The Experts below are selected from a list of 5166 Experts worldwide ranked by ideXlab platform
Kwok-yung Yuen - One of the best experts on this subject based on the ideXlab platform.
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Zika Fever and congenital Zika syndrome an unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years, <20 human cases were reported before 2007. The massive epidemics in the Pacific islands associated with the ZIKV Asian lineage in 2007 and 2013 were followed by explosive outbreaks in Latin America in 2015. Although increased mosquito breeding associated with the El Nino effect superimposed on global warming is suspected, genetic changes in its RNA virus genome may have led to better adaptation to mosquitoes, other animal reservoirs, and human. We reviewed the epidemiology, clinical manifestation, virology, pathogenesis, laboratory diagnosis, management, and prevention of this emerging infection. Laboratory diagnosis can be confounded by cross-reactivity with other circulating flaviviruses. Besides mosquito bite and transplacental transmission, the risk of other potential routes of transmission by transfusion, transplantation, sexual activity, breastfeeding, respiratory droplet, and animal bite is discussed. Epidemic control requires adequate clearance of mosquito breeding grounds, personal protection against mosquito bite, and hopefully a safe and effective vaccine.
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Zika Fever and congenital Zika syndrome: An unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years,
Jasper F W Chan - One of the best experts on this subject based on the ideXlab platform.
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Zika Fever and congenital Zika syndrome an unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years, <20 human cases were reported before 2007. The massive epidemics in the Pacific islands associated with the ZIKV Asian lineage in 2007 and 2013 were followed by explosive outbreaks in Latin America in 2015. Although increased mosquito breeding associated with the El Nino effect superimposed on global warming is suspected, genetic changes in its RNA virus genome may have led to better adaptation to mosquitoes, other animal reservoirs, and human. We reviewed the epidemiology, clinical manifestation, virology, pathogenesis, laboratory diagnosis, management, and prevention of this emerging infection. Laboratory diagnosis can be confounded by cross-reactivity with other circulating flaviviruses. Besides mosquito bite and transplacental transmission, the risk of other potential routes of transmission by transfusion, transplantation, sexual activity, breastfeeding, respiratory droplet, and animal bite is discussed. Epidemic control requires adequate clearance of mosquito breeding grounds, personal protection against mosquito bite, and hopefully a safe and effective vaccine.
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Zika Fever and congenital Zika syndrome: An unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years,
Didier Musso - One of the best experts on this subject based on the ideXlab platform.
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Emergence of Zika virus.
Virologie (Montrouge France), 2015Co-Authors: Tu-xuan Nhan, Didier MussoAbstract:Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) of the family Flaviviridae, genus Flavivirus, transmitted by the bite of infected mosquitoes. ZIKV was first isolated from a non-human primate in 1947, ZIKV infections in humans were sporadic during 60 years before emerging in the Pacific in 2007 and 2013 and in Brazil in 2015. Due to a non-specific clinical presentation, Zika Fever can be misdiagnosed with other arboviruses such as dengue and chikungunya. ZIKV infections were associated with mild illness before the large French Polynesia outbreak in 2013-2014 in which severe neurological complications were reported. Routine laboratory diagnosis of Zika Fever relies on the detection of specific ZIKV RNA by PCR. Serological diagnosis is complicated due to cross reactivity with other flaviviruses. ZIKV adapted to an urban cycle involving humans and domestic mosquito vectors that are widely distributed, such as Aedes aegypti and Ae. albopictus. This adaptation highlights the potential for ZIKV to emerge in tropical, intertropical and also temperate areas.
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Detection of Zika virus in saliva
Journal of Clinical Virology, 2015Co-Authors: Didier Musso, Emilie Robin, Anita Teissier, Claudine Roche, Tu-xuan Nhan, Van-mai Cao-lormeauAbstract:Background: During the largest Zika virus (ZIKV) outbreak ever reported that occurred from October 2013 to March 2014 in French Polynesia, we observed that several patients presenting the symptoms of acute phase Zika Fever were tested negative in blood by ZIKV real-time PCR (RT-PCR). Objectives: As we have previously detected ZIKV RNA in the saliva of a young child, we investigated the use of saliva as an alternative sample for routine ZIKV RNA detection. Study design: Over a 6 month period, 1,067 samples collected from 855 patients presenting symptoms of Zika Fever (saliva only, blood only or both samples) were tested using a specific ZIKV RT-PCR. A medical questionnaire was available for most of the patients. Results: ZIKV was more frequently detected in saliva compared to blood. For the 182 patients with both samples collected, tests were positive for 35 (19.2%) in saliva while negative in blood and tests were positive for 16 (8.8%) in blood while negative in saliva; the difference in mean days after symptoms onset and the percentage of the main symptoms of Zika Fever for patients only positive in saliva or in blood was not significant. Conclusion: The use of saliva sample increased the rate of molecular detection of ZIKV at the acute phase of the disease but did not enlarge the window of detection of ZIKV RNA. Saliva was of particular interest when blood was difficult to collect (children and neonates especially).
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potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in french polynesia november 2013 to february 2014
Eurosurveillance, 2014Co-Authors: Didier Musso, Emilie Robin, Claudine Roche, Tu-xuan Nhan, Vanmai Caolormeau, D Bierlaire, Karen Zisou, Shan A Yan, Julien BroultAbstract:Since October 2013, French Polynesia has experienced the largest documented outbreak of Zika virus (ZikaV) infection. To prevent transmission of ZikaV by blood transfusion, specific nucleic acid testing of blood donors was implemented. From November 2013 to February 2014: 42 (3%) of 1,505 blood donors, although asymptomatic at the time of blood donation, were found positive for ZikaV by PCR. Our results serve to alert blood safety authorities about the risk of post-transfusion Zika Fever.
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Zika virus infection complicated by guillain barre syndrome case report french polynesia december 2013
Eurosurveillance, 2014Co-Authors: Emily Oehler, P Larre, S Lastère, H P Mallet, Léo Baudouin, Isabelle Leparcgoffart, Laurent Watrin, Florent Valour, Didier Musso, Frédéric GhawchéAbstract:Zika Fever, considered as an emerging disease of arboviral origin, because of its expanding geographic area, is known as a benign infection usually presenting as an influenza-like illness with cutaneous rash. So far, Zika virus infection has never led to hospitalisation. We describe the first case of Guillain-Barre syndrome (GBS) occurring immediately after a Zika virus infection, during the current Zika and type 1 and 3 dengue Fever co-epidemics in French Polynesia. .
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Zika virus infection complicated by Guillain-BarrE syndrome – case report, French Polynesia, December 2013
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2014Co-Authors: Erwan Oehler, P Larre, S Lastère, H P Mallet, Léo Baudouin, Isabelle Leparc-goffart, Laurent Watrin, Florent Valour, Didier Musso, Frédéric GhawchéAbstract:Zika Fever, considered as an emerging disease of arboviral origin, because of its expanding geographic area, is known as a benign infection usually presenting as an influenza-like illness with cutaneous rash. So far, Zika virus infection has never led to hospitalisation. We describe the first case of Guillain-Barre syndrome (GBS) occurring immediately after a Zika virus infection, during the current Zika and type 1 and 3 dengue Fever co-epidemics in French Polynesia.
Duncan R. Smith - One of the best experts on this subject based on the ideXlab platform.
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Comparative analysis of a Thai congenital-Zika-syndrome-associated virus with a Thai Zika-Fever-associated virus
Archives of Virology, 2020Co-Authors: Anusara Jitsatja, Nitwara Wikan, Suwipa Ramphan, Ploenphit Promma, Atichat Kuadkitkan, Mongkol Uiprasertkul, Chayawat Phatihattakorn, Duncan R. SmithAbstract:In this study, we compared the characteristics of two strains of Zika virus (ZIKV) isolated in Thailand, one isolated from a febrile patient and one isolated from tissues of a fetus medically terminated due to congenital Zika syndrome (CZS). Replication profiles showed that the isolate from the fetal tissues replicated significantly more slowly than the Fever-associated isolate in human lung A549 cells during the first 24 hours postinfection but showed a similar growth profile over longer-term infection. A much smaller difference was observed in Aedes albopictus C6/36 cells. In a quasispecies analysis, a high proportion (approximately 20%) of nonfunctional genomes was identified, caused by an adenine insertion in the prM gene. This insertion was found to be present in two Thai Fever strains and as such may represent a common feature of Thai endemic ZIKV. Comparison between viral RNA copy number and viral titer showed that the isolate from fetal tissues was produced more efficiently than the Fever-associated isolate. Together, these results suggest that different ZIKV isolates differ in their replication capacity, and this might contribute to the fetotropic potential of a particular strain.
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Immunological evidence of Zika virus transmission in Thailand.
Asian Pacific journal of tropical medicine, 2016Co-Authors: Nitwara Wikan, Yupin Suputtamongkol, Sutee Yoksan, Duncan R. Smith, Prasert AuewarakulAbstract:Abstract Objective To identify immunological evidence of Zika virus transmission in Thailand. Methods To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated Fever patients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. Results Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. Conclusions This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika Fever in Thailand requires further investigation.
Garnet K. Y. Choi - One of the best experts on this subject based on the ideXlab platform.
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Zika Fever and congenital Zika syndrome an unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years, <20 human cases were reported before 2007. The massive epidemics in the Pacific islands associated with the ZIKV Asian lineage in 2007 and 2013 were followed by explosive outbreaks in Latin America in 2015. Although increased mosquito breeding associated with the El Nino effect superimposed on global warming is suspected, genetic changes in its RNA virus genome may have led to better adaptation to mosquitoes, other animal reservoirs, and human. We reviewed the epidemiology, clinical manifestation, virology, pathogenesis, laboratory diagnosis, management, and prevention of this emerging infection. Laboratory diagnosis can be confounded by cross-reactivity with other circulating flaviviruses. Besides mosquito bite and transplacental transmission, the risk of other potential routes of transmission by transfusion, transplantation, sexual activity, breastfeeding, respiratory droplet, and animal bite is discussed. Epidemic control requires adequate clearance of mosquito breeding grounds, personal protection against mosquito bite, and hopefully a safe and effective vaccine.
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Zika Fever and congenital Zika syndrome: An unexpected emerging arboviral disease
Journal of Infection, 2016Co-Authors: Jasper F W Chan, Cyril Chik-yan Yip, Garnet K. Y. Choi, Vincent C C Cheng, Kwok-yung YuenAbstract:Unlike its mosquito-borne relatives, such as dengue, West Nile, and Japanese encephalitis viruses, which can cause severe human diseases, Zika virus (ZIKV) has emerged from obscurity by its association with a suspected "congenital Zika syndrome", while causing asymptomatic or mild exanthematous febrile infections which are dengue- or rubella-like in infected individuals. Despite having been discovered in Uganda for almost 60 years,
