The Experts below are selected from a list of 12780 Experts worldwide ranked by ideXlab platform
Maria Carmela Lechiara - One of the best experts on this subject based on the ideXlab platform.
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benefits in cognitive function blood pressure and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment the cocoa cognition and aging cocoa study
Hypertension, 2012Co-Authors: Giovambattista Desideri, Catherine Kwikuribe, Davide Grassi, Stefano Necozione, Lorenzo Ghiadoni, Daniela Mastroiacovo, Angelo Raffaele, Livia Ferri, Raffaella Bocale, Maria Carmela LechiaraAbstract:Flavanol consumption is favorably associated with cognitive function. We Tested the hypothesis that dietary flavanols might improve cognitive function in subjects with mild cognitive impairment. We conducted a double-blind, parallel arm study in 90 elderly individuals with mild cognitive impairment randomized to consume once daily for 8 weeks a drink containing 990 mg (high flavanols), 520 mg (intermediate flavanols), or 45 mg (low flavanols) of cocoa flavanols per day. Cognitive function was assessed by Mini Mental State Examination, Trail Making Test A and B, and Verbal Fluency Test. At the end of the follow-up period, Mini Mental State Examination was similar in the 3 treatment groups (P0.13). The time required to complete Trail Making Test A and Trail Making Test B was significantly (P0.05) lower in subjects assigned to high flavanols (38.1010.94 and 104.1028.73 seconds, respectively) and intermediate flavanols (40.2011.35 and 115.9728.35 seconds, respectively) in comparison with those assigned to low flavanols (52.6017.97 and 139.2343.02 seconds, respectively). Similarly, Verbal Fluency Test score was significantly (P0.05) better in subjects assigned to high flavanols in comparison with those assigned to low flavanols (27.506.75 versus 22.308.09 words per 60 seconds). Insulin resistance, blood pressure, and lipid peroxidation also decreased among subjects in the high-flavanol and intermediate-flavanol groups. Changes of insulin resistance explained 40% of composite z score variability through the study period (partial r 2 0.4013; P0.0001). To the best of our knowledge, this is the first dietary intervention study demonstrating that the regular consumption of cocoa flavanols might be effective in improving cognitive function in elderly subjects with mild cognitive impairment. This effect appears mediated in part by an improvement in insulin sensitivity. (Hypertension. 2012;60:794-801.) ● Online Data Supplement
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benefits in cognitive function blood pressure and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment the cocoa cognition and aging cocoa study
Hypertension, 2012Co-Authors: Giovambattista Desideri, Catherine Kwikuribe, Davide Grassi, Stefano Necozione, Lorenzo Ghiadoni, Daniela Mastroiacovo, Angelo Raffaele, Livia Ferri, Raffaella Bocale, Maria Carmela LechiaraAbstract:Flavanol consumption is favorably associated with cognitive function. We Tested the hypothesis that dietary flavanols might improve cognitive function in subjects with mild cognitive impairment. We conducted a double-blind, parallel arm study in 90 elderly individuals with mild cognitive impairment randomized to consume once daily for 8 weeks a drink containing ≈990 mg (high flavanols), ≈520 mg (intermediate flavanols), or ≈45 mg (low flavanols) of cocoa flavanols per day. Cognitive function was assessed by Mini Mental State Examination, Trail Making Test A and B, and Verbal Fluency Test. At the end of the follow-up period, Mini Mental State Examination was similar in the 3 treatment groups ( P =0.13). The time required to complete Trail Making Test A and Trail Making Test B was significantly ( P P z score variability through the study period (partial r 2 =0.4013; P
Giovambattista Desideri - One of the best experts on this subject based on the ideXlab platform.
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benefits in cognitive function blood pressure and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment the cocoa cognition and aging cocoa study
Hypertension, 2012Co-Authors: Giovambattista Desideri, Catherine Kwikuribe, Davide Grassi, Stefano Necozione, Lorenzo Ghiadoni, Daniela Mastroiacovo, Angelo Raffaele, Livia Ferri, Raffaella Bocale, Maria Carmela LechiaraAbstract:Flavanol consumption is favorably associated with cognitive function. We Tested the hypothesis that dietary flavanols might improve cognitive function in subjects with mild cognitive impairment. We conducted a double-blind, parallel arm study in 90 elderly individuals with mild cognitive impairment randomized to consume once daily for 8 weeks a drink containing 990 mg (high flavanols), 520 mg (intermediate flavanols), or 45 mg (low flavanols) of cocoa flavanols per day. Cognitive function was assessed by Mini Mental State Examination, Trail Making Test A and B, and Verbal Fluency Test. At the end of the follow-up period, Mini Mental State Examination was similar in the 3 treatment groups (P0.13). The time required to complete Trail Making Test A and Trail Making Test B was significantly (P0.05) lower in subjects assigned to high flavanols (38.1010.94 and 104.1028.73 seconds, respectively) and intermediate flavanols (40.2011.35 and 115.9728.35 seconds, respectively) in comparison with those assigned to low flavanols (52.6017.97 and 139.2343.02 seconds, respectively). Similarly, Verbal Fluency Test score was significantly (P0.05) better in subjects assigned to high flavanols in comparison with those assigned to low flavanols (27.506.75 versus 22.308.09 words per 60 seconds). Insulin resistance, blood pressure, and lipid peroxidation also decreased among subjects in the high-flavanol and intermediate-flavanol groups. Changes of insulin resistance explained 40% of composite z score variability through the study period (partial r 2 0.4013; P0.0001). To the best of our knowledge, this is the first dietary intervention study demonstrating that the regular consumption of cocoa flavanols might be effective in improving cognitive function in elderly subjects with mild cognitive impairment. This effect appears mediated in part by an improvement in insulin sensitivity. (Hypertension. 2012;60:794-801.) ● Online Data Supplement
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benefits in cognitive function blood pressure and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment the cocoa cognition and aging cocoa study
Hypertension, 2012Co-Authors: Giovambattista Desideri, Catherine Kwikuribe, Davide Grassi, Stefano Necozione, Lorenzo Ghiadoni, Daniela Mastroiacovo, Angelo Raffaele, Livia Ferri, Raffaella Bocale, Maria Carmela LechiaraAbstract:Flavanol consumption is favorably associated with cognitive function. We Tested the hypothesis that dietary flavanols might improve cognitive function in subjects with mild cognitive impairment. We conducted a double-blind, parallel arm study in 90 elderly individuals with mild cognitive impairment randomized to consume once daily for 8 weeks a drink containing ≈990 mg (high flavanols), ≈520 mg (intermediate flavanols), or ≈45 mg (low flavanols) of cocoa flavanols per day. Cognitive function was assessed by Mini Mental State Examination, Trail Making Test A and B, and Verbal Fluency Test. At the end of the follow-up period, Mini Mental State Examination was similar in the 3 treatment groups ( P =0.13). The time required to complete Trail Making Test A and Trail Making Test B was significantly ( P P z score variability through the study period (partial r 2 =0.4013; P
Po-han Chou - One of the best experts on this subject based on the ideXlab platform.
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characteristics of brain connectivity during Verbal Fluency Test convolutional neural network for functional near infrared spectroscopy analysis
Journal of Biophotonics, 2021Co-Authors: Lemei Wang, Po-han Chou, Yihua Huang, Yimin Wang, Chungming Chen, Chiawei SunAbstract:Human connectome describes the complicated connection matrix of nervous system among human brain. It also possesses high potential of assisting doctors to monitor the brain injuries and recoveries in patients. In order to unravel the enigma of neuron connections and functions, previous research have strived to dig out the relations between neurons and brain regions. Verbal Fluency Test (VFT) is a general neuropsychological Test which has been used in functional connectivity investigations. In this study, we employed convolutional neural network (CNN) on a brain hemoglobin concentration changes (ΔHB) map obtained during VFT to investigate the connections of activated brain areas and different mental status. Our results show that feature of functional connectivity can be identified accurately with the employment of CNN on ΔHB mapping, which is beneficial to improve the understanding of brain functional connections. This article is protected by copyright. All rights reserved.
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reduced frontal activity during a Verbal Fluency Test in fibromyalgia a near infrared spectroscopy study
Journal of Clinical Neuroscience, 2018Co-Authors: Po-han Chou, Chiawei Sun, Kuo Tung Tang, Yi Hsing Chen, Chihmao Huang, Deryuan ChenAbstract:Abstract Fibromyalgia (FM) is a complex disorder characterized by widespread chronic pain and associated sleep problems and cognitive dysfunction. However, only few studies focusing on cognitive dysfunction in FM are available so far. In the present study, we aimed to use near infrared spectroscopy (NIRS) to evaluate the brain function in FM patients subjected to a Verbal Fluency Test (VFT). A total of 11 primary FM patients and 13 healthy individuals (HC) underwent NIRS while performing a VFT. The Fibromyalgia Impact Questionnaire (FIQ) was used to evaluate the symptom severity of FM and Beck Depression Inventory II (BDI) was used to evaluate the severities depression symptoms in study participants. Five regions of interests (ROIs) were defined: the frontal-, bilateral inferior frontal gyrus (IFG), and temporal regions. Brain activities of ROIs between the two groups were compared. In addition, we investigated the relationship between clinical symptoms and brain cortical activity in FM patients. Our results showed that there were no significant differences between HC and FM patients in age, sex, and BDI scores. We found significantly reduced brain activity over the frontal regions during a VFT in FM patients (p = .026). In addition, we found decreased frontal activity was associated with BDI scores (rho = −0.755, p = .007). Furthermore, there were no significant correlations between frontal activity and FIQ subscales. In conclusion, our study demonstrated a reduced frontal cortical activity during VFT in FM patients, and that NIRS could be a potential tool for evaluating brain function in FM patients in clinical settings.
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functional connectivity during phonemic and semantic Verbal Fluency Test a multi channel near infrared spectroscopy study conference presentation
Proceedings of SPIE, 2016Co-Authors: Chun-jung Huang, Po-han Chou, Chiawei Sun, Chingcheng ChuangAbstract:Verbal Fluency Tests (VFT) are widely used neuropsychological Tests of frontal lobe and have been frequently used in various functional brain mapping studies. There are two versions of VFT based on the type of cue: the letter Fluency task (LFT) and the category Fluency task (CFT). However, the fundamental aspect of the brain connectivity across spatial regions of the fronto-temporal regions during the VFTs has not been elucidated to date. In this study we hypothesized that different cortical functional connectivity over bilateral fronto-temporal regions can be observed by means of multi-channel fNIRS in the LFT and the CFT respectively. Our results from fNIRS (ETG-4000) showed different patterns of brain functional connectivity consistent with these different cognitive requirements. We demonstrate more brain functional connectivity over frontal and temporal regions during LFT than CFT, and this was in line with previous brain activity studies using fNIRS demonstrating increased frontal and temporal region activation during LFT and CFT and more pronounced frontal activation by the LFT.
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Functional Connectivity During Phonemic and Semantic Verbal Fluency Test: A Multichannel Near Infrared Spectroscopy Study
IEEE Journal of Selected Topics in Quantum Electronics, 2016Co-Authors: Chun-jung Huang, Po-han ChouAbstract:Verbal Fluency Tests (VFTs) are widely used frontal lobe neuropsychological Tests. They have been frequently used in various functional brain mapping studies. There are two versions of VFTs based on the type of cue: the letter Fluency task (LFT) and the category Fluency task (CFT). However, the fundamental aspects of brain connectivity across the frontotemporal regions during the VFTs have not been elucidated. In this study, we hypothesized that differences in cortical functional connectivity over the left and right frontotemporal regions may be observed by means of multichannel functional near-infrared spectroscopy (fNIRS) during the performance of LFT and CFT. Our results from fNIRS (ETG-4000) showed different patterns of brain functional connectivity during the two types of VFTs, which was consistent with the different cognitive requirements of each task. We demonstrate increased brain functional connectivity over the frontal and temporal regions during the LFT than during the CFT; these results are in line with previous brain activity studies using fNIRS to demonstrate higher frontal and temporal region activation during LFT and CFT, with more pronounced frontal activation by the LFT.
Leandro Fernandes Malloydiniz - One of the best experts on this subject based on the ideXlab platform.
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graph analysis of Verbal Fluency Test discriminate between patients with alzheimer s disease mild cognitive impairment and normal elderly controls
Frontiers in Aging Neuroscience, 2014Co-Authors: Laiss Bertola, Natalia Bezerra Mota, Mauro Copelli, Thiago Rivero, Breno S Diniz, Marco Aurelio Romanosilva, Sidarta Ribeiro, Leandro Fernandes MalloydinizAbstract:Verbal Fluency is the ability to produce a satisfying sequence of spoken words during a given time interval. The core of Verbal Fluency lies in the capacity to manage the executive aspects of language. The standard scores of the semantic Verbal Fluency Test are broadly used in the neuropsychological assessment of the elderly, and different analytical methods are likely to extract even more information from the data generated in this Test. Graph theory, a mathematical approach to analyze relations between items, represents a promising tool to understand a variety of neuropsychological states. This study reports a graph analysis of data generated by the semantic Verbal Fluency Test by cognitively healthy elderly (NC), patients with Mild Cognitive Impairment—subtypes amnestic (aMCI) and amnestic multiple domain (a+mdMCI)—and patients with Alzheimer's disease (AD). Sequences of words were represented as a speech graph in which every word corresponded to a node and temporal links between words were represented by directed edges. To characterize the structure of the data we calculated 13 speech graph attributes (SGA). The individuals were compared when divided in three (NC—MCI—AD) and four (NC—aMCI—a+mdMCI—AD) groups. When the three groups were compared, significant differences were found in the standard measure of correct words produced, and three SGA: diameter, average shorTest path, and network density. SGA sorted the elderly groups with good specificity and sensitivity. When the four groups were compared, the groups differed significantly in network density, except between the two MCI subtypes and NC and aMCI. The diameter of the network and the average shorTest path were significantly different between the NC and AD, and between aMCI and AD. SGA sorted the elderly in their groups with good specificity and sensitivity, performing better than the standard score of the task. These findings provide support for a new methodological frame to assess the strength of semantic memory through the Verbal Fluency task, with potential to amplify the predictive power of this Test. Graph analysis is likely to become clinically relevant in neurology and psychiatry, and may be particularly useful for the differential diagnosis of the elderly.
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impaired generation of new subcategories and switching in a semantic Verbal Fluency Test in older adults with mild cognitive impairment
Frontiers in Aging Neuroscience, 2014Co-Authors: Laiss Bertola, Breno S Diniz, Marco Aurelio Romanosilva, Leandro Fernandes Malloydiniz, Maria Luiza Cunha Lima, Edgar Nunes De MoraesAbstract:The semantic Verbal Fluency task is broadly used in the neuropsychological assessment of elderly subjects. Even some studies have identified differences in Verbal Fluency clustering and switching measures between subjects with normal aging and a clinical condition such as mild cognitive impairment (MCI) and Alzheimer's disease, the results are not always consistent. This study aimed to compare clustering and switching measures of an animal's semantic Verbal Fluency task among normal controls (NC, n = 25), amnestic mild cognitive impairment (aMCI; n = 25), amnestic multiple domain Mild Cognitive Impairment (a+mdMCI; n = 25) and Alzheimer's disease (AD; n = 25) Brazilian subjects. The analyses were executed considering three (unifying the MCI subtypes) and four groups. As the data were not normally distributed, we carried out non-parametric Tests (Kruskal-Wallis and Mann-Whitney Tests) to evaluate the differences in performance in the measures of the Verbal Fluency Test among the groups. The comparison demonstrated that the groups differed in the total of correct words produced, number of clusters and switching but the measure of new subcategories was the only with significant difference among the NC and all the clinical groups. The measure of new subcategories is the number of original subcategories inside the higher category of animals that the subject produced, such as farm, domestic, African animals. Our results indicate that semantic memory impairment is a visible and recent deficit that occurs even in non-demented subjects with very MCI and the implications of these findings are discussed.
Anders Gade - One of the best experts on this subject based on the ideXlab platform.
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putative Tests of frontal lobe function a pet study of brain activation during stroop s Test and Verbal Fluency
Journal of Clinical and Experimental Neuropsychology, 2002Co-Authors: Barbara Ravnkilde, Poul Videbech, Raben Rosenberg, Albert Gjedde, Anders GadeAbstract:Stroop's Test and the Verbal Fluency Test are commonly argued to be measures of the integrity of the prefrontal cortex. This assumption has only to some degree been confirmed by lesion studies. In the present study, Positron Emission Tomography (PET) with H 2 15 O was used to further validate Stroop's Test and the Verbal Fluency as measures of frontal lobe function; both Tests were implemented as activation paradigms during scanning of normal middleaged individuals. Stroop interference was found to activate the left anterior cingulate cortex, the supplementary motor cortex, thalamus, and the cerebellum. Although the prominent anterior cingulate activation is in the frontal lobe, it is not prefrontal. Verbal Fluency activated the left inferior frontal cortex and the left dorsolateral prefrontal cortex, the supplementary motor cortex, the anterior cingulate cortex and the cerebellum. These results bring this latter Test closer to being a specific Test of prefrontal function.
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putative Tests of frontal lobe function a pet study of brain activation during stroop s Test and Verbal Fluency
Journal of Clinical and Experimental Neuropsychology, 2002Co-Authors: Barbara Ravnkilde, Poul Videbech, Raben Rosenberg, Albert Gjedde, Anders GadeAbstract:Stroop's Test and the Verbal Fluency Test are commonly argued to be measures of the integrity of the prefrontal cortex. This assumption has only to some degree been confirmed by lesion studies. In the present study, Positron Emission Tomography (PET) with H 2 15 O was used to further validate Stroop's Test and the Verbal Fluency as measures of frontal lobe function; both Tests were implemented as activation paradigms during scanning of normal middleaged individuals. Stroop interference was found to activate the left anterior cingulate cortex, the supplementary motor cortex, thalamus, and the cerebellum. Although the prominent anterior cingulate activation is in the frontal lobe, it is not prefrontal. Verbal Fluency activated the left inferior frontal cortex and the left dorsolateral prefrontal cortex, the supplementary motor cortex, the anterior cingulate cortex and the cerebellum. These results bring this latter Test closer to being a specific Test of prefrontal function.
