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Osamu Yoshida - One of the best experts on this subject based on the ideXlab platform.
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virulence characteristics of eschevichia coli in Acute bacterial Prostatitis
The Journal of Infectious Diseases, 1999Co-Authors: Kenji Mitsumori, Akito Terai, Shingo Yamamoto, Satoshi Ishitoya, Osamu YoshidaAbstract:To assess the urovirulence characteristics of Escherichia coli strains causing Acute Prostatitis, urinary isolates from men with Acute Prostatitis (n=107) and from women with Acute uncomplicated pyelonephritis (n=76) were examined for the prevalence of sfa, foc, and 3 papG allele genotypes and phenotypes and for the production of alpha-hemolysin and cytotoxic necrotizing factor 1. The papG allele III and foc gene were found more frequently and the papG allele II less frequently among Prostatitis than from pyelonephritis isolates. A higher proportion of hly+ cnf1+ genotype in Prostatitis strains (64% vs. 36%) was particularly striking. Both Prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic Prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of Acute Prostatitis.
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concise communications virulence characteristics of escherichia coli in Acute bacterial Prostatitis
1999Co-Authors: Kenji Mitsumori, Akito Terai, Shingo Yamamoto, Satoshi Ishitoya, Osamu YoshidaAbstract:+cnf1 + genotype in Prostatitis strains (64% vs. 36%) was particularly striking. Both Prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic Prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of Acute Prostatitis.
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escherichia coli virulence factors and serotypes in Acute bacterial Prostatitis
International Journal of Urology, 1997Co-Authors: Akito Terai, Kenji Mitsumori, Shingo Yamamoto, Hisao Kurazono, Yusaku Okada, Yoshifumi Takeda, Osamu YoshidaAbstract:BackgroundEscherichia coli is the most frequent pathogen in both Acute bacterial Prostatitis and Acute uncomplicated urinary infections. To assess the virulence profiles of E. coli in Acute Prostatitis, the serotypes and virulence factor (VF) genotypes were determined. Methods We studied 107 E. coli isolates from cases of Acute bacterial Prostatitis, 76 isolates from Acute pyelonephritis, 194 isolates from Acute cystitis and 80 fecal isolates from healthy people. All pyelonephritis and cystitis isolates were from women. Seven urovirulence determinants were analyzed by DNA colony hybridization, including the genes for type 1 fimbria (pil), P fimbria (pap), S fimbria (sfa), afimbrial adhesin AFA-I (afal), α-hemolysin (hly), cytotoxic necrotizing factor 1 (cnfl) and aerobactin (aer). 0:H:K serotypes were also determined. Results With the exception of pil and afal, all VFs were significantly more often associated with Prostatitis, pyelonephritis and cystitis isolates than with the fecal isolates. The prevalence of sfa, hly and cnfl was higher in Prostatitis isolates than in pyelonephritis and cystitis isolates, and the pap+sfa+hly+cnf+ genotype was dominant among Prostatitis isolates (48.8%). Nine O serotypes(01, 02, 04, 06, 01 6, Ol 8, 022, 025 and 075) accounted for 79.4%, 73.7% and 78.4% of the Prostatitis, pyelonephritis and cystitis strains, respectively. There was an apparent correlation between serotype and genotype in uropathogenic E. coli. Conclusion The predominance of O serotypes in female urinary tract infections and a high percentage of multiple VFs among the Prostatitis isolates suggested that VFs play important roles in the pathogenesis of Acute bacterial Prostatitis.
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pyogenic vertebral osteomyelitis after Acute bacterial Prostatitis a case report
International Journal of Urology, 1996Co-Authors: Takeshi Soda, Satoshi Ishitoya, Keiji Ogura, Hiroshi Niibayashi, Osamu YoshidaAbstract:A case of pyogenic vertebral osteomyelitis after Acute bacterial Prostatitis in a 78-year-old man is reported. The rarity and subtle clinical presentation of this condition, and the delayed appearance of radiologic signs of progression to destructive osteomyelitis, contributed to a significant delay in diagnosis. An arterial blood culture positive for bacterial growth during the episode of Acute Prostatitis suggested that bacteremia might result from hematogenous spread of the infection to the vertebral column via the venous system. Since intensive antimicrobial therapy proved ineffective, debridement of the first and second lumbar vertebral bodies, and anterior spinal fusion from the twelfth thoracic to the third lumbar vertebrae were performed. The patient's high fever and severe lumbago subsided immediately after the surgery. The possibility of development to pyogenic vertebral osteomyelitis should be kept in mind when treating a serious genitourinary tract infection.
Du Geon Moon - One of the best experts on this subject based on the ideXlab platform.
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clinical and microbiological characteristics of spontaneous Acute Prostatitis and transrectal prostate biopsy related Acute Prostatitis is transrectal prostate biopsy related Acute Prostatitis a distinct Acute Prostatitis category
Journal of Infection and Chemotherapy, 2015Co-Authors: Jong Wook Kim, Jae Hyun Bae, Seok Ho Kang, Hong Seok Park, Du Geon MoonAbstract:Abstract Purpose This study aimed to compare the clinical and microbiological characteristics between Acute bacterial Prostatitis and transrectal biopsy-related Acute Prostatitis. Materials and methods We retrospectively reviewed the records of 135 patients hospitalized for Acute Prostatitis in three urological centers between 2004 and 2013. Acute bacterial Prostatitis was diagnosed according to typical symptoms, findings of physical examination, and laboratory test results. Clinical variables, laboratory test results, and anti-microbial susceptibility results were reviewed. Patients were classified into the spontaneous Acute Prostatitis group (S-ABP) or biopsy-related Acute Prostatitis (Bx-ABP) for comparison of their clinical, laboratory, and microbiological findings. Results The mean age of all patients was 61.7 ± 12.9 years. Compared with S-ABP patients, Bx-ABP patients were significantly older, had larger prostate volumes, higher PSA values, higher peak fever temperatures, and higher incidence of septicemia and antibiotic-resistant bacteria. Overall, of the 135 patients, 57.8% had positive bacterial urine and/or blood cultures. Bx-ABP patients had a higher incidence of bacterial (urine and/or blood) positive cultures compared to S-ABP patients (66.7% versus 55.6%). Escherichia coli was the predominant organism in both groups, but it was more common in Bx-ABP (88.9%) than in S-ABP (66.7%). Extended spectrum beta-lactamase -producing bacteria accounted for 64.7% of culture-positive patients in the Bx-ABP group compared to 13.3% in the S-ABP group. Conclusions Bx-ABP patients showed a higher incidence of septicemia and antibiotic-resistant bacteria than S-ABP patients. These results have important implications for the management and antimicrobial treatment of Bx-ABP, which may well deserve to be considered a distinct Prostatitis category.
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positive culture for extended spectrum β lactamase during Acute Prostatitis after prostate biopsy is a risk factor for progression to chronic Prostatitis
Urology, 2013Co-Authors: Ji Yun Chae, Jong Wook Kim, Du Geon Moon, Jin Wook Kim, Cheol Yong Yoon, Min Gu ParkAbstract:Objective To analyze whether strains positive for extended-spectrum β-lactamase (ESBL) affected the clinical course and progression to chronic Prostatitis in patients with postbiopsy Acute Prostatitis. Methods From 2002 to 2011, 3657 patients underwent transrectal ultrasound-guided biopsy of the prostate, and 33 patients with Acute Prostatitis were enrolled. Acute Prostatitis was defined as a fever greater than 38°C, pyuria, and tenderness on digital rectal examination. Urine and blood cultures were tested for antibiotic susceptibility. Laboratory and clinical variables according to the presence of ESBL were analyzed. Results Blood or urine culture was positive in 23 patients. The most common strain was Escherichia coli . Sixteen patients showed ESBL-positive and 18 patients were quinolone-resistant. Thirteen of 16 patients with ESBL-positive strains showed quinolone resistance, and 13 of 18 patients with quinolone resistance were ESBL-positive ( P = .621). Besides imipenem, all ESBL-positive patients were susceptible to amikacin and were highly susceptible to cefoxitin and amoxicillin/clavulanic acid. The prevalence of ESBL-positive strains has tended to increase since 2006. Patients with ESBL had higher peak fever, white blood cell count, absolute neutrophil count, and longer duration of fever and hospitalization. The progression rate to chronic Prostatitis was significantly higher in ESBL-positive patients (4/16 vs 0/17, P = .044). Conclusion Since 2006, ESBL strains have been increasing, and the presence of ESBL showed more detrimental effects on the clinical course of the patients, resulting in a higher rate of progression to chronic Prostatitis.
Kwang Suk Lee - One of the best experts on this subject based on the ideXlab platform.
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comparison of the delta neutrophil index with procalcitonin erythrocyte sedimentation rate and c reactive protein as predictors of sepsis in patients with Acute Prostatitis
Prostate international, 2018Co-Authors: Hyun Kyu Ahn, Kyo Chul Koo, Byung Ha Chung, Kwang Suk LeeAbstract:Abstract Background We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with Acute Prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of Acute urinary retention (AUR) in patients with AP. Materials and methods All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed. The clinical features, prostate-specific antigen levels, inflammatory marker levels, and urine and blood culture results were obtained from medical records. Patients who underwent urethrocystoscopy or prostate biopsy within 7 days were excluded. Results Of 132 patients (mean age, 64.8 years) in this cohort, 17 (12.9%) had sepsis and 22 (16.7%) had positive blood cultures. Escherichia coli was the most common isolate in blood and urine cultures. In multivariate analysis, the DNI and prostate-specific antigen were identified as predictors of sepsis. The DNI was a significant prognostic factor for bacteremia. In patients with AP, procalcitonin was not a significant predictor of sepsis. Of 19 patients with AUR, 10 needed Foley catheterization because of refractory AUR. C-reactive protein was a significant predictor of failure of the initial management of AUR. Conclusions The DNI is useful as a predictive factor for sepsis and bacteremia in patients with AP. Without mandatory cystostomy, intermittent catheterization could be one of the useful management options of AUR in patients with AP.
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Comparison of the delta neutrophil index with procalcitonin, erythrocyte sedimentation rate, and C-reactive protein as predictors of sepsis in patients with Acute Prostatitis
'Elsevier BV', 2018Co-Authors: Hyun Kyu Ahn, Kyo Chul Koo, Byung Ha Chung, Kwang Suk LeeAbstract:Background: We investigated the usefulness of inflammatory markers including the delta neutrophil index (DNI), erythrocyte sedimentation rate, C-reactive protein, and procalcitonin as early predictors of sepsis in patients with Acute Prostatitis (AP). In addition, we evaluated the efficacy of intermittent catheterization for the initial management of Acute urinary retention (AUR) in patients with AP. Materials and methods: All patients who presented to the emergency department and were admitted to the urology department from January 2011 to December 2013 were retrospectively reviewed. The clinical features, prostate-specific antigen levels, inflammatory marker levels, and urine and blood culture results were obtained from medical records. Patients who underwent urethrocystoscopy or prostate biopsy within 7 days were excluded. Results: Of 132 patients (mean age, 64.8 years) in this cohort, 17 (12.9%) had sepsis and 22 (16.7%) had positive blood cultures. Escherichia coli was the most common isolate in blood and urine cultures. In multivariate analysis, the DNI and prostate-specific antigen were identified as predictors of sepsis. The DNI was a significant prognostic factor for bacteremia. In patients with AP, procalcitonin was not a significant predictor of sepsis. Of 19 patients with AUR, 10 needed Foley catheterization because of refractory AUR. C-reactive protein was a significant predictor of failure of the initial management of AUR. Conclusions: The DNI is useful as a predictive factor for sepsis and bacteremia in patients with AP. Without mandatory cystostomy, intermittent catheterization could be one of the useful management options of AUR in patients with AP. Keywords: Acute bacterial Prostatitis, Bacteremia, Biological markers, Escherichia coli, Sepsi
Kwokyung Yuen - One of the best experts on this subject based on the ideXlab platform.
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granulicatella adiacens and abiotrophia defectiva bacteraemia characterized by 16s rrna gene sequencing
Journal of Medical Microbiology, 2003Co-Authors: Patrick C Y Woo, Ami Meiyuk Fung, Susanna K P Lau, Benedict Yinleung Chan, Siukau Chiu, Jade Leelee Teng, T L Que, Raymond W H Yung, Kwokyung YuenAbstract:Traditionally, the identification, epidemiology and spectrum of clinical diseases caused by Granulicatella adiacens and Abiotrophia defectiva are dependent upon their phenotypic characterization. During a 6-year period (July 1995-June 2001), seven and two alpha-haemolytic streptococci were identified as G. adiacens and A. defectiva, respectively, by 16S rRNA gene sequencing. Three patients with haematological malignancies and neutropenic fever had primary bacteraemia. Three patients with valvular problems or congenital heart disease had infective endocarditis. A patient with ischemic heart disease and cerebrovascular accident had infected aortic atheroma with dissection. A patient with recurrent pyogenic cholangitis had Acute cholangitis and a patient with polypoid cystitis and benign prostatic hypertrophy had Acute Prostatitis. Four of the nine patients died, including all three with G. adiacens infective endocarditis or infected atheroma. For the seven G. adiacens isolates, the API 20 STREP system successfully identified one and five isolates as G. adiacens with >95 % and 80-90 % confidence, respectively, whereas the Vitek System (GPI) and ATB Expression system (ID32 STREP) successfully identified none and one isolate as G. adiacens. Of the two A. defectiva isolates, none of the three systems successfully identified either of them as A. defectiva. 16S rRNA gene sequencing is the technique of choice for identifying G. adiacens and A. defectiva, and early surgical intervention should be considered when G. adiacens endocarditis is diagnosed.
Shingo Yamamoto - One of the best experts on this subject based on the ideXlab platform.
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increased biofilm formation in escherichia coli isolated from Acute Prostatitis
International Journal of Antimicrobial Agents, 2006Co-Authors: Sojun Kanamaru, Akito Terai, Hisao Kurazono, Koichi Monden, Hiromi Kumon, Yoshimitsu Mizunoe, Osamu Ogawa, Shingo YamamotoAbstract:Using crystal violet binding assay, we examined the potential for biofilm formation in 194, 76 and 107 isolates from urine of patients with uncomplicated Acute cystitis, pyelonephritis and Prostatitis, respectively. The Prostatitis isolates showed significantly higher optical density (OD) values compared with cystitis and pyelonephritis isolates (OD540: 0.82, 0.29 and 0.43, respectively, P < 0.0001). Similarly, strains of serotypes O4 and O22, which were commonly isolated from Prostatitis, exhibited significantly higher OD values than did other strains. Furthermore, when the 21 Prostatitis isolates were examined for expression of curli fimbriae, eight of 12 strains with a high OD value, but only three of nine with a low OD value, expressed curli fimbriae (P = 0.0195). These results suggest an association between Acute bacterial Prostatitis and biofilm formation.
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virulence characteristics of eschevichia coli in Acute bacterial Prostatitis
The Journal of Infectious Diseases, 1999Co-Authors: Kenji Mitsumori, Akito Terai, Shingo Yamamoto, Satoshi Ishitoya, Osamu YoshidaAbstract:To assess the urovirulence characteristics of Escherichia coli strains causing Acute Prostatitis, urinary isolates from men with Acute Prostatitis (n=107) and from women with Acute uncomplicated pyelonephritis (n=76) were examined for the prevalence of sfa, foc, and 3 papG allele genotypes and phenotypes and for the production of alpha-hemolysin and cytotoxic necrotizing factor 1. The papG allele III and foc gene were found more frequently and the papG allele II less frequently among Prostatitis than from pyelonephritis isolates. A higher proportion of hly+ cnf1+ genotype in Prostatitis strains (64% vs. 36%) was particularly striking. Both Prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic Prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of Acute Prostatitis.
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concise communications virulence characteristics of escherichia coli in Acute bacterial Prostatitis
1999Co-Authors: Kenji Mitsumori, Akito Terai, Shingo Yamamoto, Satoshi Ishitoya, Osamu YoshidaAbstract:+cnf1 + genotype in Prostatitis strains (64% vs. 36%) was particularly striking. Both Prostatitis and pyelonephritis strains expressed virulence factors similarly except for a higher proportion of nonhemolytic Prostatitis isolates. Although the pathogenetic mechanisms of urinary tract infections in men and women may differ, virulence factors such as adhesins and cytotoxins may have important roles in the pathogenesis of Acute Prostatitis.
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escherichia coli virulence factors and serotypes in Acute bacterial Prostatitis
International Journal of Urology, 1997Co-Authors: Akito Terai, Kenji Mitsumori, Shingo Yamamoto, Hisao Kurazono, Yusaku Okada, Yoshifumi Takeda, Osamu YoshidaAbstract:BackgroundEscherichia coli is the most frequent pathogen in both Acute bacterial Prostatitis and Acute uncomplicated urinary infections. To assess the virulence profiles of E. coli in Acute Prostatitis, the serotypes and virulence factor (VF) genotypes were determined. Methods We studied 107 E. coli isolates from cases of Acute bacterial Prostatitis, 76 isolates from Acute pyelonephritis, 194 isolates from Acute cystitis and 80 fecal isolates from healthy people. All pyelonephritis and cystitis isolates were from women. Seven urovirulence determinants were analyzed by DNA colony hybridization, including the genes for type 1 fimbria (pil), P fimbria (pap), S fimbria (sfa), afimbrial adhesin AFA-I (afal), α-hemolysin (hly), cytotoxic necrotizing factor 1 (cnfl) and aerobactin (aer). 0:H:K serotypes were also determined. Results With the exception of pil and afal, all VFs were significantly more often associated with Prostatitis, pyelonephritis and cystitis isolates than with the fecal isolates. The prevalence of sfa, hly and cnfl was higher in Prostatitis isolates than in pyelonephritis and cystitis isolates, and the pap+sfa+hly+cnf+ genotype was dominant among Prostatitis isolates (48.8%). Nine O serotypes(01, 02, 04, 06, 01 6, Ol 8, 022, 025 and 075) accounted for 79.4%, 73.7% and 78.4% of the Prostatitis, pyelonephritis and cystitis strains, respectively. There was an apparent correlation between serotype and genotype in uropathogenic E. coli. Conclusion The predominance of O serotypes in female urinary tract infections and a high percentage of multiple VFs among the Prostatitis isolates suggested that VFs play important roles in the pathogenesis of Acute bacterial Prostatitis.