The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
Jürgen Clausen - One of the best experts on this subject based on the ideXlab platform.
-
Veterinary Homeopathy: Systematic review of medical conditions studied by randomised trials controlled by other than placebo
BMC veterinary research, 2015Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background No systematic review has previously been carried out on randomised controlled trials (RCTs) of Veterinary Homeopathy in which the control group was an intervention other than placebo (OTP). For eligible peer-reviewed RCTs, the objectives of this study were to assess the risk of bias (RoB) and to quantify the effect size of homeopathic intervention compared with an active comparator or with no treatment.
-
Veterinary Homeopathy: Systematic review of medical conditions studied by randomised trials controlled by other than placebo
BMC Veterinary Research, 2015Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background No systematic review has previously been carried out on randomised controlled trials (RCTs) of Veterinary Homeopathy in which the control group was an intervention other than placebo (OTP). For eligible peer-reviewed RCTs, the objectives of this study were to assess the risk of bias (RoB) and to quantify the effect size of homeopathic intervention compared with an active comparator or with no treatment. Methods Our systematic review approach complied fully with the PRISMA 2009 Checklist. Cochrane methods were applied to assess RoB and to derive effect size using standard meta-analysis methods. Based on a thorough and systematic literature search, the following key attributes of the published research were distinguished: individualised Homeopathy (n = 1 RCT)/non-individualised Homeopathy (n = 19); treatment (n = 14)/prophylaxis (n = 6); active controls (n = 18)/untreated controls (n = 2). The trials were highly diverse, representing 12 different medical conditions in 6 different species. Results No trial had sufficiently low RoB to be judged as reliable evidence: 16 of the 20 RCTs had high RoB; the remaining four had uncertain RoB in several domains of assessment. For three trials with uncertain RoB and without overt vested interest, it was inconclusive whether Homeopathy combined with conventional intervention was more or was less effective than conventional intervention alone for modulation of immune response in calves, or in the prophylaxis of cattle tick or of diarrhoea in piglets. Conclusion Due to the poor reliability of their data, OTP-controlled trials do not currently provide useful insight into the effectiveness of Homeopathy in animals.
-
Veterinary Homeopathy: meta-analysis of randomised placebo-controlled trials.
Homeopathy : the journal of the Faculty of Homeopathy, 2014Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background: Meta-analysis of randomised controlled trials (RCTs) of Veterinary Homeopathy has not previously been undertaken. For all medical conditions and species collectively, we tested the hypothesis that the outcome of homeopathic intervention (treatment and/or prophylaxis, individualised and/or non-individualised) is distinguishable from corresponding intervention using placebos. Methods: All facets of the review, including literature search strategy, study eligibility, data extraction and assessment of risk of bias, were described in an earlier paper. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specific domains of assessment. Effect size was reported as odds ratio (OR). A trial was judged free of vested interest if it was not funded by a homeopathic pharmacy. Metaanalysis was conducted using the random-effects model, with hypothesis-driven sensitivity analysis based on risk of bias. Results: Nine of 15 trials with extractable data displayed high risk of bias; low or unclear risk of bias was attributed to each of the remaining six trials, only two of which comprised reliable evidence without overt vested interest. For all N = 15 trials, pooled OR = 1.69 [95% confidence interval (CI), 1.12 to 2.56]; P = 0.01. For the N = 2 trials with suitably reliable evidence, pooled OR = 2.62 [95% CI, 1.13 to 6.05]; P = 0.02). Conclusions: Meta-analysis provides some very limited evidence that clinical intervention in animals using homeopathic medicines is distinguishable from corresponding intervention using placebos. The low number and quality of the trials hinders a more decisive conclusion. Homeopathy (2014) - ,1 e6.
-
Veterinary Homeopathy: systematic review of medical conditions studied by randomised placebo-controlled trials
The Veterinary record, 2014Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:A systematic review of randomised controlled trials (RCTs) of Veterinary Homeopathy has not previously been undertaken. Using Cochrane methods, this review aims to assess risk of bias and to quantify the effect size of homeopathic intervention compared with placebo for each eligible peer-reviewed trial. Judgement in seven assessment domains enabled a trial's risk of bias to be designated as low, unclear or high. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specified domains. A trial was considered to be free of vested interest if it was not funded by a homeopathic pharmacy. The 18 eligible RCTs were disparate in nature, representing four species and 11 different medical conditions. Reliable evidence, free from vested interest, was identified in two trials: homeopathic Coli had a prophylactic effect on porcine diarrhoea (odds ratio 3.89, 95 per cent confidence interval [CI], 1.19 to 12.68, P=0.02); and individualised homeopathic treatment did not have a more beneficial effect on bovine mastitis than placebo intervention (standardised mean difference -0.31, 95 per cent CI, -0.97 to 0.34, P=0.35). Mixed findings from the only two placebo-controlled RCTs that had suitably reliable evidence precluded generalisable conclusions about the efficacy of any particular homeopathic medicine or the impact of individualised homeopathic intervention on any given medical condition in animals.
-
Veterinary Clinical Research Database for Homeopathy: Placebo-controlled trials
Complementary therapies in medicine, 2013Co-Authors: Jürgen Clausen, H. Albrecht, Robert T. MathieAbstract:Summary Background Veterinary Homeopathy has led a somewhat shadowy existence since its first introduction. Only in the last three decades has the number of clinical trials increased considerably. This literature is generally not well perceived, which may be partly a consequence of the diffuse and somewhat inaccessible nature of some of the relevant research publications. The Veterinary Clinical Research Database for Homeopathy (VetCR) was launched in 2006 to provide information on existing clinical research in Veterinary Homeopathy and to facilitate the preparation of systematic reviews. Objective The aim of the present report is to provide an overview of this first database on clinical research in Veterinary Homeopathy, with a special focus on its content of placebo controlled clinical trials and summarising what is known about placebo effects in animals. Results In April 2012, the VetCR database contained 302 data records. Among these, 203 controlled trials were identified: 146 randomised and 57 non-randomised. In 97 of those 203 trials, the homeopathic medical intervention was compared to placebo. Comment A program of formal systematic reviews of peer-reviewed randomised controlled trials in Veterinary Homeopathy is now underway; detailed findings from the program's data extraction and appraisal approach, including the assessment of trial quality (risk of bias), will be reported in due course.
Robert T. Mathie - One of the best experts on this subject based on the ideXlab platform.
-
Veterinary Homeopathy: Systematic review of medical conditions studied by randomised trials controlled by other than placebo
BMC veterinary research, 2015Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background No systematic review has previously been carried out on randomised controlled trials (RCTs) of Veterinary Homeopathy in which the control group was an intervention other than placebo (OTP). For eligible peer-reviewed RCTs, the objectives of this study were to assess the risk of bias (RoB) and to quantify the effect size of homeopathic intervention compared with an active comparator or with no treatment.
-
Veterinary Homeopathy: Systematic review of medical conditions studied by randomised trials controlled by other than placebo
BMC Veterinary Research, 2015Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background No systematic review has previously been carried out on randomised controlled trials (RCTs) of Veterinary Homeopathy in which the control group was an intervention other than placebo (OTP). For eligible peer-reviewed RCTs, the objectives of this study were to assess the risk of bias (RoB) and to quantify the effect size of homeopathic intervention compared with an active comparator or with no treatment. Methods Our systematic review approach complied fully with the PRISMA 2009 Checklist. Cochrane methods were applied to assess RoB and to derive effect size using standard meta-analysis methods. Based on a thorough and systematic literature search, the following key attributes of the published research were distinguished: individualised Homeopathy (n = 1 RCT)/non-individualised Homeopathy (n = 19); treatment (n = 14)/prophylaxis (n = 6); active controls (n = 18)/untreated controls (n = 2). The trials were highly diverse, representing 12 different medical conditions in 6 different species. Results No trial had sufficiently low RoB to be judged as reliable evidence: 16 of the 20 RCTs had high RoB; the remaining four had uncertain RoB in several domains of assessment. For three trials with uncertain RoB and without overt vested interest, it was inconclusive whether Homeopathy combined with conventional intervention was more or was less effective than conventional intervention alone for modulation of immune response in calves, or in the prophylaxis of cattle tick or of diarrhoea in piglets. Conclusion Due to the poor reliability of their data, OTP-controlled trials do not currently provide useful insight into the effectiveness of Homeopathy in animals.
-
Veterinary Homeopathy: meta-analysis of randomised placebo-controlled trials.
Homeopathy : the journal of the Faculty of Homeopathy, 2014Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:Background: Meta-analysis of randomised controlled trials (RCTs) of Veterinary Homeopathy has not previously been undertaken. For all medical conditions and species collectively, we tested the hypothesis that the outcome of homeopathic intervention (treatment and/or prophylaxis, individualised and/or non-individualised) is distinguishable from corresponding intervention using placebos. Methods: All facets of the review, including literature search strategy, study eligibility, data extraction and assessment of risk of bias, were described in an earlier paper. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specific domains of assessment. Effect size was reported as odds ratio (OR). A trial was judged free of vested interest if it was not funded by a homeopathic pharmacy. Metaanalysis was conducted using the random-effects model, with hypothesis-driven sensitivity analysis based on risk of bias. Results: Nine of 15 trials with extractable data displayed high risk of bias; low or unclear risk of bias was attributed to each of the remaining six trials, only two of which comprised reliable evidence without overt vested interest. For all N = 15 trials, pooled OR = 1.69 [95% confidence interval (CI), 1.12 to 2.56]; P = 0.01. For the N = 2 trials with suitably reliable evidence, pooled OR = 2.62 [95% CI, 1.13 to 6.05]; P = 0.02). Conclusions: Meta-analysis provides some very limited evidence that clinical intervention in animals using homeopathic medicines is distinguishable from corresponding intervention using placebos. The low number and quality of the trials hinders a more decisive conclusion. Homeopathy (2014) - ,1 e6.
-
Veterinary Homeopathy: systematic review of medical conditions studied by randomised placebo-controlled trials
The Veterinary record, 2014Co-Authors: Robert T. Mathie, Jürgen ClausenAbstract:A systematic review of randomised controlled trials (RCTs) of Veterinary Homeopathy has not previously been undertaken. Using Cochrane methods, this review aims to assess risk of bias and to quantify the effect size of homeopathic intervention compared with placebo for each eligible peer-reviewed trial. Judgement in seven assessment domains enabled a trial's risk of bias to be designated as low, unclear or high. A trial was judged to comprise reliable evidence if its risk of bias was low or was unclear in specified domains. A trial was considered to be free of vested interest if it was not funded by a homeopathic pharmacy. The 18 eligible RCTs were disparate in nature, representing four species and 11 different medical conditions. Reliable evidence, free from vested interest, was identified in two trials: homeopathic Coli had a prophylactic effect on porcine diarrhoea (odds ratio 3.89, 95 per cent confidence interval [CI], 1.19 to 12.68, P=0.02); and individualised homeopathic treatment did not have a more beneficial effect on bovine mastitis than placebo intervention (standardised mean difference -0.31, 95 per cent CI, -0.97 to 0.34, P=0.35). Mixed findings from the only two placebo-controlled RCTs that had suitably reliable evidence precluded generalisable conclusions about the efficacy of any particular homeopathic medicine or the impact of individualised homeopathic intervention on any given medical condition in animals.
-
Veterinary Clinical Research Database for Homeopathy: Placebo-controlled trials
Complementary therapies in medicine, 2013Co-Authors: Jürgen Clausen, H. Albrecht, Robert T. MathieAbstract:Summary Background Veterinary Homeopathy has led a somewhat shadowy existence since its first introduction. Only in the last three decades has the number of clinical trials increased considerably. This literature is generally not well perceived, which may be partly a consequence of the diffuse and somewhat inaccessible nature of some of the relevant research publications. The Veterinary Clinical Research Database for Homeopathy (VetCR) was launched in 2006 to provide information on existing clinical research in Veterinary Homeopathy and to facilitate the preparation of systematic reviews. Objective The aim of the present report is to provide an overview of this first database on clinical research in Veterinary Homeopathy, with a special focus on its content of placebo controlled clinical trials and summarising what is known about placebo effects in animals. Results In April 2012, the VetCR database contained 302 data records. Among these, 203 controlled trials were identified: 146 randomised and 57 non-randomised. In 97 of those 203 trials, the homeopathic medical intervention was compared to placebo. Comment A program of formal systematic reviews of peer-reviewed randomised controlled trials in Veterinary Homeopathy is now underway; detailed findings from the program's data extraction and appraisal approach, including the assessment of trial quality (risk of bias), will be reported in due course.
H. Albrecht - One of the best experts on this subject based on the ideXlab platform.
-
Veterinary Clinical Research Database for Homeopathy: Placebo-controlled trials
Complementary therapies in medicine, 2013Co-Authors: Jürgen Clausen, H. Albrecht, Robert T. MathieAbstract:Summary Background Veterinary Homeopathy has led a somewhat shadowy existence since its first introduction. Only in the last three decades has the number of clinical trials increased considerably. This literature is generally not well perceived, which may be partly a consequence of the diffuse and somewhat inaccessible nature of some of the relevant research publications. The Veterinary Clinical Research Database for Homeopathy (VetCR) was launched in 2006 to provide information on existing clinical research in Veterinary Homeopathy and to facilitate the preparation of systematic reviews. Objective The aim of the present report is to provide an overview of this first database on clinical research in Veterinary Homeopathy, with a special focus on its content of placebo controlled clinical trials and summarising what is known about placebo effects in animals. Results In April 2012, the VetCR database contained 302 data records. Among these, 203 controlled trials were identified: 146 randomised and 57 non-randomised. In 97 of those 203 trials, the homeopathic medical intervention was compared to placebo. Comment A program of formal systematic reviews of peer-reviewed randomised controlled trials in Veterinary Homeopathy is now underway; detailed findings from the program's data extraction and appraisal approach, including the assessment of trial quality (risk of bias), will be reported in due course.
-
Database on Veterinary clinical research in Homeopathy.
Homeopathy : the journal of the Faculty of Homeopathy, 2010Co-Authors: Jürgen Clausen, H. AlbrechtAbstract:Objective The aim of the present report is to provide an overview of the first database on clinical research in Veterinary Homeopathy. Procedures Detailed searches in the database ‘Veterinary Clinical Research-Database in Homeopathy’ ( http://www.carstens-stiftung.de/clinresvet/index.php ). Results The database contains about 200 entries of randomised clinical trials, non-randomised clinical trials, observational studies, drug provings, case reports and case series. Twenty-two clinical fields are covered and eight different groups of species are included. The database is free of charge and open to all interested veterinarians and researchers. Conclusion The database enables researchers and veterinarians, sceptics and supporters to get a quick overview of the status of Veterinary clinical research in Homeopathy and alleviates the preparation of systematical reviews or may stimulate reproductions or even new studies.
Stefan Alenius - One of the best experts on this subject based on the ideXlab platform.
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
2013Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:neonatal calf diarrhoea in a randomised double-blind placebo-controlled clinical trial. Acta vet. scand. 2003, 44, 97-101. – A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n=24) or a placebo (n=20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming. Antibiotics; bovine; coronavirus; Cryptosporidium; enteritis; Homeopathy; medicine; organic farming; Podophyllum; rotavirus; scour; Veterinary
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
Acta Veterinaria Scandinavica, 2003Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n = 24) or a placebo (n = 20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming. Ingen effekt av homeopatisk behandling av kalvdiarré i en klinisk studie En dubbel-blind och placebokontrollerad klinisk studie av homeopatisk behandling av spädkalvsdiarré beskrivs. Fyrtiofyra kalvar från 12 mjölkkobesättningar ingick i studien. Kalvarna behandlades med antingen det homeopatiska preparatet Podophyllum D30 (n=24) eller placebo (n=20). Varken kliniskt eller statistiskt signifikanta skillnader mellan de båda grupperna kunde påvisas. Kalvar som behandlats med Podophyllum hade diarré i medeltal 3,1 dagar jämfört med placebogruppens 2,9 dagar. Nedsatt foderlust, påverkat allmäntillstånd och feber registrerades i samma utsträckning i båda grupperna. Resultaten styrker åsikten att vetenskapliga bevis för homeopatisk effekt saknas. Att, som i länder inom EU, förorda homeopatisk behandling i ekologiskt jordbruk innebär därmed en risk för djurens hälsa och välbefinnande.
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
Acta Veterinaria Scandinavica, 2003Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n = 24) or a placebo (n = 20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming.
K. De Verdier - One of the best experts on this subject based on the ideXlab platform.
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
2013Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:neonatal calf diarrhoea in a randomised double-blind placebo-controlled clinical trial. Acta vet. scand. 2003, 44, 97-101. – A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n=24) or a placebo (n=20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming. Antibiotics; bovine; coronavirus; Cryptosporidium; enteritis; Homeopathy; medicine; organic farming; Podophyllum; rotavirus; scour; Veterinary
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
Acta Veterinaria Scandinavica, 2003Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n = 24) or a placebo (n = 20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming. Ingen effekt av homeopatisk behandling av kalvdiarré i en klinisk studie En dubbel-blind och placebokontrollerad klinisk studie av homeopatisk behandling av spädkalvsdiarré beskrivs. Fyrtiofyra kalvar från 12 mjölkkobesättningar ingick i studien. Kalvarna behandlades med antingen det homeopatiska preparatet Podophyllum D30 (n=24) eller placebo (n=20). Varken kliniskt eller statistiskt signifikanta skillnader mellan de båda grupperna kunde påvisas. Kalvar som behandlats med Podophyllum hade diarré i medeltal 3,1 dagar jämfört med placebogruppens 2,9 dagar. Nedsatt foderlust, påverkat allmäntillstånd och feber registrerades i samma utsträckning i båda grupperna. Resultaten styrker åsikten att vetenskapliga bevis för homeopatisk effekt saknas. Att, som i länder inom EU, förorda homeopatisk behandling i ekologiskt jordbruk innebär därmed en risk för djurens hälsa och välbefinnande.
-
No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial
Acta Veterinaria Scandinavica, 2003Co-Authors: K. De Verdier, P Öhagen, Stefan AleniusAbstract:A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were treated with either the homeopathic remedy Podophyllum (D30) (n = 24) or a placebo (n = 20). No clinically or statistically significant difference between the 2 groups was demonstrated. Calves treated with Podophyllum had an average of 3.1 days of diarrhoea compared with 2.9 days for the placebo group. Depression, inappetence and fever were presented equally in the 2 groups. These results support the widely held opinion that scientific proof for the efficacy of Veterinary Homeopathy is lacking. In the European Union this implies a considerable risk for animal welfare, since in some countries priority is given to homeopathic treatments in organic farming.
