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Nur Lailatul Rahmah - One of the best experts on this subject based on the ideXlab platform.

  • aplikasi perlakuan pendahuluan pulsed electric field pef pada ekstraksi tanin biji pinang Areca catechu kajian frekuensi dan waktu pef
    Journal of Agroindustrial Technology, 2019
    Co-Authors: Nur Lailatul Rahmah, Dan Irwina Nova Dila
    Abstract:

    Areca catechu contains tannins compounds acting as antioxidants. Extraction process is required to obtain these compounds from Areca nut. Pretreatment before extraction using Pulsed Electric Field (PEF) has shown improvement of yield as well as the quality of antioxidant extracts compared with control. The experimental design of this research was Factorial Random Design with two factors. The first factor was frequency of PEF with three levels of 1, 1.5, and 2 kHz and the second factor was PEF application time with three levels of 20, 25, and 30 seconds. The extract of Areca seed from PEF extraction with combination of frequency and time of PEF using magnetic field 450 v/cm did not provide significanty different yield and quality. The selection of best treatment was based on the economic aspects and analysis of variance, since there was no significant difference between each parameter and treatment. The best frequency and duration of PEF on yield and antioxidant quality of Areca nut extract were 1 kHz and 20 second with a yield of 5.6%; moisture content of 7.78%; IC50 value of 277,56 ppm; and tannins content of 442.36 mg GAE/g. FTIR spectrophotometric analysis results showed that the resulting absorption has a functional group that supports the presence of tannins.Keywords: fresh Areca nut, electroporation, electrical pulse

  • APLIKASI PERLAKUAN PENDAHULUAN PULSED ELECTRIC FIELD (PEF) PADA EKSTRAKSI TANIN BIJI PINANG (Areca catechu) (KAJIAN FREKUENSI DAN WAKTU PEF)
    Department of Agroindustrial Technology Bogor Agricultural University, 2019
    Co-Authors: Irwina Nova Dila, Nur Lailatul Rahmah
    Abstract:

    Areca catechu contains tannins compounds acting as antioxidants. Extraction process is required to obtain these compounds from Areca nut. Pretreatment before extraction using Pulsed Electric Field (PEF) has shown improvement of yield as well as the quality of antioxidant extracts compared with control. The experimental design of this research was Factorial Random Design with two factors. The first factor was frequency of PEF with three levels of 1, 1.5, and 2 kHz and the second factor was PEF application time with three levels of 20, 25, and 30 seconds. The extract of Areca seed from PEF extraction with combination of frequency and time of PEF using magnetic field 450 v/cm did not provide significanty different yield and quality. The selection of best treatment was based on the economic aspects and analysis of variance, since there was no significant difference between each parameter and treatment. The best frequency and duration of PEF on yield and antioxidant quality of Areca nut extract were 1 kHz and 20 second with a yield of 5.6%; moisture content of 7.78%; IC50 value of 277,56 ppm; and tannins content of 442.36 mg GAE/g. FTIR spectrophotometric analysis results showed that the resulting absorption has a functional group that supports the presence of tannins.Keywords: fresh Areca nut, electroporation, electrical puls

Irina Stepanov - One of the best experts on this subject based on the ideXlab platform.

  • analysis of alkaloids in Areca nut containing products by liquid chromatography tandem mass spectrometry
    Journal of Agricultural and Food Chemistry, 2017
    Co-Authors: Vipin Jain, Apurva Garg, Mark Parascandola, Pankaj Chaturvedi, Samir S. Khariwala, Irina Stepanov
    Abstract:

    Chewing of Areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes, particularly oral and esophageal cancers. Areca nut-specific alkaloids arecoline, Arecaidine, guvacoline, and guvacine have been implicated in both the abuse liability and the carcinogenicity of the Areca nut. Therefore, variations in the levels of Areca alkaloids could potentially contribute to variations in addictive and carcinogenic potential across Areca nut-containing products. Here, we developed an accurate and robust liquid chromatography–tandem mass-spectrometry (LC–MS/MS) method for simultaneous quantitation of all four Areca alkaloids and applied this method to the analysis of a range of products obtained from India, China, and the United States. The results of the analyses revealed substantial variations in the levels of alkaloids across the tested products, wit...

  • Analysis of Alkaloids in Areca Nut-Containing Products by Liquid Chromatography–Tandem Mass Spectrometry
    2017
    Co-Authors: Vipin Jain, Apurva Garg, Mark Parascandola, Pankaj Chaturvedi, Samir S. Khariwala, Irina Stepanov
    Abstract:

    Chewing of Areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes, particularly oral and esophageal cancers. Areca nut-specific alkaloids arecoline, Arecaidine, guvacoline, and guvacine have been implicated in both the abuse liability and the carcinogenicity of the Areca nut. Therefore, variations in the levels of Areca alkaloids could potentially contribute to variations in addictive and carcinogenic potential across Areca nut-containing products. Here, we developed an accurate and robust liquid chromatography–tandem mass-spectrometry (LC–MS/MS) method for simultaneous quantitation of all four Areca alkaloids and applied this method to the analysis of a range of products obtained from India, China, and the United States. The results of the analyses revealed substantial variations in the levels of alkaloids across the tested products, with guvacine being the most abundant (1.39–8.16 mg/g), followed by arecoline (0.64–2.22 mg/g), Arecaidine (0.14–1.70 mg/g), and guvacoline (0.17–0.99 mg/g). Substantial differences in the relative contribution of individual alkaloids to the total alkaloid content were also observed among the different products. Our results highlight the need for systematic surveillance of constituent levels in Areca nut-containing products and a better understanding of the relationship between the chemical profile and the harmful potential of these products

Saman Warnakulasuriya - One of the best experts on this subject based on the ideXlab platform.

  • defining a global research and policy agenda for betel quid and Areca nut
    Lancet Oncology, 2017
    Co-Authors: Hedieh Mehrtash, Mark Parascandola, Prakash C Gupta, Kalina Duncan, Annette M David, Ellen R Gritz, Ravi Mehrotra, Amer Siddiq Amer Nordin, Paul C Pearlman, Saman Warnakulasuriya
    Abstract:

    Betel quid and Areca nut are known risk factors for many oral and oesophageal cancers, and their use is highly prevalent in the Asia-Pacific region. Additionally, betel quid and Areca nut are associated with health effects on the cardiovascular, nervous, gastrointestinal, metabolic, respiratory, and reproductive systems. Unlike tobacco, for which the WHO Framework Convention on Tobacco Control provides evidence-based policies for reducing tobacco use, no global policy exists for the control of betel quid and Areca nut use. Multidisciplinary research is needed to address this neglected global public health emergency and to mobilise efforts to control betel quid and Areca nut use. In addition, future research is needed to advance our understanding of the basic biology, mechanisms, and epidemiology of betel quid and Areca nut use, to advance possible prevention and cessation programmes for betel quid and Areca nut users, and to design evidence-based screening and early diagnosis programmes to address the growing burden of cancers that are associated with use.

  • oral lichenoid contact lesions induced by Areca nut and betel quid chewing a mini review
    Journal of Investigative and Clinical Dentistry, 2012
    Co-Authors: Peter A Reichart, Saman Warnakulasuriya
    Abstract:

    Betel quid (BQ) and Areca nut chewing is widely prevalent in many parts of Asia and Asian-migrant communities throughout the world. Global reports estimate 600 million users. Sufficient evidence of carcinogenicity has been found for BQ and its main ingredient, Areca nut. BQ Areca nut users have an increased risk of potentially malignant disorders. Among chewers, BQ remains in contact with the oral mucosa for prolonged periods. This review examines the clinical and pathological aspects of lichenoid lesions caused by Areca nut and BQ, a condition that has received little attention in the published literature.

  • Areca betel nut chewing habit among high school children in the commonwealth of the northern mariana islands micronesia
    Bulletin of The World Health Organization, 2005
    Co-Authors: Eric Oakley, L Demaine, Saman Warnakulasuriya
    Abstract:

    Objective To investigate the prevalence of its use by high-school children in Saipan in Micronesia. Usage of the Areca nut is indigenous to south Asia and the western and south Pacific. Some serious health effects of Areca nut chewing are recognized and the International Agency for Research on Cancer has recently classified regular use of Areca nut as being carcinogenic to humans. Information on usage by young people, however, is scarce. Methods Data on consumption of Areca nut were obtained by a self-administered questionnaire. Following an oral mucosal examination using WHO criteria any detectable oral mucosal diseases were recorded. Findings Of 309 schoolchildren surveyed (mean age 16.3 ± 1.5 years), 63.4% claimed regular use, the highest level recorded in any school population survey. Significant oral diseases detected were oral leukoplakia in 13% and oral submucous fibrosis in 8.8% of children. Conclusion These findings from Saipan suggest that Areca nut chewing starts at a young age in Micronesia. As many users develop dependency this raises important concerns regarding its consequences for oral health.

  • Areca nut use an independent risk factor for oral cancer
    BMJ, 2002
    Co-Authors: Saman Warnakulasuriya, Chetan Trivedy, T J Peters
    Abstract:

    Areca nut is the seed of the fruit of the oriental palm, Areca catechu . It is the basic ingredient of a variety of widely used chewed products. Thin slices of the nut, either natural or processed, may be mixed with a variety of substances including slaked lime (calcium hydroxide) and spices such as cardamom, coconut, and saffron. Most significantly, they may be mixed with tobacco products or wrapped in the leaf of the piper betel plant. Hence the more common name betel nut. Areca nut is used by an estimated 200-400 million people, mainly IndoAsians and Chinese.1 It is used by men and women—in some societies the latter predominate. All age groups and social classes use the product. Areca nut has a long history of use and is deeply ingrained in many sociocultural and religious activities.2 Of particular interest in the United Kingdom, and perhaps other developed countries, is that use of Areca nut continues and is often enhanced following migration. Thus British Asians have brought the use of Areca from India (some via East Africa), Pakistan, Bangladesh, and other countries in the region …

  • global epidemiology of Areca nut usage
    Addiction Biology, 2002
    Co-Authors: Prakash C Gupta, Saman Warnakulasuriya
    Abstract:

    A substantial proportion of the world's population is engaged in chewing Areca nut and the habit is endemic throughout the Indian subcontinent, large parts of south Asia and Melanesia. A large variety of ingredients, including tobacco, may be used along with Areca nut constituting a betel quid. The composition and method of chewing can vary widely from country to country and these population variations are described in this review. Some populations are known to use Areca nut without tobacco providing good opportunities to further research the carcinogenecity of Areca nut. Some interesting trends on chewing patterns have emerged from recent data, suggesting a decline in the habit in some countries such as Thailand while the prevalence of Areca nut use is rising in India and Taiwan.

Mark Parascandola - One of the best experts on this subject based on the ideXlab platform.

  • defining a global research and policy agenda for betel quid and Areca nut
    Lancet Oncology, 2017
    Co-Authors: Hedieh Mehrtash, Mark Parascandola, Prakash C Gupta, Kalina Duncan, Annette M David, Ellen R Gritz, Ravi Mehrotra, Amer Siddiq Amer Nordin, Paul C Pearlman, Saman Warnakulasuriya
    Abstract:

    Betel quid and Areca nut are known risk factors for many oral and oesophageal cancers, and their use is highly prevalent in the Asia-Pacific region. Additionally, betel quid and Areca nut are associated with health effects on the cardiovascular, nervous, gastrointestinal, metabolic, respiratory, and reproductive systems. Unlike tobacco, for which the WHO Framework Convention on Tobacco Control provides evidence-based policies for reducing tobacco use, no global policy exists for the control of betel quid and Areca nut use. Multidisciplinary research is needed to address this neglected global public health emergency and to mobilise efforts to control betel quid and Areca nut use. In addition, future research is needed to advance our understanding of the basic biology, mechanisms, and epidemiology of betel quid and Areca nut use, to advance possible prevention and cessation programmes for betel quid and Areca nut users, and to design evidence-based screening and early diagnosis programmes to address the growing burden of cancers that are associated with use.

  • analysis of alkaloids in Areca nut containing products by liquid chromatography tandem mass spectrometry
    Journal of Agricultural and Food Chemistry, 2017
    Co-Authors: Vipin Jain, Apurva Garg, Mark Parascandola, Pankaj Chaturvedi, Samir S. Khariwala, Irina Stepanov
    Abstract:

    Chewing of Areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes, particularly oral and esophageal cancers. Areca nut-specific alkaloids arecoline, Arecaidine, guvacoline, and guvacine have been implicated in both the abuse liability and the carcinogenicity of the Areca nut. Therefore, variations in the levels of Areca alkaloids could potentially contribute to variations in addictive and carcinogenic potential across Areca nut-containing products. Here, we developed an accurate and robust liquid chromatography–tandem mass-spectrometry (LC–MS/MS) method for simultaneous quantitation of all four Areca alkaloids and applied this method to the analysis of a range of products obtained from India, China, and the United States. The results of the analyses revealed substantial variations in the levels of alkaloids across the tested products, wit...

  • Analysis of Alkaloids in Areca Nut-Containing Products by Liquid Chromatography–Tandem Mass Spectrometry
    2017
    Co-Authors: Vipin Jain, Apurva Garg, Mark Parascandola, Pankaj Chaturvedi, Samir S. Khariwala, Irina Stepanov
    Abstract:

    Chewing of Areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes, particularly oral and esophageal cancers. Areca nut-specific alkaloids arecoline, Arecaidine, guvacoline, and guvacine have been implicated in both the abuse liability and the carcinogenicity of the Areca nut. Therefore, variations in the levels of Areca alkaloids could potentially contribute to variations in addictive and carcinogenic potential across Areca nut-containing products. Here, we developed an accurate and robust liquid chromatography–tandem mass-spectrometry (LC–MS/MS) method for simultaneous quantitation of all four Areca alkaloids and applied this method to the analysis of a range of products obtained from India, China, and the United States. The results of the analyses revealed substantial variations in the levels of alkaloids across the tested products, with guvacine being the most abundant (1.39–8.16 mg/g), followed by arecoline (0.64–2.22 mg/g), Arecaidine (0.14–1.70 mg/g), and guvacoline (0.17–0.99 mg/g). Substantial differences in the relative contribution of individual alkaloids to the total alkaloid content were also observed among the different products. Our results highlight the need for systematic surveillance of constituent levels in Areca nut-containing products and a better understanding of the relationship between the chemical profile and the harmful potential of these products

Dan Irwina Nova Dila - One of the best experts on this subject based on the ideXlab platform.

  • aplikasi perlakuan pendahuluan pulsed electric field pef pada ekstraksi tanin biji pinang Areca catechu kajian frekuensi dan waktu pef
    Journal of Agroindustrial Technology, 2019
    Co-Authors: Nur Lailatul Rahmah, Dan Irwina Nova Dila
    Abstract:

    Areca catechu contains tannins compounds acting as antioxidants. Extraction process is required to obtain these compounds from Areca nut. Pretreatment before extraction using Pulsed Electric Field (PEF) has shown improvement of yield as well as the quality of antioxidant extracts compared with control. The experimental design of this research was Factorial Random Design with two factors. The first factor was frequency of PEF with three levels of 1, 1.5, and 2 kHz and the second factor was PEF application time with three levels of 20, 25, and 30 seconds. The extract of Areca seed from PEF extraction with combination of frequency and time of PEF using magnetic field 450 v/cm did not provide significanty different yield and quality. The selection of best treatment was based on the economic aspects and analysis of variance, since there was no significant difference between each parameter and treatment. The best frequency and duration of PEF on yield and antioxidant quality of Areca nut extract were 1 kHz and 20 second with a yield of 5.6%; moisture content of 7.78%; IC50 value of 277,56 ppm; and tannins content of 442.36 mg GAE/g. FTIR spectrophotometric analysis results showed that the resulting absorption has a functional group that supports the presence of tannins.Keywords: fresh Areca nut, electroporation, electrical pulse