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Annona muricata

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Christophe Gleye – 1st expert on this subject based on the ideXlab platform

  • apolar Annonaceous acetogenins from the fruit pulp of Annona muricata
    Molecules, 2009
    Co-Authors: Alice Melot, Christophe Gleye, Djibril Fall, Pierre Champy

    Abstract:

    A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and -B (5+6) were also isolated.

  • Coronin from roots of Annona muricata, a putative intermediate in acetogenin biosynthesis (1).
    Planta Medica, 2001
    Co-Authors: Christophe Gleye, Alain Laurens, Blandine Akendengue, Reynald Hocquemiller

    Abstract:

    A novel acetogenin, coronin, was isolated from the roots of Annona muricata L. The structure was elucidated by a combination of chemical and spectral methods including MS and NMR measurements. Coronin is probably an intermediate in the biosynthetic pathway of bis-tetrahydrofuran acetogenins, and is proposed as a biogenetic precursor of neoannonin-B.

  • Robustocin, a New Acetogenin from the Seeds of Annona muricata
    Natural Product Letters, 2000
    Co-Authors: Christophe Gleye, Alain Laurens, Nancy Rafidiarison, Philippe Duret, Reynald Hocquemiller

    Abstract:

    Abstract A new Annonaceous acetogenin, robustocin, was isolated from the seeds of Annona muricata (Annonaceae). Its structure was deduced by NMR and mass spectrometric methods. Absolute configurations were determined by the Mosher’s ester methodology. This compound is the first bis-THF acetogenin with only one hydroxyl group.

Reynald Hocquemiller – 2nd expert on this subject based on the ideXlab platform

  • Coronin from roots of Annona muricata, a putative intermediate in acetogenin biosynthesis (1).
    Planta Medica, 2001
    Co-Authors: Christophe Gleye, Alain Laurens, Blandine Akendengue, Reynald Hocquemiller

    Abstract:

    A novel acetogenin, coronin, was isolated from the roots of Annona muricata L. The structure was elucidated by a combination of chemical and spectral methods including MS and NMR measurements. Coronin is probably an intermediate in the biosynthetic pathway of bis-tetrahydrofuran acetogenins, and is proposed as a biogenetic precursor of neoannonin-B.

  • Robustocin, a New Acetogenin from the Seeds of Annona muricata
    Natural Product Letters, 2000
    Co-Authors: Christophe Gleye, Alain Laurens, Nancy Rafidiarison, Philippe Duret, Reynald Hocquemiller

    Abstract:

    Abstract A new Annonaceous acetogenin, robustocin, was isolated from the seeds of Annona muricata (Annonaceae). Its structure was deduced by NMR and mass spectrometric methods. Absolute configurations were determined by the Mosher’s ester methodology. This compound is the first bis-THF acetogenin with only one hydroxyl group.

  • isolation and structure elucidation of sabadelin an acetogenin from roots of Annona muricata
    Phytochemistry, 1999
    Co-Authors: Christophe Gleye, A Laurens, Olivier Laprevote, Laurent Serani, Reynald Hocquemiller

    Abstract:

    Abstract A new acetogenin, sabadelin, has been isolated from the roots of Annona muricata and was characterised using tandem mass spectrometry (MS/MS). The structure determination of this compound was strengthened by epoxidation and transformation leading to a known mono-tetrahydrofuran acetogenin. Sabadelin is probably an intermediate in the biosynthetic pathway of mono-THF acetogenins, and it is proposed as a biogenetic precursor of cis -panatellin.

Nik Mohd Afizan Nik Abd Rahman – 3rd expert on this subject based on the ideXlab platform

  • anti cancer effect of Annona muricata linn leaves crude extract amce on breast cancer cell line
    BMC Complementary and Alternative Medicine, 2016
    Co-Authors: Syed Umar Faruq Syed Najmuddin, Muhammad Firdaus Romli, Muhajir Hamid, Noorjahan Banu Mohammed Alitheen, Nik Mohd Afizan Nik Abd Rahman

    Abstract:

    Annona muricata Linn which comes from Annonaceae family possesses many therapeutic benefits as reported in previous studies and to no surprise, it has been used in many cultures to treat various ailments including headaches, insomnia, and rheumatism to even treating cancer. However, Annona muricata Linn obtained from different cultivation area does not necessarily offer the same therapeutic effects towards breast cancer (in regards to its bioactive compound production). In this study, anti-proliferative and anti-cancer effects of Annona muricata crude extract (AMCE) on breast cancer cell lines were evaluated. A screening of nineteen samples of Annona muricata from different location was determined by MTT assay on breast cancer cell lines (MCF-7, MDA-MB-231, and 4 T1) which revealed a varied potency (IC50) amongst them. Then, based on the IC50 profile from the anti-proliferative assay, further downward assays such as cell cycle analysis, Annexin V/FITC, AO/PI, migration, invasion, and wound healing assay were performed only with the most potent leaf aqueous extract (B1 AMCE) on 4 T1 breast cancer cell line to investigate its anti-cancer effect. Then, the in vivo anti-cancer study was conducted where mice were fed with extract after inducing the tumor. At the end of the experiment, histopathology of tumor section, tumor nitric oxide level, tumor malondialdehyde level, clonogenic assay, T cell immunophenotyping, and proteome profiler analysis were performed. Annona muricata crude extract samples exhibited different level of cytotoxicity toward breast cancer cell lines. The selected B1 AMCE reduced the tumor’s size and weight, showed anti-metastatic features, and induced apoptosis in vitro and in vivo of the 4 T1 cells. Furthermore, it decreased the level of nitric oxide and malondialdehyde in tumor while also increased the level of white blood cell, T-cell, and natural killer cell population. The results suggest that, B1 AMCE is a promising candidate for cancer treatment especially in breast cancer and deserves further research as an alternative to conventional drugs while also stressed out the selection of soursop sample which plays a significant role in determining its potential therapeutic effect on cancer.