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Jack W Jennings - One of the best experts on this subject based on the ideXlab platform.
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Combination acetabular radiofrequency Ablation and cementoplasty using a navigational radiofrequency Ablation Device and ultrahigh viscosity cement: technical note
Skeletal Radiology, 2016Co-Authors: Adam N. Wallace, Devin Vaswani, Randy O. Chang, Ambrose J Huang, Jack W JenningsAbstract:Background Percutaneous radiofrequency Ablation and cementoplasty is an alternative palliative therapy for painful metastases involving axial load-bearing bones. This technical report describes the use of a navigational radiofrequency probe to ablate acetabular metastases from an anterior approach followed by instillation of ultrahigh viscosity cement under CT-fluoroscopic guidance. Materials and methods The tumor Ablation databases of two institutions were retrospectively reviewed to identify patients who underwent combination acetabular radiofrequency Ablation and cementoplasty using the STAR Tumor Ablation and StabiliT Vertebral Augmentation Systems (DFINE; San Jose, CA). Pre-procedure acetabular tumor volume was measured on cross-sectional imaging. Pre- and post-procedure pain scores were measured using the Numeric Rating Scale (10-point scale) and compared. Partial pain improvement was categorically defined as ≥ 2-point pain score reduction. Patients were evaluated for evidence of immediate complications. Electronic medical records were reviewed for evidence of delayed complications. Results During the study period, 12 patients with acetabular metastases were treated. The median tumor volume was 54.3 mL (range, 28.3–109.8 mL). Pre- and post-procedure pain scores were obtained from 92 % (11/12) of the cohort. The median pre-procedure pain score was 8 (range, 3–10). Post-procedure pain scores were obtained 7 days (82 %; 9/11), 11 days (9.1 %; 1/11) or 21 days (9.1 %; 1/11) after treatment. The median post-treatment pain score was 3 (range, 1–8), a statistically significant difference compared with pre-treatment ( P = 0.002). Categorically, 73 % (8/11) of patients reported partial pain relief after treatment. No immediate symptomatic complications occurred. Three patients (25 %; 3/12) were discharged to hospice within 1 week of treatment. No delayed complications occurred in the remaining 75 % (9/12) of patients during median clinical follow-up of 62 days (range, 14–178 days). Conclusions Palliative percutaneous acetabular radiofrequency Ablation and cementoplasty can be feasibly performed from an anterior approach using a navigational Ablation probe and ultrahigh viscosity cement instilled under CT-fluoroscopic guidance.
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combination acetabular radiofrequency Ablation and cementoplasty using a navigational radiofrequency Ablation Device and ultrahigh viscosity cement technical note
Skeletal Radiology, 2016Co-Authors: Adam N. Wallace, Devin Vaswani, Randy O. Chang, Ambrose J Huang, Jack W JenningsAbstract:Background Percutaneous radiofrequency Ablation and cementoplasty is an alternative palliative therapy for painful metastases involving axial load-bearing bones. This technical report describes the use of a navigational radiofrequency probe to ablate acetabular metastases from an anterior approach followed by instillation of ultrahigh viscosity cement under CT-fluoroscopic guidance.
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treatment of metastatic posterior vertebral body osseous tumors by using a targeted bipolar radiofrequency Ablation Device technical note
Radiology, 2014Co-Authors: Travis J Hillen, Praveen Anchala, Michael V Friedman, Jack W JenningsAbstract:The articulating radiofrequency Ablation Device provides access to posterior vertebral body tumors that were difficult to access previously by using conventional Ablation Devices and allows for safe and controlled Ablation of posterior vertebral body tumors without thermal nerve injury.
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treatment of metastatic spinal lesions with a navigational bipolar radiofrequency Ablation Device a multicenter retrospective study
Pain Physician, 2014Co-Authors: Praveen Anchala, Travis J Hillen, Winston D Irving, Nam D Tran, Frank D Vrionis, Douglass M Coldwell, Bassem A. Georgy, Michael V Friedman, Allan L. Brook, Jack W JenningsAbstract:BACKGROUND: Spinal metastatic lesions are a common occurrence among oncology patients and contribute to significant morbidity. Treatment options have been limited in their effectiveness and scope to this point. OBJECTIVE: This study aims to report the safety and efficacy of radiofrequency Ablation (RFA) of malignant spinal lesions using a novel RFA bipolar tumor Ablation system which includes a navigational electrode containing 2 active thermocouples. STUDY DESIGN: IRB approved multicenter retrospective review of patients receiving RFA as a treatment of metastatic osseous lesions between March 2012 and March 2013. SETTING: This study consists of patients from 5 large academic centers. METHOD: One hundred twenty-eight metastatic lesions were identified in 92 patients who underwent a total of 96 procedures. Cement augmentation was performed when the vertebral body was at risk or had a pathological fracture. Visual analogue scale (VAS) scores were obtained preoperatively as well as postoperatively at the one week, one month, and 6 month time points. Interval change in the patients' pain medications was recorded. Postoperative imaging was used to assess tumor burden at the treated level when available. RESULTS: RFA was technically successful in all of the lesions without complication or thermal injury. Our study demonstrated significant (P < 0.01) decreases in the VAS scores at one week, one month, and 6 months postoperatively. In our largest center, 54% of our patients experienced a decrease and 30% had no change in their pain medications postoperatively. Sixty-two percent of the spinal lesions in this largest institution were located in the posterior vertebral body. Post-Ablation imaging confirmed size of Ablation zones consistent with that measured by the thermocouples. LIMITATIONS: The main limitations of this study are the heterogeneous patient population, data set, and potential confounding variable of concurrent cement augmentation. CONCLUSION: The STAR System is an RFA Device that was safely and effectively used in the treatment of spine metastatic osseous lesions. This new Device allows RFA treatment of previously untreatable lesions with resultant reduction in pain that was not controlled by systemic or radiation therapy.
Kanji Kawachi - One of the best experts on this subject based on the ideXlab platform.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Journal of gastroenterology and hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field
Journal of Gastroenterology and Hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:BACKGROUND AND AIMS We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. METHOD The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. RESULTS The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). CONCLUSION This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
Gerald D Dodd - One of the best experts on this subject based on the ideXlab platform.
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effect of change in portal vein flow rates on hepatic Ablations created with a bipolar radiofrequency Ablation Device
Radiology, 2017Co-Authors: Gerald D Dodd, Anthony C Lanctot, Kimberly E LindAbstract:Our study shows that the size and shape of coagulation necrosis created by the bipolar radiofrequency Ablation Device tested in this study is not affected significantly by changes in portal vein blood flow rates.
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Effect of Change in Portal Venous Blood Flow Rates on the Performance of a 2.45-GHz Microwave Ablation Device.
Radiology, 2015Co-Authors: Gerald D Dodd, Anthony C Lanctot, Sarah M. Kreidler, Deborah H. GlueckAbstract:We have shown that the size and shape of coagulation created by a 2.45-GHz microwave Ablation Device is not significantly affected by physiological fluctuations in portal venous flow rates.
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Effect of Change in Portal Venous Blood Flow Rates on the Performance of a 2.45-GHz Microwave Ablation Device.
Radiology, 2015Co-Authors: Gerald D Dodd, Anthony C Lanctot, Sarah M. Kreidler, Deborah H. GlueckAbstract:To investigate the effect of change in portal venous blood flow rates on the size and shape of Ablations created by a 2.45-GHz microwave Ablation Device. This study was exempt from review by the institutional animal care and use committee. An in vitro bovine liver model perfused with autologous blood via the portal vein at five flow rates (60, 70, 80, 90, and 100 mL/min per 100 g of liver) was used to evaluate the effect of change in flow rates on the size and shape of coagulation created by a 2.45-GHz, 140-W microwave Ablation Device operated for 5 and 10 minutes. Three Ablations per Ablation time were conducted in each of 10 livers, with two livers perfused at each flow rate. Short- and long-axis diameters were measured from gross specimens, and volume and sphericity index were calculated. General linear mixed models that accounted for correlations within the liver were used to evaluate the effects of lobe, flow, and Ablation time on size and sphericity index of Ablations. Flow did not have a significant effect on the size or shape of coagulation created at 5 or 10 minutes (P > .05 for all tests). The mean short- and long-axis diameters and volume were 3.2 cm (95% confidence interval [CI]: 3.1, 3.3), 5.6 cm (95% CI: 5.4, 5.8), and 30.2 cm(3) (95% CI: 28.4, 32.1) for the 5-minute Ablations and 3.8 cm (95% CI: 3.7, 3.9), 6.5 cm (95% CI: 6.3, 6.7), and 49.3 cm(3) (95% CI: 47.5, 51.2), for the 10-minute Ablations, respectively. The mean sphericity index for both 5- and 10-minute Ablations was 34.4% (95% CI: 32%, 36.7%). Change in portal venous blood flow rates did not have an effect on the size and shape of Ablations created by a 2.45-GHz microwave Ablation Device.
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In vitro blood-perfused bovine liver model: a physiologic model for evaluation of the performance of radiofrequency Ablation Devices.
Journal of Vascular and Interventional Radiology, 2011Co-Authors: Michael D. Orsi, Gerald D Dodd, R Cardan, Hayden W. Head, Stephanie K. Burns, Dana Blakemore, Jeffrey D. Blume, Tyler J. GreenAbstract:Abstract Purpose To describe an in vitro blood-perfused bovine liver model for the testing of radiofrequency (RF) Ablation Devices and compare the performance of a specific RF Ablation Device in the model relative to three other biologic models. Materials and Methods Fresh bovine livers were used to create three in vitro models: blood-perfused, Krebs–Henseleit (KH) solution–perfused, and nonperfused. The perfused models were connected to a heart–lung machine via the portal vein and perfused with heparinized autologous blood or KH solution under physiologic conditions. Six swine were used as in vivo liver models. A cluster electrode and RF Ablation system was operated in impedance mode for 12 minutes in all models. Ablated livers were sectioned, with long- and short-axis measurements of the Ablations obtained, and statistical analysis was performed. Results A total of 39, 23, 17, and 12 Ablations were performed in 14, 6, 5, and 6 blood-perfused bovine livers, KH solution–perfused bovine livers, nonperfused bovine livers, and in vivo porcine livers, respectively. On cut specimens, the average diameters of Ablation zones were 4.00 cm (95% CI, 3.88–4.13) in blood-perfused livers, 4.34 cm (95% CI, 4.14–4.50) in KH solution–perfused livers, 4.67 cm (95% CI, 4.50–4.83) in nonperfused livers, and 3.56 cm (95% CI, 3.26–3.83) in in vivo porcine livers. In all models, the Ablation zone diameters were normally distributed. Conclusions In the in vitro blood-perfused bovine liver model, the size of Ablations produced by an RF Ablation Device are closer in size to those seen in porcine liver in vivo compared with the lesions produced in KH solution–perfused or nonperfused bovine liver.
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radiofrequency Ablation of hepatic tumors variability of lesion size using a single Ablation Device
American Journal of Roentgenology, 2004Co-Authors: Richard S Montgomery, Gerald D Dodd, Andres Rahal, John R Leyendecker, Linda G HubbardAbstract:OBJECTIVE. In this study, we examined the variability of lesion sizes produced by a single radiofrequency Ablation using the same Device and algorithm in patients with small malignant hepatic tumors.MATERIALS AND METHODS. A review of the clinical records of 208 patients who underwent radiofrequency Ablation of malignant hepatic tumors during a 6-year period revealed 31 patients with small tumors that were treated with a single Ablation. Clinical data were recorded using standardized work sheets. Tumor and lesion sizes after Ablation were measured from CT scans. The influences of tumor size, tumor type, presence or absence of cirrhosis, and tissue temperature on the Ablation size were analyzed.RESULTS. The size of tumor before treatment ranged from 0.8 to 4.0 cm (mean diameter [± SD] = 1.8 ± 0.9 cm) with corresponding volumes of 0.27–30.24 mL (mean volume = 27.1 ± 15.9 mL). The lesion sizes after Ablation ranged from 1.7 to 5.3 cm (mean diameter = 3.6 ± 0.7 cm) with corresponding volumes of 2.29–75.87 mL (...
Koichi Sato - One of the best experts on this subject based on the ideXlab platform.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Journal of gastroenterology and hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field
Journal of Gastroenterology and Hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:BACKGROUND AND AIMS We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. METHOD The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. RESULTS The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). CONCLUSION This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
Yuji Watanabe - One of the best experts on this subject based on the ideXlab platform.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field.
Journal of gastroenterology and hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
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Novel tumor-Ablation Device for liver tumors utilizing heat energy generated under an alternating magnetic field
Journal of Gastroenterology and Hepatology, 2008Co-Authors: Koichi Sato, Yuji Watanabe, Atsushi Horiuchi, Shungo Yukumi, Takashi Doi, Motohira Yoshida, Yuji Yamamoto, Tsunehiro Maehara, Takashi Naohara, Kanji KawachiAbstract:BACKGROUND AND AIMS We have developed a novel tumor-Ablation Device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents. This novel Device can repeatedly heat liver tumors at lower temperature than usual heating Devices, such as radiofrequency Ablation therapy, with slight infliction of pain. This study assesses its heating effect on rat liver tumors as local therapy. METHOD The small needle was manufactured from MgFe(2)O(4) particles by sintering at 1100 degrees C. After a MgFe(2)O(4) needle was inserted into liver tumors comprising of dRLh-84 cells, the tumors were heated for 30 min under an AMF. We examined cellular activity by using nicotinamide adenine dinucleotide (NADH) diaphorase staining and terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick-end labeling (TUNEL) staining, and evaluated the effect of suppressing tumor growth by sequentially comparing the tumor diameter with that of the control group. RESULTS The mean temperature of the heated tumors was 60.2 +/- 1.8 degrees C. The tumor cells were constricted, and chromatin of nuclei had shrunk immediately after heating. The heat-injury area that contained the tumors was negative for NADH diaphorase activity. After 3 days, the tumor cells in the heat-injury area became positive for TUNEL staining, which detects cell death. At 7 days, the mean tumor diameters were significantly smaller in the heating group than in the control group (6.15 +/- 0.47 mm vs 16.89 +/- 2.69 mm; P < 0.05). CONCLUSION This Device, utilizing heat energy induced by ferromagnetic metal under an AMF, appears useful as local thermotherapy for human liver cancer.
