The Experts below are selected from a list of 6576 Experts worldwide ranked by ideXlab platform
Thomas Kissel - One of the best experts on this subject based on the ideXlab platform.
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biodegradable polymers and their potential use in parenteral Veterinary Drug delivery systems
Advanced Drug Delivery Reviews, 2004Co-Authors: Gesine Winzenburg, Carsten Schmidt, Stefan Fuchs, Thomas KisselAbstract:Biodegradable polymers have been extensively studied for numerous Drug delivery systems for human health purposes. The ever-increasing value of animals to human society allows the application of pharmaceutical developments in the Veterinary field from those developed in human medicine. Although many similarities between the human and animal health industries exist there are also notable differences. This paper provides an insight into the animal health market with regard to the challenges and special considerations associated with Veterinary Drug delivery. It also gives an overview of biodegradable polymers that are used or have been tested in the Veterinary field. The purpose of this paper is to highlight some recent developments in this area and to investigate the directions in which Veterinary pharmaceutics is heading. In particular, examples of existing biodegradable Veterinary Drug delivery systems are presented together with applications including intravaginal devices, injectables and implantable systems.
Roberto Romerogonzalez - One of the best experts on this subject based on the ideXlab platform.
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analysis of pesticide and Veterinary Drug residues in baby food by liquid chromatography coupled to orbitrap high resolution mass spectrometry
Talanta, 2015Co-Authors: Maria Luz Gomezperez, Roberto Romerogonzalez, Vidal Jose Luis Martinez, Antonia Garrido FrenichAbstract:Abstract Pesticide and Veterinary Drug residues have been simultaneously determined in several baby foods as meat, fish and vegetable-based baby food. A generic extraction method without clean-up step was applied. Moreover, the use of a representative matrix for proper quantification of all target compounds was studied and the best results were obtained when vegetable-based baby food was used as representative matrix, allowing the reliable quantification of more than 300 compounds. The method was validated and good recoveries were obtained for most of compounds at concentrations higher than 50 µg kg−1. Limits of detection (LOD) ranged from 0.5 to 50 µg kg−1, whereas limits of quantification (LOQ) were established between 10 and 100 µg kg−1. Limits of identification (LOIs) ranged from 0.5 to 50 µg kg−1. This method was applied to the analysis of 46 different baby food samples and no positive samples were found.
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analysis of Veterinary Drug residues in cheese by ultra high performance lc coupled to triple quadrupole ms ms
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Maria Luz Gomez Perez, Roberto Romerogonzalez, Jose Luis Martinez Vidal, Antonia Garrido FrenichAbstract:A simple, reliable, and fast multiresidue method has been developed for the determination of 17 Veterinary Drugs belonging to several families (macrolides, sulfonamides, and anthelmintics) in cheese at trace levels. Ultra-high-performance LC coupled to MS/MS has been used for the analysis of these compounds in less than 9 min. Veterinary Drug residues have been extracted from cheese samples using a QuEChERS (quick, easy, cheap, effective, rugged, and safe)-based extraction procedure without applying any further clean-up step. Matrix-matched calibration was used for quantification and recoveries were calculated at three concentration levels (10, 50, and 100 μg/kg). The obtained values ranged from 70 to 110% for the selected compounds except for tylosin and josamycin at 100 μg/kg (111.7 and 112.7%, respectively). Intra- and interday precision were also evaluated and RSDs were lower than 25% in all the cases. LOQs ranged from 0.3 μg/kg (for thiabendazole, oxfendazole, mebendazole, josamycin, and fenbendazole) to 10.5 μg/kg (abamectin), whereas decision limit and detection capability ranged from 2.3 (thiabendazole) to 11.3 (abamectin) and 4.2 (thiabendazole) to 14.3 μg/kg (abamectin), respectively. Finally, 13 samples were analyzed and traces of thiabendazole were detected in two different cheeses.
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multiclass method for fast determination of Veterinary Drug residues in baby food by ultra high performance liquid chromatography tandem mass spectrometry
Food Chemistry, 2012Co-Authors: Maria Del Mar Aguileraluiz, Roberto Romerogonzalez, J Martinez L Vidal, Garrido A FrenichAbstract:A simple and rapid multiresidue method for the determination of different Veterinary Drug residues in meat-based baby food (MBF) and powdered milk-based infant formulae (PMIF) has been developed. The method involves an extraction procedure based on buffered QuEChERS (quick, easy, cheap, effective, rugged and safe) methodology, without any further clean-up step, followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The method has been validated in two baby food matrices (MBF and PMIF) at three different concentration levels, obtaining suitable recoveries and precision (inter and intra-day precision) values. Quantification was carried out using matrix-matched standard calibration. Furthermore, the decision limit (CCα) and the decision capability (CCβ) were evaluated, ranging from 0.5 to 16.2 μg/kg and from 1.2 to 22.4 μg/kg, respectively. Finally, the method was applied to the analysis of several kinds of baby food samples and traces of some Veterinary Drugs were detected.
Yolanda Pico - One of the best experts on this subject based on the ideXlab platform.
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determination of pesticides and Veterinary Drug residues in food by liquid chromatography mass spectrometry a review
Analytica Chimica Acta, 2016Co-Authors: Ana Masia, Maria Morales Suarezvarela, Agustin Llopisgonzalez, Yolanda PicoAbstract:Monitoring of pesticides and Veterinary Drug residues is required to enforce legislation and guarantee food safety. Liquid chromatography-mass spectrometry (LC-MS) is the prevailing technique for assessing both types of residues because LC offers a versatile and universal separation mechanism suitable for non-gas chromatography (GC) amenable and the majority of GC-amenable compounds. This characteristic becomes more relevant when LC is coupled to MS because the high sensitivity and specificity of the detector allows to apply generic sample preparation procedures, which simultaneously extract a wide variety of residues with different physico-chemical properties. Determination of metabolites and degradation products, non-target suspected screening of an increasing number of residues, and even unknowns identification are also becoming inherent LC-MS advantages thanks to the latest advances. For routine analysis and, in particular, for official surveillance purposes in food control, analytical methods properly validated following strict guidelines are needed. After a brief introduction and an outline of the legislation applicable around the world, aspects such as improvement of specificity of high-throughput methods, resolution and mass accuracy of identification strategies and quantitative accuracy are critically reviewed in this article. In them, extraction, separation and determination are emphasized. The main objective is to offer an assessment of the state of the art and identify research needs and future trends in determining pesticide and Veterinary Drug residues in food by LC-MS.
Antonia Garrido Frenich - One of the best experts on this subject based on the ideXlab platform.
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analysis of pesticide and Veterinary Drug residues in baby food by liquid chromatography coupled to orbitrap high resolution mass spectrometry
Talanta, 2015Co-Authors: Maria Luz Gomezperez, Roberto Romerogonzalez, Vidal Jose Luis Martinez, Antonia Garrido FrenichAbstract:Abstract Pesticide and Veterinary Drug residues have been simultaneously determined in several baby foods as meat, fish and vegetable-based baby food. A generic extraction method without clean-up step was applied. Moreover, the use of a representative matrix for proper quantification of all target compounds was studied and the best results were obtained when vegetable-based baby food was used as representative matrix, allowing the reliable quantification of more than 300 compounds. The method was validated and good recoveries were obtained for most of compounds at concentrations higher than 50 µg kg−1. Limits of detection (LOD) ranged from 0.5 to 50 µg kg−1, whereas limits of quantification (LOQ) were established between 10 and 100 µg kg−1. Limits of identification (LOIs) ranged from 0.5 to 50 µg kg−1. This method was applied to the analysis of 46 different baby food samples and no positive samples were found.
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analysis of Veterinary Drug residues in cheese by ultra high performance lc coupled to triple quadrupole ms ms
IEEE Journal of Solid-state Circuits, 2013Co-Authors: Maria Luz Gomez Perez, Roberto Romerogonzalez, Jose Luis Martinez Vidal, Antonia Garrido FrenichAbstract:A simple, reliable, and fast multiresidue method has been developed for the determination of 17 Veterinary Drugs belonging to several families (macrolides, sulfonamides, and anthelmintics) in cheese at trace levels. Ultra-high-performance LC coupled to MS/MS has been used for the analysis of these compounds in less than 9 min. Veterinary Drug residues have been extracted from cheese samples using a QuEChERS (quick, easy, cheap, effective, rugged, and safe)-based extraction procedure without applying any further clean-up step. Matrix-matched calibration was used for quantification and recoveries were calculated at three concentration levels (10, 50, and 100 μg/kg). The obtained values ranged from 70 to 110% for the selected compounds except for tylosin and josamycin at 100 μg/kg (111.7 and 112.7%, respectively). Intra- and interday precision were also evaluated and RSDs were lower than 25% in all the cases. LOQs ranged from 0.3 μg/kg (for thiabendazole, oxfendazole, mebendazole, josamycin, and fenbendazole) to 10.5 μg/kg (abamectin), whereas decision limit and detection capability ranged from 2.3 (thiabendazole) to 11.3 (abamectin) and 4.2 (thiabendazole) to 14.3 μg/kg (abamectin), respectively. Finally, 13 samples were analyzed and traces of thiabendazole were detected in two different cheeses.
Xiaogang Chu - One of the best experts on this subject based on the ideXlab platform.
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application of the mechanical high pressure method combined with high performance liquid chromatography tandem mass spectrometry for determination of Veterinary Drug residues in incurred chicken and rabbit muscle tissues
Journal of Food Protection, 2019Co-Authors: Mingxia Liu, Xiaogang Chu, Zhen Wang, Yalei Dong, Yuping ZhangAbstract:Rapid sample preparation is a key step in the field of food safety. A mechanical high-pressure method using a laboratory-made meat press machine was first introduced in this study to process the incurred muscle samples of chicken and rabbit. By applying high pressure to animal muscle, the meat juice was obtained. After extraction and purification, Veterinary Drug residues in the juice were qualitatively and quantitatively analyzed by using high-performance liquid chromatography-tandem mass spectrometry. The sample press conditions and extraction solvents were optimized. Under the optimal conditions, all Veterinary Drug residues, including tetracycline, enrofloxacin, clenbuterol, ampicillin, lincomycin, erythromycin, and sulfadiazine, in the incurred samples were detected. The residual concentration of Drugs in samples obtained by using the mechanical high-pressure method can reach up to 94.0% of that obtained by using the common homogenization method, suggesting that Drug residues exist in the tissue juice, which justifies the use of the mechanical high-pressure method. Moreover, with the mechanical high-pressure method, the sample preparation time was shortened by five times, and the consumption of the extraction solvent was reduced by 50%, relative to the homogenization method.
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high throughput untargeted screening of Veterinary Drug residues and metabolites in tilapia using high resolution orbitrap mass spectrometry
Analytica Chimica Acta, 2017Co-Authors: Wei Jia, Xiaogang Chu, James Chang, Perry G Wang, Ying Chen, Feng ZhangAbstract:Abstract An analytical method was developed and validated for simultaneous analysis of one hundred and thirty-seven Veterinary Drug residues and metabolites from sixteen different classes in tilapia utilizing an improved fully non-targeted way of data acquisition with fragmentation. The automated on-line extraction procedure was achieved in a simple disposable pipet extraction. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC Q-Orbitrap) was used for the separation and detection of all the analytes. The methodology was validated by taking into consideration the guidelines specified in European SANCO/12571/2013 Guideline 2013 and Commission Decision 2002/657/EC. The extraction recoveries ranged from 81% to 111%. The limits of decision ranged from 0.01 to 2.73 μg kg −1 and the detection capabilities ranged from 0.01 to 4.73 μg kg −1 . The one hundred and thirty-seven compounds behave dynamic 0.1–500 μg kg −1 , with correlation coefficient >0.99. The fully non-targeted data acquisition way improves both sensitivity and selectivity for the fragments, which is beneficial for screening performance and identification capability. This validated method has been successfully applied on screening of Veterinary Drug residues and metabolites in muscle of tilapia, an important and intensively produced fish in aquaculture.
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high throughput screening of pesticide and Veterinary Drug residues in baby food by liquid chromatography coupled to quadrupole orbitrap mass spectrometry
Journal of Chromatography A, 2014Co-Authors: Wei Jia, Xiaogang Chu, Yun Ling, Junrong Huang, James ChangAbstract:A new analytical method was developed and validated for simultaneous analysis of 333 pesticide and Veterinary Drug residues in baby food. Response surface methodology was employed to optimize a generic extraction method. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-ESI Q-Orbitrap) was used for the separation and detection of all the analytes. The method was validated by taking into consideration the guidelines specified in Commission Decision 2002/657/EC and SANCO/12571/2013. The extraction recoveries were in a range of 79.8-110.7%, with coefficient of variation 0.99. The limits of detection for the analytes are in the range 0.01-5.35μgkg(-1). The limits of quantification for the analytes are in the range 0.01-9.27μgkg(-1). This method has been successfully applied on screening of pesticide and Veterinary Drugs in ninety-three commercial baby food samples, and tilmicosin, fenbendazole, tylosin tartrate and thiabendazole were detected in some samples tested in this study. The present study is very useful for fast screening of different food contaminants.