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Rajesh Kumar - One of the best experts on this subject based on the ideXlab platform.
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a dose dependent Adaptogenic and safety evaluation of rhodiola imbricata edgew a high altitude rhizome
Food and Chemical Toxicology, 2008Co-Authors: Vanita Gupta, Shalini Saggu, R C Sawhney, Rajkumar Tulsawani, Rajesh KumarAbstract:Abstract To examine the dose dependent Adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 °C)–hypoxia (428 mm Hg)–restraint (C–H–R) exposure. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. The acute and sub-acute toxicity of the extract was also studied in rats. Sub-acute toxicity studies included administration of single oral dose of 1 g/kg and 2 g/kg of extract once daily for 14 days and maximal effective single oral dose of 100 mg/kg once daily for 30 days. At the end of each treatment period the biochemical parameters related to liver function, kidney function, lipids (triglycerides, cholesterol) and hematological parameters were estimated in serum and blood. Biochemical and hematological analysis showed no significant changes in any of the parameters examined in treated group’s animal, in comparison to control animals. No significant change was observed in organ weight/body weight ratios, of any organ studied in comparison to control rats. The oral LD 50 of the extract was observed to be >10 g/kg, indicating an adequate margin of safety. No histopathological changes were observed in the vital organs studied of the treated animals. These results suggest that aqueous extract of R. imbricata root possess potent Adaptogenic activity with no acute and sub-acute toxicity.
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Adaptogenic and safety evaluation of seabuckthorn hippophae rhamnoides leaf extract a dose dependent study
Food and Chemical Toxicology, 2007Co-Authors: Shalini Saggu, H M Divekar, Vanita Gupta, R C Sawhney, P K Banerjee, Rajesh KumarAbstract:Abstract The effects of seabuckthorn (Hippophae rhamnoides L., Elaeagnaceae), leaf aqueous extract were examined in rats for its Adaptogenic activity and toxicity. Dose dependent Adaptogenic study of extract was carried out at different doses administered orally, 30 min prior to cold (5 °C)–hypoxia (428 mmHg)–restraint (C–H–R) exposure. After sub-acute toxicity studies on 10 and 20 times doses of maximal effective dose administered for 14 days (single oral dose of 1 g/kg and 2 g/kg once daily) and maximal effective dose administered for 30 days (single oral dose of 100 mg/kg once daily), biochemical and hematological parameters were studied in the serum and blood. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. No significant changes were observed in organ weight/body weight ratios, of any vital organ studied (except liver and kidney in 1 g/kg and 2 g/kg body weight doses, respectively), and biochemical and hematological parameters of the sub-acute drug treated animals in comparison to control rats. In acute toxicity study LD50 of the extract was observed to be >10 g/kg when given orally. These results indicate that seabuckthorn leaf aqueous extract possess potent Adaptogenic activity with no toxicity even after sub-acute (30 days) maximal effective dose administration.
Vanita Gupta - One of the best experts on this subject based on the ideXlab platform.
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a dose dependent Adaptogenic and safety evaluation of rhodiola imbricata edgew a high altitude rhizome
Food and Chemical Toxicology, 2008Co-Authors: Vanita Gupta, Shalini Saggu, R C Sawhney, Rajkumar Tulsawani, Rajesh KumarAbstract:Abstract To examine the dose dependent Adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 °C)–hypoxia (428 mm Hg)–restraint (C–H–R) exposure. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. The acute and sub-acute toxicity of the extract was also studied in rats. Sub-acute toxicity studies included administration of single oral dose of 1 g/kg and 2 g/kg of extract once daily for 14 days and maximal effective single oral dose of 100 mg/kg once daily for 30 days. At the end of each treatment period the biochemical parameters related to liver function, kidney function, lipids (triglycerides, cholesterol) and hematological parameters were estimated in serum and blood. Biochemical and hematological analysis showed no significant changes in any of the parameters examined in treated group’s animal, in comparison to control animals. No significant change was observed in organ weight/body weight ratios, of any organ studied in comparison to control rats. The oral LD 50 of the extract was observed to be >10 g/kg, indicating an adequate margin of safety. No histopathological changes were observed in the vital organs studied of the treated animals. These results suggest that aqueous extract of R. imbricata root possess potent Adaptogenic activity with no acute and sub-acute toxicity.
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Adaptogenic and safety evaluation of seabuckthorn hippophae rhamnoides leaf extract a dose dependent study
Food and Chemical Toxicology, 2007Co-Authors: Shalini Saggu, H M Divekar, Vanita Gupta, R C Sawhney, P K Banerjee, Rajesh KumarAbstract:Abstract The effects of seabuckthorn (Hippophae rhamnoides L., Elaeagnaceae), leaf aqueous extract were examined in rats for its Adaptogenic activity and toxicity. Dose dependent Adaptogenic study of extract was carried out at different doses administered orally, 30 min prior to cold (5 °C)–hypoxia (428 mmHg)–restraint (C–H–R) exposure. After sub-acute toxicity studies on 10 and 20 times doses of maximal effective dose administered for 14 days (single oral dose of 1 g/kg and 2 g/kg once daily) and maximal effective dose administered for 30 days (single oral dose of 100 mg/kg once daily), biochemical and hematological parameters were studied in the serum and blood. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. No significant changes were observed in organ weight/body weight ratios, of any vital organ studied (except liver and kidney in 1 g/kg and 2 g/kg body weight doses, respectively), and biochemical and hematological parameters of the sub-acute drug treated animals in comparison to control rats. In acute toxicity study LD50 of the extract was observed to be >10 g/kg when given orally. These results indicate that seabuckthorn leaf aqueous extract possess potent Adaptogenic activity with no toxicity even after sub-acute (30 days) maximal effective dose administration.
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anti stress and Adaptogenic activity of l arginine supplementation
Evidence-based Complementary and Alternative Medicine, 2005Co-Authors: Vanita Gupta, H M Divekar, Shalini Saggu, Asheesh Gupta, S K Grover, Ratan KumarAbstract:In the present study, oral supplementation of l-arginine in rats was evaluated for its anti-stress and Adaptogenic activity using the cold (5°C)–hypoxia (428 mmHg)–restraint (C-H-R) animal model. A dose-dependent study of l-arginine was carried out at doses of 12.5, 25.0, 50.0, 100.0, 200.0 and 500.0 mg/kg body weight, administered orally 30 min prior to C-H-R exposure. The time taken by the rat to attain a rectal temperature of 23°C (Trec 23°C) during C-H-R exposure and its recovery to Trec 37°C at normal atmospheric pressure and 32 ± 1°C were used as biomarkers of anti-stress and Adaptogenic activity. Biochemical parameters related to lipid peroxidation, anti-oxidants, cell membrane permeability, nitric oxide and stress, with and without administration of the least effective l-arginine dose, were measured in rats on attaining Trec 23°C and Trec 37°C. The least effective Adaptogenic dose of l-arginine was 100.0 mg/kg body weight. The C-H-R exposure of control rats, on attaining Trec 23°C, resulted in a significant increase in plasma malondialdehyde (MDA), blood lactate dehydrogenase (LDH) and a decrease in blood catalase (CAT) and plasma testosterone levels. On recovery (Trec 37°C) of control rats, there was a further decrease in CAT and plasma testosterone, and an increase in LDH. l-Arginine supplementation resulted in a significant decrease in plasma MDA, an increase in blood superoxide dismutase (SOD), CAT levels maintained at control values and a lower increase in LDH compared with controls (45.3 versus 58.5% and 21.5 versus 105.2%) on attaining Trec 23°C during C-H-R exposure and on recovery to Trec 37°C. The results suggested that l-arginine possesses potent anti-stress activity during C-H-R exposure and recovery from C-H-R-induced hypothermia.
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antistress and Adaptogenic activity of lecithin supplementation
Journal of Alternative and Complementary Medicine, 2002Co-Authors: Ratan Kumar, H M Divekar, Vanita Gupta, Kaushal K SrivastavaAbstract:Objective: Investigation of lecithin administration in rats for its antistress and Adaptogenic activity. Design: Lecithin was administered orally (1 mg/g body weight) to rats 0.5 hour, 1.5 hours, 3.0 hours, and 6.0 hours prior to cold (5°C)-hypoxia (428 mm Hg)-restraint (C-H-R) exposure and serum choline estimation. The rectal temperature (Trec) of the rats was monitored during the exposure and the recovery periods. The time for decrease of Trec to 23°C and its recovery to 37°C were used as indices of antistress and Adaptogenic activity. Results: Lecithin administration 3-6 hours prior to C-H-R exposure was found to have significant Adaptogenic activity that correlated with increased serum choline levels. Lecithin administration prior to C-H-R exposure increased the stress tolerance of the rats by delaying the time for decrease of Trec to 23°C during C-H-R exposure. It also helped shorten poststress recovery as observed by decreased time to attain Trec of 37°C from C-H-R-induced hypothermia (Trec, 23°C). ...
Milen I. Georgiev - One of the best experts on this subject based on the ideXlab platform.
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Rhodiola rosea L.: from golden root to green cell factories
Phytochemistry Reviews, 2016Co-Authors: Andrey S. Marchev, Zsuzsanna György, Iman Mirmazloum, Ina Y. Aneva, Albena T. Dinkova-kostova, Milen I. GeorgievAbstract:Rhodiola rosea L. is a worldwide popular plant with Adaptogenic activities that have been and currently are exploited in the traditional medicine of many countries, as well as, examined in a number of clinical trials. More than 140 chemical structures have been identified which belong to several natural product classes, including phenylpropanoid glycosides, phenylethanoids, flavonoids and essential oils, and are mainly stored in the rhizomes and the roots of the plant. A number of mechanisms contribute to the Adaptogenic activities of R. rosea preparations and its phytochemical constituents. Among them, the intrinsic inducible mammalian stress responses and their effector proteins, such as heat shock protein 70 (Hsp70), are the most prominent. Due to its popular medicinal use, which has led to depletion of its natural habitats, R. rosea is now considered as endangered in most parts of the world. Conservation, cultivation and micropropagation are all implemented as potential preservation strategies. A number of in vitro systems of R. rosea are being developed as sources of pharmaceutically valuable secondary metabolites. These are greatly facilitated by advances in elucidation of the biosynthetic pathways and the enzymes, which catalyse the production of these secondary metabolites in the plant. In addition, biotechnological approaches show promise towards achieving sustainable production of R. rosea secondary metabolites.
Shalini Saggu - One of the best experts on this subject based on the ideXlab platform.
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a dose dependent Adaptogenic and safety evaluation of rhodiola imbricata edgew a high altitude rhizome
Food and Chemical Toxicology, 2008Co-Authors: Vanita Gupta, Shalini Saggu, R C Sawhney, Rajkumar Tulsawani, Rajesh KumarAbstract:Abstract To examine the dose dependent Adaptogenic activity aqueous extract of Rhodiola imbricata root was orally administered in rats at different doses, 30 min prior to cold (5 °C)–hypoxia (428 mm Hg)–restraint (C–H–R) exposure. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. The acute and sub-acute toxicity of the extract was also studied in rats. Sub-acute toxicity studies included administration of single oral dose of 1 g/kg and 2 g/kg of extract once daily for 14 days and maximal effective single oral dose of 100 mg/kg once daily for 30 days. At the end of each treatment period the biochemical parameters related to liver function, kidney function, lipids (triglycerides, cholesterol) and hematological parameters were estimated in serum and blood. Biochemical and hematological analysis showed no significant changes in any of the parameters examined in treated group’s animal, in comparison to control animals. No significant change was observed in organ weight/body weight ratios, of any organ studied in comparison to control rats. The oral LD 50 of the extract was observed to be >10 g/kg, indicating an adequate margin of safety. No histopathological changes were observed in the vital organs studied of the treated animals. These results suggest that aqueous extract of R. imbricata root possess potent Adaptogenic activity with no acute and sub-acute toxicity.
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Adaptogenic and safety evaluation of seabuckthorn hippophae rhamnoides leaf extract a dose dependent study
Food and Chemical Toxicology, 2007Co-Authors: Shalini Saggu, H M Divekar, Vanita Gupta, R C Sawhney, P K Banerjee, Rajesh KumarAbstract:Abstract The effects of seabuckthorn (Hippophae rhamnoides L., Elaeagnaceae), leaf aqueous extract were examined in rats for its Adaptogenic activity and toxicity. Dose dependent Adaptogenic study of extract was carried out at different doses administered orally, 30 min prior to cold (5 °C)–hypoxia (428 mmHg)–restraint (C–H–R) exposure. After sub-acute toxicity studies on 10 and 20 times doses of maximal effective dose administered for 14 days (single oral dose of 1 g/kg and 2 g/kg once daily) and maximal effective dose administered for 30 days (single oral dose of 100 mg/kg once daily), biochemical and hematological parameters were studied in the serum and blood. The maximal effective Adaptogenic dose of the extract was 100 mg/kg body weight. No significant changes were observed in organ weight/body weight ratios, of any vital organ studied (except liver and kidney in 1 g/kg and 2 g/kg body weight doses, respectively), and biochemical and hematological parameters of the sub-acute drug treated animals in comparison to control rats. In acute toxicity study LD50 of the extract was observed to be >10 g/kg when given orally. These results indicate that seabuckthorn leaf aqueous extract possess potent Adaptogenic activity with no toxicity even after sub-acute (30 days) maximal effective dose administration.
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anti stress and Adaptogenic activity of l arginine supplementation
Evidence-based Complementary and Alternative Medicine, 2005Co-Authors: Vanita Gupta, H M Divekar, Shalini Saggu, Asheesh Gupta, S K Grover, Ratan KumarAbstract:In the present study, oral supplementation of l-arginine in rats was evaluated for its anti-stress and Adaptogenic activity using the cold (5°C)–hypoxia (428 mmHg)–restraint (C-H-R) animal model. A dose-dependent study of l-arginine was carried out at doses of 12.5, 25.0, 50.0, 100.0, 200.0 and 500.0 mg/kg body weight, administered orally 30 min prior to C-H-R exposure. The time taken by the rat to attain a rectal temperature of 23°C (Trec 23°C) during C-H-R exposure and its recovery to Trec 37°C at normal atmospheric pressure and 32 ± 1°C were used as biomarkers of anti-stress and Adaptogenic activity. Biochemical parameters related to lipid peroxidation, anti-oxidants, cell membrane permeability, nitric oxide and stress, with and without administration of the least effective l-arginine dose, were measured in rats on attaining Trec 23°C and Trec 37°C. The least effective Adaptogenic dose of l-arginine was 100.0 mg/kg body weight. The C-H-R exposure of control rats, on attaining Trec 23°C, resulted in a significant increase in plasma malondialdehyde (MDA), blood lactate dehydrogenase (LDH) and a decrease in blood catalase (CAT) and plasma testosterone levels. On recovery (Trec 37°C) of control rats, there was a further decrease in CAT and plasma testosterone, and an increase in LDH. l-Arginine supplementation resulted in a significant decrease in plasma MDA, an increase in blood superoxide dismutase (SOD), CAT levels maintained at control values and a lower increase in LDH compared with controls (45.3 versus 58.5% and 21.5 versus 105.2%) on attaining Trec 23°C during C-H-R exposure and on recovery to Trec 37°C. The results suggested that l-arginine possesses potent anti-stress activity during C-H-R exposure and recovery from C-H-R-induced hypothermia.
Laura Mattioli - One of the best experts on this subject based on the ideXlab platform.
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Adaptogenic and central nervous system effects of single doses of 3 rosavin and 1 salidroside rhodiola rosea l extract in mice
Phytotherapy Research, 2007Co-Authors: Marina Perfumi, Laura MattioliAbstract:Rhodiola rosea L., or ‘golden root’, is a popular plant in traditional medicine in Eastern Europe and Asia, with a reputation for improving depression, enhancing work performance, eliminating fatigue and treating symptoms of asthenia subsequent to intense physical and psychological stress. Due to these therapeutic properties, R. rosea is considered to be one of the most active Adaptogenic drugs. To confirm and extend results obtained in the few preclinical and clinical studies available in English language journals, the purpose of the present study was to re-investigate the effects produced by a single oral administration of an R. rosea hydroalcohol extract (containing 3% rosavin and 1% salidroside) on the central nervous system in mice. The extract was tested on antidepressant, Adaptogenic, anxiolytic, nociceptive and locomotor activities at doses of 10, 15 and 20 mg/kg, using predictive behavioural tests and animal models. The results show that this R. rosea extract significantly, but not dose-dependently, induced antidepressant-like, Adaptogenic, anxiolytic-like and stimulating effects in mice. This study thus provides evidence of the efficacy of R. rosea extracts after a single administration, and confirms many preclinical and clinical studies indicating the Adaptogenic and stimulating effects of such R. rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time. Copyright © 2006 John Wiley & Sons, Ltd.
