The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Gerhard Buchbauer - One of the best experts on this subject based on the ideXlab platform.
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relaxing effect of Ylang Ylang Oil on humans after transdermal absorption
Phytotherapy Research, 2006Co-Authors: Tapanee Hongratanaworakit, Gerhard BuchbauerAbstract:The aim of this study was to investigate the effects of Ylang Ylang Oil (Cananga odorata, Annonaceae) on human physiological parameters and self-evaluation after transdermal absorption. Forty healthy volunteers participated in the experiments. Physiological parameters recorded were skin temperature, pulse rate, breathing rate and blood pressure. Self-evaluation was assessed by means of visual analog scales (VAS). The Ylang Ylang Oil caused a significant decrease of blood pressure and a significant increase of skin temperature. At the behavioral level, subjects in the Ylang Ylang Oil group rated themselves more calm and more relaxed than subjects in the control group. These findings are likely to represent a relaxing effect of the Ylang Ylang Oil and provide some evidence for the usage of the Ylang Ylang Oil in aromatherapy such as causing a relief of depression and stress in humans.
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evaluation of the harmonizing effect of Ylang Ylang Oil on humans after inhalation
Planta Medica, 2004Co-Authors: Tapanee Hongratanaworakit, Gerhard BuchbauerAbstract:Scientific evaluations of the effects of fragrances on humans are rather scarce. The aim of this investigation was to study the effects of Ylang-Ylang Oil (Cananga odorata, Annonaceae) on hu-man physiological parameters and self-evaluation. Twenty-four healthy volunteers participated in the experiments. Fragrances were administered by inhalation. Physiological parameters recorded were skin temperature, pulse rate, breathing rate and blood pressure. Self-evaluation was assessed in terms of alertness, attentiveness, calmness, mood, relaxation and vigor. Additionally, fragrances were rated in terms of pleasantness, intensity and effect. The present investigation showed that Ylang-Ylang Oil may be characterized by the concept of "harmonization" rather than relaxation/sedation. Compared to an odorless placebo, Ylang-Ylang Oil caused significant decreases in blood pressure and pulse rate as well as significant increases of subjective attentiveness and alertness. Correlational analyses revealed that the observed effects are mainly due to a subjective odor experience.
James S. Mccarthy - One of the best experts on this subject based on the ideXlab platform.
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acaricidal activity of eugenol based compounds against scabies mites
PLOS ONE, 2010Co-Authors: Cielo Pasay, Kate E. Mounsey, D Vyszenskimoher, Graeme Irvine Stevenson, Rohan A Davis, Katherine Thea Andrews, James S. MccarthyAbstract:Backgound Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.
Cielo Pasay - One of the best experts on this subject based on the ideXlab platform.
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acaricidal activity of eugenol based compounds against scabies mites
PLOS ONE, 2010Co-Authors: Cielo Pasay, Kate E. Mounsey, D Vyszenskimoher, Graeme Irvine Stevenson, Rohan A Davis, Katherine Thea Andrews, James S. MccarthyAbstract:Backgound Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.
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Acaricidal Activity of Eugenol Based Compounds against
2010Co-Authors: Scabies Mites, Kate E. Mounsey, Cielo Pasay, Graeme Stevenson, Rohan Davis, Larry Arlian, Marjorie Morgan, Diann Vyszenski-moher, Kathy Andrews, James MccarthyAbstract:Backgound: Human scabies is a debilitating skin disease caused by the ‘‘itch mite’ ’ Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings: Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions: The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for futur
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Acaricidal activity of eugenol based compounds against scabies mites. PLoS One 5: e12079
2010Co-Authors: Scabies Mites, Kate E. Mounsey, Cielo Pasay, Graeme Stevenson, Rohan Davis, Larry Arlian, Marjorie Morgan, Diann Vyszenski-moher, Kathy Andrews, James MccarthyAbstract:Backgound: Human scabies is a debilitating skin disease caused by the ‘‘itch mite’ ’ Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings: Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions: The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies
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Acaricidal activity of eugenol based compounds against scabies mites.
Public Library of Science (PLoS), 2010Co-Authors: Cielo Pasay, Kate E. Mounsey, Graeme Stevenson, Rohan Davis, Larry Arlian, Marjorie Morgan, Diann Vyszenski-moher, Kathy Andrews, James MccarthyAbstract:Human scabies is a debilitating skin disease caused by the "itch mite" Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties.Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues--acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact.The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies
Katherine Thea Andrews - One of the best experts on this subject based on the ideXlab platform.
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acaricidal activity of eugenol based compounds against scabies mites
PLOS ONE, 2010Co-Authors: Cielo Pasay, Kate E. Mounsey, D Vyszenskimoher, Graeme Irvine Stevenson, Rohan A Davis, Katherine Thea Andrews, James S. MccarthyAbstract:Backgound Human scabies is a debilitating skin disease caused by the “itch mite” Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in combination with oral ivermectin. Recent reports of acaricide tolerance in scabies endemic communities in Northern Australia have prompted efforts to better understand resistance mechanisms and to identify potential new acaricides. In this study, we screened three essential Oils and four pure compounds based on eugenol for acaricidal properties. Methodology/Principal Findings Contact bioassays were performed using live permethrin-sensitive S. scabiei var suis mites harvested from pigs and permethrin-resistant S. scabiei var canis mites harvested from rabbits. Results of bioassays showed that clove Oil was highly toxic against scabies mites. Nutmeg Oil had moderate toxicity and Ylang Ylang Oil was the least toxic. Eugenol, a major component of clove Oil and its analogues –acetyleugenol and isoeugenol, demonstrated levels of toxicity comparable to benzyl benzoate, the positive control acaricide, killing mites within an hour of contact. Conclusions The acaricidal properties demonstrated by eugenol and its analogues show promise as leads for future development of alternative topical acaricides to treat scabies.
Ioana G. Carabin - One of the best experts on this subject based on the ideXlab platform.
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Safety assessment of Ylang-Ylang (Cananga spp.) as a food ingredient
Food and Chemical Toxicology, 2008Co-Authors: George A. Burdock, Ioana G. CarabinAbstract:Ylang-Ylang Oil is used in the food industry as a flavor ingredient. It is a complex chemical mixture in the form of an essential Oil extracted by water or water-and-steam distillation from the fresh flowers of Cananga odorata Hook. f. & Thomson. Ylang-Ylang Oil has been reported to cause dermal sensitization reactions in animals and humans, but it is unclear what constituent(s) within the essential Oil comprise the offending agent(s) and whether some Ylang-Ylang Oils that have had certain constituent(s) removed are any less prone to cause such allergic reactions. There is no indication in the literature that food exposure to Ylang-Ylang Oil has caused allergic reactions. One subchronic inhalation toxicity study, involving Ylang-Ylang Oil as part of a larger fragrance raw materials mixture, gave no indication of causing adverse effects, but the relevance to risk assessment of oral food flavoring use exposures is likely minimal. No further toxicity data for Ylang-Ylang Oil have been reported. Notwithstanding the foregoing, Ylang-Ylang Oil has a long history of fragrance and food flavoring use, with no indication that its estimated consumption from food flavoring use (0.0001 mg/kg/day) has led to any adverse human health effects. These data indicate that at the current level of intake as a food ingredient, Ylang-Ylang Oil does not pose a health risk to humans. ?? 2007.
