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Sun Qin-feng - One of the best experts on this subject based on the ideXlab platform.

  • Study of Acute Inflammation during root canal therapy of residual roots and crowns
    Chinese Journal of Conservative Dentistry, 2004
    Co-Authors: Sun Qin-feng
    Abstract:

    AIM:To study the reason and incidence of Acute Inflammation during root canal therapy of residual roots and crowns.METHODS:Eighty-three patients were randomly assigned to either the one-appointment or two-appointments root canal therapy.The causes of Acute Inflammation were analyzed.RESULTS:The incidence of the Acute Inflammation from both methods had no significant difference,but the incidence of Acute phlegmon of two-appointment root canal therapy was more than that of one-appointments ( P 0.05).The Acute Inflammation was related to the root preparation,root filling and periapical leision.CONCLUSION:Root canal therapy should be done strictly.One-appointments root canal therapy may be employed in the treatment of residual roots and crowns. [

Kiyofumi Furusawa - One of the best experts on this subject based on the ideXlab platform.

  • Acute Inflammation in horizontal incompletely impacted third molar with radiolucency in the elderly
    Clinical interventions in aging, 2009
    Co-Authors: Minoru Yamaoka, Yusuke Ono, Masahide Ishizuka, Kouichi Yasuda, Takashi Uematsu, Masahiro Takahashi, Takayuki Uchihashi, Kiyofumi Furusawa
    Abstract:

    Although radiolucency has been shown as a risk of infection, the poorly understood effects of aging on radiolucency correlate with Acute pericoronitis, which has a high risk of infection extending any complications. We reviewed the records of 346 consecutive patients aged more than 41 years to evaluate whether pericoronal radiolucency below the crown in mandibular horizontal incompletely impacted third molars is related to Acute Inflammation. The frequency of Acute Inflammation in teeth with pericoronal radiolucency below the crown was similar to that in teeth without; however, the odds ratio of Acute Inflammation exhibited in women aged more than 61 years compared to women aged 41–50 years was 9.77 (95% confidence interval [CI]: 1.67–57.29; P <

  • Acute Inflammation at a mandibular solitary horizontal incompletely impacted molar.
    International journal of general medicine, 2009
    Co-Authors: Minoru Yamaoka, Yusuke Ono, Masahide Ishizuka, Yoko Hasumi-nakayama, Ryosuke Doto, Kouichi Yasuda, Takashi Uematsu, Kiyofumi Furusawa
    Abstract:

    Acute Inflammation is frequently seen in the elderly around incompletely impacted molars located apart from molars or premolars. To identify the factors causing Acute Inflammation in the solitary molars without second molars or without second and first molars, ages of patients and rates of Acute Inflammation in 75 horizontal incompletely impacted mandibular molars in contact or not in contact with molars in subjects 41 years old or older were studied using orthopantomographs. Acute Inflammation was seen in nine third molars out of 48 third molars in contact with second molars (18.8%), whereas Acute Inflammation was seen in 11 molars out of 19 solitary molars without second molars or without first and second molars (57.9%) (p < 0.01). The mean age of 48 subjects with third molars in contact with the second molar was 50.42 +/- 7.62 years, and the mean age of 19 subjects with isolated molars was 65.16 +/- 10.41 years (p < 0.0001). These indicate that a solitary horizontal incompletely impacted molar leads more frequently to Acute Inflammation along with aging due to possible bone resorption resulting from teeth loss.

  • Radiolucency below the crown of mandibular horizontal incompletely impacted third molars and Acute Inflammation in men with diabetes.
    Clinical cosmetic and investigational dentistry, 2009
    Co-Authors: Minoru Yamaoka, Yusuke Ono, Masahide Ishizuka, Kouichi Yasuda, Takashi Uematsu, Kiyofumi Furusawa
    Abstract:

    Although mandibular third molar has a high risk of infection extending any complications, the influence of diabetes on radiolucency and Acute Inflammation in pericoronitis remains unclear. The present study was to evaluate whether radiolucency below the crown is related to Acute Inflammation in mandibular horizontal incompletely impacted third molars and to review the records of 140 men more than 45 years with and without diabetes. The odds ratio of exhibiting Acute Inflammation was 3.38 (95% CI: 1.13-10.16, p < 0.05) and that of exhibiting severe Acute Inflammation was 15.38 (95% CI: 3.56-66.49, p < 0.0001), indicating an association of Acute pericoronitis in diabetes. The frequency of radiolucency below the crown and below the root in diabetics was similar to that in nondiabetics. However, the odds ratio of exhibiting both radiolucency below the crown and Acute Inflammation under the diabetic condition was 4.85 (95% CI: 1.60-14.73, p < 0.01), whereas that of diabetics showing both radiolucency below the root and Acute Inflammation was 0.46 (95% CI: 0.06-3.74, p = 0.74). Radiolucency below the crown and Acute Inflammation were associated with diabetes, but that below root and Acute Inflammation were not associated with diabetes, indicating that the region below the crown carries susceptibility to Acute pericoronitis, whereas the periodontium shows a protective effect against Acute pericoronitis.

Matthew Spite - One of the best experts on this subject based on the ideXlab platform.

  • Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology
    Circulation research, 2016
    Co-Authors: Brian E. Sansbury, Matthew Spite
    Abstract:

    Acute Inflammation is a host-protective response that is mounted in response to tissue injury and infection. Initiated and perpetuated by exogenous and endogenous mediators, Acute Inflammation must be resolved for tissue repair to proceed and for homeostasis to be restored. Resolution of Inflammation is an actively regulated process governed by an array of mediators as diverse as those that initiate Inflammation. Among these, resolvins have emerged as a genus of evolutionarily conserved proresolving mediators that act on specific cellular receptors to regulate leukocyte trafficking and blunt production of inflammatory mediators, while also promoting clearance of dead cells and tissue repair. Given that chronic unresolved Inflammation is emerging as a central causative factor in the development of cardiovascular diseases, an understanding of the endogenous processes that govern normal resolution of Acute Inflammation is critical for determining why sterile maladaptive cardiovascular Inflammation perpetuates. Here, we provide an overview of the process of resolution with a focus on the enzymatic biosynthesis and receptor-dependent actions of resolvins and related proresolving mediators in immunity, thrombosis, and vascular biology. We discuss how nutritional and current therapeutic approaches modulate resolution and propose that harnessing resolution concepts could potentially lead to the development of new approaches for treating chronic cardiovascular Inflammation in a manner that is not host disruptive.

  • novel lipid mediators promote resolution of Acute Inflammation impact of aspirin and statins
    Circulation Research, 2010
    Co-Authors: Matthew Spite, Charles N. Serhan
    Abstract:

    The resolution of Acute Inflammation is a process that allows for inflamed tissues to return to homeostasis. Resolution was held to be a passive process, a concept now overturned with new evidence demonstrating that resolution is actively orchestrated by distinct cellular events and endogenous chemical mediators. Among these, lipid mediators, such as the lipoxins, resolvins, protectins, and newly identified maresins, have emerged as a novel genus of potent and stereoselective players that counter-regulate excessive Acute Inflammation and stimulate molecular and cellular events that define resolution. Given that uncontrolled, chronic Inflammation is associated with many cardiovascular pathologies, an appreciation of the endogenous pathways and mediators that control timely resolution can open new terrain for therapeutic approaches targeted at stimulating resolution of local Inflammation, as well as correcting the impact of chronic Inflammation in cardiovascular disorders. Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.

Charles N. Serhan - One of the best experts on this subject based on the ideXlab platform.

  • Resolution of Acute Inflammation In The Lung
    Annual review of physiology, 2013
    Co-Authors: Bruce D. Levy, Charles N. Serhan
    Abstract:

    Acute Inflammation in the lung is essential to health. So too is its resolution. In response to invading microbes, noxious stimuli, or tissue injury, an Acute inflammatory response is mounted to protect the host. To limit Inflammation and prevent collateral injury of healthy, uninvolved tissue, the lung orchestrates the formation of specialized proresolving mediators, specifically lipoxins, resolvins, protectins, and maresins. These immunoresolvents are agonists for resolution that interact with specific receptors on leukocytes and structural cells to blunt further Inflammation and promote catabasis. This process appears to be defective in several common lung diseases that are characterized by excess or chronic Inflammation. Here, we review the molecular and cellular effectors of resolution of Acute Inflammation in the lung.

  • novel lipid mediators promote resolution of Acute Inflammation impact of aspirin and statins
    Circulation Research, 2010
    Co-Authors: Matthew Spite, Charles N. Serhan
    Abstract:

    The resolution of Acute Inflammation is a process that allows for inflamed tissues to return to homeostasis. Resolution was held to be a passive process, a concept now overturned with new evidence demonstrating that resolution is actively orchestrated by distinct cellular events and endogenous chemical mediators. Among these, lipid mediators, such as the lipoxins, resolvins, protectins, and newly identified maresins, have emerged as a novel genus of potent and stereoselective players that counter-regulate excessive Acute Inflammation and stimulate molecular and cellular events that define resolution. Given that uncontrolled, chronic Inflammation is associated with many cardiovascular pathologies, an appreciation of the endogenous pathways and mediators that control timely resolution can open new terrain for therapeutic approaches targeted at stimulating resolution of local Inflammation, as well as correcting the impact of chronic Inflammation in cardiovascular disorders. Here, we overview and update the biosynthesis and actions of proresolving lipid mediators, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.

Bo Fernhall - One of the best experts on this subject based on the ideXlab platform.

  • Influence of fitness and age on the endothelial response to Acute Inflammation.
    Experimental physiology, 2018
    Co-Authors: Elizabeth C. Schroeder, Abbi D. Lane-cordova, Sushant M. Ranadive, Tracy Baynard, Bo Fernhall
    Abstract:

    NEW FINDINGS What is the central question of the study? What are the effects of age and fitness on the vascular response to Acute Inflammation in younger and older adults? What is the main finding and its importance? In older adults, cardiorespiratory fitness level has a differential impact on endothelial function after Acute Inflammation. Compared with older adults with low fitness, older, moderately fit adults have a greater decrease in endothelial function, similar to that of younger adults. These findings have important implications in support of the beneficial effects of higher cardiorespiratory fitness in maintaining vascular reactivity and the ability to respond to stressors. ABSTRACT Inflammation is associated with greater risk of cardiovascular events and reduced vascular function with ageing. Higher cardiorespiratory fitness is associated with lower risk of cardiovascular events and better vascular function. We evaluated the role of fitness in the vascular response to Acute Inflammation in 26 younger adults (YA) and 62 older adults (OA). We used an influenza vaccine to induce Acute Inflammation. Blood pressure, flow-mediated dilatation (FMD), augmentation index, carotid elastic modulus and inflammatory markers were measured before and 24 h after vaccination. Peak oxygen uptake was measured via a treadmill test. 'Fit' was defined as a peak oxygen uptake greater than the age- and sex-determined 50th percentile according to the American College of Sports Medicine. An interaction effect existed for the FMD response during Acute Inflammation (P   0.05). The reduction in FMD in YA was similar between fitness groups (P > 0.05). All groups had similar reductions in mean arterial pressure and increases in inflammatory markers. The augmentation index and carotid elastic modulus did not change during Acute Inflammation. In conclusion, in OA, higher fitness is associated with a greater decrease in endothelial function during Acute Inflammation, and this response is similar to that of young adults. This suggests that moderately fit OA may maintain vascular reactivity in response to stress, indicating preserved vascular function in moderately fit versus low-fit OA.

  • Effects of ageing and physical activity on blood pressure and endothelial function during Acute Inflammation.
    Experimental physiology, 2016
    Co-Authors: Abbi D. Lane-cordova, Tracy Baynard, Shane A. Phillips, Jeffrey A. Woods, Robert W. Motl, Bo Fernhall
    Abstract:

    NEW FINDINGS What is the central question of this study? Do older and younger adults have similar vascular endothelial and blood pressure responses to Acute Inflammation? Does physical activity affect these responses? What is the main finding and its importance? Older adults reduce blood pressure whereas younger adults reduce endothelial function during Acute Inflammation. Physical activity does not provide protection against these Inflammation-induced changes. This is important because older adults regularly experience Acute increases in systemic Inflammation that may predispose older adults to cardiovascular events through dysregulation of blood pressure. Ageing is characterized by chronic, low-grade Inflammation that is related to endothelial dysfunction and arterial stiffness. Physical activity can protect older adults (OAs) from cardiovascular dysfunction and increased Inflammation. Acute Inflammation causes transient endothelial dysfunction and arterial stiffening in younger adults (YAs), but may not have the same effect in OAs. We hypothesized that Acute Inflammation would increase blood pressure (BP) and endothelial impairment to a greater extent in OAs versus YAs, but that physical activity would be protective. We induced Inflammation with an influenza vaccine in 22 OAs (55-75 years old) and 31 YAs (18-35 years old) and measured brachial flow-mediated dilatation (FMD), BP and serum inflammatory markers before vaccination and at 24 and 48 h afterwards. Physical activity data were collected using accelerometry. During Inflammation, only OAs reduced systolic BP (from 120 ± 3 to 115 ± 2 to 115 ± 3 mmHg, P   0.05 for all). We conclude that Acute Inflammation reduced FMD only in YAs and reduced BP only in OAs. Physical activity did not affect arterial function during Acute Inflammation. Clinicians should be aware that all OAs are vulnerable to Inflammation-mediated reductions in BP and cardiovascular complications.

  • Aging, not age-associated Inflammation, determines blood pressure and endothelial responses to Acute Inflammation.
    Journal of hypertension, 2016
    Co-Authors: Abbi D. Lane-cordova, Sushant M. Ranadive, Tracy Baynard, Rebecca M. Kappus, Marc D. Cook, Shane A. Phillips, Jeffrey A. Woods, Kenneth R. Wilund, Bo Fernhall
    Abstract:

    BACKGROUND Aging is characterized by a state of chronic, low-grade Inflammation that impairs vascular function. Acute Inflammation causes additional decrements in vascular function, but these responses are not uniform in older compared with younger adults. We sought to determine if older adults with low levels of baseline Inflammation respond to Acute Inflammation in a manner similar to younger adults. We hypothesized age-related differences in the vascular responses to Acute Inflammation, but that older adults with low baseline Inflammation would respond similarly to younger adults. METHOD Inflammation was induced with an influenza vaccine in 96 participants [older = 67 total, 38 with baseline C-reactive protein (CRP) > 1.5 mg/l and 29 with CRP