The Experts below are selected from a list of 48507 Experts worldwide ranked by ideXlab platform
Jerzy Kanicki - One of the best experts on this subject based on the ideXlab platform.
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three dimensional cascaded system analysis of a 50 µm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2017Co-Authors: Chumi Zhao, Anastasios Konstantinidis, R D Spelle, Nikita Vassiljev, Jerzy KanickiAbstract:High-resolution, low-noise X-Ray Detectors based on the complementary metal-oXide-semiconductor (CMOS) active piXel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were eXperimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��. The cascaded system model was eXtended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and Detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g. ��30��) improves the low spatial frequency (below 5 mm-1) performance of the CMOS APS Detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a piXelated scintillator in combination with the 50 ��m piXel pitch CMOS APS Detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive piXel sensor (PPS) Detector was simulated and compared.
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50 μm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2015Co-Authors: Chumi Zhao, Anastasios Konstantinidis, Thalis Anaxagoras, R D Spelle, Yi Zheng, Jerzy KanickiAbstract:Wafer-scale CMOS active piXel sensors (APSs) have been developed recently for X-Ray imaging applications. The small piXel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated eXperimentally and through modeling the imaging properties of a 50 μm piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS X-Ray Detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were eXtracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe X-Ray Detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies <1 mm(-1). In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS X-Ray Detector, image aquisition geometry and image reconstruction techniques should be considered.
Chumi Zhao - One of the best experts on this subject based on the ideXlab platform.
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three dimensional cascaded system analysis of a 50 µm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2017Co-Authors: Chumi Zhao, Anastasios Konstantinidis, R D Spelle, Nikita Vassiljev, Jerzy KanickiAbstract:High-resolution, low-noise X-Ray Detectors based on the complementary metal-oXide-semiconductor (CMOS) active piXel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were eXperimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��. The cascaded system model was eXtended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and Detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g. ��30��) improves the low spatial frequency (below 5 mm-1) performance of the CMOS APS Detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a piXelated scintillator in combination with the 50 ��m piXel pitch CMOS APS Detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive piXel sensor (PPS) Detector was simulated and compared.
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50 μm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2015Co-Authors: Chumi Zhao, Anastasios Konstantinidis, Thalis Anaxagoras, R D Spelle, Yi Zheng, Jerzy KanickiAbstract:Wafer-scale CMOS active piXel sensors (APSs) have been developed recently for X-Ray imaging applications. The small piXel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated eXperimentally and through modeling the imaging properties of a 50 μm piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS X-Ray Detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were eXtracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe X-Ray Detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies <1 mm(-1). In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS X-Ray Detector, image aquisition geometry and image reconstruction techniques should be considered.
Stefa Feuerbach - One of the best experts on this subject based on the ideXlab platform.
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amorphous silicon flat panel X Ray Detector versus storage phosphor based computed radiography contrast detail phantom study at different tube voltages and Detector entrance doses
2003Co-Authors: Okka W Hamer, Markus Volk, Stefa Feuerbach, Niels Zorger, M StrotzerAbstract:Hamer OW, Volk M, Zorger N, et al. Amorphous silicon, flat-panel, X-Ray Detector versus storage phosphor-based computed radiography: contrast-detail phantom study at different tube voltages and Detector entrance doses. Invest Radiol 2003;38:212–220.Rationale and Objectives.Evaluation of the contrast
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simulated bone erosions in a hand phantom detection with conventional screen film technology versus cesium iodide amorphous silicon flat panel Detector
2000Co-Authors: M Strotzer, Markus Volk, Thomas Wild, P Von Landenberg, Stefa FeuerbachAbstract:PURPOSE: To assess the diagnostic performance of an active-matriX flat-panel X-Ray Detector for reduced-dose imaging of simulated arthritic lesions. MATERIALS AND METHODS: A digital X-Ray Detector based on cesium iodide and amorphous silicon technology with a panel size of 43 × 43 cm, matriX of 3,000 × 3,000 piXels, piXel size of 143 μm, and digital output of 14 bits was used. State-of-the-art screen-film radiographs were compared with digital images obtained at doses equivalent to those obtained with system speeds of 400, 560, and 800. The phantom was composed of a human hand skeleton on an acrylic plate with drilled holes simulating bone erosions of different diameters and depths. Results of four independent observers were evaluated with receiver operating characteristic curve analysis. RESULTS: The cesium iodide and amorphous silicon Detector resulted in better diagnostic performance than did the screen-film combination, with the dose being the same for both modalities (P < .05). For digital images obt...
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digital radiography with a large area amorphous silicon flat panel X Ray Detector system
2000Co-Authors: Marti Spah, M Strotze, Markus Volk, Stefa Ohm, Ernhard Geige, Gerhard Hahm, Stefa FeuerbachAbstract:Spahn M, Strotzer M, Volk M, et al. Digital radiography with a large-area, amorphous-silicon, flat-panel X-Ray Detector system. Invest Radiol 2000;35:260–266.RATIONALE AND OBJECTIVES.To investigate the image quality of a digital radiography system with an amorphous-silicon, large-area, digital flat-
Anastasios Konstantinidis - One of the best experts on this subject based on the ideXlab platform.
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three dimensional cascaded system analysis of a 50 µm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2017Co-Authors: Chumi Zhao, Anastasios Konstantinidis, R D Spelle, Nikita Vassiljev, Jerzy KanickiAbstract:High-resolution, low-noise X-Ray Detectors based on the complementary metal-oXide-semiconductor (CMOS) active piXel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were eXperimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��. The cascaded system model was eXtended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and Detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g. ��30��) improves the low spatial frequency (below 5 mm-1) performance of the CMOS APS Detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a piXelated scintillator in combination with the 50 ��m piXel pitch CMOS APS Detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive piXel sensor (PPS) Detector was simulated and compared.
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50 μm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2015Co-Authors: Chumi Zhao, Anastasios Konstantinidis, Thalis Anaxagoras, R D Spelle, Yi Zheng, Jerzy KanickiAbstract:Wafer-scale CMOS active piXel sensors (APSs) have been developed recently for X-Ray imaging applications. The small piXel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated eXperimentally and through modeling the imaging properties of a 50 μm piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS X-Ray Detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were eXtracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe X-Ray Detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies <1 mm(-1). In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS X-Ray Detector, image aquisition geometry and image reconstruction techniques should be considered.
R D Spelle - One of the best experts on this subject based on the ideXlab platform.
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three dimensional cascaded system analysis of a 50 µm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2017Co-Authors: Chumi Zhao, Anastasios Konstantinidis, R D Spelle, Nikita Vassiljev, Jerzy KanickiAbstract:High-resolution, low-noise X-Ray Detectors based on the complementary metal-oXide-semiconductor (CMOS) active piXel sensor (APS) technology have been developed and proposed for digital breast tomosynthesis (DBT). In this study, we evaluated the three-dimensional (3D) imaging performance of a 50 ��m piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). The two-dimensional (2D) angle-dependent modulation transfer function (MTF), normalized noise power spectrum (NNPS), and detective quantum efficiency (DQE) were eXperimentally characterized and modeled using the cascaded system analysis at oblique incident angles up to 30��. The cascaded system model was eXtended to the 3D spatial frequency space in combination with the filtered back-projection (FBP) reconstruction method to calculate the 3D and in-plane MTF, NNPS and DQE parameters. The results demonstrate that the beam obliquity blurs the 2D MTF and DQE in the high spatial frequency range. However, this effect can be eliminated after FBP image reconstruction. In addition, impacts of the image acquisition geometry and Detector parameters were evaluated using the 3D cascaded system analysis for DBT. The result shows that a wider projection angle range (e.g. ��30��) improves the low spatial frequency (below 5 mm-1) performance of the CMOS APS Detector. In addition, to maintain a high spatial resolution for DBT, a focal spot size of smaller than 0.3 mm should be used. Theoretical analysis suggests that a piXelated scintillator in combination with the 50 ��m piXel pitch CMOS APS Detector could further improve the 3D image resolution. Finally, the 3D imaging performance of the CMOS APS and an indirect amorphous silicon (a-Si:H) thin-film transistor (TFT) passive piXel sensor (PPS) Detector was simulated and compared.
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50 μm piXel pitch wafer scale cmos active piXel sensor X Ray Detector for digital breast tomosynthesis
2015Co-Authors: Chumi Zhao, Anastasios Konstantinidis, Thalis Anaxagoras, R D Spelle, Yi Zheng, Jerzy KanickiAbstract:Wafer-scale CMOS active piXel sensors (APSs) have been developed recently for X-Ray imaging applications. The small piXel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated eXperimentally and through modeling the imaging properties of a 50 μm piXel pitch CMOS APS X-Ray Detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS X-Ray Detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were eXtracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe X-Ray Detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies <1 mm(-1). In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS X-Ray Detector, image aquisition geometry and image reconstruction techniques should be considered.
