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Michael F. Holick - One of the best experts on this subject based on the ideXlab platform.
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the Vitamin D Deficiency panDemic approaches for Diagnosis treatment anD prevention
Reviews in Endocrine & Metabolic Disorders, 2017Co-Authors: Michael F. HolickAbstract:Vitamin D Deficiency anD insufficiency is a global health issue that afflicts more than one billion chilDren anD aDults worlDwiDe. The consequences of Vitamin D Deficiency cannot be unDer estimateD. There has been an association of Vitamin D Deficiency with a myriaD of acute anD chronic illnesses incluDing preeclampsia, chilDhooD Dental caries, perioDontitis, autoimmune DisorDers, infectious Diseases, carDiovascular Disease, DeaDly cancers, type 2 Diabetes anD neurological DisorDers. This review is to put into perspective the controversy surrounDing the Definition for Vitamin D Deficiency anD insufficiency as well as proviDing guiDance for how to treat anD prevent Vitamin D Deficiency.
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Vitamin D Deficiency
The New England journal of medicine, 2007Co-Authors: Michael F. HolickAbstract:Once fooDs in the UniteD States were fortifieD with Vitamin D, rickets appeareD to have been conquereD, anD many consiDereD major health problems from Vitamin D Deficiency resolveD. But Vitamin D Deficiency is common. This review consiDers the role of Vitamin D in skeletal anD nonskeletal health anD suggests strategies for the prevention anD treatment of Vitamin D Deficiency.
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Vitamin D Deficiency: What a Pain It Is
Mayo Clinic Proceedings, 2003Co-Authors: Michael F. HolickAbstract:years anD olDer than 60 years haD Vitamin D Deficiencies, with the younger group having significantly lower levels of 25-hyDroxyVitamin D. The association between nonspecific musculoskeletal pain anD Vitamin D Deficiency was suspecteD because of a higher prevalence of these symptoms During winter than summer. The stuDy patients rangeD in age from 10 to 65 years, anD all haD symptoms of Vitamin D Deficiency. Of the more than 90% of patients who were meDically evaluateD for persistent musculoskeletal pain 1 year or more before screening, none haD been testeD previously for Vitamin D Deficiency. See also page 1463.
Satheesh Nair - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Vitamin D Deficiency in chronic liver Disease
Digestive Diseases and Sciences, 2010Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe ( 32 ng/ml. Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (<7 ng/ml) was more common among patients with cirrhosis compareD with noncirrhotics (29.5% versus 14.1%, P value = 0.05). Female genDer, African American race, anD cirrhosis were inDepenDent preDictors of severe Vitamin D Deficiency in chronic liver Disease. Vitamin D Deficiency is universal (92%) among patients with chronic liver Disease, anD at least one-thirD of them suffer from severe Vitamin D Deficiency. African American females are at highest risk of Vitamin D Deficiency.
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Prevalence of Vitamin D Deficiency in Chronic Liver Disease
Digestive Diseases and Sciences, 2010Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. MethoDs One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe (32 ng/ml. Results Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (
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Prevalence of Vitamin D Deficiency in Chronic Liver Disease
Digestive Diseases and Sciences, 2009Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe ( 32 ng/ml. Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (
Catherine M. Gordon - One of the best experts on this subject based on the ideXlab platform.
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Vitamin D Deficiency in ChilDren anD Its Health Consequences
Clinical Reviews in Bone and Mineral Metabolism, 2009Co-Authors: Amy D. Divasta, Kristen K. Veen, Catherine M. GordonAbstract:This chapter reviews Data on the prevalence of Vitamin D Deficiency, risk factors that preDispose chilDren anD aDolescents to this problem, anD current approaches to routine Vitamin D supplementation anD treatment of Vitamin D Deficiency. The increasing worlD-wiDe prevalence of Vitamin D Deficiency among otherwise healthy peDiatric patients is exploreD. Risk factors for Vitamin D Deficiency have been iDentifieD anD incluDe, among others, northern geographical location, Dark skin pigmentation, female genDer, lack of supplementation, anD Diseases associateD with malabsorption. While supplementation strategies to prevent Vitamin D Deficiency have not been stanDarDizeD for infants, chilDren, anD aDolescents, previous stuDies comparing Different Doses have been testeD in both healthy youth, as well as those with chronic Disease. There is even less consensus on the appropriate treatment Doses for young patients iDentifieD to have this Deficiency. Health outcomes Data are critically neeDeD to proviDe guiDance regarDing the most appropriate supplementation anD treatment regimens for the peDiatric age group.
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Vitamin D Deficiency in chilDren anD aDolescents: EpiDemiology, impact anD treatment
Reviews in Endocrine and Metabolic Disorders, 2008Co-Authors: Catherine M. GordonAbstract:Vitamin D Deficiency is highly prevalent among chilDren anD aDolescents worlDwiDe. The high rates of Vitamin D Deficiency During chilDhooD are of major public health relevance, given the growing eviDence that Vitamin D Deficiency may play a key role in the pathophysiology of many chronic Diseases beyonD rickets, incluDing autoimmune conDitions, carDiovascular Diseases, anD cancer. IDentification, treatment, anD prevention of Vitamin D Deficiency in chilDhooD may therefore have profounD health effects throughout the life span. In this review, we Discuss the Definitions, epiDemiology, clinical implications, anD treatment of Vitamin D Deficiency in chilDren anD aDolescents.
J Arteh - One of the best experts on this subject based on the ideXlab platform.
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prevalence of Vitamin D Deficiency in chronic liver Disease
Digestive Diseases and Sciences, 2010Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe ( 32 ng/ml. Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (<7 ng/ml) was more common among patients with cirrhosis compareD with noncirrhotics (29.5% versus 14.1%, P value = 0.05). Female genDer, African American race, anD cirrhosis were inDepenDent preDictors of severe Vitamin D Deficiency in chronic liver Disease. Vitamin D Deficiency is universal (92%) among patients with chronic liver Disease, anD at least one-thirD of them suffer from severe Vitamin D Deficiency. African American females are at highest risk of Vitamin D Deficiency.
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Prevalence of Vitamin D Deficiency in Chronic Liver Disease
Digestive Diseases and Sciences, 2010Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. MethoDs One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe (32 ng/ml. Results Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (
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Prevalence of Vitamin D Deficiency in Chronic Liver Disease
Digestive Diseases and Sciences, 2009Co-Authors: J Arteh, S Narra, Satheesh NairAbstract:Vitamin D Deficiency has been associateD with cholestatic liver Disease such as primary biliary cirrhosis. Some stuDies have suggesteD that cirrhosis can preDispose patients to Development of osteoporosis because of altereD calcium anD Vitamin D homeostasis. The aim of this stuDy was to Determine the prevalence of Vitamin D Deficiency in patients with chronic liver Disease. One hunDreD anD eighteen consecutive patients (43 with hepatitis C cirrhosis, 57 with hepatitis C but no cirrhosis, 18 with nonhepatitis C-relateD cirrhosis) attenDing the University of Tennessee Hepatology Clinic haD their 25-hyDroxyVitamin D level measureD. Severity of Vitamin D Deficiency was graDeD as milD (20–32 ng/ml), moDerate (7–19 ng/ml) or severe ( 32 ng/ml. Of patients, 109/118 (92.4%) haD some Degree of Vitamin D Deficiency. In the hepatitis C cirrhosis group, 16.3% (7/43) haD milD, 48.8% (21/43) haD moDerate, anD 30.2% (13/43) haD severe Vitamin D Deficiency. In the hepatitis C noncirrhotic group, 22.8% (19/57) haD milD, 52.6% (30/57) haD moDerate, anD 14% (8/57) haD severe Vitamin D Deficiency. In the nonhepatitis C-relateD cirrhosis group, 38.9% (7/18) haD milD, 27.8% (5/18) haD moDerate, anD 27.8% (5/18) haD severe Vitamin D Deficiency. Severe Vitamin D Deficiency (
Song Shuju - One of the best experts on this subject based on the ideXlab platform.
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Vitamin D Deficiency During pregnancy anD its effect on the fetus
Chinese Journal of Osteoporosis, 2013Co-Authors: Song ShujuAbstract:Vitamin D Deficiency is a major public health problem in moDern societies. Vitamin D enhances intestinal calcium absorption anD plays a critical role in bone mineralization. Vitamin D Deficiency can cause rickets in chilDren anD osteopenia anD osteoporosis in aDults. Recently,other than its classical actions on bone,researchers have founD that Vitamin D Deficiency is also associateD with the occurrence of various Diseases. A wiDe range of populations suffers from Vitamin D Deficiency,which can happen in all ages,especially in pregnant women. The reasons leaDing to Vitamin D Deficiency in pregnant women are various,anD the main reason is the insufficiency of cutaneous UV exposure anD the increaseD DemanD of Vitamin D During pregnancy. Vitamin D Deficiency During pregnancy may affect conDitions of the fetus anD infant,such as skeletal anD brain Development,heart Disease,anD type 1Diabetes. Therefore,appropriate Vitamin D supplementation is important for preventing Vitamin D Deficiency in pregnancy anD for improving the obstetric quality anD maternal anD chilD health.
