The Experts below are selected from a list of 1065 Experts worldwide ranked by ideXlab platform
John B. Miller - One of the best experts on this subject based on the ideXlab platform.
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comparison of choroidal neovascularization secondary to White Dot Syndromes and age related macular degeneration by using optical coherence tomography angiography
Clinical Ophthalmology, 2018Co-Authors: Jay C. Wang, Inês Laíns, Lucia Sobrin, Kenneth Matthew Mckay, Arjun B Sood, John B. MillerAbstract:Purpose To characterize and compare choroidal neovascularization (CNV) secondary to White Dot Syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A). Methods This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed. Results Three patients with multifocal choroiditis and panuveitis, one patient each with birdshot chorioretinopathy, presumed ocular histoplasmosis syndrome, and persistent placoid maculopathy, and eleven patients with AMD with sufficient image quality were included. CNV associated with WDS was significantly smaller than that secondary to AMD (0.56±0.32 vs 2.79±1.80 mm2, β=-2.22, P=0.01), while no difference in VD was detected (0.46±0.09 vs 0.44±0.09, β=0.02, P=0.71). Conclusion CNV networks secondary to WDS appear to be smaller than those secondary to AMD but have similar VD. OCT-A is a powerful tool to investigate properties of CNV from various etiologies. Larger studies are needed for further characterization and understanding of CNV pathogenesis in inflammatory conditions.
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Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography.
Ophthalmic surgery lasers & imaging retina, 2017Co-Authors: Jay C. Wang, Inês Laíns, Lucia Sobrin, John B. MillerAbstract:Background and objective To compare patterns of choroidal hypoperfusion in White Dot Syndromes (WDS) using optical coherence tomography angiography (OCTA). Patients and methods Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent White Dot syndrome (MEWDS) were selected. This study was approved by the institutional review board at Massachusetts Eye and Ear. Results Unique patterns of choroidal hypoperfusion were observed. In POHS and MEWDS, areas of choroidal hypoperfusion correlated well with clinically observed pathology, but in APMPPE and BCR, they were more widespread. Conclusion OCTA can identify different patterns of choroidal hypoperfusion in APMPPE, BCR, POHS, and MEWDS, which appears to be a shared feature of WDS. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:638-646.].
H Nida Sen - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Patients with a White Dot Syndrome
Manual of Retinal Diseases, 2016Co-Authors: Jared E Knickelbein, Robert B. Nussenblatt, H Nida SenAbstract:The term White Dot Syndromes (WDS) refers to a group of inflammatory eye diseases that predominantly affect the outer retina, retinal pigment epithelium (RPE), choriocapillaris, choroid, or a combination of these sites. The WDS covered in this section are limited to those that are more commonly seen and include:
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Multimodal Imaging of the White Dot Syndromes and Related Diseases.
Journal of clinical & experimental ophthalmology, 2016Co-Authors: Jared E Knickelbein, H Nida SenAbstract:The White Dot Syndromes encompass a group of rare posterior uveitis conditions that are characterized by outer retinal and/or choroidal hypopigmented lesions that are thought to be inflammatory in nature. The size, shape, and location of lesions in the fundus aid in differentiating these conditions. Multimodal imaging, including modalities such as fundus autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, among others, has become integral in diagnosing and monitoring many of the White Dot Syndromes. Furthermore, multimodal imaging modalities have provided insights into the pathogenesis and exact sites within the retina and choroid affected by White Dot Syndromes.
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Fundus autofluorescence imaging of the White Dot Syndromes.
Archives of ophthalmology (Chicago Ill. : 1960), 2010Co-Authors: Steven Yeh, Lisa J Faia, Farzin Forooghian, Wai T. Wong, Catherine A Cukras, Julie C. Lew, Keith Wroblewski, Eric D. Weichel, Catherine B. Meyerle, H Nida SenAbstract:The White Dot Syndromes (WDSs) comprise a heterogeneous group of posterior uveitic Syndromes characterized by multiple lesions of the posterior pole due to inflammation of the choroid, retinal pigment epithelium (RPE), and retina.1,2 The WDSs classically include acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroidopathy (SPC), birdshot retinochoroidopathy (BRC), multiple evanescent White Dot syndrome (MEWDS), and multifocal choroiditis (MFC). Other conditions sometimes included in this category of diseases include relentless placoid chorioretinitis (RPC),3 presumed tuberculosis-associated serpiginouslike choroidopathy (TB-SPLC),4 acute zonal occult outer retinopathy (AZOOR),5 persistent placoid maculopathy,6 and ampiginous choroiditis.7 Classification of a WDS typically requires an assessment of the patient age, history of a viral prodrome, laterality of the disease process, lesion size, fluorescein angiographic characteristics, and the clinical course.1 For instance, APMPPE and SPC are associated with early blockage and late hyperfluorescence on fluorescein angiography; SPC, however, is associated with a relapsing disease course requiring immunosuppressive medications. Although these disease features have helped us to classify the various disease entities, our understanding of the pathogenic mechanisms of inflammation that underlie these disease processes is limited. Fundus autofluorescence (FAF) has been used for the evaluation of the RPE in degenerative, inflammatory, and neoplastic disease conditions.8-10 The FAF signal is derived primarily from lipofuscin accumulation within the RPE and may be indicative of altered structure and function.11,12 The ocular tissues involved in the WDSs include the RPE, choroid, and outer retinal layers. However, whether the RPE is primarily involved in disease pathogenesis or secondarily affected by adjacent chorioretinal inflammation (eg, choroidal vasculitis with secondary RPE perturbation in APMPPE) remains unclear. Alterations in the FAF signal have been observed in case series and several case reports of patients with BRC,13 MFC,14 APMPPE,15,16 MEWDS,17,18 and SPC.19 One important question that remains is whether FAF patterns may be used to distinguish these disease entities. Another question is whether FAF changes may help in the detection and localization of ongoing inflammatory disease activity. We reviewed our experience with FAF imaging in a large series of patients with WDSs during periods of disease activity and quiescence. We describe herein the FAF characteristics from a spectrum of patients with various WDSs and correlate visual impairment with pathologic foveal hypoautofluorescence.
Harry W. Flynn - One of the best experts on this subject based on the ideXlab platform.
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Multiple evanescent White Dot Syndromes
Journal of Ophthalmic Inflammation and Infection, 2012Co-Authors: Ruwan A. Silva, Thomas A. Albini, Harry W. FlynnAbstract:Purpose The aim of this study is to report a patient with multipe evanescent White Dot syndrome (MEWDS) presenting with classic foveal granularity and pathology localized to the outer retina. Methods Case study methodology was used in the current study. Results A 34-year-old Caucasian female presented with photopsias and blurry vision in her left eye. Examination, particularly the foveal granularity noted in her affected eye, was archetypal for the diagnosis of MEWDS. Fundus autofluorescence, fluorescein and indocyanine green angiography were also consistent with this diagnosis. Spectral-domain optical coherence tomography (SD-OCT) demonstrated increased retinal pigment epithelium granularity and disruption of the photoreceptor inner segment–outer segment junction subfoveally. Conclusions Foveal granularity may be the most specific feature of MEWDS with SD-OCT capable of localizing pathology to the outer retina—a historically controversial finding.
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Multiple evanescent White Dot Syndromes
Journal of ophthalmic inflammation and infection, 2011Co-Authors: Ruwan A. Silva, Thomas A. Albini, Harry W. FlynnAbstract:Purpose The aim of this study is to report a patient with multipe evanescent White Dot syndrome (MEWDS) presenting with classic foveal granularity and pathology localized to the outer retina.
Jay C. Wang - One of the best experts on this subject based on the ideXlab platform.
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comparison of choroidal neovascularization secondary to White Dot Syndromes and age related macular degeneration by using optical coherence tomography angiography
Clinical Ophthalmology, 2018Co-Authors: Jay C. Wang, Inês Laíns, Lucia Sobrin, Kenneth Matthew Mckay, Arjun B Sood, John B. MillerAbstract:Purpose To characterize and compare choroidal neovascularization (CNV) secondary to White Dot Syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A). Methods This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed. Results Three patients with multifocal choroiditis and panuveitis, one patient each with birdshot chorioretinopathy, presumed ocular histoplasmosis syndrome, and persistent placoid maculopathy, and eleven patients with AMD with sufficient image quality were included. CNV associated with WDS was significantly smaller than that secondary to AMD (0.56±0.32 vs 2.79±1.80 mm2, β=-2.22, P=0.01), while no difference in VD was detected (0.46±0.09 vs 0.44±0.09, β=0.02, P=0.71). Conclusion CNV networks secondary to WDS appear to be smaller than those secondary to AMD but have similar VD. OCT-A is a powerful tool to investigate properties of CNV from various etiologies. Larger studies are needed for further characterization and understanding of CNV pathogenesis in inflammatory conditions.
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Distinguishing White Dot Syndromes With Patterns of Choroidal Hypoperfusion on Optical Coherence Tomography Angiography.
Ophthalmic surgery lasers & imaging retina, 2017Co-Authors: Jay C. Wang, Inês Laíns, Lucia Sobrin, John B. MillerAbstract:Background and objective To compare patterns of choroidal hypoperfusion in White Dot Syndromes (WDS) using optical coherence tomography angiography (OCTA). Patients and methods Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent White Dot syndrome (MEWDS) were selected. This study was approved by the institutional review board at Massachusetts Eye and Ear. Results Unique patterns of choroidal hypoperfusion were observed. In POHS and MEWDS, areas of choroidal hypoperfusion correlated well with clinically observed pathology, but in APMPPE and BCR, they were more widespread. Conclusion OCTA can identify different patterns of choroidal hypoperfusion in APMPPE, BCR, POHS, and MEWDS, which appears to be a shared feature of WDS. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:638-646.].
Jared E Knickelbein - One of the best experts on this subject based on the ideXlab platform.
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Evaluation of Patients with a White Dot Syndrome
Manual of Retinal Diseases, 2016Co-Authors: Jared E Knickelbein, Robert B. Nussenblatt, H Nida SenAbstract:The term White Dot Syndromes (WDS) refers to a group of inflammatory eye diseases that predominantly affect the outer retina, retinal pigment epithelium (RPE), choriocapillaris, choroid, or a combination of these sites. The WDS covered in this section are limited to those that are more commonly seen and include:
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Multimodal Imaging of the White Dot Syndromes and Related Diseases.
Journal of clinical & experimental ophthalmology, 2016Co-Authors: Jared E Knickelbein, H Nida SenAbstract:The White Dot Syndromes encompass a group of rare posterior uveitis conditions that are characterized by outer retinal and/or choroidal hypopigmented lesions that are thought to be inflammatory in nature. The size, shape, and location of lesions in the fundus aid in differentiating these conditions. Multimodal imaging, including modalities such as fundus autofluorescence, optical coherence tomography, fluorescein angiography, and indocyanine green angiography, among others, has become integral in diagnosing and monitoring many of the White Dot Syndromes. Furthermore, multimodal imaging modalities have provided insights into the pathogenesis and exact sites within the retina and choroid affected by White Dot Syndromes.
