduced in the Urological Department of Saint John Emergency Clinical Hospital in 2002 and rapidly became a routine procedure. During September 2002-October 2006, flexible nephroscopy was performed in 113 patients for: lithiasis (107 cases), uretero-pelvic junction stenosis (3 cases), caliceal diverticulum (1 case), caliceal urothelial tumors (2 cases). In all cases a 24F flexible nephroscope was used. The energy sources consisted in an electrohydraulic lithotripsy device or Ho:YAG/Nd:YAG lasers. The success rate in patients with lithiasis was 94.4%. Antegrade endopyelotomy was successfully performed in all 3 cases. Evaluation at 6, 12 and 18 months revealed a normal pyelocaliceal system in 2 cases and a significant reduction of hydronephrosis in the third one. In the patient with caliceal diverticulum, evaluation at 6 and 12 months described a large communication with the pyelocaliceal system and no lithiasis recurrence. No recurrences occurred in the patients with conservatively treated caliceal urothelial tumors. Minor complications were encountered in 7% of the cases. Flexible nephroscopy decreases the necessity for multiple access trajects, supracostal access trajects or multiple procedures, thus reducing the morbidity associated with percutaneous interventions.
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complications of 2735 retrograde semirigid ureteroscopy procedures a single center experience
Journal of Endourology, 2006Co-Authors: Petrisor Geavlete, D. Georgescu, Gheorghe Niţă, V Mirciulescu, V CauniAbstract:Background and Purpose: Ureteroscopy is nowadays one of the techniques most widely used for upper Urinary- Tract Pathology. Our goal is to describe its complications in a large series of patients. Patients and Methods: Between June 1994 and February 2005, 2436 patients aged 5 to 87 years underwent retrograde ureteroscopy (2735 procedures) under video and fluoroscopic assistance. We used semirigid ureteroscopes (8/9.8F Wolf, 6.5F Olympus, 8F and 10F Storz) for 384 diagnostic and 2351 therapeutic procedures. Upper Urinary-Tract lithiasis (2041 cases), ureteropelvic junction stenosis (95 cases), benign ureteral stenosis (29 cases), tumoral extrinsic ureteral stenosis (84 cases), iatrogenic trauma (35 cases), superficial ureteral tumors (16 cases), superficial pelvic tumors (7 cases), and ascending displaced stents (44 cases) were the indications. The mean follow-up period was 56 months (range 4–112 months). Results: The rate of intraoperative incidents was 5.9% (162 cases). Intraoperative incidents consisted...
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Flexible ureteroscopic approach in upper Urinary Tract Pathology
Chirurgia (Bucharest Romania : 1990), 2006Co-Authors: Petrisor Geavlete, Răzvan Mulţescu, D. GeorgescuAbstract:In many prestigious centers, flexible ureteroscopy (FU) has rapidly evolved into a routine application. Our goal was to evaluate the efficiency of FU in upper Urinary Tract Pathology. Between October 2002 and January 2006, 106 patients underwent FU for upper Urinary Tract Pathology: retrograde (23 for diagnosis, 7 for follow up after conservative treatment of upper Urinary Tract TCC and 67 therapeutical) and antegrade (9 cases) procedures. Therapeutical retrograde FU was indicated for: stones (59 cases), symptomatic pyelocaliceal diverticulum with intra-diverticular lithiasis (7 cases) and pyelocaliceal TCC (3 cases). Antegrade FU was performed 9 cases with ureteral or uretero-enteric strictures. In all cases we used a 7.5F Storz flexible ureteroscope. As energy sources we used Nd:YAG laser and an electrohydraulic lithotripsy device. Diagnosis retrograde FU identified upper Urinary Tract abnormalities in 95.7%. In the patients with lithiasis, the procedure was considered a success if complete stone clearance or lithotripsy in fragments smaller than 3 mm was achieved. The over-all success rate in these cases was 72.7%. In 57.1% with pyelocaliceal diverticula laser incision of the narrow isthmus was practiced, followed by electrohydraulic lithotripsy of the stones. All the 4 cases were stone-free at the end of the procedure. In 66.7% of patient with TCC, evaluation at 6 and 12 and 18 months demonstrated no tumoral recurrence. In 77.8% patients with ureteral or uretero-enteric strictures who underwent antegrade FU, postoperative evaluation at 6 and 18 months showed good results. No intra- or postoperative complications were described. According to our experience, FU could be an efficient method in upper Urinary Tract Pathology diagnosis and treatment in selected cases. FU has opened a vista of endless limits in upper Urinary Tract endoscopy.
Bogdan Geavlete - One of the best experts on this subject based on the ideXlab platform.
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retrograde flexible ureteroscopic approach of upper Urinary Tract Pathology what is the status in 2014
International Journal of Urology, 2014Co-Authors: Petrisor Geavlete, Razvan Multescu, Bogdan GeavleteAbstract:Flexible uretero-renoscopy witnessed dramatic technological improvements, ultimately translating in more diverse indications, better instrument durability, procedural efficacy and safety. Diagnostic exploration of the upper Urinary Tract, treatment of selected cases of ureteral and especially pyelocaliceal stones, caliceal diverticulum and infundibular stenosis, treatment, and follow-up of upper Urinary Tract tumors are the main indications for this approach. We review the technique, results and complications of retrograde flexible ureteroscopy, with an emphasis on the latest developments of the method.
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Conventional Fiberoptic Flexible Ureteroscope Versus Fourth Generation Digital Flexible Ureteroscope: A Critical Comparison
Journal of endourology, 2010Co-Authors: Razvan Multescu, Bogdan Geavlete, Dragoş Georgescu, Petrisor GeavleteAbstract:AbsTract Background and Purpose: Development of flexible renoureteroscopy had a significant impact on the diagnosis and management of upper Urinary Tract Pathology. The aim of our study was to compare the performances of a fiberoptic flexible ureteroscope (FFU) with those of a digital flexible ureteroscope (DFU). Material and Methods: We compared the maneuverability, visibility, and fragility of a Storz 11274AA FFU and of an Olympus URF-Vo DFU. In 44 diagnostic retrograde procedures (22 with FFU and 22 with DFU), the maneuverability and visibility were evaluated with a score ranging from 1 to 5. The success of the inferior calix approach, maximal deflection, irrigation flow, and the endoscopes' fatigability were also compared. Results: FFU and DFU received mean scores of 3.64 vs 4.27 for maneuverability and 3.27 vs 4.68 for visibility. In four cases, acute infundibulopelvic angle and long infundibulum prevented the inferior calix approach with FFU. In two cases, the approach of the narrow infundibulum was...
Marijn M Speeckaert - One of the best experts on this subject based on the ideXlab platform.
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renal tubular epithelial cells add value in the diagnosis of upper Urinary Tract Pathology
Clinical Chemistry and Laboratory Medicine, 2020Co-Authors: Matthijs Oyaert, Marijn M Speeckaert, Jerina Boelens, Joris R DelangheAbstract:Background Diagnosis of upper Urinary Tract infections (UTI) is challenging. We evaluated the analytical and diagnostic performance characteristics of renal tubular epithelial cells (RTECs) and transitional epithelial cells (TECs) on the Sysmex UF-5000 urine sediment analyzer. Methods Urinary samples from 506 patients presenting with symptoms of a UTI were collected. Only samples for which a Urinary culture was available were included. Analytical (imprecision, accuracy, stability and correlation with manual microscopy) and diagnostic performance (sensitivity and specificity) were evaluated. Results The Sysmex UF-5000 demonstrated a good analytical performance. Depending on the storage time, storage conditions (2-8 °C or 20-25 °C) and Urinary pH, RTECs and TECs were stable in urine for at least 4 h. Using Passing-Bablok and Bland-Altman analysis, an acceptable agreement was observed between the manual and automated methods. Compared to TECs, RTECs demonstrated an acceptable diagnostic performance for the diagnosis of upper UTI. Conclusions While TECs do not seem to serve as a helpful marker, increased Urinary levels of RTECs add value in the diagnosis of upper UTI and may be helpful in the discrimination between upper and lower UTIs.
Birgitte J Vennervald - One of the best experts on this subject based on the ideXlab platform.
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impact of schistosoma haematobium infection on Urinary Tract Pathology nutritional status and anaemia in school aged children in two different endemic areas of the niger river basin mali
Acta Tropica, 2011Co-Authors: Moussa Sacko, Pascal Magnussen, Adama D Keita, Mamadou Traore, Aly Landoure, Aissata Doucoure, Henry Madsen, Birgitte J VennervaldAbstract:AbsTract The aim of the present study was to contribute to define Urinary schistosomiasis-related morbidity indicators and to understand the relationship between infection intensity and disease burden among school-aged children in different endemic areas of Mali. A cross sectional study was undertaken in two different endemic settings: Koulikoro district, along the river and Selingue dam area in the Niger River Basin in order to compare and describe morbidity related to Schistosoma haematobium infection. A total of 667 children aged 7–14 were enrolled in the study. Among these, 333 were from Koulikoro district (175 boys and 158 girls) and 334 from Selingue dam area (169 boys and 165 girls). The overall prevalence of S. haematobium in the two areas was 91.5%; Koulikoro (97.0%) and Selingue (85.9%) and this difference was significant after adjusting for age, sex and clustering within villages. Prevalence of heavy infection (≥50 eggs per 10 ml of urine), 57.6% in Koulikoro and 43.8% in Selingue, did not differ significantly after adjusting for age, sex and clustering within villages. The transmission of Schistosoma mansoni was mainly confined to Selingue dam area (12.5%) and was nearly absent in Koulikoro district (1.1%). Blood in urine was the most frequently reported clinical symptom, more common in Koulikoro (76.8%) than in Selingue (57.6%). In a multivariable logistic regression model adjusting for sex, age group, egg intensity category and clustering within villages, Selingue had higher prevalence of macro-haematuria, Urinary Tract Pathology, upper Urinary Tract Pathology and total Pathology than Koulikoro, while micro-haematuria did not differ between the two areas. Morbidity measures increased to some extent with egg intensity category, especially micro-haematuria. The results obtained from this study are of importance for planning intervention as for monitoring and evaluation of control in different endemic settings in Mali.
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urine circulating soluble egg antigen in relation to egg counts hematuria and Urinary Tract Pathology before and after treatment in children infected with schistosoma haematobium in kenya
American Journal of Tropical Medicine and Hygiene, 1999Co-Authors: Anthony I Kahama, Birgitte J Vennervald, John H Ouma, Adel E Odek, Ruth W Kihara, Yeri Kombe, Titus Nkulila, Christoph Hatz, Andre M DeelderAbstract:A cohort of 117 school children infected with Schistosoma haematobium was followed-up after therapy with praziquantel (0, 2, 4, 6, 12, and 18 months) and various infection and morbidity parameters (egg counts, hematuria, soluble egg antigen [SEA] in urine, and ultrasonography-detectable Pathology) were quantified. At the onset of the study, 97% of the children were positive for S. haematobium with a geometric mean egg count of 45.7 eggs/10 ml of urine. Eighty-one percent of the children were positive for SEA in urine with a geometric mean SEA concentration of 218.8 ng/ml of urine. Ninety-two percent and 56% of the children were microhematuria positive and macrohematuria positive, respectively. Two months after treatment, all infection and morbidity indicators had significantly decreased. Reinfection after treatment as determined by detection of eggs in urine was observed by four months post-treatment while the other parameters remained low. The clearance of SEA was slower than that of egg counts while Pathology resolved at an even slower pace. Levels of SEA and egg output showed similar correlations with ultrasound detectable Pathology; these correlations were better than the correlation between hematuria and Pathology.
