The Experts below are selected from a list of 252 Experts worldwide ranked by ideXlab platform
Geir Bjørklund - One of the best experts on this subject based on the ideXlab platform.
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The sesquiterpene α-bisabolol in the adipocyte−cancer desmoplastic crosstalk: does it have an action on epithelial−mesenchymal transition mechanisms?
International Journal of Clinical Oncology, 2017Co-Authors: Salvatore Chirumbolo, Geir BjørklundAbstract:Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial−mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
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The sesquiterpene α-bisabolol in the adipocyte−cancer desmoplastic crosstalk: does it have an action on epithelial−mesenchymal transition mechanisms?
International Journal of Clinical Oncology, 2016Co-Authors: Salvatore Chirumbolo, Geir BjørklundAbstract:Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial−mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
Salvatore Chirumbolo - One of the best experts on this subject based on the ideXlab platform.
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The sesquiterpene α-bisabolol in the adipocyte−cancer desmoplastic crosstalk: does it have an action on epithelial−mesenchymal transition mechanisms?
International Journal of Clinical Oncology, 2017Co-Authors: Salvatore Chirumbolo, Geir BjørklundAbstract:Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial−mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
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The sesquiterpene α-bisabolol in the adipocyte−cancer desmoplastic crosstalk: does it have an action on epithelial−mesenchymal transition mechanisms?
International Journal of Clinical Oncology, 2016Co-Authors: Salvatore Chirumbolo, Geir BjørklundAbstract:Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial−mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma. This review addresses the issue on the basis of the most recent reported literature in the field.
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Alpha-bisabolol, not a matter for cancer therapy. Commentary: “Research on the immunosuppressive activity of ingredients contained in sunscreens”
Frontiers in Pharmacology, 2015Co-Authors: Salvatore ChirumboloAbstract:A recent paper showed that bisabolol contained in cosmetics drastically dampened peripheral blood lymphocyte proliferation induced by phytohemoagglutinin (PHA) and enhanced the production of tumor growth factor-beta 1 (TGF-β1) on NCTC 2544 keratinocytes, although it did not change the activity of monocytes and dendritic cells (Frikeche et al., 2015). The authors showed that some organic molecules present in sunscreens impaired DC maturation, or inhibited lymphocyte proliferation as well as increased of TGF-β1 in the cell environment. Alpha-bisabolol [6-methyl-2-(4-methylcycloex-3-en-1-yl)hept-5-en-2-ol] is a sesquiterpene alcohol, present in different isomers (Figure (Figure1)1) that has been described since many years as a promising anti-tumoral compound (da Silva et al., 2010; Seki et al., 2011) It reduces mammary tumor mass in mice and promotes the natural killer (NK) cells response (Costarelli et al., 2010). Alpha-bisabolol is present in Matricaria chamomilla L. essential oils and a potent pro-apoptotic molecule (Cavalieri et al., 2011). The myth of treating cancer with chamomile extracts would find unexpected support, as this plant contains flavonoids, as apigenin-7-O-glucoside and other phytochemicals, which act as anti-proliferative and pro-apoptotic molecules, (Srivastava and Gupta, 2007). Frikeche et al. showed that bisabolol behaves as a potent immuno-suppressant, an evidence that should raise fundamental issues about the role of plant-derived molecules on the tumor microenvironment, besides their direct effect on malignant cells (Frikeche et al., 2015). Figure 1 Alpha-bisabolol different isomers and farnesol, a possible catabolyte. Darra et al., reported that the anti-neoplastic action exerted by α-bisabolol, derives fundamentally by its ability in inducing mitochondria-mediated apoptosis in cancer cells (Darra et al., 2007, 2008; Cavalieri et al., 2009). In particular, α-bisabolol is preferentially incorporated into malignant cells through lipid rafts and directly interacts with Bid protein (Darra et al., 2008). This mechanism, which may account for the reported anti-tumoral effect, has never been assessed in vivo and particularly Darra's in vitro evidence did not include the role of immune cells in the tumor microenvironment during α-bisabolol treatment. Promising results showed that α-bisabolol is active against primary acute leukemia cells, in synergism with tyrosine inhibitors, suggesting that its main target is the hematopoietic cell (Cavalieri et al., 2011; Bonifacio et al., 2012). Frikeche et al. would suggest that the immunosuppressive action performed by α-bisabolol on lymphocytes may have dramatic consequences on tumor development (Frikeche et al., 2015). Yet, some concern is about α-bisabolol and lipid rafts. Actually, gamma-delta phenotype T cells (TCR-γδ cells), increase lipid rafts when activated by involving membrane cholesterol (Kabouridis et al., 2000; Mahammad et al., 2010; Cheng et al., 2013). Due to its preferential entry through lipid rafts, α-bisabolol may induce apoptosis in activated T cells, while simultaneously switches off lymphocyte activation (Frikeche et al., 2015). Alpha-bisabolol tropism for immune cells may have fundamental effects on tumor immune microenvironment, probably by impairing T-cell activation and lymphocyte switching and promoting cancer editing, causing evasion from inflammation and generating immune tolerance (Vinay et al., 2015). Immune suppression in the tumor microenvironment is fundamentally mediated by CD4+CD25+FoxP3+ regulatory T cells (Tregs), as the major mechanism of tumor immune escape, a crucial hurdle for tumor immunotherapy (Jacobs et al., 2012). Bisabolol enhances TGF-β in in vitro cultured keratinocytes (Frikeche et al., 2015) and the cytokine is necessary for the progression of tumors such as hepatocellular carcinoma, acting by inducing Tregs polarization (Shen et al., 2015). In melanoma models, cancer cells induce immune escape and suppression by up-regulating CD4+CD25+FoxP3+ regulatory T cells, through TGF-β expression (Baumgartner et al., 2007). If α-bisabolol is able to increase TGF-β release, its chemopreventive potential might appear therefore quite controversial. At least apparently, α-bisabolol might induce immune suppression and tolerance by increasing the release of cytokines promoting cancer editing. Furthermore, α-bisabolol does not affect the ability of dendritic cells (DCs) to produce IL-12p70 (Johansson et al., 2011; Frikeche et al., 2015). DCs produce IL-12p70 after engulfment of apoptotic lymphocytes and this mechanism should induce immune tolerance in the absence of lymphocyte activation (Johansson et al., 2011). Furthermore, TCR-γδ cells are able to recognize several unknown antigens on tumor cells. Some metabolites of the mevalonate pathway, among which is farnesol, a possible catabolyte of α-bisabolol (Dewick, 2002), should act as tumor ligands, which can activate TCR-γδ cells (Gober et al., 2003). The role of TCR-γδ cells in tumors should appear encouraging (Hannani et al., 2012; Marquez-Medina et al., 2012), but these cells have also an immunosuppressive role when induced by TGF-β1 (Gu et al., 2014). Critical points to be addressed regards therefore the role of this sesquiterpene alcohol on immune regulation and hence on the immune competence in fighting cancer. This closely depends on the immune context where malignant cells are developing, besides to the bioavailability of α-bisabolol in situ. Despite its promising activity as an anti-tumor molecule, α-bisabolol does not possess so different features respect to the widest family of plant-derived anti-inflammatory and chemopreventive polyphenols (Chirumbolo, 2010). The ability to induce cell apoptosis is shared with several other plant derived compounds, such as quercetin (Primikyri et al., 2014), genistein (Choi et al., 2007), apigenin (Papachristou et al., 2013), catechins (Yoon et al., 2014), resveratrol (Wang et al., 2011) and many others, for which these few examples are reported. The pro-apoptosis action should be interpreted at the light of the stress response mechanism activated by cells, a property shared by any plant-derived polyphenol, representing a general hallmark of these molecules (Fresco et al., 2010). Tumor cells have critically different patterns of stress response and they rapidly activate apoptosis pathway when stimulated by damage or stress signals, whose burden is particularly difficult to address. In this context a major role is played by endoplasmic reticulum stress (ER stress) and the unfolding protein response (UPR), besides to mitochondria (Maurel et al., 2015). While these mechanisms shed a light on the cellular impact of plant phytochemicals, their role on the cancer immune micro-environment is yet far to be fully understood. In vitro research usually neglected this issue, as most of investigations based on cell lines obviously never consider the immune microenvironment existing in the in vivo situation. In this perspective, the recent article by Frikeche et al., raises some criticism about the actual role of α-bisabolol as a real, promising chemopreventive molecule. Alpha bisabolol might affect mitochondrial permeability transition also in non cancer cells (Leanza et al., 2013, 2014) and recent reports showed a massive death of endothelial cells by apoptosis induced from 5.0 μM α-bisabolol (Magnelli et al., 2010), a dose about 10-times lower than the one used to BCR-ABL cell viability in primary acute leukemia (Bonifacio et al., 2012). As with other phytochemicals, the role of α-bisabolol on cancer therapy should be expanded in future debates, while any further proposals to investigate this organic compound on in vitro cancer lines, such as MiaPaCa, should be considered with caution.
A. T. Henriques - One of the best experts on this subject based on the ideXlab platform.
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The ability of Bipolaris sorokiniana to modify geraniol and (−)-alpha-bisabolol as exogenous substrates
Applied Microbiology and Biotechnology, 2003Co-Authors: R. P. Limberger, L. Ferreira, T. Castilhos, A. M. Aleixo, R. Z. Petersen, J. C. Germani, J. A. Zuanazzi, A. G. Fett-neto, A. T. HenriquesAbstract:The biocatalytic potential of Bipolaris sorokiniana was investigated in its ability to modify the monoterpene geraniol and the sesquiterpene alpha-bisabolol as exogenous substrates, using phosphate buffer as reaction medium. The cultures showed a promising oxidative profile, with conversion of geraniol to 6-methyl-5-hepten-2-one (74.9% yield) in a 5-day incubation and alpha-bisabolol to bisabolol oxide B (84.2% yield), in a 7-day incubation.
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The ability of Bipolaris sorokiniana to modify geraniol and (-)-alpha-bisabolol as exogenous substrates.
Applied microbiology and biotechnology, 2003Co-Authors: R. P. Limberger, L. Ferreira, T. Castilhos, A. M. Aleixo, R. Z. Petersen, J. C. Germani, J. A. Zuanazzi, A. G. Fett-neto, A. T. HenriquesAbstract:The biocatalytic potential of Bipolaris sorokiniana was investigated in its ability to modify the monoterpene geraniol and the sesquiterpene alpha-bisabolol as exogenous substrates, using phosphate buffer as reaction medium. The cultures showed a promising oxidative profile, with conversion of geraniol to 6-methyl-5-hepten-2-one (74.9% yield) in a 5-day incubation and alpha-bisabolol to bisabolol oxide B (84.2% yield), in a 7-day incubation.
Luigi Perbellini - One of the best experts on this subject based on the ideXlab platform.
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In vivo effect of alpha-bisabolol, a nontoxic sesquiterpene alcohol, on the induction of spontaneous mammary tumors in HER-2/neu transgenic mice.
Oncology Research, 2009Co-Authors: Laura Costarelli, Hisanori Suzuki, Marco Malavolta, Robertina Giacconi, Catia Cipriano, Nazzarena Gasparini, Silvia Tesei, Sara Pierpaoli, Fiorenza Orlando, Luigi PerbelliniAbstract:Abstract Breast cancer represents the most commonly diagnosed invasive malignancy in pre- and postmenopausal women in both developed and underdeveloped countries. Taking into account that treatment options, including surgery, have not been able to deal with the growing incidence of breast malignancy, it is required to develop mechanism-based novel agents for its prevention. Wide interest in some natural compounds as antiinflammatory agents and as alternative to the traditional medicines is increasing because they do not provoke any adverse effects and are effective in multiple organs, alpha-Bisabolol (BISA), a small oily sesquiterpene alcohol, was reported as chemopreventive agent in induced rat mammary carcinogenesis. The aim of the present study is to investigate the role played by two doses of BISA (via intramammary infusion) on the induction and development of mammary tumor in HER-2/neu transgenic mice as well as the BISA effect after tumor surgical resection. The main data show that (a) optimal dosage of BISA is 10 mg/mouse rather than 3.6 mg/mouse with no adverse effects (e.g., alopecia); (b) the number of the palpable tumor masses decreases in mice treated with 10 mg/mouse of BISA; (c) mice after surgical resection of the primary tumor and treatment with BISA (10 mg) are free from tumor for more weeks, after the surgical treatment; (d) using array analysis, some genes implicated in carcinogenesis mechanisms (NF-kappaBia, Map2k, Mapkl4, and HER2/ neu), angiogenesis process (Fgf), and inhibition of apoptosis (Birc5) are differently regulated after BISA treatment, with a downregulation of the HER2/neu as well as of Fgf and Birc5 genes; (e) the NK cell cytotoxicity increases in tumor-treated mice, especially after the removal of the first tumor mass. Such effectiveness could be important to achieve goals for a possible combination of BISA to conventional therapies in breast cancer and to tumor surgical removal (adjuvant therapy), as suggested for other sesquiterpene analogs.
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Alpha-bisabolol: unexpected plant-derived weapon in the struggle against tumour survival?
Italian Journal of Biochemistry, 2007Co-Authors: Elena Darra, Giorgio Lenaz, Elisabetta Cavalieri, Romana Fato, Sofia Mariotto, Christian Bergamini, Carcereri De Prati A, Luigi Perbellini, Serena Leoni, Hisanori SuzukiAbstract:Despite enormous scientific and economic effort tumour still is one of the most terrible pathologies among human population all over the world. Products derived from the plant kingdom have often offered an opportunity to counteract or alleviate this illness. Here, we summarize the short story of the study of an extraordinary effect of one plant compound towards transformed cells derived from highly malignant tumours. Alpha-bisabolol, a sesquiterpene widely present in plants, selectively kills transformed cells by apoptosis without affecting the viability of normal cells. One of its intracellular targets seems to be situated on mitochondria and is possibly identified as the permeability transition pore, as judged from rapid mitochondrial membrane potential dissipation induced by alpha-bisabolol and the failure to kill cells in the presence of cyclosporine A. Preferential adsorption of alpha-bisabolol into lipid rafts, rich in tumour cells, may explain the selective action of this compounds towards tumour cells. Furthermore, Surface Plasmon Resonance analysis indicates that alpha-bisabolol directly interacts with Bid protein, a member of the Bcl2 family deeply involved in apoptosis, suggesting a possibility that Bid, or similar protein(s), may be involved in a putative intracellular transport system of alpha-bisabolol from plasma membrane to mitochondria. Experiments with animals indicate that alpha-bisabolol is not toxic and is accumulated, through blood flow, in every tissues examined. Further animal studies to test its effect are currently under way.
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Determination of alpha-bisabolol in human blood by micro-HPLC-ion trap MS and head space-GC-MS methods.
Journal of chromatography. B Analytical technologies in the biomedical and life sciences, 2004Co-Authors: Luigi Perbellini, Sofia Mariotto, Rossella Gottardo, Alessia Caprini, Federica Bortolotti, Franco TagliaroAbstract:Alpha-bisabolol is a compound present in some essential oils, widely distributed in several plants, including camomile. Two different methods for analysing an essential oil, such as alpha-bisabolol in human blood are reported: the first uses micro-liquid chromatography-electrospray ionisation-mass spectrometry (muHPLC-ESI-MS), whereas the second is based on "head space" injection coupled to gas chromatography-mass spectrometry (HS-GC-MS). For LC-ESI-MS, human blood samples, spiked with alpha-bisabolol, were extracted with hexane and evaporated to dryness under air stream. The residue was then reconstituted with methanol and injected into a C18 column, connected to an ion trap mass spectrometer equipped with an ESI source. Spectra were recorded in the positive ion, selected ion monitoring mode. The detection limit of alpha-bisabolol in blood was 0.125 micromol/l. The preparation of samples for the analysis in HS-GC-MS was limited to blood dilution with water (0.5 ml blood + 1 ml water). Head space vials were heated at 125 degrees C for 1 h before automatic injection. The HS-GC-MS detection limit (0.13 micromol/l) was similar to that achieved with the muHPLC-ESI-MS method. Successful tests were performed to verify if alpha-bisabolol could be directly measured by the HS-GC-MS method in different biological samples (blood, urine, faeces, homogenate tissues) from rats treated with the camomile essential oil.
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Determination of alpha-bisabolol in human blood by micro-HPLC-ion trap-MS and head space-GC-MS methods
Journal of Chromatography B, 2004Co-Authors: Luigi Perbellini, Sofia Mariotto, Rossella Gottardo, Alessia Caprini, Federica Bortolotti, Franco TagliaroAbstract:Abstract Alpha-bisabolol is a compound present in some essential oils, widely distributed in several plants, including camomile. Two different methods for analysing an essential oil, such as alpha-bisabolol in human blood are reported: the first uses micro-liquid chromatography–electrospray ionisation-mass spectrometry (μHPLC–ESI-MS), whereas the second is based on “head space” injection coupled to gas chromatography–mass spectrometry (HS-GC–MS). For LC–ESI-MS, human blood samples, spiked with alpha-bisabolol, were extracted with hexane and evaporated to dryness under air stream. The residue was then reconstituted with methanol and injected into a C18 column, connected to an ion trap mass spectrometer equipped with an ESI source. Spectra were recorded in the positive ion, selected ion monitoring mode. The detection limit of alpha-bisabolol in blood was 0.125 μmol/l. The preparation of samples for the analysis in HS-GC–MS was limited to blood dilution with water (0.5 ml blood + 1 ml water). Head space vials were heated at 125 °C for 1 h before automatic injection. The HS-GC–MS detection limit (0.13 μmol/l) was similar to that achieved with the μHPLC–ESI-MS method. Successful tests were performed to verify if alpha-bisabolol could be directly measured by the HS-GC–MS method in different biological samples (blood, urine, faeces, homogenate tissues) from rats treated with the camomile essential oil.
José Roberto Soares Scolforo - One of the best experts on this subject based on the ideXlab platform.
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Influence of altitude, age and diameter on yield and alpha-bisabolol... INFLUENCE OF ALTITUDE, AGE AND DIAMETER ON YIELD AND ALPHA-BISABOLOL CONTENT OF CANDEIA TREES (Eremanthus erythropappus )
2020Co-Authors: Cláudia Lopes, Selvati De Oliveira Mori, José Otávio Brito, José Roberto Soares Scolforo, Edson José Vidal, Lourival Marin MendesAbstract:The heartwood of candeia tree is a source of essential oil rich in alpha-bisabolol, a substance widely used in the cosmetic and pharmaceutical industry. Bearing in mind the economic importance of alpha-bisabolol, this work aimed to evaluate the influence of tree age on the yield and content of alpha-bisabolol present in essential oil from candeia, considering two distinct reliefs and three diameter classes, in Aiuruoca region, south Minas Gerais state. The two distinct reliefs correspond respectively to one section of the stand growing at 1,000m of altitude (Area 1) and another section growing at 1,100m of altitude (Area 2). In each section, 15 trees were felled from among 3 different diameter classes. Discs were removed from the base of each tree to estimate their age by doing growth ring count. Soil samples were taken and subjected to physical and chemical analysis. The logs were reduced into chips and random samples were taken for distillation to extract essential oil. The method used was steam distillation at a pressure of 2 kgf/ cm 2 /2.5 h. The chemical analysis was performed in a gas chromatograph (GC) based on the alpha-bisabolol standard reference. The yield of essential oil from trees in Area 1 was higher than that from trees in Area 2, with the same pattern of influence for older trees. In Area 2, the alpha-bisabolol content was higher in younger trees. No differences were found between the relevant parameters in relation to diameter classes.
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Influence of altitude, age and diameter on yield and alpha-bisabolol content of candeia trees (Eremanthus erythropappus).
Cerne, 2020Co-Authors: Cláudia Lopes Selvati De Oliveira Mori, José Otávio Brito, José Roberto Soares Scolforo, Edson José Vidal, Lourival Marin MendesAbstract:The heartwood of candeia tree is a source of essential oil rich in alpha-bisabolol, a substance widely used in the cosmetic and pharmaceutical industry. Bearing in mind the economic importance of alpha-bisabolol, this work aimed to evaluate the influence of tree age on the yield and content of alpha-bisabolol present in essential oil from candeia, considering two distinct reliefs and three diameter classes, in Aiuruoca region, south Minas Gerais state. The two distinct reliefs correspond respectively to one section of the stand growing at 1,000m of altitude (Area 1) and another section growing at 1,100m of altitude (Area 2). In each section, 15 trees were felled from among 3 different diameter classes. Discs were removed from the base of each tree to estimate their age by doing growth ring count. Soil samples were taken and subjected to physical and chemical analysis. The logs were reduced into chips and random samples were taken for distillation to extract essential oil. The method used was steam distillation at a pressure of 2 kgf/ cm 2 /2.5 h. The chemical analysis was performed in a gas chromatograph (GC) based on the alpha-bisabolol standard reference. The yield of essential oil from trees in Area 1 was higher than that from trees in Area 2, with the same pattern of influence for older trees. In Area 2, the alpha-bisabolol content was higher in younger trees. No differences were found between the relevant parameters in relation to diameter classes.
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Market chain analysis of candeia timber ( Eremanthus eruthropappus ) MARKET CHAIN ANALYSIS OF CANDEIA TIMBER ( Eremanthus erythropappus )
2020Co-Authors: Antônio Donizette De Oliveira, José Roberto Soares Scolforo, Ivonise Silva Andrade Ribeiro, José Márcio De Mello, Fausto Weimar, Acerbi Junior, José Fábio CamolesiAbstract:This study characterized and analysed the market chain of candeia timber intended for oil production, and estimated the marketing margin retained by each chain participant. The study site encompassed two regions of Minas Gerais state whose distinctive mark is great abundance of native candeia forest ( Eremanthus erythropappus ). Data were collected through interviews with rural workers, candeia woodland owners and manufacturers of candeia oil and alpha-bisabolol. The marketing margin was computed as the percentage retained by each chain participant on each kilo of alpha-bisabolol sold. It was concluded that alpha- bisabolol distributors are the participants reaping the greatest marketing margin, and also that rural producers should sell candeia timber directly to oil manufacturers, with no middlemen wholesalers, in order to boost their marketing margin.
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Eremanthus eruthropappus ) MARKET CHAIN ANALYSIS OF CANDEIA TIMBER ( Eremanthus erythropappus )
2020Co-Authors: Antônio Donizette De Oliveira, José Roberto Soares Scolforo, Ivonise Silva Andrade Ribeiro, José Márcio De Mello, Fausto Weimar, Acerbi Junior, José Fábio CamolesiAbstract:This study characterized and analysed the market chain of candeia timber intended for oil production, and estimated the marketing margin retained by each chain participant. The study site encompassed two regions of Minas Gerais state whose distinctive mark is great abundance of native candeia forest ( Eremanthus erythropappus ). Data were collected through interviews with rural workers, candeia woodland owners and manufacturers of candeia oil and alpha-bisabolol. The marketing margin was computed as the percentage retained by each chain participant on each kilo of alpha-bisabolol sold. It was concluded that alpha- bisabolol distributors are the participants reaping the greatest marketing margin, and also that rural producers should sell candeia timber directly to oil manufacturers, with no middlemen wholesalers, in order to boost their marketing margin.
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Nanostructured polylactic acid/candeia essential oil mats obtained by electrospinning
Journal of Nanomaterials, 2020Co-Authors: Cláudia Lopes Selvati De Oliveira Mori, José Roberto Soares Scolforo, Nathália Almeida Dos Passos, Juliano E. Oliveira, Thiza Falqueto Altoé, Fábio Akira Mori, Luiz H. C. Mattoso, Gustavo Henrique Denzin TonoliAbstract:This work aims to evaluate the effect of inclusion of different contents of candeia (Eremanthus erythropappus) essential oil (whose alpha-bisabolol is the main terpene) on the properties of polylactic acid (PLA) nanostructured mats and their relationship with fiber morphology and structure. The interaction occurring between the PLA and the candeia essential oil was confirmed by thermal and microscopy analysis. Addition of candeia essential oil increased nanofiber diameter and decreased the glass transition and melting temperatures of the nanofibers, suggesting lower energy input for processing. Scanning electron microscopy (SEM) images provided evidence of a homogeneous structure for the nanostructured mats. X-ray diffraction did not show differences in the crystallization of the nanofibers. This ongoing research confirms the possibility of incorporation of candeia essential oil in the production of nanofibers that will be studied for multipurpose applications.
