Scan Science and Technology

Contact Leading Edge Experts & Companies

14,000,000 Leading Edge Experts on the ideXlab platform


Leading Edge Experts

on the ideXlab platform

Annona muricata

The Experts below are selected from a list of 3198 Experts worldwide ranked by ideXlab platform

Annona muricata - Free Register to Access Experts & Abstracts

Christophe Gleye - One of the best experts on this subject based on the ideXlab platform.

Reynald Hocquemiller - One of the best experts on this subject based on the ideXlab platform.

Nik Mohd Afizan Nik Abd Rahman - One of the best experts on this subject based on the ideXlab platform.

  • anti cancer effect of Annona muricata linn leaves crude extract amce on breast cancer cell line
    BMC Complementary and Alternative Medicine, 2016
    Co-Authors: Syed Umar Faruq Syed Najmuddin, Muhammad Firdaus Romli, Muhajir Hamid, Noorjahan Banu Mohammed Alitheen, Nik Mohd Afizan Nik Abd Rahman

    Annona muricata Linn which comes from Annonaceae family possesses many therapeutic benefits as reported in previous studies and to no surprise, it has been used in many cultures to treat various ailments including headaches, insomnia, and rheumatism to even treating cancer. However, Annona muricata Linn obtained from different cultivation area does not necessarily offer the same therapeutic effects towards breast cancer (in regards to its bioactive compound production). In this study, anti-proliferative and anti-cancer effects of Annona muricata crude extract (AMCE) on breast cancer cell lines were evaluated. A screening of nineteen samples of Annona muricata from different location was determined by MTT assay on breast cancer cell lines (MCF-7, MDA-MB-231, and 4 T1) which revealed a varied potency (IC50) amongst them. Then, based on the IC50 profile from the anti-proliferative assay, further downward assays such as cell cycle analysis, Annexin V/FITC, AO/PI, migration, invasion, and wound healing assay were performed only with the most potent leaf aqueous extract (B1 AMCE) on 4 T1 breast cancer cell line to investigate its anti-cancer effect. Then, the in vivo anti-cancer study was conducted where mice were fed with extract after inducing the tumor. At the end of the experiment, histopathology of tumor section, tumor nitric oxide level, tumor malondialdehyde level, clonogenic assay, T cell immunophenotyping, and proteome profiler analysis were performed. Annona muricata crude extract samples exhibited different level of cytotoxicity toward breast cancer cell lines. The selected B1 AMCE reduced the tumor’s size and weight, showed anti-metastatic features, and induced apoptosis in vitro and in vivo of the 4 T1 cells. Furthermore, it decreased the level of nitric oxide and malondialdehyde in tumor while also increased the level of white blood cell, T-cell, and natural killer cell population. The results suggest that, B1 AMCE is a promising candidate for cancer treatment especially in breast cancer and deserves further research as an alternative to conventional drugs while also stressed out the selection of soursop sample which plays a significant role in determining its potential therapeutic effect on cancer.

Dimo Theophile - One of the best experts on this subject based on the ideXlab platform.

  • antidiabetic and antioxidant effects of Annona muricata Annonaceae aqueous extract on streptozotocin induced diabetic rats
    Journal of Ethnopharmacology, 2014
    Co-Authors: Ngueguim Tsofack Florence, Massa Zibi Benoit, Kouamouo Jonas, Tchuidjang Alexandra, Dzeufiet Djomeni Paul Desire, Kamtchouing Pierre, Dimo Theophile

    Abstract Ethnopharmacological relevance The leaves of Annona muricata are used in Cameroon to manage diabetes and its complications. The aim of this study was to evaluate the antidiabetic, antioxidant activities and the potential toxicity of aqueous extract of Annona muricata in streptozotocin-induced diabetic rats. Material and methods Oral administration of Annona muricata aqueous extract (100 mg/kg or 200 mg/kg) was studied in normal and streptozotocin-induced diabetic rats. In long term treatment, 2 weeks after streptozotocin-induced diabetic rats, animals received plant extract during 28 consecutive days. For a protective effect, extract was administered 3 days prior to streptozotocin exposure and animals were observed 2 weeks without treatment. Results The plant extract was not effective in normal rats. In diabetic rats, single administration of the extract significantly reduced blood glucose levels by 75% and 58.22% respectively at the dose of 100 mg/kg and 200 mg/kg as compared to the initial value. Treatment of normal rats 3 days prior to diabetes induction showed that, Annona muricata extract has no effect within 72 h following STZ injection. However, after 14 days post-treatment, the extract at the dose of 100 mg/kg significantly reduced blood glucose levels as compared with initial value and diabetic control rats. Immunohistochemical staining of pancreatic β-cells of diabetic rats treated with the dose of 100 mg/kg expressed strong staining for β-cell compared to diabetic control. In a long-term study daily administration of Annona muricata aqueous extract for 28 days to diabetic rats, reduced blood glucose levels, serum creatinine, MDA, AST, ALT activity, and nitrite levels LDL-cholesterol. Total cholesterol, triglycerides, SOD, and CAT activity contents were restored. Conclusion These different results show that the antidiabetic activity of Annona muricata aqueous extract can be explained by its hypolipidaemic effect, its antioxidant and protective action on pancreatic β-cells, which in turn improve glucose metabolism.

A Cave - One of the best experts on this subject based on the ideXlab platform.