The Experts below are selected from a list of 258 Experts worldwide ranked by ideXlab platform
Robert A Soslow - One of the best experts on this subject based on the ideXlab platform.
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Invasion patterns of metastatic high-grade serous carcinoma of ovary or fallopian tube associated with BRCA deficiency
Modern Pathology, 2014Co-Authors: M Carolina Reyes, Angela G Arnold, Noah D Kauff, Douglas A Levine, Robert A SoslowAbstract:High-grade serous carcinomas of the Uterine Adnexa with BRCA1 deficiency (high-grade serous carcinomas- BRCA ) have recently been described to demonstrate characteristic histopathological features. We hypothesize that metastatic high-grade serous carcinomas- BRCA cases exhibit characteristic morphological features as well. We studied 102 high-grade serous carcinomas with known BRCA1 and BRCA2 genotype from the archives of the Department of Pathology at Memorial Sloan-Kettering Cancer Center. The primary site morphological characteristics of these cases were reported previously; we now focus solely on tumor morphology in sites other than the Uterine Adnexa (ie, metastatic sites). The study group consisted of the following case types: 13 BRCA1 germline mutations; 5 BRCA1 somatic mutations; 10 BRCA1 promoter methylation; 4 BRCA2 germline mutations; 1 BRCA2 somatic mutation; 11 lacking BRCA1 or BRCA2 abnormality; 58 cases lacking BRCA1 or BRCA2 germline mutation. Two observers independently scored invasion patterns and microscopic tumor architecture while blinded to genotype. Concordance between observers and correlations between metastatic patterns and the following indices were studied: genotype, primary site tumor characteristics, and BRCA1 immunohistochemistry. Concordance between observers was excellent ( κ values >0.9). All cases with BRCA1 or 2 abnormalities showed either pushing pattern metastases (76%) or infiltrative metastases composed only of micropapillae (24%). In contrast, all cases lacking BRCA1 or 2 abnormalities showed infiltrative metastases that contained combinations of papillary, glandular, and, rarely, cribriform and micropapillary architecture ( P
Cem Turan - One of the best experts on this subject based on the ideXlab platform.
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Low-grade endometrial stromal sarcoma with retroperitoneal metastases: an unusual case report
Archives of Gynecology and Obstetrics, 2008Co-Authors: Kadir Guzelmeric, Bahar Ergen, Zehra Meltem Pirimoğlu, Melin Ozgun Gecer, Orhan Ünal, Cem TuranAbstract:Background Endometrial stromal sarcoma (ESS) is an uncommon malign neoplasm, and its occurrence outside the uterus is extremely rare in the absence of metastasis or extension of a primary Uterine neoplasm. When arising in the pelvis or abdominal cavity, ESS is associated with Uterine Adnexa or serosal surface of various organs. Case We present the case of a 46-year-old woman with lower abdominal pain and regular menstruation who underwent laparotomy after a diagnosis of pelvic mass mimicking a right adnexial tumor. Exploration of the pelvis revealed a retroperitoneal mass of 15 cm in diameter in the right illiac fossa without accompanying pelvic or paraaortic lymphadenopathy. Uterus and ovaries were bilaterally normal in size. The pathology showed low-grade ESS of the uterus with direct spread to retroperitoneum without serosal metastases. Conclusion This case shows that despite its well-known good prognostic nature, low-grade ESS may behave as an aggressive malignancy.
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Low-grade endometrial stromal sarcoma with retroperitoneal metastases: an unusual case report
Archives of Gynecology and Obstetrics, 2007Co-Authors: Kadir Guzelmeric, Bahar Ergen, Zehra Meltem Pirimoğlu, Melin Ozgun Gecer, Orhan Ünal, Cem TuranAbstract:Background Endometrial stromal sarcoma (ESS) is an uncommon malign neoplasm, and its occurrence outside the uterus is extremely rare in the absence of metastasis or extension of a primary Uterine neoplasm. When arising in the pelvis or abdominal cavity, ESS is associated with Uterine Adnexa or serosal surface of various organs.
M. Varras - One of the best experts on this subject based on the ideXlab platform.
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Ruptured tubo-ovarian abscess as a complication of IVF treatment: clinical, ultrasonographic and histopathologic findings. A case report.
Clinical and Experimental Obstetrics & Gynecology, 2020Co-Authors: M. Varras, A. Tsikini, D. Polyzos, E. Antypa, Apessou D, M. TsouroulasAbstract:Abstract Tuboovarian abscess is a rare complication of IVF treatment, which can be lethal on rupture. Hereby, we present a case of a ruptured tubo-ovarian abscess, following transvaginal ultrasound-guided oocyte retrieval for IVF and transcervical embryo trasfer in a 38-year-old white female patient with five years of primary infertility who underwent aspiration of bilateral hydrosalpinges at the time of oocyte retrieval. This case suggests that the reactivation of latent pelvic infection due to a previous pelvic inflammatory disease (PID) was the possible route of infection after transvaginal ultrasound-directed follicle aspiration--transcervical embryo transfer. We conclude that physicians should consider the diagnosis of tubo-ovarian abscess in the differential diagnosis of abdominal pain, fever and leukocytosis after ovum retrieval and transcervical embryo transfer for IVF treatment. Preservation of the uterus and unaffected Uterine Adnexa should be attempted in such cases if future pregnancy is desired.
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Uterine Adnexal torsion: pathologic and gray-scale ultrasonographic findings.
Clinical and Experimental Obstetrics & Gynecology, 2020Co-Authors: M. Varras, A. Tsikini, D. Polyzos, Ch. Samara, G. Hadjopoulos, Ch. AkrivisAbstract:INTRODUCTION: Uterine Adnexal torsion is a rare and potentially lethal condition that may arise most unexpectedly in women of any age. It may be partial or complete, the later often resulting in necrosis, gangrene and peritonitis if untreated. The purpose of the study was to determine the spectrum of the histologic and gray-scale sonographic pictures in a series of surgically proven cases of Uterine Adnexal torsion. METHODS: The study population for the pathologic analysis of twisted Uterine Adnexa included 92 patients with surgical confirmation of torsion of the Uterine Adnexa; all the patients were treated radically. All the pathology records were reviewed retrospectively over a 10-year period (from 1992 to 2002) by the coding of ovarian, fallopian tube or Adnexal torsion. The gray-scale sonographic findings were analysed in 20 patients who underwent sonographic examination before surgery and Adnexal torsion was confirmed at surgery. RESULTS: Neoplasms constituted 46% (42/92) and cysts formed 48% (44/92) of all the twisted Uterine Adnexa. Normal-sized twisted Adnexa were found in five patients (5%) while in one patient simultaneous torsion of both normal fallopian tubes was found (1%). The prevalence of the twisted neoplasms was 16 mature teratomas, nine serous cystadenomas, five mucinous cystadenomas, three serous borderline carcinomas, two fibroma/thecomas, two mucinous borderline carcinomas, two malignant granulosal-stromal cell tumours, one malignant dysgerminoma, one immature teratoma and one clear cell adenocarcinoma. The twisted cysts were 18 serous cysts, 11 paraovarian cysts, nine corpus luteum cysts, three hydrosalpinges, one mucinous cyst and one endometrioma. In one case the torsion of the right ovary was due to hyperstimulation of the ovaries with gonadotropin therapy for IVF treatment. Gray-scale sonographic examination demonstrated cystic lesions in 80% (16/20), solid masses in 5% (1/20) and normal Adnexa in 15%; cul-de-sac fluid was present in 55% (11/20). Laparotomy revealed reactive cul-de-sac fluid in ten of these cases (50%) and haemoperitoneum in one (5%). CONCLUSION: Adnexal torsion is most commonly associated with benign processes (89%) and usually occurs in patients under 50 years old (80%). The spectrum of sonographic findings varies due to the Adnexal pathology, the degree and the duration of Adnexal torsion.
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Asynchronous bilateral Adnexal torsion in a 13-year-old adolescent: our experience of a rare case with review of the literature.
Journal of Adolescent Health, 2005Co-Authors: M. Varras, Christodoulos Akrivis, Asymo Demou, N. AntoniouAbstract:Adnexal torsion is a serious condition and delay in surgical intervention may result in loss of the tube and/or ovary. Children and adolescents who have suffered from Uterine Adnexal torsion may be at risk for asynchronous torsion of the contralateral Uterine Adnexa. We report the case of sequential bilateral torsion of Uterine Adnexa in a 13-year-old girl, resulting in right and subsequently left salpingo-oophorectomy because of gross evidence of total necrosis in both Uterine Adnexa. After the castration the patient was started on hormone replacement therapy. Families of children who suffered from ovarian torsion and unilateral ovarian loss should be educated about the risk of the contralateral ovary for future torsion and should be encouraged to seek immediate medical help with the recurrence of abdominal pain.
Laurie Ailles - One of the best experts on this subject based on the ideXlab platform.
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Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of Uterine Adnexa
Modern Pathology, 2020Co-Authors: Laudine Communal, Mauricio Medrano, Fabrice Sircoulomb, Joshua Paterson, Martin Köbel, Kurosh Rahimi, Paul Hoskins, Dongsheng Tu, Stephanie Lheureux, Laurie AillesAbstract:High-grade serous carcinoma of Uterine Adnexa (HGSC) is the most frequent histotype of epithelial ovarian cancer and has a poor 5-year survival rate due to late-stage diagnosis and the poor efficacy of standard treatments. Novel biomarkers of cancer outcome are needed to identify new targetable pathways and improve personalized treatments. Cell-surface screening of 26 HGSC cell lines by high-throughput flow cytometry identified junctional adhesion molecule 1 (JAM-A, also known as F11R) as a potential biomarker. Using a multi-labeled immunofluorescent staining coupled with digital image analysis, protein levels of JAM-A were quantified in tissue microarrays from three HGSC patient cohorts: a discovery cohort ( n = 101), the Canadian Ovarian Experimental Unified Resource cohort (COEUR, n = 1158), and the Canadian Cancer Trials Group OV16 cohort ( n = 267). Low JAM-A level was associated with poorer outcome in the three cohorts by Kaplan–Meier ( p = 0.023, p
Veena Devadiga - One of the best experts on this subject based on the ideXlab platform.
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unilateral absence of Uterine Adnexa
Indian Journal of Pathology & Microbiology, 2010Co-Authors: Alfred Joseph Augustine, Radhakrishna Nayak, Veena DevadigaAbstract:The unilateral absence of Uterine Adnexa is a rarely described entity. It may be due to developmental failure or auto amputation following Adnexal torsion.[1] Such a condition may be discovered during investigation for infertility or primary amenorrhea in asymptomatic cases with or without past history of acute abdomen pain. It may be incidentally detected as a migratory abdominal calcification during radiologic investigation and also during postmortem examination
