Valvata

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 507 Experts worldwide ranked by ideXlab platform

Ümit Şafak - One of the best experts on this subject based on the ideXlab platform.

  • Micropaleontological Investigation of Paleogene- Neogene Sediments (Edirne-Ke?an, Uzunköprü, Meriç, Süloğlu Drillings) in Edirne Thrace Region
    2016
    Co-Authors: Ümit Şafak, Manolya Güldürek
    Abstract:

    Bu çalışma, MTA tarafından 1972-1997 yılları arasında, Edirne yöresinde açılmış 6 adet sondajdan alınan örneklerin mikropaleontolojik değerlendirilmesi amacı ile yapılmıştır. Çalışmada killi, siltli kil birimlerini içeren Ergene Formasyonu ile kiltaşı, silttaşı, linyit bantlı kiltaşı, bitki izli marn-kil ardalanması ve kumtaşı seviyelerinden oluşan Danişmen Formasyonu'nda ostrakod faunası ile iyi korunmuş mikro-mollüskler gözlenmiştir. Örneklerinin içerdiği mikrofaunaya dayanarak çalışmanın yürütüldüğü istifin yaşı Oligosen-Pliyosen olarak belirlenmiştir. Edirne yöresi sondaj örneklerinde Danişmen Formasyonu içerisinde Erken-Geç Oligosen (Rupeliyen-Şattiyen)'i temsil eden Cytheromorpha zinndorfi (Lienenklaus), Neocyprideis apostolescui (Keij), N. williamsoniana (Bosquet), Hemicyprideis montosa (Jones ve Sherborn), Cytheridea pernota Oertli ve Keij, Ilyocypris boehli Triebel, Candona (Pseudocandona) fertilis Triebel gibi ostrakod cins ve türleri ile Oligosen seviyelerinde Avimactra sp., Viviparus sp, Valvata sp., Planorbis sp. gibi mikro mollüskler; Ergene Formasyonu içerisinde Geç Miyosen-Pliyosen'de Heterocypris salina, Heterocypris sp., Ilyocypris cf. bradyi Sars gibi ostrakod türleri bulunmuştur. Araştırma sonuçları, bu bölgede daha önce yapılmış diğer çalışmalar, Paris-Akiten Havzası ve Avrupa kuzeybatısında yapılmış ostrakod çalışmaları ile karşılaştırılmıştır. Bu çalışmada elde edilen fosil topluluğu; Edirne yöresi Paleojen-Neojen birimlerinin ağırlıklı olarak limnik ve lagüner koşullarda gelişmiş olduğunu göstermektedir.The aim of this study is assessing micropaleontological properties of 6 drilling samples which taken from Edirne region. Research drilled by MTA between 1972-1997 years, was carried out on six drillings in the Edirne region. Studied region exhibits clay, silty clay (Ergene Formation) with claystone, siltstone, lignite band claystone, plant trace marl- clay intercalated and observed ostracod fauna with well preserved micromollusca obtained from level of sandstone (Danişmen Formation). The age of the sequence of the work carried out by (Oligocene -Pliocene), respectively with this samples which are including the microfauna. The drilling samples in Edirne region, Danişmen formation is representing early-late Oligocene (Rupelian-Chattian) include ostracoda species such as Cytheromorpha zinndorfi (Lienenklaus), Neocyprideis apostolescui (Keij), N. williamsoniana (Bosquet), Hemicyprideis montosa (Jones&Sherborn), Cytheridea pernota Oertli&Keij, Ilyocypris boehli Triebel, Candona (Pseudocandona) fertilis Triebel and the level of Oligocene include micro mullusca such as such as Avimactra sp., Viviparus sp, Valvata sp., Planorbis sp. which are founded in the whole study area. In the examples of Ergene Formation in Late Miocene-Pliocene such as Heterocypris salina, Heterocypris sp., Ilyocypris cf. bradyi Sars. In this study were compared ostracoda works with previous studies conducted in this region, Paris-Akiten basin and northwest of Europe. Micropaleontological examination give this result with drilling core samples; mainly the Edirne region Paleogene-Neogene units were found to be enhanced in limnic and lagoons conditions

  • Environmental Properties and Ostracod Fauna of Oligocene-Mio-Pliocene Sediments in the Tekirdağ (HacusungurDrill) Region
    2015
    Co-Authors: Ümit Şafak
    Abstract:

    Bu çalışma, Hacusungur Köyü (Tekirdağ)'nde MTA tarafından kömür arama amaçlı açılmış sondajdaki örneklerin mikropaleontolojik incelemesi amacıyla yapılmıştır. Mikropaleontolojik incelemeler, yapılan sondajla üst seviyeden tabana doğru Miyo-Pliyosen ve Oligosen yaşlı çökellerin kesildiğini göstermiştir. İstif tavandan tabana doğru sarımsı renkli kille başlayıp, linyit bantlı-organik izli kil, laminalı-yeşilimsi gri renkli silt, ince kum bantlı-organik boyamalı kil, bitki izli silt ile devam etmekte, kil-kömür ardalanımı, silttaşı, kumtaşı, balık pulu fosili içeren kiltaşı istifi ile sona ermektedir. Ostrakod faunasına dayalı ayrıntılı inceleme sonucunda sondajdan alınan yıkama örneklerinde Cytheromorpha zinndorfi (Lienenklaus), Cladarocythere apostolescui (Margerie), Hemicyprideis montosa (Jones&Sherborn), H. elongata Keen, Cytheridea pernota Oertli ve Keij, Loxoconcha aequapuncta Deltel, Ilyocypris boehli Triebel, Candona (Pseudocandona) sp., Cypridopsis soyeri (Margerie), Cypria sp. gibi ostrakod faunası yanında Avimactra, Viviparus, Valvata, Modiolus, Planorbis, Potamides gibi mikro mollüskler tanımlanmıştır. Cladarocythere brahik, Cytheromorpha, Hemicyprideis, Loxoconcha brahik-litoral, Cytheridea brahik-epineritik, Ilyocypris, Candona, Candona (Pseudocandona), Cypridopsis, Cypria oligohalin tuzluluk-tatlısu; Avimactra brahik; Viviparus, Valvata, Modiolus, Potamides, Planorbis tatlısu koşullarına işaret eden ostrakod, pelesipod ve gastropod cinsleridir. Bu sondajda tanımlanan fauna ile linyitli düzeylerin çökelme ortamının, lagün-litoral koşulların yanı sıra ortama tatlı su gelişinin de devam etmesi sonucunda oluşan lagün ve göl alanları olduğu gözlenmektedir.This micropaleontological research has been carried out by MTA in order to analyse the samples of the borehole which was opened for the coal investigation in the Hacusungur Village. The results of the micropaleontological research show that Pliocene and Oligocene has been drilled from top to bottom. The succession starts with yellowish clay, which passes to lignite-banded organic tape clay, laminated greenish silt, fine sand with organic painted clay, herb-banded silt and ends with alternations of clay-coal, siltstone, sandstone, claystone including the fish scale. After a detailed examination of samples obtained from drilling, the ostracod fauna has been obtained; Cytheromorpha zinndorfi (Lienenklaus), Cladarocythereapostolescui(Margerie),Hemicyprideis montosa(Jones&Sherborn), H. elongata Keen, Cytheridea pernotaOertli&Keij, LoxoconchaaequapunctaDeltel, Ilyocypris boehliTriebel, Candona (Pseudocandona)sp., Cypridopsis soyeri(Margerie), Cypriasp. and apart fromostracod fauna there are some micro-mollusks identified such as Avimactra, Viviparus, Valvata, Modiolus,Planorbis, Potamides.Among the ostracod, pelecypod and gastropod species obtained, Cladarocythere brackish, Cytheromorpha, Hemicyprideis, Loxoconcha indicate brakish-lithoral, Cytheridea indicates brackish-epineritic,Ilyocypris, Candona, Candona (Pseudocandona), Cypridopsis, Cypriaoligohaline salinity-fresh water: Avimactraindicates brackish;Viviparus, Valvata, Modiolus, Potamides, Planorbis indicate fresh water conditions: The fauna recovered from this drilling suggest that the deposition of the layers with lignite occurred in lagoonal-littoral conditions and took place in lagoon and lake areas that were formed by continued influx of fresh water.In addition to the previous studies conducted in the study ares, the findings were compared with the other ostracod studies carried out in the northwest Europe and Paris-Akiten Basin, and similar results were obtained

  • HINIS (ERZURUM, DOĞU ANADOLU) YÖRESİNDEKİ VOLKANO-SEDİMANTER YOLÜSTÜ FORMASYONU OSTRAKOD FAUNASI VE ORTAMSAL ÖZELLİKLERİ
    General Directorate of Mineral Research and Exploration, 2013
    Co-Authors: Ümit Şafak
    Abstract:

    Erzurum İli güneydoğusunda, Hınıs İlçesi yakın civarında yüzeyleyen volkano-sedimanter Yolüstü formasyonu; çakıltaşı, marn, aglomera, kiltaşı, tüfit, kum-çakıl-bitki kırıntılı traverten kireçtaşı, gölsel kireçtaşı ve tüflü-killi kireçtaşından oluşmaktadır. Bu formasyon içerisinde bitki kırıntılı sert traverten kireçtaşları ile yumuşak tüflü-killi kireçtaşı litolojisinin bulunduğu kesimler özellikle seçilmek suretiyle 3 adet ölçülü stratigrafi kesiti alınmıştır. Bu kesitlerden alınan yıkama örnekleri incelenip değerlendirilmiş, acı ve tatlı su koşullarını yansıtan ostrakodlar bulunmuştur. Birimde genellikle Ponto- Kaspik havzaya özgü olan 5 ostrakod cins ve 12 türü tanımlanmış olup, sistematik konumları verilmiştir. Ayrıca rekristalize görünümlü tüflü-killi, pekişmiş sert kireçtaşı seviyelerinden iyi korunamamış 2 gastropod cinsi ve 1 türü, 1 pelesipod türü olmak üzere, az sayıda mikro mollüskler bulunmuştur. İstif içerisinde Leptocythere (Amnicythere) cf. litiva Livental, Tyrrhenocythere bailovi (Suzin), Loxoconcha granulata Sars, L. cf. diligena Kulieva, L. agilis Ruggieri, Candona (Caspiocypris) araxica Freels, C. (Caspiocypris) erzurumensis Freels, C. (Caspiocypris) aff. alta (Zalanyi), C. (Typhlocypris) amblygonica Freels, C. (Candona) parallela pannonica Zalanyi, C. (Candona) burdurensis Freels, C. (Candona) candida (O.F.Müller), C. (Candona) sp. 1 Freels gibi ostrakod ve Valvata piscinalis (O.F.Müller), Viviparus sp. gibi gastropod, Dreissena polymorpha (Palas) gibi pelesipod cins ve türleri tanımlanmıştır. Başlıca fosil ortamları için Leptocythere ve Tyrrhenocythere acısu, Loxoconcha mesohalin, Candona (Caspiocypris), C. (Typhlocypris) oligohalin , Candona (Candona), Valvata, Viviparus ve Dreissena tatlısu ortam koşulları göstermektedir

  • Hınıs (erzurum, doğu anadolu) yöresindeki volkano-sedimanter yolüstü formasyonu ostrakod faunası ve ortamsal özelliklerİ
    2013
    Co-Authors: Ümit Şafak
    Abstract:

    Erzurum İli güneydoğusunda, Hınıs İlçesi yakın civarında yüzeyleyen volkano-sedimanter Yolüstü formasyonu; çakıltaşı, marn, aglomera, kiltaşı, tüfit, kum-çakıl-bitki kırıntılı traverten kireçtaşı, gölsel kireçtaşı ve tüflü-killi kireçtaşından oluşmaktadır. Bu formasyon içerisinde bitki kırıntılı sert traverten kireçtaşları ile yumuşak tüflü-killi kireçtaşı litolojisinin bulunduğu kesimler özellikle seçilmek suretiyle 3 adet ölçülü stratigrafi kesiti alınmıştır. Bu kesitlerden alınan yıkama örnekleri incelenip değerlendirilmiş, acı ve tatlı su koşullarını yansıtan ostrakodlar bulunmuştur. Birimde genellikle Ponto- Kaspik havzaya özgü olan 5 ostrakod cins ve 12 türü tanımlanmış olup, sistematik konumları verilmiştir. Ayrıca rekristalize görünümlü tüflü-killi, pekişmiş sert kireçtaşı seviyelerinden iyi korunamamış 2 gastropod cinsi ve 1 türü, 1 pelesipod türü olmak üzere, az sayıda mikro mollüskler bulunmuştur. İstif içerisinde Leptocythere (Amnicythere) cf. litiva Livental, Tyrrhenocythere bailovi (Suzin), Loxoconcha granulata Sars, L. cf. diligena Kulieva, L. agilis Ruggieri, Candona (Caspiocypris) araxica Freels, C. (Caspiocypris) erzurumensis Freels, C. (Caspiocypris) aff. alta (Zalanyi), C. (Typhlocypris) amblygonica Freels, C. (Candona) parallela pannonica Zalanyi, C. (Candona) burdurensis Freels, C. (Candona) candida (O.F.Müller), C. (Candona) sp. 1 Freels gibi ostrakod ve Valvata piscinalis (O.F.Müller), Viviparus sp. gibi gastropod, Dreissena polymorpha (Palas) gibi pelesipod cins ve türleri tanımlanmıştır. Başlıca fosil ortamları için Leptocythere ve Tyrrhenocythere acısu, Loxoconcha mesohalin, Candona (Caspiocypris), C. (Typhlocypris) oligohalin , Candona (Candona), Valvata, Viviparus ve Dreissena tatlısu ortam koşulları göstermektedir.The volcano-sedimentary Yolüstü Formation, which outcrops in the vicinity of Hınıs town, located to the southeast of Erzurum City, consists of conglomerate, marl, agglomerate, claystone, tuffite, plant detritus bearing, sandy, gravelly travertine limestone,lacustrine limestone and tuffaceous-clayey limestone. In this formation, carefully selected 3 measured stratigraphic sections, which are predominantly represented by lithologies of hard travertine limestones with plant fragments and soft tuffaceous-clayey limestone, were studied and sampled for its ostracoda content. Examination and evaluation of the washed samples collected from these sections revealed both freshwater and brackish water ostracods. In this unit, 5 genera and 12 species of ostracoda, which are generally characteristic forms of the Ponto-Caspian basin, were identified and their taxonomies were established. In addition to ostracods, few micro mollusks, including 2 genera and 1 species of gastropoda and 1 species of pelecypod (poorlypreserved) were also found in the layers of recrystallized-like tuffaceous-clayey, hard limestone. In the sequence, the following genera and species of osracoda, gastropoda and a pelecypod were deteremined: Leptocythere (Amnicythere) cf. litiva Livental, Tyrrhenocythere bailovi (Suzin), Loxoconcha granulata Sars, L. cf. diligena Kulieva, L. agilis Ruggieri, Candona (Caspiocypris) araxica Freels, C. (Caspiocypris) erzurumensis Freels, C. (Caspiocypris) aff. alta (Zalanyi), C. (Typhlocypris) amblygonica Freels, C. (Candona) parallela pannonica Zalanyi, C. (Candona) burdurensis Freels, C. (Candona) candida (O.F.Müller), C. (Candona) sp. 1 Freels, Valvata piscinalis (O.F.Müller), Viviparus sp. and Dreissena polymorpha (Palas). The characteristics of the main fossil content indicate brackish water (Leptocythere and Tyrrhenocythere), mesohaline (Loxoconcha), oligohaline (Candona (Caspiocypris) and C. (Typhlocypris)) and freshwater (Candona (Candona), Valvata, Viviparus and Dreissena) environments respectively

J. Garric - One of the best experts on this subject based on the ideXlab platform.

Changquan Ling - One of the best experts on this subject based on the ideXlab platform.

  • new triterpenoids with cytotoxic activity from actinidia Valvata
    International Journal of Molecular Sciences, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Huiqing Zhang, Yanlong Yang, Changquan Ling
    Abstract:

    Two new triterpenoids, 30-O-β-D-glucopyranosyloxy-2α,3α,24-trihydroxyurs-12, 18-diene-28-oic acid O-β-D-glucopyranosyl ester (1) and 2α,3β,3,30-tetrahydroxyurs-12, 18-diene-28-oic acid O-β-D-glucopyranosyl ester (2) were isolated from roots of Actinidia Valvata Dunn. Their structures were elucidated by means of extensive spectroscopic studies. Both these two new compounds showed moderate cytotoxic activity in vitro against BEL-7402 and SMMC-7721 tumor cell line.

  • total saponin from root of actinidia Valvata dunn inhibits hepatoma 22 growth and metastasis in vivo by suppression angiogenesis
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Xiaofeng Zhai, Yuanhui Zhang, Changquan Ling
    Abstract:

    The root of Actinidia Valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia Valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth. The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups. Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study. The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons.

  • total saponin from root of actinidia Valvata dunn prevents the metastasis of human hepatocellular carcinoma cells
    Chinese Journal of Integrative Medicine, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Changquan Ling
    Abstract:

    Objective To extract the active component from the root of Actinidia Valvata Dunn and to investigate the effects on hepatocellular carcinoma (HCC) cells in vitro.

  • novel flavonoids from the leaves of actinidia Valvata dunn structural elucidation and antioxidant activity
    Planta Medica, 2011
    Co-Authors: Hailiang Xin, Jiayu Sheng, Changquan Ling
    Abstract:

    Two novel flavonoids, kaempferol 3- O- α-L-rhamnopyranosyl (1-3) (2,4-di- O-acetyl- α-L-rhamnopyranosyl) (1-6) β-D-galactopyranoside ( 1) and kaempferol 3- O- α-L-rhamnopyranosyl (1-3) (4- O-acetyl- α-L-rhamnopyranosyl) (1-6) β-D-galactopyranoside ( 2), along with three known ones, kaempferol-3- O- β-D-galactopyranoside ( 3), kaempferol ( 4), and 7-hydroxychromone ( 5), have been isolated from the leaves of ACTINIDIA Valvata Dunn, and their structures were elucidated based on spectroscopic methods. Compounds 1 - 3 exhibited dose-dependent activity in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, superoxide anion radicals, and hydroxyl radicals, and inhibited lipid peroxidation of mouse liver homogenate IN VITRO.

  • two new polyoxygenated triterpenoids from actinidia Valvata
    Helvetica Chimica Acta, 2008
    Co-Authors: Hailiang Xin, Xiaoqiang Yue, Yani Zhang, Yongzi Wang, Changquan Ling
    Abstract:

    Two new polyoxygenated triterpenoids, (2β,3α,6α)-2,3,6,20,23,30-hexahydroxyurs-12-en-28-oic acid (1) and (2β,3α)-2,3,20,23,24,30-hexahydroxyurs-12-en-28-oic acid O-β-D-glucopyranosyl ester (2) were isolated from the roots of Actinidia ValvataDunn. Their structures were elucidated by means of extensive spectroscopic studies. Both compounds showed moderate cytotoxic activity in vitro against the BEL-7402 and SMMC-7721 tumor cell lines.

Virginie Ducrot - One of the best experts on this subject based on the ideXlab platform.

Hailiang Xin - One of the best experts on this subject based on the ideXlab platform.

  • Research Article Total Saponin from Root of Actinidia Valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis
    2016
    Co-Authors: Guoyin Zheng, Hailiang Xin, Xiaofeng Zhai
    Abstract:

    Copyright © 2012 Guo-Yin Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The root of Actinidia Valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia Valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth. The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups. Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study. The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons. 1

  • dynamic changes of flavonoids in actinidia Valvata leaves at different growing stages measured by hplc ms ms
    Chinese Journal of Natural Medicines, 2016
    Co-Authors: D U Qiaohui, Qiaoyan Zhang, Ting Han, Yiping Jiang, Cheng Peng, Hailiang Xin
    Abstract:

    Flavonoids are a large group of phenolic secondary metabolites havinga wide range of biochemical and pharmacological effects. Quantitative analysis of flavonoid profiles in the genus Actinidia, which has not been intensively conducted, is useful to a better understanding of the pattern and distribution of flavonoids. In the present work, a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed to profile the flavonoids, which was then used to determine the dynamic change of 17 biologically active flavonoids in the leaves of Actinidia Valvata at the main growing stages, including glucuronides and acylated di- and triglycosides of flavonoids. The contents of flavonoid triglycosides were significantly higher than other flavonoids. The highest concentrations of kaemperol glycosides were observed in June, while other flavonoids showed highest concentrations in October. On the other hand, the contents of four isorhamnetin glycosides were increased sharply in September to October. The flavonoid profiles seem to be related to temperature, UV-B, and water deficit. Further studies are required to examine the functions of flavonoids in the Actinidia Valvata and the underlying molecular mechanisms of actions.

  • new triterpenoids with cytotoxic activity from actinidia Valvata
    International Journal of Molecular Sciences, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Huiqing Zhang, Yanlong Yang, Changquan Ling
    Abstract:

    Two new triterpenoids, 30-O-β-D-glucopyranosyloxy-2α,3α,24-trihydroxyurs-12, 18-diene-28-oic acid O-β-D-glucopyranosyl ester (1) and 2α,3β,3,30-tetrahydroxyurs-12, 18-diene-28-oic acid O-β-D-glucopyranosyl ester (2) were isolated from roots of Actinidia Valvata Dunn. Their structures were elucidated by means of extensive spectroscopic studies. Both these two new compounds showed moderate cytotoxic activity in vitro against BEL-7402 and SMMC-7721 tumor cell line.

  • total saponin from root of actinidia Valvata dunn inhibits hepatoma 22 growth and metastasis in vivo by suppression angiogenesis
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Xiaofeng Zhai, Yuanhui Zhang, Changquan Ling
    Abstract:

    The root of Actinidia Valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia Valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth. The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups. Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study. The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons.

  • total saponin from root of actinidia Valvata dunn prevents the metastasis of human hepatocellular carcinoma cells
    Chinese Journal of Integrative Medicine, 2012
    Co-Authors: Guoyin Zheng, Hailiang Xin, Changquan Ling
    Abstract:

    Objective To extract the active component from the root of Actinidia Valvata Dunn and to investigate the effects on hepatocellular carcinoma (HCC) cells in vitro.

Related terms

Valvata - 15 days free trial to Access Experts & Abstracts