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Joel R. Coats – One of the best experts on this subject based on the ideXlab platform.

  • Amyris and Siam-wood Essential Oils: Insect Activity of Sesquiterpenes
    ACS Symposium Series, 2009
    Co-Authors: Gretchen Elizabeth Paluch, Junwei Zhu, Lyric C. Bartholomay, Joel R. Coats

    Abstract:

    Recent investigations on the sesquiterpene-rich Amyris (Amyris balsamifera L.) and Siam-wood (Fokienia hodginsii L.) essential oils revealed significant arthropod repellency and toxicity responses. Amyris essential oil and one of its major components, elemol, were evaluated in laboratory bioassays and identified as effective mosquito repellents, specifically characterized by high levels of contact and minimal spatial repellency. Mosquito responses to catnip (Nepeta cataria L.) essential oil are characterized with high spatial activity, but lack significant contact repellency. Sampling within the static-air bioassay chamber with solid-phase microextraction provided measurements of the relative concentration and distribution of volatiles. These results supported the differences observed in repellency between essential oil treatments. Essential oil mixtures containing both spatial (catnip) and contact (Amyris) repellents were made and showed high levels of residual control via both modes of action. Siam-wood essential oil scored high in both spatial and contact efficacy against mosquitoes. Observations during this study included signs of toxicity. Two of the primary components of Siam-wood essential oil were tested for 24-hour house fly (Musca domestica L.) topical mortality. Transnerolidol and fokienol were found to possess similar insecticidal activity (topical LD 50 values ranged from 0.17-0.21 μmol/fly). Amyris essential oil was selected for additional testing with brown dog ticks (Rhipicephalus sanguineus Latreille) in a ‘barrier’ repellency assay. Individuals were observed repeatedly avoiding and moving away from surfaces treated with Amyris essential oil.

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  • Quantitative Structure−Activity Relationship of Botanical Sesquiterpenes: Spatial and Contact Repellency to the Yellow Fever Mosquito, Aedes aegypti
    Journal of agricultural and food chemistry, 2009
    Co-Authors: Gretchen Elizabeth Paluch, Lyric C. Bartholomay, Justin Adam Grodnitzky, Joel R. Coats

    Abstract:

    The plant terpenoids encompass a diversity of structures and have many functional roles in nature, including protection against pest arthropods. Previous studies in this laboratory have identified naturally occurring sesquiterpenes contained in essential oils from two plants, Amyris (Amyris balsamifera) and Siam-wood (Fokienia hodginsii), that are significantly repellent to a spectrum of arthropod pests. In efforts to further examine the biological activity of this class of compounds 12 of these plant-derived sesquiterpenes have been isolated, purified, and assayed for spatial and contact repellency against the yellow fever mosquito, Aedes aegypti. These data were used to develop quantitative structure−activity relationships that identified key properties of the sesquiterpene molecule, including electronic and structural parameters that were used to predict optimal repellent activity. There were notable similarities in the models developed for spatial repellency over five time points and for contact repel…

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  • adult repellency and larvicidal activity of five plant essential oils against mosquitoes
    Journal of The American Mosquito Control Association, 2006
    Co-Authors: Junwei Zhu, Joel R. Coats, Xiaopeng Zeng, Ting Liu, Kuen Qian, Yuhua Han, Suqin Xue, Brad J Tucker, Gretchen Schultz, Wayne A Rowley

    Abstract:

    ABSTRACT The larvicidal activity and repellency of 5 plant essential oils—thyme oil, catnip oil, Amyris oil, eucalyptus oil, and cinnamon oil—were tested against 3 mosquito species: Aedes albopictus, Ae. aegypti, and Culex pipiens pallens. Larvicidal activity of these essentials oils was evaluated in the laboratory against 4th instars of each of the 3 mosquito species, and Amyris oil demonstrated the greatest inhibitory effect with LC50 values in 24 h of 58 µg/ml (LC90  =  72 µg/ml) for Ae. aegypti, 78 µg/ml (LC90  =  130 µg/ml) for Ae. albopictus, and 77 µg/ml (LC90  =  123 µg/ml) for Cx. p. pallens. The topical repellency of these selected essential oils and deet against laboratory-reared female blood-starved Ae. albopictus was examined. Catnip oil seemed to be the most effective and provided 6-h protection at both concentrations tested (23 and 468 µg/cm2). Thyme oil had the highest effectiveness in repelling this species, but the repellency duration was only 2 h. The applications using these natural pr…

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Melody Bomgardner – One of the best experts on this subject based on the ideXlab platform.

  • Amyris makes CBG via fermentation
    C&EN Global Enterprise, 2020
    Co-Authors: Melody Bomgardner

    Abstract:

    Amyris, a producer of fermentation-derived ingredients, says it has scaled up production of cannabigerol (CBG), a cannabinoid that can be used in skin-care and cosmetic products. CBG is the precurs…

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  • Amyris exits vitamin E in deal with DSM
    C&EN Global Enterprise, 2019
    Co-Authors: Melody Bomgardner

    Abstract:

    Biobased specialty firm Amyris will wrap up a years-long vitamin E deal by selling its royalty rights to partner DSM for $57 million. Amyris will no longer be in the vitamin E business, but the two firms will continue to work together. In 2017, Amyris sold its plant in Brotas, Brazil, to DSM. Now DSM will produce Amyris’s molecules for markets including flavors and fragrances, skin care, sweeteners, and cannabinoids. That deal will be worth up to $40 million over the next 3 years, Amyris says.

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  • Newcomers head for zero-calorie sweetener market
    C&EN Global Enterprise, 2018
    Co-Authors: Melody Bomgardner

    Abstract:

    Companies based on fermentation technology are pushing into the business of making rebaudioside M, a zero-calorie sweetener extracted from the stevia plant. The Bay Area biotech firm Amyris says it will launch a Reb M-based sweetener in 2019. It intends to produce the molecule from sugarcane syrup on a large scale via fermentation with modified microbes. Plant-extracted stevia sweeteners can contain bitter-tasting molecules, Amyris says. Reb M is considered the sweetest of steviol glycosides, but it exists in only tiny quantities in the stevia plant. Amyris has linked up with ASR Group, the cane-sugar refiner that owns the Domino Sugar and C&H Sugar brands. ASR has agreed to buy 80% of Amyris’s sweetener output for three years. The company also has partnerships with Brazilian firms, including the cane-sugar producer Raizen. Shoppers in the South American country will be the first to try a tabletop sweetener version of Reb M, made

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Brent R. Copp – One of the best experts on this subject based on the ideXlab platform.

  • Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline
    Tetrahedron Letters, 2005
    Co-Authors: Anna C. Giddens, Helena I. Boshoff, Scott G. Franzblau, Clifton E. Barry, Brent R. Copp

    Abstract:

    Abstract Texaline, an antimycobacterial oxazole-containing alkaloid previously isolated from Amyris texana and A. elemifera, and related compounds have been synthesized in order to explore aspects of the structure–antituberculosis activity relationship. While texaline was found to be inactive in our assays, simpler diaryloxazoles were more active whilst also exhibiting modest toxic selectivity, leading to their identification as potential lead compounds.

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