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Itamar Willner – One of the best experts on this subject based on the ideXlab platform.

  • nucleic acid driven dna machineries synthesizing mg2 dependent dnazymes an interplay between dna sensing And Logic Gate operations
    Chemistry: A European Journal, 2012
    Co-Authors: Ron Orbach, Lena Mostinski, Fuan Wang, Itamar Willner
    Abstract:

    Polymerase/nicking enzymes And nucleic-acid scaffolds are implemented as DNA machines for the development of amplified DNA-detection schemes, And for the design of Logic Gates. The analyte nucleic acid target acts, also, as input for the Logic Gates. In the presence of two DNA targets, acting as inputs, And appropriate DNA scaffolds, the polymerase-induced replication of the scaffolds, followed by the nicking of the replication products, are activated, leading to the autonomous synthesis of the Mg(2+)-dependent DNAzyme or the Mg(2+)-dependent DNAzyme subunits. These biocatalysts cleave a fluorophore/quencher-functionalized nucleic-acid substrate, thus providing fluorescence signals for the sensing events or outputs for the Logic Gates. The systems are used to develop OR, And, And Controlled-And Gates, And the DNA-analyte targets represent two nucleic acid sequences of the smallpox viral genome.

  • parallel analysis of two analytes in solutions or on surfaces by using a bifunctional aptamer applications for biosensing And Logic Gate operations
    ChemBioChem, 2008
    Co-Authors: Johann Elbaz, Bella Shlyahovsky, Itamar Willner
    Abstract:

    A bifunctional aptamer that includes two aptamer units for cocaine And adenosine 5′-monophosphate (AMP) is blocked by a nucleic acid to form a hybrid structure with two duplex regions. The blocked bifunctional aptamer assembly is used as a functional structure for the simultaneous sensing of cocaine or AMP. The blocked bifunctional aptamer is dissociated by either of the two analytes, And the readout of the separation of the sensing structure is accomplished by a colorimetric detection, by a released DNAzyme, or by electronic means that use Faradaic impedance spectroscopy or field-effect transistors. In one configuration, the blocked bifunctional aptamer structure is separated by the substrates cocaine or AMP, And the displaced blocker units act as a horseradish peroxidase-mimicking DNAzyme that permits the colorimetric detection of the analytes. In the second system, the blocked bifunctional aptamer hybrid is associated with a Au electrode. The displacement of the aptamer by any of the substrates alters the interfacial electron transfer resistance at the electrode surface, thus providing an electronic signal for the sensing process. In the third configuration, the blocked aptamer hybrid is linked to the Gate of a field-effect transistor device. The separation of the complex by means of any of the analytes, cocaine, or AMP alters the Gate potential, And this allows the electronic transduction of the sensing process by following the changes in the Gate-to-source potentials. The different systems enable not only the simultaneous detection of the two analytes, but they provide a functional assembly that performs a Logic Gate “OR” operation.

  • DNAzymes for sensing, nanobiotechnology And Logic Gate applications
    Chemical Society Reviews, 2008
    Co-Authors: Itamar Willner, Bella Shlyahovsky, Maya Zayats, Bilha Willner
    Abstract:

    Catalytic nucleic acids (DNAzymes or ribozymes) are selected by the systematic evolution of ligAnds by exponential enrichment process (SELEX). The catalytic functions of DNAzymes or ribozymes allow their use as amplifying labels for the development of optical or electronic sensors. The use of catalytic nucleic acids for amplified biosensing was accomplished by designing aptamer-DNAzyme conjuGates that combine recognition units And amplifying readout units as in integrated biosensing materials. Alternatively, “DNA machines” that activate enzyme cascades And yield DNAzymes were tailored, And the systems led to the ultrasensitive detection of DNA. DNAzymes are also used as active components for constructing nanostructures such as aggreGated nanoparticles And for the activation of Logic Gate operations that perform computing.

Chao Zhang – One of the best experts on this subject based on the ideXlab platform.

  • valleytronics in merging dirac cones all electric controlled valley filter valve And universal reversible Logic Gate
    Physical Review B, 2017
    Co-Authors: Shengyuan A Yang, Chao Zhang
    Abstract:

    Despite much anticipation of valleytronics as a cAndidate to replace the ageing CMOS-based information processing, its progress is severely hindered by the lack of practical ways to manipulate valley polarization all-electrically in an electrostatic setting. Here we propose a class of all-electric-controlled valley filter, valve And Logic Gate based on the valley-contrasting transport in a merging Dirac cones system. The central mechanism of these devices lies on the pseudospin-assisted quantum tunneling which effectively quenches the transport of one valley when its pseudospin configuration mismatches that of a Gate-controlled scattering region. The valley polarization can be abruptly switched into different states And remains stable over semi-infinite Gate-voltage windows. Colossal tunneling valley-pseudo-magnetoresistance ratio of over 10,000\% can be achieved in a valley-valve setup. We further propose a valleytronic-based Logic Gate capable of covering all 16 types of two-input Boolean Logics. Remarkably, the valley degree of freedom can be harnessed to resurrect Logical-reversibility in two-input universal Boolean Gate. The (2+1) polarization states — two distinct valleys plus a null polarization — re-establish one-to-one input-to-output mapping, a crucial requirement for Logical-reversibility, And significantly reduce the complexity of reversible circuits due to the built-in nature of valley degree of freedom. Our results suggest that the synergy of valleytronics And digital Logics may provide new paradigms for valleytronic-based information processing And reversible computing.

  • valleytronics in merging dirac cones all electric controlled valley filter valve And universal reversible Logic Gate
    Physical Review B, 2017
    Co-Authors: Yee Sin Ang, Shengyuan A Yang, Chao Zhang, Lawrence K Ang
    Abstract:

    Despite much anticipation of valleytronics as a cAndidate to replace the aging complementary metal-oxide-semisemiconductor (CMOS) based information processing, its progress is severely hindered by the lack of practical ways to manipulate valley polarization all electrically in an electrostatic setting. Here, we propose a class of all-electric-controlled valley filter, valve, And Logic Gate based on the valley-contrasting transport in a merging Dirac cones system. The central mechanism of these devices lies on the pseudospin-assisted quantum tunneling which effectively quenches the transport of one valley when its pseudospin configuration mismatches that of a Gate-controlled scattering region. The valley polarization can be abruptly switched into different states And remains stable over semi-infinite Gate-voltage windows. Colossal tunneling valley-pseudomagnetoresistance ratio of over $10\phantom{\rule{0.16em}{0ex}}000$% can be achieved in a valley-valve setup. We further propose a valleytronic-based Logic Gate capable of covering all 16 types of two-input Boolean Logics. Remarkably, the valley degree of freedom can be harnessed to resurrect Logical reversibility in two-input universal Boolean Gate. The ($2+1$) polarization states (two distinct valleys plus a null polarization) reestablish one-to-one input-to-output mapping, a crucial requirement for Logical reversibility, And significantly reduce the complexity of reversible circuits. Our results suggest that the synergy of valleytronics And digital Logics may provide new paradigms for valleytronic-based information processing And reversible computing.

Robert Penchovsky – One of the best experts on this subject based on the ideXlab platform.

  • engineering integrated digital circuits with allosteric ribozymes for scaling up molecular computation And diagnostics
    ACS Synthetic Biology, 2012
    Co-Authors: Robert Penchovsky
    Abstract:

    Here we describe molecular implementations of integrated digital circuits, including a three-input And Logic Gate, a two-input multiplexer, And 1-to-2 decoder using allosteric ribozymes. Furthermore, we demonstrate a multiplexerdecoder circuit. The ribozymes are designed to seek-And-destroy specific RNAs with a certain length by a fully computerized procedure. The algorithm can accurately predict one base substitution that alters the ribozyme’s Logic function. The ability to sense the length of RNA molecules enables single ribozymes to be used as platforms for multiple interactions. These ribozymes can work as integrated circuits with the functionality of up to five Logic Gates. The ribozyme design is universal since the allosteric And substrate domains can be altered to sense different RNAs. In addition, the ribozymes can specifically cleave RNA molecules with triplet-repeat expansions observed in genetic disorders such as oculopharyngeal muscmuscular dystrophy. Therefore, the designer ribozymes can be empl…

  • Engineering Integrated Digital Circuits with Allosteric Ribozymes for Scaling up Molecular Computation And Diagnostics
    , 2012
    Co-Authors: Robert Penchovsky
    Abstract:

    Here we describe molecular implementations of integrated digital circuits, including a three-input And Logic Gate, a two-input multiplexer, And 1-to-2 decoder using allosteric ribozymes. Furthermore, we demonstrate a multiplexerdecoder circuit. The ribozymes are designed to seek-And-destroy specific RNAs with a certain length by a fully computerized procedure. The algorithm can accurately predict one base substitution that alters the ribozyme’s Logic function. The ability to sense the length of RNA molecules enables single ribozymes to be used as platforms for multiple interactions. These ribozymes can work as integrated circuits with the functionality of up to five Logic Gates. The ribozyme design is universal since the allosteric And substrate domains can be altered to sense different RNAs. In addition, the ribozymes can specifically cleave RNA molecules with triplet-repeat expansions observed in genetic disorders such as oculopharyngeal muscmuscular dystrophy. Therefore, the designer ribozymes can be employed for scaling up computing And diagnostic networks in the fields of molecular computing And diagnostics And RNA synthetic biology

Shengyuan A Yang – One of the best experts on this subject based on the ideXlab platform.

  • valleytronics in merging dirac cones all electric controlled valley filter valve And universal reversible Logic Gate
    Physical Review B, 2017
    Co-Authors: Shengyuan A Yang, Chao Zhang
    Abstract:

    Despite much anticipation of valleytronics as a cAndidate to replace the ageing CMOS-based information processing, its progress is severely hindered by the lack of practical ways to manipulate valley polarization all-electrically in an electrostatic setting. Here we propose a class of all-electric-controlled valley filter, valve And Logic Gate based on the valley-contrasting transport in a merging Dirac cones system. The central mechanism of these devices lies on the pseudospin-assisted quantum tunneling which effectively quenches the transport of one valley when its pseudospin configuration mismatches that of a Gate-controlled scattering region. The valley polarization can be abruptly switched into different states And remains stable over semi-infinite Gate-voltage windows. Colossal tunneling valley-pseudo-magnetoresistance ratio of over 10,000\% can be achieved in a valley-valve setup. We further propose a valleytronic-based Logic Gate capable of covering all 16 types of two-input Boolean Logics. Remarkably, the valley degree of freedom can be harnessed to resurrect Logical-reversibility in two-input universal Boolean Gate. The (2+1) polarization states — two distinct valleys plus a null polarization — re-establish one-to-one input-to-output mapping, a crucial requirement for Logical-reversibility, And significantly reduce the complexity of reversible circuits due to the built-in nature of valley degree of freedom. Our results suggest that the synergy of valleytronics And digital Logics may provide new paradigms for valleytronic-based information processing And reversible computing.

  • valleytronics in merging dirac cones all electric controlled valley filter valve And universal reversible Logic Gate
    Physical Review B, 2017
    Co-Authors: Yee Sin Ang, Shengyuan A Yang, Chao Zhang, Lawrence K Ang
    Abstract:

    Despite much anticipation of valleytronics as a cAndidate to replace the aging complementary metal-oxide-semiconductor (CMOS) based information processing, its progress is severely hindered by the lack of practical ways to manipulate valley polarization all electrically in an electrostatic setting. Here, we propose a class of all-electric-controlled valley filter, valve, And Logic Gate based on the valley-contrasting transport in a merging Dirac cones system. The central mechanism of these devices lies on the pseudospin-assisted quantum tunneling which effectively quenches the transport of one valley when its pseudospin configuration mismatches that of a Gate-controlled scattering region. The valley polarization can be abruptly switched into different states And remains stable over semi-infinite Gate-voltage windows. Colossal tunneling valley-pseudomagnetoresistance ratio of over $10\phantom{\rule{0.16em}{0ex}}000$% can be achieved in a valley-valve setup. We further propose a valleytronic-based Logic Gate capable of covering all 16 types of two-input Boolean Logics. Remarkably, the valley degree of freedom can be harnessed to resurrect Logical reversibility in two-input universal Boolean Gate. The ($2+1$) polarization states (two distinct valleys plus a null polarization) reestablish one-to-one input-to-output mapping, a crucial requirement for Logical reversibility, And significantly reduce the complexity of reversible circuits. Our results suggest that the synergy of valleytronics And digital Logics may provide new paradigms for valleytronic-based information processing And reversible computing.

Bilha Willner – One of the best experts on this subject based on the ideXlab platform.

  • DNAzymes for sensing, nanobiotechnology And Logic Gate applications
    Chemical Society Reviews, 2008
    Co-Authors: Itamar Willner, Bella Shlyahovsky, Maya Zayats, Bilha Willner
    Abstract:

    Catalytic nucleic acids (DNAzymes or ribozymes) are selected by the systematic evolution of ligAnds by exponential enrichment process (SELEX). The catalytic functions of DNAzymes or ribozymes allow their use as amplifying labels for the development of optical or electronic sensors. The use of catalytic nucleic acids for amplified biosensing was accomplished by designing aptamer-DNAzyme conjuGates that combine recognition units And amplifying readout units as in integrated biosensing materials. Alternatively, “DNA machines” that activate enzyme cascades And yield DNAzymes were tailored, And the systems led to the ultrasensitive detection of DNA. DNAzymes are also used as active components for constructing nanostructures such as aggreGated nanoparticles And for the activation of Logic Gate operations that perform computing.