The Experts below are selected from a list of 183 Experts worldwide ranked by ideXlab platform
José O. Rivera - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of Polypharmacy, Polyherbacy, Nutritional Supplement Use and Potential Product Interactions among Older Adults Living on the United States-Mexico Border
Drugs & Aging, 2009Co-Authors: Amanda M. Loya, Armando González-stuart, José O. RiveraAbstract:Background and objective The use of multiple medications, herbs or nutritional Supplements can lead to adverse consequences, particularly in the elderly. A significant consequence resulting from polypharmacy, polyherbacy and nutritional supplement use is the potential for interactions to occur among the various products. The primary objective of this study was to estimate the prevalence of polypharmacy, polyherbacy, nutritional supplement use and potential product interactions among older adults living on the US-Mexico border. Methods This was a descriptive study that involved the administration of a bilingual (English/Spanish) questionnaire to a convenience sample of adults aged ≥60 years recruited from senior centres located within the most populated US-Mexico border region from June 2005 to March 2006. Participant demographics were collected in addition to information about current use of prescription medications, over-the-counter (OTC) medications, herbal products and nutritional Supplements (i.e. nutraceuticals and vitamins or minerals). The outcomes measured were the number of prescription medications, OTC medications, herbal products, vitamins/minerals and nutraceuticals per participant. Furthermore, the number of potential interactions and major interactions between drugs, herbal products and nutritional Supplements were identified for each participant. Additionally, product use patterns between men and women and among locations within the border region were compared. Results One-hundred-and-thirty participants (mean age 71.4 years) were recruited to complete the questionnaire. The prevalence of polypharmacy among all participants was 72.3% (n = 94), with 38.5% (n = 50) taking five or more concomitant medications (major polypharmacy). Twenty-one participants (16.2%) in the study sample reported taking two or more herbal products (polyherbacy). Thirty-four participants (26.2%) reported taking two or more vitamin/mineral Supplements and nine (6.9%) reported using two or more nutraceuticals. Participants living on the US side of the border had higher rates of major polypharmacy, polyherbacy and use of nutritional Supplements than those living on the Mexican side of the border. Overall, there were no significant differences in medication, herbal product and nutritional supplement use patterns between men and women. Evaluation of potential interactions revealed that 46.2% (n = 60) of participants were at risk of having at least one potential drug-drug interaction. Regarding drug and herbal product-supplement interactions, 31.5% (n = 41) of participants were at risk of having at least one possible interaction. Conclusions The prevalence of polypharmacy among older adults living on the US side of the border was similar to national trends (estimates suggest that one-quarter to one-half of US adults aged ≥65 years take five or more medications). However, polypharmacy was less common in older adults living on the Mexican side of the border. Additionally, herb use was higher in older adults living on the US-Mexico border than has been reported in national surveys of US adults, which indicate that less than one-quarter of adults have used a herbal product within the previous 12 months. Furthermore, this study demonstrated that older adults living on the US side of the border consumed more herbs and nutritional Supplements than their Mexican counterparts. In addition to describing product use patterns on the border, these findings suggest that almost half of the older adult participants were at risk for a potential drug-drug interaction, with approximately one-third having a potential interaction between their medications, herbs or nutritional Supplements.
Ping Yang - One of the best experts on this subject based on the ideXlab platform.
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Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients? Results from the Mayo Clinic lung cancer cohort.
Lung Cancer, 2005Co-Authors: Aminah Jatoi, Brent A. Williams, Randolph S. Marks, Marie-christine Aubry, Jason A. Wampfler, Erin E. Finke, Frank Nichols, Ping YangAbstract:BACKGROUND: Some previous studies report that 80% of cancer patients take multivitamin and/or mineral Supplements. To our knowledge, the consequences of such self-directed supplementation have not been examined previously in non-small cell lung cancer (NSCLC) patients. The goal of this study was to determine whether vitamin/mineral supplementation is associated with improved survival and quality of life in a cohort of NSCLC patients. METHODS: NSCLC patients or their proxies who responded to a questionnaire on vitamin/mineral use were assessed for survival and quality of life. RESULTS: A total of 1129 patients or their proxies responded to a vitamin/mineral questionnaire. Seven hundred and fourteen were vitamin/mineral users of either multivitamins or other specific vitamin/mineral Supplements, and the rest non-users. Median survival was 4.3 years versus 2.0 years for vitamin/mineral users and non-users, respectively. A Cox proportional hazards model showed a relative risk of death of 0.74 (95% confidence interval (CI): 0.44, 0.65) (p < 0.01) in favor of vitamin/mineral use after adjustment for multiple prognostic factors, including tumor stage. The Lung Cancer Symptom Scale (LCSS) showed better quality of life among vitamin/mineral users (mean difference in score of 3 (95% CI: 0.8, 5.1) (p < 0.01); and after adjusting for related variables, there remained a trend in favor of vitamin/mineral use mean difference 1.8 (95% CI: 0.2, 3.9) (p = 0.08). CONCLUSIONS: Vitamin/mineral supplementation is associated with better survival and quality of life in this cohort of NSCLC patients. Future prospective clinical trials should focus on the role of such Supplements in patients with NSCLC.
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Self-directed vitamin/mineral supplementation in non-small cell lung cancer (NSCLC) patients: Does it impact survival and quality of life?
Cancer Research, 2004Co-Authors: Aminah Jatoi, Brent A. Williams, Francis C. Nichols, Randolph S. Marks, Marie-christine Aubry, Jason A. Wampfler, Erin E. Finke, Ping YangAbstract:1403 Background: Previous studies report that 80% of cancer patients take multivitamin and/or mineral Supplements. To our knowledge, the consequences of such self-directed supplementation on survival and quality of life have not been examined previously in NSCL patients. Objective: To determine whether vitamin/mineral supplementation is associated with improved survival and quality of life in a cohort of NSCLC patients. Design: Retrospective analysis of prospectively gathered data. Patients: NSCLC patients or their proxies who responded to a questionnaire on vitamin/mineral use. Main Outcome Measures: Survival and quality of life. Results: A total of 1129 patients or their proxies responded to a vitamin/mineral questionnaire. 714 were vitamin/mineral users of either multivitamins or other specific vitamin/mineral Supplements, and the rest non-users. Median survival was 4.3 versus 2.0 years for vitamin/mineral users and non-users, respectively. A Cox proportional hazards model showed a relative risk of death of 0.54 (95% confidence interval (CI): 0.44, 0.65); p
Carl L. Keen - One of the best experts on this subject based on the ideXlab platform.
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Vitamin and mineral supplement use among children attending elementary schools in Korea: a survey of eating habits and dietary consequences
Nutrition Research, 2002Co-Authors: Carl L. KeenAbstract:Abstract We surveyed the mothers of 2,904 Korean elementary schoolchildren (1st–6th grade) for their children’s vitamin/mineral supplement use, and dietary consequences of this use. Thirty two percent of subjects provided their schoolchildren with vitamin/mineral Supplements. Supplement use was higher in schoolchildren in lower grades, in higher socioeconomic groups, and in larger cities, than their counterparts. MultiVitamin-Mineral Supplements were provided most frequently. Dietary habits were poorer in schoolchildren who did use Supplements than in those who did not. Supplements were given ‘to ensure that they are healthy and strong’ and ‘to ensure their optimal nutrition’. Intakes of vitamin A, niacin, folic acid, vitamin C, Fe, and Zn from diet and Supplements often exceeded upper safe levels (ULs). Therefore, there may be a link between eating habits and vitamin/mineral supplement use among schoolchildren. Total intake of some nutrients was in excess of ULs. The health consequences of supplement use by this group merit additional study.
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Vitamin and mineral supplement use by healthy teenagers in Korea: motivating factors and dietary consequences.
Nutrition, 2001Co-Authors: Carl L. KeenAbstract:Abstract The use of vitamin and mineral Supplements is increasing among young individuals. We surveyed 972 Korean teenagers (age 13–18 y ) for their use of vitamin/mineral Supplements, their motivational factors, and the dietary consequences of supplement use. Prevalence of vitamin/mineral supplement use was 31%. Supplement use was highest in high-school students, females, individuals living in rural communities, and individuals from families in high socioeconomic strata. The Supplements used most frequently were vitamin C, multivitamins, and vitamin A. Supplement users had a more positive view of the potential health benefits of Supplements than did non-users. Most Supplements were taken daily. Vitamins B2, B6, and C were the most frequently ingested nutrients from vitamin/mineral Supplements. Vitamin/mineral intakes from Supplements had a wide range, with mean intakes typically exceeding Korean or the U.S./Canadian recommended dietary allowances. Vitamins B12, B1, and C and iron comprised 2770%, 1930%, 1120%, and 1026%, respectively, of the Korean recommended dietary allowances. When nutrient intakes from the diet and Supplements were combined, intakes of niacin, vitamin C, and iron exceeded the recommended upper-intake levels for these nutrients. The health benefits and risks of supplement use by teenagers merits further study.
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Patterns of vitamin/mineral supplement usage by adolescents attending athletic high schools in Korea.
International Journal of Sport Nutrition, 1999Co-Authors: Carl L. KeenAbstract:An excessive use of vitamin/mineral Supplements is considered by many to be a common health problem. We surveyed 1,355 adolescent boys and girls attending athletic high schools in Korea for their usage patterns of vitamin/mineral Supplements. The usage rate of the vitamin/mineral Supplements was 35.8%. The most favored Supplements were vitamin C, multivitamins, and calcium. The reasons most cited for taking Supplements were "to recover from fatigue," and "to maintain health." Vitamin and mineral intakes occurred over a wide range; mean intake values were typically higher than the Korean RDA. Vitamins B , B12 and C were consumed in very high amounts at 29.7,17.9 and 11.1 times the Korean RDA, respectively. When the intakes of nutrients from Supplements and diet were combined, it was observed that the intakes of niacin, folic acid, vitamin C, and iron exceeded levels that have been proposed as upper safe limits. The above data underscore the need to provide sound nutritional education to athletic adolescent...
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Should Vitamin-Mineral Supplements be recommended for all women with childbearing potential?
The American Journal of Clinical Nutrition, 1994Co-Authors: Carl L. Keen, S Zidenberg-cherrAbstract:Interest in maternal nutritional status as a critical factor for prenatal development has increased. When supplemented before conception, iodine prevents cretinism and folic acid reduces neural tube defect risks. Other nutrient Supplements may also reduce pregnancy complications. Thus, should Supplements be advocated for all women with childbearing potential? Potential supplementation benefits include 1) improved nutritional status, 2) reduced risk of some developmental defects, 3) improved antioxidant and immune defense systems, 3) lower incidence and/or slower progression of some diseases, and 5) harmonization of government and health care professionals' dietary recommendations for optimal health
Amanda M. Loya - One of the best experts on this subject based on the ideXlab platform.
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Prevalence of Polypharmacy, Polyherbacy, Nutritional Supplement Use and Potential Product Interactions among Older Adults Living on the United States-Mexico Border
Drugs & Aging, 2009Co-Authors: Amanda M. Loya, Armando González-stuart, José O. RiveraAbstract:Background and objective The use of multiple medications, herbs or nutritional Supplements can lead to adverse consequences, particularly in the elderly. A significant consequence resulting from polypharmacy, polyherbacy and nutritional supplement use is the potential for interactions to occur among the various products. The primary objective of this study was to estimate the prevalence of polypharmacy, polyherbacy, nutritional supplement use and potential product interactions among older adults living on the US-Mexico border. Methods This was a descriptive study that involved the administration of a bilingual (English/Spanish) questionnaire to a convenience sample of adults aged ≥60 years recruited from senior centres located within the most populated US-Mexico border region from June 2005 to March 2006. Participant demographics were collected in addition to information about current use of prescription medications, over-the-counter (OTC) medications, herbal products and nutritional Supplements (i.e. nutraceuticals and vitamins or minerals). The outcomes measured were the number of prescription medications, OTC medications, herbal products, vitamins/minerals and nutraceuticals per participant. Furthermore, the number of potential interactions and major interactions between drugs, herbal products and nutritional Supplements were identified for each participant. Additionally, product use patterns between men and women and among locations within the border region were compared. Results One-hundred-and-thirty participants (mean age 71.4 years) were recruited to complete the questionnaire. The prevalence of polypharmacy among all participants was 72.3% (n = 94), with 38.5% (n = 50) taking five or more concomitant medications (major polypharmacy). Twenty-one participants (16.2%) in the study sample reported taking two or more herbal products (polyherbacy). Thirty-four participants (26.2%) reported taking two or more vitamin/mineral Supplements and nine (6.9%) reported using two or more nutraceuticals. Participants living on the US side of the border had higher rates of major polypharmacy, polyherbacy and use of nutritional Supplements than those living on the Mexican side of the border. Overall, there were no significant differences in medication, herbal product and nutritional supplement use patterns between men and women. Evaluation of potential interactions revealed that 46.2% (n = 60) of participants were at risk of having at least one potential drug-drug interaction. Regarding drug and herbal product-supplement interactions, 31.5% (n = 41) of participants were at risk of having at least one possible interaction. Conclusions The prevalence of polypharmacy among older adults living on the US side of the border was similar to national trends (estimates suggest that one-quarter to one-half of US adults aged ≥65 years take five or more medications). However, polypharmacy was less common in older adults living on the Mexican side of the border. Additionally, herb use was higher in older adults living on the US-Mexico border than has been reported in national surveys of US adults, which indicate that less than one-quarter of adults have used a herbal product within the previous 12 months. Furthermore, this study demonstrated that older adults living on the US side of the border consumed more herbs and nutritional Supplements than their Mexican counterparts. In addition to describing product use patterns on the border, these findings suggest that almost half of the older adult participants were at risk for a potential drug-drug interaction, with approximately one-third having a potential interaction between their medications, herbs or nutritional Supplements.
Aminah Jatoi - One of the best experts on this subject based on the ideXlab platform.
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Is voluntary vitamin and mineral supplementation associated with better outcome in non-small cell lung cancer patients? Results from the Mayo Clinic lung cancer cohort.
Lung Cancer, 2005Co-Authors: Aminah Jatoi, Brent A. Williams, Randolph S. Marks, Marie-christine Aubry, Jason A. Wampfler, Erin E. Finke, Frank Nichols, Ping YangAbstract:BACKGROUND: Some previous studies report that 80% of cancer patients take multivitamin and/or mineral Supplements. To our knowledge, the consequences of such self-directed supplementation have not been examined previously in non-small cell lung cancer (NSCLC) patients. The goal of this study was to determine whether vitamin/mineral supplementation is associated with improved survival and quality of life in a cohort of NSCLC patients. METHODS: NSCLC patients or their proxies who responded to a questionnaire on vitamin/mineral use were assessed for survival and quality of life. RESULTS: A total of 1129 patients or their proxies responded to a vitamin/mineral questionnaire. Seven hundred and fourteen were vitamin/mineral users of either multivitamins or other specific vitamin/mineral Supplements, and the rest non-users. Median survival was 4.3 years versus 2.0 years for vitamin/mineral users and non-users, respectively. A Cox proportional hazards model showed a relative risk of death of 0.74 (95% confidence interval (CI): 0.44, 0.65) (p < 0.01) in favor of vitamin/mineral use after adjustment for multiple prognostic factors, including tumor stage. The Lung Cancer Symptom Scale (LCSS) showed better quality of life among vitamin/mineral users (mean difference in score of 3 (95% CI: 0.8, 5.1) (p < 0.01); and after adjusting for related variables, there remained a trend in favor of vitamin/mineral use mean difference 1.8 (95% CI: 0.2, 3.9) (p = 0.08). CONCLUSIONS: Vitamin/mineral supplementation is associated with better survival and quality of life in this cohort of NSCLC patients. Future prospective clinical trials should focus on the role of such Supplements in patients with NSCLC.
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Self-directed vitamin/mineral supplementation in non-small cell lung cancer (NSCLC) patients: Does it impact survival and quality of life?
Cancer Research, 2004Co-Authors: Aminah Jatoi, Brent A. Williams, Francis C. Nichols, Randolph S. Marks, Marie-christine Aubry, Jason A. Wampfler, Erin E. Finke, Ping YangAbstract:1403 Background: Previous studies report that 80% of cancer patients take multivitamin and/or mineral Supplements. To our knowledge, the consequences of such self-directed supplementation on survival and quality of life have not been examined previously in NSCL patients. Objective: To determine whether vitamin/mineral supplementation is associated with improved survival and quality of life in a cohort of NSCLC patients. Design: Retrospective analysis of prospectively gathered data. Patients: NSCLC patients or their proxies who responded to a questionnaire on vitamin/mineral use. Main Outcome Measures: Survival and quality of life. Results: A total of 1129 patients or their proxies responded to a vitamin/mineral questionnaire. 714 were vitamin/mineral users of either multivitamins or other specific vitamin/mineral Supplements, and the rest non-users. Median survival was 4.3 versus 2.0 years for vitamin/mineral users and non-users, respectively. A Cox proportional hazards model showed a relative risk of death of 0.54 (95% confidence interval (CI): 0.44, 0.65); p
