Alkylresorcinol - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Alkylresorcinol

The Experts below are selected from a list of 1848 Experts worldwide ranked by ideXlab platform

Alkylresorcinol – Free Register to Access Experts & Abstracts

Arkadiusz Kozubek – One of the best experts on this subject based on the ideXlab platform.

  • Various effects of the photosystem II–inhibiting herbicides on 5-n-Alkylresorcinol accumulation in rye seedlings.
    Pesticide Biochemistry and Physiology, 2014
    Co-Authors: Elżbieta G. Magnucka, Stanislaw J. Pietr, Arkadiusz Kozubek, Robert Zarnowski

    Abstract:

    Abstract The effect of three PSII-inhibiting herbicides, lenacil, linuron, and pyrazon, on the accumulation of 5- n –Alkylresorcinols in rye seedlings ( Secale cereale L.) grown under various light and thermal conditions was studied. All used chemicals increased resorcinolic lipid content in both green and etiolated plants grown at 29 °C. At 22 °C pyrazon and lenacil decreased the content of Alkylresorcinols in plants kept in the darkness and increased their amount in the light-grown seedlings. In turn, level of resorcinolic lipids was decreased by linuron in both etiolated and green plants. At the lowest tested temperature lenacil enhanced production of Alkylresorcinols only in etiolated rye seedlings, whereas the light-independent stimulatory action of pyrazon on Alkylresorcinol accumulation in rye grown at 15 °C was observed. Additionally, only the latter did not exert a negative effect on rye seedling growth under any of tested conditions. Compared with respective controls, the herbicides used also markedly modified the qualitative pattern of resorcinolic homologs. Interestingly, the observed changes generally favored the enhanced antifungal activity of these compounds. Our study provides novel information on the influence of PSII inhibitors on Alkylresorcinol metabolism in rye seedlings. The unquestionable achievement of this work is the observation that low dose of pyrazon mainly stimulated both growth and Alkylresorcinol synthesis in rye seedlings, a non-target plant. Moreover, our experimental work showed unambiguously that the observed pyrazon-driven accumulation and homolog pattern modification of Alkylresorcinols dramatically improved the resistance of winter rye to infections caused by Rhizoctonia cerealis .

  • Alkylresorcinols in rye (Secale cereale L.) grains. V. Chromatographic analysis of 5-n-alk(en)ylresorcinols during their preparation
    Acta Societatis Botanicorum Poloniae, 2014
    Co-Authors: Arkadiusz Kozubek, Franciszek Tłuścik, Wanda Mejbaum-katzenellenebogen

    Abstract:

    Analysis of 5-n-alk(en)ylresorcinols during the coarse of their preparation from rye grains showed that changes of the composition of 5-n-Alkylresorcinol homologues in acetone oil; raw preparation, and Alkylresorcinol fraiction obtained after chromatography on silica gel, were insignificant. About 20% of alk(en)-ylresorcinals were washed out from acetone oil with pentane. Over 50% of alk(en)ylresorcinols eluted by pentane constituted homologues with unsaturated hydrocarbon chains (5-n-alkenylresorcinols). Preparation obtained after chromatagraphic separation constituted a mixtureof 5-n-alk(en)ylresorcinols width saturated hydrocarbon chains (5-n-Alkylresorcinols).

  • antioxidant activity of rye bran Alkylresorcinols and extracts from whole grain cereal products
    Food Chemistry, 2009
    Co-Authors: Mariola Korycinska, Karolina Czelna, Anna Jaromin, Arkadiusz Kozubek

    Abstract:

    Abstract The antioxidant properties of rye bran Alkylresorcinols (C15:0–C25:0) and extracts from whole-grain cereal products were evaluated using their radical-scavenging activity on DPPH and the chemiluminescence method (CL). DPPH radical reduction varied from ∼10% to ∼60% for the Alkylresorcinol homologues at concentrations from 5 to 300 μM and was not dependent on the length of the alkyl side chain of the particular homologue. Differences in the EC 50 values for the studied compounds were not statistically significant, the values varying from 157 μM for homologue C23:0 to 195 μM for homologue C15:0. Moreover, values of EC 50 for all the Alkylresorcinol homologues were significantly higher than those for Trolox and α-, δ-, and γ-tocopherols, compounds with well-defined antioxidant activity and used as positive controls. CL inhibition was evaluated for all the tested Alkylresorcinol homologues at concentrations of 5 and 10 μM and varied from ∼27% to ∼77%. Similar to the DPPH method, the slight differences in CL inhibition suggest that the length of the alkyl side chain had no major impact on their antioxidant properties. The extracts from whole-grain products were added to the DPPH and CL reaction systems and their antioxidant activities were tested and compared with the total amount of Alkylresorcinols evaluated in the extracts. DPPH radical and CL reduction for the whole-grain products varied from ∼7% to ∼43% and from ∼37% to ∼91%, respectively. A clear relationship between DPPH radical and CL reduction levels and the amount of total Alkylresorcinols was obtained for whole-grain breakfast cereals, in which the reduction level decreased in the order rye > wheat > mixed > barley. Therefore it may be considered that the antioxidant activity of Alkylresorcinols could be of potential importance to the food industry, which is continuously searching for natural antioxidants for the protection of food products during their processing and storage.

Alastair B Ross – One of the best experts on this subject based on the ideXlab platform.

  • Serum Alkylresorcinols as Biomarkers of Dietary Gluten Exposure in Celiac disease
    The FASEB Journal, 2017
    Co-Authors: Alastair B Ross, Rok Seon Choung, Eric V Marietta, Carol T. Van Dyke, Joseph A Murray

    Abstract:

    Background Therapy for celiac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established.

    Aims To evaluate the utility of Alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse.

    Methods Alkylresorcinol concentrations were compared among treated CD patients (n=34), untreated CD patients (n=36), and controls (n=33). Furthermore, 7 additional CD patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, Alkylresorcinol concentrations were compared in the serum of 5 mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of Alkylresorcinol concentrations was also evaluated.

    Results Total Alkylresorcinol concentrations were significantly lower in treated CD patients (median [IQR], 3 (2–8) nmol/L), compared to untreated CD patients (median [IQR], 32 [11–74] nmol/L; P

  • serum Alkylresorcinols as biomarkers of dietary gluten exposure in coeliac disease
    Alimentary Pharmacology & Therapeutics, 2017
    Co-Authors: Rok Seon Choung, Joseph A Murray, Eric V Marietta, Carol T Van Dyke, Alastair B Ross

    Abstract:

    Therapy for coeliac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established. Aim: To evaluate the utility of Alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse. Methods: Alkylresorcinol concentrations were compared among treated patients with coeliac disease (n = 34), untreated coeliac disease patients (n = 36) and controls (n = 33). Furthermore, seven additional coeliac disease patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, Alkylresorcinol concentrations were compared in the serum of five mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of Alkylresorcinol concentrations was also evaluated. Results: Total Alkylresorcinol concentrations were significantly lower in treated with coeliac disease [median (IQR), 3 (2–8) nmol/L], compared to untreated patients [median (IQR), 32 (11–74) nmol/L; P < 0.0001] or healthy controls [median (IQR), 54 (23–112) nmol/L; P < 0.0001]. Moreover, Alkylresorcinol concentrations in coeliac disease patients significantly decreased after introduction of a GFD (median, 34 nmol/L at diagnosis vs. 5 nmol/L after GFD, P = 0.02). In the mice, median (IQR) total Alkylresorcinol concentrations in serum samples of mice fed lifelong with a gluten-free chow was 1.8 (1.6–2.3) nmol/L, which was further significantly increased to 16 (11–22) nmol/L after 8 days of feeding with the gluten-free chow that had gluten added to it. (P = 0.008). Conclusion: Serum Alkylresorcinol concentrations could be a useful marker for dietary gluten in coeliac disease.

  • serum Alkylresorcinols as biomarkers of dietary gluten exposure in celiac disease
    The FASEB Journal, 2017
    Co-Authors: Alastair B Ross, Rok Seon Choung, Eric V Marietta, Carol T Van Dyke, Joseph A Murray

    Abstract:

    Background Therapy for celiac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established.

    Aims To evaluate the utility of Alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse.

    Methods Alkylresorcinol concentrations were compared among treated CD patients (n=34), untreated CD patients (n=36), and controls (n=33). Furthermore, 7 additional CD patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, Alkylresorcinol concentrations were compared in the serum of 5 mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of Alkylresorcinol concentrations was also evaluated.

    Results Total Alkylresorcinol concentrations were significantly lower in treated CD patients (median [IQR], 3 (2–8) nmol/L), compared to untreated CD patients (median [IQR], 32 [11–74] nmol/L; P<.0001) or healthy controls (median [IQR], 54 [23–112] nmol/L; P<.0001). Moreover, Alkylresorcinol concentrations in CD patients significantly decreased after introduction of a GFD (median, 34 nmol/L at diagnosis vs. 5 nmol.L after GFD, p=0.02). In the mice, median (IQR) total Alkylresorcinol concentrations in serum samples of mice fed lifelong with a gluten-free chow was 1.8 (1.6–2.3) nmol/L, which was further significantly increased to 16 (11–22) nmol/L after 8 days of feeding with the gluten free chow that had gluten added to it. (p=.008).

    Conclusion Serum Alkylresorcinol concentrations could be a useful marker for dietary gluten in CD.

Herman Adlercreutz – One of the best experts on this subject based on the ideXlab platform.

  • Plasma Alkylresorcinol Metabolites as Biomarkers for Whole-Grain Intake and Their Association with Prostate Cancer: A Swedish Nested Case–Control Study
    Cancer Epidemiology Biomarkers & Prevention, 2013
    Co-Authors: Isabel Drake, Matti J. Tikkanen, Herman Adlercreutz, Emily Sonestedt, Bo Gullberg, Anders Bjartell, Håkan Olsson, Elisabet Wirfält, Peter Wallström

    Abstract:

    Background:Observational studies have mostly found no association between self-reported whole-grain (WG) intake and prostate cancer (PCa). Plasma Alkylresorcinol metabolites have been suggested as biomarkers for WG intake in free-living populations. Methods:We investigated the major dietary and lifestyle determinants of plasma Alkylresorcinol metabolites in a nested case-control study (1,016 cases and 1817 controls) in the Malmo Diet and Cancer Study. Multivariate adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated to assess the association between plasma Alkylresorcinol metabolites and PCa using logistic regression. Results:WG intake, waist circumference, educational level and smoking status were the main determinants of Alkylresorcinol metabolites. We observed significant correlations between Alkylresorcinol metabolites and WG (r=0.31) and fiber (r=0.27) intake. Metabolite concentration was positively associated with PCa risk (P overall effect = 0.0004) but the association was not linear (P = 0.04). The lowest risk was seen among men with moderate plasma concentrations. The OR for high compared to moderate plasma Alkylresorcinol metabolites was 1.41 (95% CI: 1.10-1.80) for PCa. Conclusions:Results suggest that plasma Alkylresorcinol metabolites are mainly determined by WG intake in this nested-case control study of Swedish men. The increased risk of PCa seen among men with high plasma Alkylresorcinol metabolites requires further study, but residual confounding, detection bias or competing risk of non-PCa related deaths are plausible explanations that could not be ruled out. Impact:We found no evidence of a protective effect of WG on incident PCa. Further validation of Alkylresorcinol metabolites as a biomarker for WG intake is needed.

  • Pharmacokinetics of Alkylresorcinol metabolites in human urine.
    British Journal of Nutrition, 2011
    Co-Authors: Päivi P. Söderholm, Matti J. Tikkanen, Johan Lundin, Anja Koskela, Herman Adlercreutz

    Abstract:

    : Wholegrain cereals are reported to promote beneficial health effects. Wholegrain wheat and rye are almost exclusive sources of Alkylresorcinols, and intact Alkylresorcinols together with their plasma and urinary metabolites, 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), have been proposed as biomarkers of the intake of these foods in humans. The pharmacokinetics of Alkylresorcinols and their metabolites in plasma have been determined but not that of the urinary metabolites. We aimed to characterise the urinary pharmacokinetics of Alkylresorcinol metabolites in humans to evaluate their potential as biomarkers of wholegrain wheat and rye. A group of fifteen volunteers followed a low-Alkylresorcinol diet for 2 d before ingesting a single dose of rye bread, containing 100 mg Alkylresorcinols. Urine was collected between baseline (0 h) and 25 h after administration. Thereafter Alkylresorcinol metabolites were quantified by HPLC with coulometric electrode array detection. Maximum excretion rates were observed at 5-6 h for both metabolites, DHPPA being predominant over DHBA and also possessing a greater area under the curve0-25 h. Total urinary recovery between 0 and 25 h yielded 43 % of ingested Alkylresorcinols, and at 25 h significant amounts of metabolites were still retained in the body, suggesting that even a spot urine sample may be sufficient to indicate whether or not wholegrain wheat or rye is a daily dietary component. These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data.

  • Plasma pharmacokinetics of Alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake
    The American journal of clinical nutrition, 2009
    Co-Authors: Päivi P. Söderholm, Matti J. Tikkanen, Johan Lundin, Anja Koskela, Herman Adlercreutz

    Abstract:

    Background: Alkylresorcinols are phenolic compounds that are present almost exclusively in rye and wheat fiber. Alkylresorcinols are absorbed and thereafter metabolized to 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), which have been detected in human urine and plasma. Objective: The objective was to determine the plasma pharmacokinetics of DHBA and DHPPA in human subjects to estimate whether they show potential as biomarkers for whole-grain rye and/or wheat intake. Design: Fifteen human volunteers followed a low-Alkylresorcinol diet for 2 d before ingesting a single dose of high-fiber rye bread containing 45 mg Alkylresorcinols. Plasma samples were collected for 25 h, and the Alkylresorcinol metabolites were quantified by HPLC with coulometric electrode array detection. Results: Maximum concentrations were reached at ’6 h for both metabolites, although interindividual variation was found. The halflife was significantly (P , 0.0002) longer for DHPPA (16.3 h) than for DHBA (10.1 h). No significant differences were discovered between women and men in the half-life of each metabolite, which, from a pharmacokinetic point of view, is the most important parameter. The area under the curve differed significantly between DHBA and DHPPA (P , 0.0001) and between women and men (P = 0.03 for DHBA and P = 0.01 for DHPPA). However, when corrected for body weight, the difference between sexes was no longer significant. Conclusions: Our results suggest that DHBA and DHPPA are both good candidate biomarkers for whole-grain rye and/or wheat intake; however, DHPPA is the better indicator because of its longer half-life. This could provide a practical tool when investigating the association between diet and diseases. Am J Clin Nutr doi: 10.3945/ajcn. 2009.28290.