The Experts below are selected from a list of 75 Experts worldwide ranked by ideXlab platform
Peter L. Rady - One of the best experts on this subject based on the ideXlab platform.
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Disfiguring Generalized Verrucosis in an Indonesian Man With Idiopathic CD4 Lymphopenia
Archives of dermatology, 2010Co-Authors: Bachti Alisjahbana, Rachmat Dinata, Endang Sutedja, Irene Suryahudaya, Hardisiswo Soedjana, Nucki Nursjamsi Hidajat, Rista D. Soetikno, Ezra Oktaliansah, April Deng, Peter L. RadyAbstract:Background Human papillomaVirus (HPV) infections cause a spectrum of clinical disease states, depending on the causative HPV and the characteristics of the infected host, especially the status of cell-mediated immunity. Generalized verrucosis is an unusual clinical presentation of a disseminated HPV infection associated with severe immunodeficiency status. Observations We present a case of extreme disfigurement associated with an HPV-2 (common Wart Virus) infection. Virologic studies, immune status of the patient, and treatment(s) are summarized. Conclusions The severe disfigurement of this patient was a result of an underlying severe immunodeficiency, permissive for a disseminated HPV-2 infection that was allowed to progress for many years before the initiation of therapy. Such a rare case illustrates the natural history of generalized verrucosis in the setting of severe immunodeficiency in the absence of sustained medical interventions. Medical and surgical treatments resulted in marked improvement in the general health of this patient, as well as improvement of the disfigurement that resulted from the generalized verrucosis.
Terence J. Ryan - One of the best experts on this subject based on the ideXlab platform.
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human papillomaVirus type 6 induced condylomata an unusual complication of intertrigo
British Journal of Dermatology, 1993Co-Authors: J A Yell, S Mann, K Fleming, Rodney Sinclair, Terence J. RyanAbstract:Summary A 79-year-old virgo intacta presented with a 20-year-history of intertrigo. and a 3-month history of superimposed Warty masses beneath both breasts and in the groin and perianal areas. There was no evidence of immunosuppression. Histology of the Warty lesions showed squamous papillomata. with evidence of Wart Virus infection. Human papillomaVirus (HPV) type 6 was identified by in situ DNA hybridization, in the submammary lesions. This is an unusual manifestation of both intertrigo and Wart Virus infection. HPV-6 is classically found in anogenital Warts. We assume that these Warts were acquired by a non-venereal route and/or by congenital infection some 78 years ago. We suggest that it is the warm, moist environment, rather than the specific site, which encourages HPV-6 to flourish.
J Wardle - One of the best experts on this subject based on the ideXlab platform.
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Attitudes towards HPV testing: a qualitative study of beliefs among Indian, Pakistani, African-Caribbean and white British women in the UK
British Journal of Cancer, 2003Co-Authors: K Mccaffery, S Forrest, J Waller, M Desai, A Szarewski, J WardleAbstract:This study examined attitudes to human papillomaVirus (HPV) testing among a purposively selected sample of women from four ethnic groups: white British, African Caribbean, Pakistani and Indian. The design was qualitative, using focus group discussion to elicit women's attitudes towards HPV testing in the context of cervical cancer prevention. The findings indicate that although some women welcomed the possible introduction of HPV testing, they were not fully aware of the sexually transmitted nature of cervical cancer and expressed anxiety, confusion and stigma about HPV as a sexually transmitted infection. The term ‘Wart Virus’, often used by medical professionals to describe high-risk HPV to women, appeared to exacerbate stigma and confusion. Testing positive for HPV raised concerns about women's sexual relationships in terms of trust, fidelity, blame and protection, particularly for women in long-term monogamous relationships. Participation in HPV testing also had the potential to communicate messages of distrust, infidelity and promiscuity to women's partners, family and community. Concern about the current lack of available information about HPV was clearly expressed and public education about HPV was seen as necessary for the whole community, not only women. The management of HPV within cervical screening raises important questions about informed participation. Our findings suggest that HPV testing has the potential to cause psychosocial harm to women and their partners and families.
Timothy S. Baker - One of the best experts on this subject based on the ideXlab platform.
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Conserved Features in PapillomaVirus and
2014Co-Authors: Polyomavirus Capsids, Norman H Olson, David M. Belnap, John W. Kreider, Jay C. Brown, William W Newcomb, Nancy M. Cladel, Neil D. Christensen, Timothy S. BakerAbstract:1Department of Biological Capsids of papilloma and polyoma Viruses (papovaVirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedralSciences, Purdue University West Lafayette, IN 47907 lattice (triangulation number of seven, T = 7). Cottontail rabbit papillo-USA maVirus (CRPV) was reported previously to be a T = 7laevo (left-handed) structure, whereas human Wart Virus, simian Virus 40, and murine2Departments of Pathology polyomaVirus were shown to be T = 7dextro (right-handed). The CRPV and Microbiology and structure determined by cryoelectron microscopy and image reconstruction Immunology, Hershey Medical was similar to previously determined structures of bovine papillomaVirus Center, Hershey, PA 17033 type 1 (BPV-1) and human papillomaVirus type 1 (HPV-1). CRPV capsids USA were observed in closed (compact) and open (swollen) forms. Both form
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Conserved Features in PapillomaVirus and PolyomaVirus Capsids
Journal of Molecular Biology, 1996Co-Authors: David M. Belnap, Norman H Olson, John W. Kreider, Jay C. Brown, William W Newcomb, Timothy S. BakerAbstract:Abstract Capsids of papilloma and polyoma Viruses (papovaVirus family) are composed of 72 pentameric capsomeres arranged on a skewed icosahedral lattice (triangulation number of seven, T=7). Cottontail rabbit papillo maVirus (CRPV) was reported previously to be a T=7 laevo (left-handed) structure, whereas human Wart Virus, simian Virus 40, and murine polyomaVirus were shown to be T=7 dextro (right-handed). The CRPV structure determined by cryoelectron microscopy and image reconstruction was similar to previously determined structures of bovine papillomaVirus type 1 (BPV-1) and human papillomaVirus type 1 (HPV-1). CRPV capsids were observed in closed (compact) and open (swollen) forms. Both forms have star-shaped capsomeres, as do BPV-1 and HPV-1, but the open CRPV capsids are ≈2 nm larger in radius. The lattice hands of all papillomaViruses examined in this study were found to be T=7 dextro . In the region of maximum contact, papillomaVirus capsomeres interact in a manner similar to that found in polyomaViruses. Although papilloma and polyoma Viruses have differences in capsid size (≈60 versus ≈50 nm), capsomere morphology (11 to 12 nm star-shaped versus 8 nm barrel-shaped), and intercapsomere interactions (slightly different contacts between capsomeres), papovaVirus capsids have a conserved, 72-pentamer, T=7 dextro structure. These features are conserved despite significant differences in amino acid sequences of the major capsid proteins. The conserved features may be a consequence of stable contacts that occur within capsomeres and flexible links that form among capsomeres.
Bachti Alisjahbana - One of the best experts on this subject based on the ideXlab platform.
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Disfiguring Generalized Verrucosis in an Indonesian Man With Idiopathic CD4 Lymphopenia
Archives of dermatology, 2010Co-Authors: Bachti Alisjahbana, Rachmat Dinata, Endang Sutedja, Irene Suryahudaya, Hardisiswo Soedjana, Nucki Nursjamsi Hidajat, Rista D. Soetikno, Ezra Oktaliansah, April Deng, Peter L. RadyAbstract:Background Human papillomaVirus (HPV) infections cause a spectrum of clinical disease states, depending on the causative HPV and the characteristics of the infected host, especially the status of cell-mediated immunity. Generalized verrucosis is an unusual clinical presentation of a disseminated HPV infection associated with severe immunodeficiency status. Observations We present a case of extreme disfigurement associated with an HPV-2 (common Wart Virus) infection. Virologic studies, immune status of the patient, and treatment(s) are summarized. Conclusions The severe disfigurement of this patient was a result of an underlying severe immunodeficiency, permissive for a disseminated HPV-2 infection that was allowed to progress for many years before the initiation of therapy. Such a rare case illustrates the natural history of generalized verrucosis in the setting of severe immunodeficiency in the absence of sustained medical interventions. Medical and surgical treatments resulted in marked improvement in the general health of this patient, as well as improvement of the disfigurement that resulted from the generalized verrucosis.
