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Richter Duk Pablo - One of the best experts on this subject based on the ideXlab platform.
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A new rotating-disk sorptive extraction mode, with a copolymer of divinylbenzene and N-vinylpyrrolidone trapped in the cavity of the disk, used for determination of florfenicol residues in porcine plasma Microextraction Techniques
'Springer Science and Business Media LLC', 2014Co-Authors: Cañas Alejandro, Valdebenito Samuel, Richter Duk PabloAbstract:A novel extraction approach was developed based on rotating-disk sorptive extraction (RDSE). In this approach the rotating-disk extraction device consists of a Teflon disk, with a cavity that is loaded with a commercial sorbent phase selected according to the polarity of the analyte. To avoid leakage of the sorbent, the cavity is covered with a fiberglass filter and sealed with a Teflon ring. The proposed novel analytical RDSE technique was used in this study to determine florfenicol levels in plasma as a model analyte, or sample system, to describe the pharmacokinetics of a Veterinary Formulation. The sorbent used for this application was the copolymer of divinylbenzene and N-vinylpyrrolidone (Oasis HLB), which was selected because the florfenicol molecule contains both hydrophilic and lipophilic moieties. After the extraction, final determination of the analyte was performed by HPLC-DAD. Calibration plots and other analytical features were obtained after 90 min of extraction. The ca
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A new rotating-disk sorptive extraction mode, with a copolymer of divinylbenzene and N-vinylpyrrolidone trapped in the cavity of the disk, used for determination of florfenicol residues in porcine plasma
'Springer Science and Business Media LLC', 2014Co-Authors: Cañas Alejandro, Valdebenito Samuel, Richter Duk PabloAbstract:Artículo de publicación ISIA novel extraction approach was developed based on rotating-disk sorptive extraction (RDSE). In this approach the rotating-disk extraction device consists of a Teflon disk, with a cavity that is loaded with a commercial sorbent phase selected according to the polarity of the analyte. To avoid leakage of the sorbent, the cavity is covered with a fiberglass filter and sealed with a Teflon ring. The proposed novel analytical RDSE technique was used in this study to determine florfenicol levels in plasma as a model analyte, or sample system, to describe the pharmacokinetics of a Veterinary Formulation. The sorbent used for this application was the copolymer of divinylbenzene and N-vinylpyrrolidone (Oasis HLB), which was selected because the florfenicol molecule contains both hydrophilic and lipophilic moieties. After the extraction, final determination of the analyte was performed by HPLC– DAD. Calibration plots and other analytical features were obtained after 90 min of extraction. The calibration plot was linear over the interval 0.4–16 μg mL−1 (n=6), with R2= 0.9999. Recovery and repeatability were determined using a blank plasma sample spiked with 4.8 μg mL−1 florfenicol. A recovery of 91.5 %, with a relative standard deviation (RSD) of 8.8 %, was obtained when the extraction was evaluated using six different rotating-disk devices. Precision was also assessed, using the same disk (containing the same sorbent phase) for eight aliquots of the same sample. The RSD under these conditions was 10.2 %, clearly indicating that the sorptive phase could possibly be re-used. Accordingly, RDSE is a suitable sample preparation alternative to liquid–liquid extraction (LLE), solid-phase extraction (SPE), and stir-bar sorptive extraction (SBSE).FONDECYT (project 1100085) for financial support
Cañas Alejandro - One of the best experts on this subject based on the ideXlab platform.
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A new rotating-disk sorptive extraction mode, with a copolymer of divinylbenzene and N-vinylpyrrolidone trapped in the cavity of the disk, used for determination of florfenicol residues in porcine plasma Microextraction Techniques
'Springer Science and Business Media LLC', 2014Co-Authors: Cañas Alejandro, Valdebenito Samuel, Richter Duk PabloAbstract:A novel extraction approach was developed based on rotating-disk sorptive extraction (RDSE). In this approach the rotating-disk extraction device consists of a Teflon disk, with a cavity that is loaded with a commercial sorbent phase selected according to the polarity of the analyte. To avoid leakage of the sorbent, the cavity is covered with a fiberglass filter and sealed with a Teflon ring. The proposed novel analytical RDSE technique was used in this study to determine florfenicol levels in plasma as a model analyte, or sample system, to describe the pharmacokinetics of a Veterinary Formulation. The sorbent used for this application was the copolymer of divinylbenzene and N-vinylpyrrolidone (Oasis HLB), which was selected because the florfenicol molecule contains both hydrophilic and lipophilic moieties. After the extraction, final determination of the analyte was performed by HPLC-DAD. Calibration plots and other analytical features were obtained after 90 min of extraction. The ca
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A new rotating-disk sorptive extraction mode, with a copolymer of divinylbenzene and N-vinylpyrrolidone trapped in the cavity of the disk, used for determination of florfenicol residues in porcine plasma
'Springer Science and Business Media LLC', 2014Co-Authors: Cañas Alejandro, Valdebenito Samuel, Richter Duk PabloAbstract:Artículo de publicación ISIA novel extraction approach was developed based on rotating-disk sorptive extraction (RDSE). In this approach the rotating-disk extraction device consists of a Teflon disk, with a cavity that is loaded with a commercial sorbent phase selected according to the polarity of the analyte. To avoid leakage of the sorbent, the cavity is covered with a fiberglass filter and sealed with a Teflon ring. The proposed novel analytical RDSE technique was used in this study to determine florfenicol levels in plasma as a model analyte, or sample system, to describe the pharmacokinetics of a Veterinary Formulation. The sorbent used for this application was the copolymer of divinylbenzene and N-vinylpyrrolidone (Oasis HLB), which was selected because the florfenicol molecule contains both hydrophilic and lipophilic moieties. After the extraction, final determination of the analyte was performed by HPLC– DAD. Calibration plots and other analytical features were obtained after 90 min of extraction. The calibration plot was linear over the interval 0.4–16 μg mL−1 (n=6), with R2= 0.9999. Recovery and repeatability were determined using a blank plasma sample spiked with 4.8 μg mL−1 florfenicol. A recovery of 91.5 %, with a relative standard deviation (RSD) of 8.8 %, was obtained when the extraction was evaluated using six different rotating-disk devices. Precision was also assessed, using the same disk (containing the same sorbent phase) for eight aliquots of the same sample. The RSD under these conditions was 10.2 %, clearly indicating that the sorptive phase could possibly be re-used. Accordingly, RDSE is a suitable sample preparation alternative to liquid–liquid extraction (LLE), solid-phase extraction (SPE), and stir-bar sorptive extraction (SBSE).FONDECYT (project 1100085) for financial support
Erdal Dinc - One of the best experts on this subject based on the ideXlab platform.
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spectrophotometric multicomponent resolution of a Veterinary Formulation containing oxfendazole and oxyclozanide by multivariate calibration prediction techniques
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat KanburAbstract:Four multivariate calibration-prediction techniques, classical least-squares, inverse least-squares, principal component regression and partial least-squares regression were applied to the spectrophotometric multicomponent analysis of a Veterinary Formulation containing oxfendazole (OXF) and oxyclozanide (OXC) without any separation step. The multivariate calibrations were constructed by measuring the absorbance values at 14 points in the 285-350 nm wavelength range and by using the training set of standard mixtures containing OXF and OXC in the different compositions. The validity of building multivariate calibrations was checked by using the synthetic mixtures of both drugs. The multivariate calibration models were successfully applied to the spectrophotometric determination of OXF and OXC in laboratory prepared mixtures and a Veterinary Formulation. The results obtained were statistically compared with each other.
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comparative study of the ratio spectra derivative spectrophotometry derivative spectrophotometry and vierordt s method applied to the analysis of oxfendazole and oxyclozanide in a Veterinary Formulation
Analusis, 1997Co-Authors: Erdal Dinc, Feyyaz OnurAbstract:Trois nouvelles methodes spectrophotometriques (spectrophotometrie de derivee premiere, spectrophotometrie de derivee premiere des spectres divises et la methode de Vierordt) ont ete proposees pour le dosage de l'oxyclozanide et de l'oxfendazole en melange binaire. Ces methodes ne necessitent pas de separation preliminaire. Pour la spectrometrie de derivee premiere, les valeurs de dA/dl sont mesurees a 308,8 nm pour l'oxyclozanide et a 326,0 nm pour l'oxfendazole. Leurs courbes d'etalonnage sont lineaires pour 8 a 32 μg.mL -1 d'oxyclozanide et pour 4 a 16 μg.mL -1 d'oxfendazole. Pour la deuxieme methode, l'etalonnage a ete effectue pour 4 a 32 μg.mL -1 de signaux analytiques des spectres divises obtenus a 255,0 et 273,1 nm pour l'oxyclozanide et a 281,8 et 304,6 nm pour l'oxfendazole. Pour la methode de Vierordt, les valeurs A 1 1 (% 1, 1 cm) de l'oxyclozanide et de l'oxfendazole sont calculees a 308,7 et 326,1 nm a partir de leurs spectres d'absorption d'ordre zero, et les concentrations de ces deux composes actifs en melange binaire sont determinees a l'aide des valeurs A 1 1 (%, 1, 1 cm). Ces trois methodes ont ete appliquees au dosage des deux composes dans une Formulation veterinaire.
Murat Kanbur - One of the best experts on this subject based on the ideXlab platform.
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spectrophotometric multicomponent resolution of a Veterinary Formulation containing oxfendazole and oxyclozanide by multivariate calibration prediction techniques
Journal of Pharmaceutical and Biomedical Analysis, 2002Co-Authors: Erdal Dinc, Murat KanburAbstract:Four multivariate calibration-prediction techniques, classical least-squares, inverse least-squares, principal component regression and partial least-squares regression were applied to the spectrophotometric multicomponent analysis of a Veterinary Formulation containing oxfendazole (OXF) and oxyclozanide (OXC) without any separation step. The multivariate calibrations were constructed by measuring the absorbance values at 14 points in the 285-350 nm wavelength range and by using the training set of standard mixtures containing OXF and OXC in the different compositions. The validity of building multivariate calibrations was checked by using the synthetic mixtures of both drugs. The multivariate calibration models were successfully applied to the spectrophotometric determination of OXF and OXC in laboratory prepared mixtures and a Veterinary Formulation. The results obtained were statistically compared with each other.
Salome Ballesteros - One of the best experts on this subject based on the ideXlab platform.
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two suicidal fatalities due to the ingestion of chlorfenvinphos Formulations simultaneous determination of the pesticide and the petroleum distillates in tissues by gas chromatography flame ionization detection and gas chromatography mass spectrometr
Journal of Analytical Toxicology, 2012Co-Authors: Maria A Martinez, Salome BallesterosAbstract:Chlorfenvinphos (CFVP) is an organophosporus insecticide designated as a threat agent by the National Institutes of Health (NIH). However, there are very few reported cases of poisonings in humans and none with postmortem toxicological analysis. We report the first two fatalities due to suicidal massive ingestion of a Veterinary Formulation containing CFVP and petroleum distillates. Case 1: A 24-year-old woman was found dead by her mother. According to the police records, the room was filled with an odor of solvents or pesticides and feces. There was an empty bottle of Supona(®) near the body and a suicide note on a Bible on a table. The only relevant postmortem finding was that the lungs appeared congested and edematous. Case 2: A 60-year-old man committed in his van by ingesting an unknown product. The vehicle was locked and had an odor that resembled an acid, sulfate, or solvent according to different witnesses. There was a suicide note as well as multiple containers containing automobile products nearby. The stomach of the victim was filled with abundant pale greenish fluid with a similar odor to that presented in the vehicle. The simultaneous toxicological screening and quantitation of CFVP and petroleum distillates [a mixture of trimethylbenzene isomers (TMBs)] was performed by means of gas chromatography with flame-ionization detection (GC-FID) and confirmation was performed using gas chromatography-mass spectrometry (GC-MS). Disposition of CFVP and TMBs in different tissues were, respectively, as follows: Case 1: heart blood, 8.6 and 3.7 mg/L; liver, 60.0 and 33.4 mg/kg; and stomach contents, 1132 mg/L (792.4 mg total) and 377.0 mg/L (263.9 mg total). Case 2: heart blood, 4.4 and 6.5 mg/L; urine, 1.4 and detected ( Language: en
