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Alginate Dressing

The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform

M S Agren – 1st expert on this subject based on the ideXlab platform

  • a fibre free Alginate Dressing in the treatment of split thickness skin graft donor sites
    Journal of The European Academy of Dermatology and Venereology, 1998
    Co-Authors: H H Steenfos, M S Agren

    Abstract:

    Background Alginate Dressings are gaining acceptance in wound management although comparative published data with conventional treatment is inconclusive. Aims The aim of this randomised controlled study was to compare a fibre-free Alginate Dressing (Comfeel SeaSorb) with conventional treatment of standardised split-thickness skin graft donor sites in 17 patients regarding initial absorption of blood and healing. Results The Alginate Dressing absorbed 40% (P < 0.05) more blood, measured as total iron content of used Dressings, during the first 10 post-wounding minutes than fine mesh gauze, resulting in less subsequent bleeding. Light microscopic examination of punch biopsies obtained from 10 wounds on post-operative day 6 demonstrated that nine wounds treated with the Alginate Dressing compared with seven wounds treated conventionally with paraffin-impregnated gauze (Jelonet8) were completely epithelialised, a statistically non-significant difference (P = 0.46). Conclusions In conclusion, the fibre-free Alginate Dressing showed increased initial blood absorption resulting in quicker haemostasis but showed no greater beneficial effect on epithelialisation of split-thickness skin graft donor sites compared with conventional topical treatment. 0 1998 Elsevier Science B.V. All rights reserved

Steven L Percival – 2nd expert on this subject based on the ideXlab platform

  • the visualisation and speed of kill of wound isolates on a silver Alginate Dressing
    International Wound Journal, 2012
    Co-Authors: Samuel James Hooper, Steven L Percival, Katja E Hill, D W P Thomas, Anthony Joseph Hayes, David Wynne Williams

    Abstract:

    In chronic wound management, Alginate Dressings are used to absorb exudate and reduce the microbial burden. Silver Alginate offers the added benefit of an additional antimicrobial pressure on contaminating microorganisms. This present study compares the antimicrobial activity of a RESTORE silver Alginate Dressing with a silver-free control Dressing using a combination of in vitro culture and imaging techniques. The wound pathogens examined included Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, β-haemolytic Streptococcus, and strictly anaerobic bacteria. The antimicrobial efficacy of the Dressings was assessed using log10 reduction and 13-day corrected zone of inhibition (CZOI) time-course assays. Confocal laser scanning microscopy (CLSM) was used to visualise the relative proportions of live/dead microorganisms sequestered into the Dressings over 24 hours and estimate the comparative speed of kill. The RESTORE silver Alginate Dressing showed significantly greater log10 reductions and CZOIs for all microorganisms compared with the control, indicating the antimicrobial effect of ionic silver. Antimicrobial activity was evident against all test organisms for up to 5 days and, in some cases, up to 12 days following an on-going microbial challenge. Imaging bacteria sequestered in the silver-free Dressing showed that each microbial species aggregated in the Dressing and remained viable for more than 20 hours. Growth was not observed inside of the Dressing, indicating a possible microbiostatic effect of the Alginate fibres. In comparison, organisms in the RESTORE silver Alginate Dressing were seen to lose viability at a considerably greater rate. After 16 hours of contact with the RESTORE silver Alginate Dressing, >90% of cells of all bacteria and yeast were no longer viable. In conclusion, collectively, the data highlights the rapid speed of kill and antimicrobial suitability of this RESTORE silver Alginate Dressing on wound isolates and highlights its overwhelming ability to manage a microbial wound bioburden in the management of infected wounds.

  • the antimicrobial efficacy of a silver Alginate Dressing against a broad spectrum of clinically relevant wound isolates
    International Wound Journal, 2011
    Co-Authors: Steven L Percival, W Slone, S Linton, T Okel, L Corum, J G Thomas

    Abstract:

    : Wound Dressings impregnated with silver have a role to play in aiding to reduce both the Dressing and wound microbial bioburden. It is therefore imperative that antimicrobial wound Dressings have efficacy on a broad range of clinical significant microorganisms. Accordingly, this study aimed to determine the antimicrobial efficacy of a silver Alginate Dressing against 115 wound isolates that had been isolated routinely from patients at West Virginia University Hospital. Standardised corrected zones of inhibition (CZOIs) were performed on all clinical isolates. It was found that the silver Alginate Dressing was able to inhibit the growth of all microorganisms tested. In particular, the silver Alginate Dressing inhibited the growth of Candida albicans and yeasts with CZOI of 3-11·5 mm. All meticillin-resistant Staphylococcus aureus (MRSA) strains were found to be sensitive to the silver Alginate Dressing with a CZOI range calculated at 3-7·8 mm. Sensitivity to the silver Alginate Dressing was also evident for S. aureus and vancomycin-resistant Enterococci. CZOIs of 4·25 mm were calculated for Enterococcus faecium and 9·8 mm for viridans streptococcus. The bacteria which demonstrated the highest tolerance to ionic silver included Enterobacter cloacae and Acinetobacter baumannii. Contrary to this the most responsive microorganisms to ionic silver included strains of staphylococci, viridans streptococcus and Candida albicans. No antibiotic-resistant isolates, as identified by Kirby Bauer Clinical Laboratory Standards Institute classification system, were found to be resistant to ionic silver. When a selected number of microorganisms were grown in the biofilm phenotypic state enhanced tolerance to silver was observed, compared to their non biofilm counterparts. Overall, this study has demonstrated the broad antimicrobial activity of a silver Alginate Dressing on wound isolates grown in the non biofilm and biofilm state. This finding is clinically relevant as both the non biofilm and biofilm phenotypic states of microorganisms are evident in wounds and therefore significant to delayed healing. Consequently, it is imperative that antimicrobial wound Dressings demonstrate antimicrobial activity against microorganisms in both phenotypic states.

  • in vitro antimicrobial efficacy of a silver Alginate Dressing on burn wound isolates
    Journal of Wound Care, 2011
    Co-Authors: J G Thomas, W Slone, S Linton, T Okel, L Corum, Steven L Percival

    Abstract:

    Objective: To test the antimicrobial effectiveness of a silver Alginate Dressing on opportunistic pathogens, namely meticillin-sensitive Staphylococcus aureus (MSSA) and meticillin-resistant Staphylococcus aureus (MRSA), Klebsiella spp., Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Escherichia coli, Enterobacter sakazakii, Enterobacter cloacae, Serratia marcescens, Chryseobacterium indologenes, Proteus vulgaris and Acinetobacter baumannii. Method: In total, 40 microorganisms were isolated from patients attending three burn centres in the US and evaluated for their susceptibility to a silver Alginate wound Dressing, employing a corrected zone of inhibition assay, conducted on Mueller Hinton agar (MHA). Results: The sizes of the corrected zones of inhibition varied between and within genera. For example, all Acinetobacter baumannii strains were found to be sensitive to ionic silver at PH 7, with a mean of 2.8mm, compared with 3.5mm at PH 5.5. The silver Alginate Dressing also demonst…

J G Thomas – 3rd expert on this subject based on the ideXlab platform

  • In vitro antimicrobial efficacy of a silver Alginate Dressing on burn wound isolates.
    Journal of wound care, 2020
    Co-Authors: J G Thomas, W Slone, S Linton, T Okel, L Corum, S L Percival

    Abstract:

    To test the antimicrobial effectiveness of a silver Alginate Dressing on opportunistic pathogens, namely meticillin-sensitive Staphylococcus aureus (MSSA) and meticillin-resistant Staphylococcus aureus (MRSA), Klebsiella spp., Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Escherichia coli, Enterobacter sakazakii, Enterobacter cloacae, Serratia marcescens, Chryseobacterium indologenes, Proteus vulgaris and Acinetobacter baumannii.
    In total, 40 microorganisms were isolated from patients attending three burn centres in the US and evaluated for their susceptibility to a silver Alginate wound Dressing, employing a corrected zone of inhibition assay, conducted on Mueller Hinton agar (MHA).
    The sizes of the corrected zones of inhibition varied between and within genera. For example, all Acinetobacter baumannii strains were found to be sensitive to ionic silver at pH 7, with a mean of 2.8mm, compared with 3.5mm at pH 5.5. The silver Alginate Dressing also demonstrated activity on all strains of Enterobacter and Escherichia coli, with susceptibility to the silver Alginate Dressing enhanced at pH 5.5. For Enterococcus spp. the average corrected zone of inhibition at pH 7 was 3.6mm, versus 4.9mm at pH 5.5. All strains of Pseudomonas aeruginosa were found to be sensitive to the silver Alginate Dressing. The average corrected zone of inhibition was 6.9mm at pH 7, compared with 8mm at pH 5.5. For MRSA and Staphylococcus aureus, it ranged from 4.5mm to 7.5mm at pH 7. When the pH was decreased to 5.5, the corrected zone of inhibition increased.
    This study demonstrates the activity of a silver Alginate Dressing on a wide range of burn isolates, including antibiotic-resistant bacteria, isolated from three different burn centres in the US. It also highlights the possible importance of pH and its potential effects on antimicrobial performance and microbial susceptibility. However, more extensive testing is required to substantiate this.
    SLP is employed by Advanced Medical Solutions Ltd.

  • the antimicrobial efficacy of a silver Alginate Dressing against a broad spectrum of clinically relevant wound isolates
    International Wound Journal, 2011
    Co-Authors: Steven L Percival, W Slone, S Linton, T Okel, L Corum, J G Thomas

    Abstract:

    : Wound Dressings impregnated with silver have a role to play in aiding to reduce both the Dressing and wound microbial bioburden. It is therefore imperative that antimicrobial wound Dressings have efficacy on a broad range of clinical significant microorganisms. Accordingly, this study aimed to determine the antimicrobial efficacy of a silver Alginate Dressing against 115 wound isolates that had been isolated routinely from patients at West Virginia University Hospital. Standardised corrected zones of inhibition (CZOIs) were performed on all clinical isolates. It was found that the silver Alginate Dressing was able to inhibit the growth of all microorganisms tested. In particular, the silver Alginate Dressing inhibited the growth of Candida albicans and yeasts with CZOI of 3-11·5 mm. All meticillin-resistant Staphylococcus aureus (MRSA) strains were found to be sensitive to the silver Alginate Dressing with a CZOI range calculated at 3-7·8 mm. Sensitivity to the silver Alginate Dressing was also evident for S. aureus and vancomycin-resistant Enterococci. CZOIs of 4·25 mm were calculated for Enterococcus faecium and 9·8 mm for viridans streptococcus. The bacteria which demonstrated the highest tolerance to ionic silver included Enterobacter cloacae and Acinetobacter baumannii. Contrary to this the most responsive microorganisms to ionic silver included strains of staphylococci, viridans streptococcus and Candida albicans. No antibiotic-resistant isolates, as identified by Kirby Bauer Clinical Laboratory Standards Institute classification system, were found to be resistant to ionic silver. When a selected number of microorganisms were grown in the biofilm phenotypic state enhanced tolerance to silver was observed, compared to their non biofilm counterparts. Overall, this study has demonstrated the broad antimicrobial activity of a silver Alginate Dressing on wound isolates grown in the non biofilm and biofilm state. This finding is clinically relevant as both the non biofilm and biofilm phenotypic states of microorganisms are evident in wounds and therefore significant to delayed healing. Consequently, it is imperative that antimicrobial wound Dressings demonstrate antimicrobial activity against microorganisms in both phenotypic states.

  • in vitro antimicrobial efficacy of a silver Alginate Dressing on burn wound isolates
    Journal of Wound Care, 2011
    Co-Authors: J G Thomas, W Slone, S Linton, T Okel, L Corum, Steven L Percival

    Abstract:

    Objective: To test the antimicrobial effectiveness of a silver Alginate Dressing on opportunistic pathogens, namely meticillin-sensitive Staphylococcus aureus (MSSA) and meticillin-resistant Staphylococcus aureus (MRSA), Klebsiella spp., Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Escherichia coli, Enterobacter sakazakii, Enterobacter cloacae, Serratia marcescens, Chryseobacterium indologenes, Proteus vulgaris and Acinetobacter baumannii. Method: In total, 40 microorganisms were isolated from patients attending three burn centres in the US and evaluated for their susceptibility to a silver Alginate wound Dressing, employing a corrected zone of inhibition assay, conducted on Mueller Hinton agar (MHA). Results: The sizes of the corrected zones of inhibition varied between and within genera. For example, all Acinetobacter baumannii strains were found to be sensitive to ionic silver at PH 7, with a mean of 2.8mm, compared with 3.5mm at PH 5.5. The silver Alginate Dressing also demonst…