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Arsenic Compound

The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform

Walter Goessler – 1st expert on this subject based on the ideXlab platform

  • homoarsenocholine a novel Arsenic Compound detected for the first time in nature
    Talanta, 2018
    Co-Authors: Simone Braeuer, Jan Borovicka, Toma N Glasnov, Gema Guedes De La Cruz, Kenneth B Jensen, Walter Goessler

    Abstract:

    Abstract The Arsenic speciation was determined in macrofungi of the Ramaria genus with HPLC coupled to inductively coupled plasma mass spectrometry. Besides Arsenic species that are already known for macrofungi, like arsenobetaine or arsenocholine, two Compounds that were only known from marine samples so far (trimethylarsoniopropanate and dimethylarsinoylacetate) were found for the first time in a terrestrial sample. An unknown Arsenical was isolated and identified as homoarsenocholine. This could be a key intermediate for further elucidation of the biotransformation mechanisms of Arsenic.

  • A unique Arsenic speciation profile in Elaphomyces spp. (“deer truffles”)—trimethylarsine oxide and methylarsonous acid as significant Arsenic Compounds
    Analytical and Bioanalytical Chemistry, 2018
    Co-Authors: Simone Braeuer, Jan Borovicka, Walter Goessler

    Abstract:

    Arsenic and its species were investigated for the first time in nine collections of Elaphomyces spp. (“deer truffles”) from the Czech Republic with inductively coupled plasma mass spectrometry (ICPMS) and high-performance liquid chromatography coupled to ICPMS. The total Arsenic concentrations ranged from 12 to 42 mg kg^−1 dry mass in samples of E. asperulus and from 120 to 660 mg kg^−1 dry mass in E. granulatus and E. muricatus . These concentrations are remarkably high for terrestrial organisms and demonstrate the Arsenic-accumulating ability of these fungi. The dominating Arsenic species in all samples was methylarsonic acid which accounted for more than 30% of the extractable Arsenic. Arsenobetaine, dimethylarsinic acid, and inorganic Arsenic were present as well, but only at trace concentrations. Surprisingly, we found high amounts of trimethylarsine oxide in all samples (0.32–28% of the extractable Arsenic). Even more remarkable was that all but two samples contained significant amounts of the highly toxic trivalent Arsenic Compound methylarsonous acid (0.08–0.73% of the extractable Arsenic). This is the first report of the occurrence of trimethylarsine oxide and methylarsonous acid at significant concentrations in a terrestrial organism. Our findings point out that there is still a lot to be understood about the biotransformation pathways of Arsenic in the terrestrial environment. Graphical abstract Trimethylarsine oxide and methylarsonous acid in “deer truffles”

  • a unique Arsenic speciation profile in elaphomyces spp deer truffles trimethylarsine oxide and methylarsonous acid as significant Arsenic Compounds
    Analytical and Bioanalytical Chemistry, 2018
    Co-Authors: Simone Braeuer, Jan Borovicka, Walter Goessler

    Abstract:

    Arsenic and its species were investigated for the first time in nine collections of Elaphomyces spp. (“deer truffles”) from the Czech Republic with inductively coupled plasma mass spectrometry (ICPMS) and high-performance liquid chromatography coupled to ICPMS. The total Arsenic concentrations ranged from 12 to 42 mg kg−1 dry mass in samples of E. asperulus and from 120 to 660 mg kg−1 dry mass in E. granulatus and E. muricatus. These concentrations are remarkably high for terrestrial organisms and demonstrate the Arsenic-accumulating ability of these fungi. The dominating Arsenic species in all samples was methylarsonic acid which accounted for more than 30% of the extractable Arsenic. Arsenobetaine, dimethylarsinic acid, and inorganic Arsenic were present as well, but only at trace concentrations. Surprisingly, we found high amounts of trimethylarsine oxide in all samples (0.32–28% of the extractable Arsenic). Even more remarkable was that all but two samples contained significant amounts of the highly toxic trivalent Arsenic Compound methylarsonous acid (0.08–0.73% of the extractable Arsenic). This is the first report of the occurrence of trimethylarsine oxide and methylarsonous acid at significant concentrations in a terrestrial organism. Our findings point out that there is still a lot to be understood about the biotransformation pathways of Arsenic in the terrestrial environment.

Kitao Fujiwara – 2nd expert on this subject based on the ideXlab platform

  • evaluation of in vivo acute immunotoxicity of arsenocholine a trimethyl Arsenic Compound in seafood
    Applied Organometallic Chemistry, 2005
    Co-Authors: Teruaki Sakurai, Masayuki Ochiai, Chikara Kojima, Takami Ohta, Kitao Fujiwara

    Abstract:

    In this study, we observed the first in vivo acute immunotoxicity of a trimethyl(2-hydroxyethyl)arsonium cation, namely arsenocholine (AsCho), which is present in marine animals that are ingested daily as seafood in many countries. It has been reported that AsCho has significant acute in vivo toxicity. A high dose of the synthetic pure AsCho was administered to CDF 1 mice intraperitoneally (0.1 g kg -1 mouse weight) or orally (a total of 10.0 g kg -1 mouse weight); its effect on the immune organs and immune effector cells was assessed. Administered AsCho, especially via the oral route, showed weak and partial, but significant, in vivo immunotoxicity in mice, although it did not cause any severe acute inflammatory responses.

  • effects of arsenobetaine a major organic Arsenic Compound in seafood on the maturation and functions of human peripheral blood monocytes macrophages and dendritic cells
    Applied Organometallic Chemistry, 2004
    Co-Authors: Takami Ohta, Teruaki Sakurai, Kitao Fujiwara

    Abstract:

    We examine the in vitro immunotoxicity of synthetically pure arsenobetaine [AsBe; trimethyl (carboxymethyl) arsonium zwitterion], which is a major organic Arsenic Compound in seafood, on various human immune cells, such as peripheral blood monocytes, monocyte-derived macrophages and monocyte-derived dendritic cells (DCs). In particular, we examine the differentiation of monocytes into macrophages or DCs by comparing the effects of AsBe with those pentavalent inorganic arsenate. AsBe neither enhanced nor inhibited the differentiation of human monocytes into macrophages or DCs, and also did not affect their various immune functions. Furthermore, AsBe had no cytolethality in monocyte-derived macrophages or DCs even at a concentration of 5 mmol l−1. In contrast, inorganic arsenate showed strong cytolethality in these human immune cells in vitro at micromolar concentrations. These data indicate that the organic Arsenic Compound AsBe in seafood has no in vitro immunotoxicity in human immune cells. Copyright © 2004 John Wiley & Sons, Ltd.

  • evaluation of in vivo acute immunotoxicity of a major organic Arsenic Compound arsenobetaine in seafood
    International Immunopharmacology, 2004
    Co-Authors: Teruaki Sakurai, Masayuki Ochiai, Chikara Kojima, Takami Ohta, Kitao Fujiwara

    Abstract:

    Abstract In this study, we observed the in vivo acute immunotoxicity of a trimethyl Arsenic Compound, arsenobetaine (AsBe), which is present in large quantities in various marine animals that are daily ingested as seafood in many countries. The synthetic pure AsBe was orally administered to CDF 1 mice at a dose of 1.625 g/kg mouse weight once a day on days −6, −4, −2 and 0 (four times, total 6.5 g/kg mouse weight), and its effect on the immune organs and immune effector cells were assessed until day 8. Orally administered AsBe was temporally distributed to the immune organs, such as the spleen and thymus, but was not very toxic both quantitatively and qualitatively on these immune organs and immune effector cells, splenocytes, thymocytes, Peyer’s patch lymphocytes and peritoneal macrophages. This finding suggests that the ingestion of AsBe contained in marine animals is relatively safe to the health of people who often consume marine animals in their daily diet.

Teruaki Sakurai – 3rd expert on this subject based on the ideXlab platform

  • toxicity of a trivalent organic Arsenic Compound dimethylarsinous glutathione in a rat liver cell line trl 1215
    British Journal of Pharmacology, 2006
    Co-Authors: Teruaki Sakurai, Chikara Kojima, Y Kobayashi, S Hirano, Masumi H Sakurai, M P Waalkes, S Himeno

    Abstract:

    Background and purpose:
    Although inorganic arsenite (AsIII) is toxic in humans, it has recently emerged as an effective chemotherapeutic agent for acute promyelocytic leukemia (APL). In humans and most animals, AsIII is enzymatically methylated in the liver to weakly toxic dimethylarsinic acid (DMAsV) that is a major pentavalent methylArsenic metabolite. Recent reports have indicated that trivalent methylArsenicals are produced through methylation of AsIII and participate in Arsenic poisoning. Trivalent methylArsenicals may be generated as Arsenical–glutathione conjugates, such as dimethylarsinous glutathione (DMAsIIIG), during the methylation process. However, less information is available on the cytotoxicity of DMAsIIIG.

  • evaluation of in vivo acute immunotoxicity of arsenocholine a trimethyl Arsenic Compound in seafood
    Applied Organometallic Chemistry, 2005
    Co-Authors: Teruaki Sakurai, Masayuki Ochiai, Chikara Kojima, Takami Ohta, Kitao Fujiwara

    Abstract:

    In this study, we observed the first in vivo acute immunotoxicity of a trimethyl(2-hydroxyethyl)arsonium cation, namely arsenocholine (AsCho), which is present in marine animals that are ingested daily as seafood in many countries. It has been reported that AsCho has significant acute in vivo toxicity. A high dose of the synthetic pure AsCho was administered to CDF 1 mice intraperitoneally (0.1 g kg -1 mouse weight) or orally (a total of 10.0 g kg -1 mouse weight); its effect on the immune organs and immune effector cells was assessed. Administered AsCho, especially via the oral route, showed weak and partial, but significant, in vivo immunotoxicity in mice, although it did not cause any severe acute inflammatory responses.

  • effects of arsenobetaine a major organic Arsenic Compound in seafood on the maturation and functions of human peripheral blood monocytes macrophages and dendritic cells
    Applied Organometallic Chemistry, 2004
    Co-Authors: Takami Ohta, Teruaki Sakurai, Kitao Fujiwara

    Abstract:

    We examine the in vitro immunotoxicity of synthetically pure arsenobetaine [AsBe; trimethyl (carboxymethyl) arsonium zwitterion], which is a major organic Arsenic Compound in seafood, on various human immune cells, such as peripheral blood monocytes, monocyte-derived macrophages and monocyte-derived dendritic cells (DCs). In particular, we examine the differentiation of monocytes into macrophages or DCs by comparing the effects of AsBe with those pentavalent inorganic arsenate. AsBe neither enhanced nor inhibited the differentiation of human monocytes into macrophages or DCs, and also did not affect their various immune functions. Furthermore, AsBe had no cytolethality in monocyte-derived macrophages or DCs even at a concentration of 5 mmol l−1. In contrast, inorganic arsenate showed strong cytolethality in these human immune cells in vitro at micromolar concentrations. These data indicate that the organic Arsenic Compound AsBe in seafood has no in vitro immunotoxicity in human immune cells. Copyright © 2004 John Wiley & Sons, Ltd.