The Experts below are selected from a list of 1204944 Experts worldwide ranked by ideXlab platform
Guido Groeseneken - One of the best experts on this subject based on the ideXlab platform.
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Modeling the single-Gate, double-Gate, And Gate-all-around tunnel field-effect transistor
Journal of Applied Physics, 2010Co-Authors: Anne S. Verhulst, Bart Sorée, Daniele Leonelli, William G. Vandenberghe, Guido GroesenekenAbstract:Tunnel field-effect transistors (TFETs) are potential successors of metal-oxide-semiconductor FETs because scaling the supply voltage below 1 V is possible due to the absence of a subthreshold-swing limit of 60 mV/decade. The modeling of the TFET performance, however, is still preliminary. We have developed models allowing a direct comparison between the single-Gate, double-Gate, And Gate-all-around configuration at high drain voltage, when the drain-voltage dependence is negligible, And we provide improved insight in the TFET physics. The dependence of the tunnel current on device parameters is analyzed, in particular, the scaling with Gate-dielectric thickness, channel thickness, And dielectric constants of Gate dielectric And channel material. We show that scaling the Gate-dielectric thickness improves the TFET performance more than scaling the channel thickness And that improvements are often overestimated. There is qualitative agreement between our model And our experimental data.
Martin Fussenegger - One of the best experts on this subject based on the ideXlab platform.
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implantable synthetic cytokine converter cells with And Gate logic treat experimental psoriasis
Science Translational Medicine, 2015Co-Authors: Lina Schukur, Barbara Geering, Ghislaine Charpinel Hamri, Martin FusseneggerAbstract:Psoriasis is a chronic inflammatory skin disease characterized by a relapsing-remitting disease course And correlated with increased expression of proinflammatory cytokines, such as tumor necrosis factor (TNF) And interleukin 22 (IL22). Psoriasis is hard to treat because of the unpredictable And asymptomatic flare-up, which limits hAndling of skin lesions to symptomatic treatment. Synthetic biology-based gene circuits are uniquely suited for the treatment of diseases with complex dynamics, such as psoriasis, because they can autonomously couple the detection of disease biomarkers with the production of therapeutic proteins. We designed a mammalian cell synthetic cytokine converter that quantifies psoriasis-associated TNF And IL22 levels using serially linked receptor-based synthetic signaling cascades, processes the levels of these proinflammatory cytokines with And-Gate logic, And triggers the corresponding expression of therapeutic levels of the anti-inflammatory/psoriatic cytokines IL4 And IL10, which have been shown to be immunomodulatory in patients. Implants of microencapsulated cytokine converter transgenic designer cells were insensitive to simulated bacterial And viral infections as well as psoriatic-unrelated inflammation. The designer cells specifically prevented the onset of psoriatic flares, stopped acute psoriasis, improved psoriatic skin lesions And restored normal skin-tissue morphology in mice. The antipsoriatic designer cells were equally responsive to blood samples from psoriasis patients, suggesting that the synthetic cytokine converter captures the clinically relevant cytokine range. Implanted designer cells that dynamically interface with the patient's metabolism by detecting specific disease metabolites or biomarkers, processing their blood levels with synthetic circuits in real time, And coordinating immediate production And systemic delivery of protein therapeutics may advance personalized gene- And cell-based therapies.
Anne S. Verhulst - One of the best experts on this subject based on the ideXlab platform.
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Modeling the single-Gate, double-Gate, And Gate-all-around tunnel field-effect transistor
Journal of Applied Physics, 2010Co-Authors: Anne S. Verhulst, Bart Sorée, Daniele Leonelli, William G. Vandenberghe, Guido GroesenekenAbstract:Tunnel field-effect transistors (TFETs) are potential successors of metal-oxide-semiconductor FETs because scaling the supply voltage below 1 V is possible due to the absence of a subthreshold-swing limit of 60 mV/decade. The modeling of the TFET performance, however, is still preliminary. We have developed models allowing a direct comparison between the single-Gate, double-Gate, And Gate-all-around configuration at high drain voltage, when the drain-voltage dependence is negligible, And we provide improved insight in the TFET physics. The dependence of the tunnel current on device parameters is analyzed, in particular, the scaling with Gate-dielectric thickness, channel thickness, And dielectric constants of Gate dielectric And channel material. We show that scaling the Gate-dielectric thickness improves the TFET performance more than scaling the channel thickness And that improvements are often overestimated. There is qualitative agreement between our model And our experimental data.
Hyun Kwang Jeong - One of the best experts on this subject based on the ideXlab platform.
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analytical models for drain current And Gate capacitance in amorphous ingazno thin film transistors with effective carrier density
IEEE Electron Device Letters, 2011Co-Authors: Dongsik Kong, Hyun Kwang JeongAbstract:Analytical drain current And Gate capacitance models for amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) over sub- And above-threshold regions are proposed by adopting an effective carrier density for the dominant carrier density. The effective carrier density fully considers the free carriers in the conduction bAnd, the localized subgap deep states, And tail states over the bAndgap for analytical I-V And C-V characteristics. The proposed analytical models are verified by comparing the measured I-V And C-V characteristics. The proposed models make a time-efficient simulation of a-IGZO TFT-based circuits possible due to their analytical form.
Weidong Wang - One of the best experts on this subject based on the ideXlab platform.
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p53 activated by And Gate genetic circuit under radiation And hypoxia for targeted cancer gene therapy
Cancer science, 2015Co-Authors: Miao Ding, Xingyong Wang, Weidong WangAbstract:Radio-activated gene therapy has been developed as a novel therapeutic strategy against cancer; however, expression of therapeutic gene in peritumoral tissues will result in unacceptable toxicity to normal cells. To restrict gene expression in targeted tumor mass, we used hypoxia And radiation tolerance features of tumor cells to develop a synthetic And Gate genetic circuit through connecting radiation sensitivity promoter cArG6, heat shock response elements SNF1, HSF1 And HSE4 with retroviral vector plxsn. Their construction And dynamic activity process were identified through downstream enhanced green fluorescent protein And wtp53 expression in non-small cell lung cancer A549 cells And in a nude mice model. The result showed that And Gate genetic circuit could be activated by lower required radiation dose (6 Gy) And after activated, And Gate could induce significant apoptosis effects And growth inhibition of cancer cells in vitro And in vivo. The radiation- And hypoxia-activated And Gate genetic circuit, which could lead to more powerful target tumoricidal activity represented a promising strategy for both targeted And effective gene therapy of human lung adenocarcinoma And low dose activation character of the And Gate genetic circuit implied that this model could be further exploited to decrease side-effects of clinical radiation therapy.
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The radiation dose-regulated And Gate genetic circuit, a novel targeted And real-time monitoring strategy for cancer gene therapy.
Cancer gene therapy, 2012Co-Authors: Miao Ding, E Zhang, Xin Wang, Weidong WangAbstract:The radiation dose-regulated And Gate genetic circuit, a novel targeted And real-time monitoring strategy for cancer gene therapy
