The Experts below are selected from a list of 162 Experts worldwide ranked by ideXlab platform
M. Brodsky - One of the best experts on this subject based on the ideXlab platform.
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Allergic Conjunctivitis and contact lenses: experience with olopatadine hydrochloride 0.1% therapy.
Acta ophthalmologica Scandinavica. Supplement, 2000Co-Authors: M. BrodskyAbstract:. Objective: The efficacy of Patanol®, a topically applied anti-allergic agent, was evaluated in a group of patients with allergic Conjunctivitis due to contact lens wear (GROUP I) and a group comprised of seasonal allergic Conjunctivitis patients, Vernal Conjunctivitis patients and atopic keratoConjunctivitis patients (GROUP II). Methods: One drop of Patanol® was administered to each eye twice daily. Signs and symptoms were assessed 7, 14, and 28 days after initiation of drug therapy. Results: Itching/burning, tearing, hyperemia and papillary reaction were reduced to scores of 0/1 (absent/mild) in 85%, 90%, 81% and 62%, respectively, of GROUP I patients at Day 28. The allergic conditions in GROUP II patients also improved with Patanol® treatment. Itching/burning, tearing, hyperemia and papillary reactions were absent/mild in 60%, 76%, 96% and 90%, respectively, of these patients at Day 28. Conclusion: Patanol® treatment effectively and rapidly alleviated the signs and symptoms of allergic Conjunctivitis due to contact lens wear as well as Vernal Conjunctivitis, atopic keratoConjunctivitis and the common seasonal allergic Conjunctivitis. Patanol® allowed allergic patients to be more comfortable while permitting them to continue using contact lenses.
Javier A. Montero - One of the best experts on this subject based on the ideXlab platform.
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Component-resolved diagnostics in Vernal Conjunctivitis.
Current opinion in allergy and clinical immunology, 2016Co-Authors: Alicia Armentia, Sanchís E, Javier A. MonteroAbstract:PURPOSE OF REVIEW Conventional diagnostic tests in allergy are insufficient to clarify the cause of Vernal Conjunctivitis. Component-resolved diagnostic (CRD) by microarray allergen assay may be useful in detecting allergens that might be involved in the inflammatory process. RECENT FINDINGS In a recent trial in patients suffered from eosinophilic esophagitis, after 2 years of the CRD-guided exclusion diet and specific immunotherapy, significant clinical improvement was observed, and 68% of patients were discharged (cure based on negative biopsy, no symptoms, and no medication intake). Our new objective was to evaluate IgE-mediated hypersensitivity by CRD in tears and serum from patients with Vernal Conjunctivitis and treat patients with identified triggering allergens by specific immunotherapy. Twenty-five patients with Vernal Conjunctivitis were evaluated. The identified triggering allergens were n Lol p 1 (11 cases), n Cyn d 1 (eight cases), group 4 and 6 grasses (six cases) and group 5 of grasses (five cases). Prick test and pollen IgE were positive in one case. Clinical improvement was observed in 13/25 Vernal Conjunctivitis patients after 1-year specific immunotherapy. SUMMARY CRD seems to be a more sensitive diagnostic tool compared with prick test and IgE detection. Specific CRD-led immunotherapy may achieve clinical improvements in Vernal Conjunctivitis patients.
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Component-resolved diagnostics in Vernal Conjunctivitis
Annals of allergy asthma & immunology : official publication of the American College of Allergy Asthma & Immunology, 2015Co-Authors: Alicia Armentia, Sanchís E, Javier A. Montero, Beatriz Iglesias, Darío Iglesias, Blanca Martín, Delia Fernández, Fé Munoz, Jesus BermejoAbstract:Abstract Background Conventional diagnostic tests in allergy are insufficient to clarify the origin of Vernal Conjunctivitis (VC). Objectives To evaluate IgE-mediated hypersensitivity by component-resolved diagnosis (CRD) in tears and serum from patients with VC and to evaluate how to treat patients with identified triggering allergens by specific immunotherapy. Methods Patients were divided into 3 groups: (1) patients with VC (25 patients), (2) patients allergic to grass pollen with seasonal allergic Conjunctivitis (AC) (50 patients), and (3) healthy blood donors (50 patients). If triggering allergens were detected, specific conventional immunotherapy was administered for 1 year. Results Twenty-five patients with VC were evaluated. The identified triggering allergens were n Lol p 1 (11 patients), n Cyn d 1 (8 patients), group 4 and 6 grasses (6 patients), and group 5 grasses (5 patients). Prick test and pollen IgE test results were positive in one patient. Clinical improvement was observed in 13 of the 25 patients with VC after 1 year of specific immunotherapy. Conclusion CRD seems to be a more sensitive diagnostic tool compared with prick test and IgE detection. Specific CRD-led immunotherapy may achieve clinical improvements in patients with VC.
Alicia Armentia - One of the best experts on this subject based on the ideXlab platform.
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Component-resolved diagnostics in Vernal Conjunctivitis.
Current opinion in allergy and clinical immunology, 2016Co-Authors: Alicia Armentia, Sanchís E, Javier A. MonteroAbstract:PURPOSE OF REVIEW Conventional diagnostic tests in allergy are insufficient to clarify the cause of Vernal Conjunctivitis. Component-resolved diagnostic (CRD) by microarray allergen assay may be useful in detecting allergens that might be involved in the inflammatory process. RECENT FINDINGS In a recent trial in patients suffered from eosinophilic esophagitis, after 2 years of the CRD-guided exclusion diet and specific immunotherapy, significant clinical improvement was observed, and 68% of patients were discharged (cure based on negative biopsy, no symptoms, and no medication intake). Our new objective was to evaluate IgE-mediated hypersensitivity by CRD in tears and serum from patients with Vernal Conjunctivitis and treat patients with identified triggering allergens by specific immunotherapy. Twenty-five patients with Vernal Conjunctivitis were evaluated. The identified triggering allergens were n Lol p 1 (11 cases), n Cyn d 1 (eight cases), group 4 and 6 grasses (six cases) and group 5 of grasses (five cases). Prick test and pollen IgE were positive in one case. Clinical improvement was observed in 13/25 Vernal Conjunctivitis patients after 1-year specific immunotherapy. SUMMARY CRD seems to be a more sensitive diagnostic tool compared with prick test and IgE detection. Specific CRD-led immunotherapy may achieve clinical improvements in Vernal Conjunctivitis patients.
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Component-resolved diagnostics in Vernal Conjunctivitis
Annals of allergy asthma & immunology : official publication of the American College of Allergy Asthma & Immunology, 2015Co-Authors: Alicia Armentia, Sanchís E, Javier A. Montero, Beatriz Iglesias, Darío Iglesias, Blanca Martín, Delia Fernández, Fé Munoz, Jesus BermejoAbstract:Abstract Background Conventional diagnostic tests in allergy are insufficient to clarify the origin of Vernal Conjunctivitis (VC). Objectives To evaluate IgE-mediated hypersensitivity by component-resolved diagnosis (CRD) in tears and serum from patients with VC and to evaluate how to treat patients with identified triggering allergens by specific immunotherapy. Methods Patients were divided into 3 groups: (1) patients with VC (25 patients), (2) patients allergic to grass pollen with seasonal allergic Conjunctivitis (AC) (50 patients), and (3) healthy blood donors (50 patients). If triggering allergens were detected, specific conventional immunotherapy was administered for 1 year. Results Twenty-five patients with VC were evaluated. The identified triggering allergens were n Lol p 1 (11 patients), n Cyn d 1 (8 patients), group 4 and 6 grasses (6 patients), and group 5 grasses (5 patients). Prick test and pollen IgE test results were positive in one patient. Clinical improvement was observed in 13 of the 25 patients with VC after 1 year of specific immunotherapy. Conclusion CRD seems to be a more sensitive diagnostic tool compared with prick test and IgE detection. Specific CRD-led immunotherapy may achieve clinical improvements in patients with VC.
Erkki Tuovinen - One of the best experts on this subject based on the ideXlab platform.
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Clinical trial of the topical use of disodium cromoglycate in Vernal, allergic and chronic Conjunctivitis.
Acta ophthalmologica, 2009Co-Authors: Markku Leino, Erkki TuovinenAbstract:Thirty-three patients were treated with disodium cromoglycate (DSCG). Of these 5 had Vernal Conjunctivitis, 18 had allergic Conjunctivitis and 10 had mild chronic Conjunctivitis in which the exact aetiology could not be determined. 70% of patients with DSCG as the only medication achieved at least some beneficial effect being almost exclusively in the groups of either Vernal or allergic Conjunctivitis. The basic trend seemed to indicate a reduction in severity during the treatment with DSCG in allergic diseases.
Sukumar Baluswamy - One of the best experts on this subject based on the ideXlab platform.
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Perilimbal bulbar conjunctival pigmentation in Vernal Conjunctivitis: prospective evaluation of a new clinical sign in an Indian population.
Cornea, 2004Co-Authors: Srinivas K Rao, Swaminathan Meenakshi, Bhaskar Srinivasan, Sukumar BaluswamyAbstract:OBJECTIVES To prospectively evaluate the occurrence of perilimbal conjunctival pigmentation in patients with Vernal Conjunctivitis and normal controls; to document the location, extent, density, and color of such pigmentation; and to correlate these changes with disease severity. METHODS Prospective, noninterventional case-control study. Demographic data, disease symptoms and duration, clinical signs of disease severity and extent, and characteristics of the perilimbal pigmentation were recorded. RESULTS Twenty-five patients with Vernal Conjunctivitis and 30 controls were studied. The mean age of the patients (21 M, 4 F) and controls (18 M, 12 F) was 7.5 +/- 3.7 years and 10.3 +/- 3.1 years, respectively. Perilimbal pigmentation was seen in all patients with Vernal Conjunctivitis and in none of the controls. The palpebral conjunctival changes and patient symptoms correlated with the severity of the disease in patients with Vernal Conjunctivitis. However, the extent of perilimbal pigmentation did not correlate with the symptoms and signs of Vernal Conjunctivitis or the density of palisadal pigment. CONCLUSIONS Perilimbal bulbar conjunctival pigmentation appears to be a consistent finding in patients with Vernal Conjunctivitis that is both specific and sensitive. It is also present in eyes with inactive disease and hence is a useful clinical sign that aids diagnosis in patients with mild or quiescent disease. Further studies are required to establish the histopathologic correlation of this finding and its etiopathogenesis. It is also important to establish whether this finding occurs with the same frequency in eyes of whites, as this study was performed in a cohort of Asian patients who have greater limbal pigmentation and a higher incidence of limbal changes in Vernal Conjunctivitis.
