The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Fuhang Song - One of the best experts on this subject based on the ideXlab platform.
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new diketopiperazines from a marine derived fungus strain Aspergillus versicolor mf180151
Marine Drugs, 2019Co-Authors: Jieyu Gao, Huanqin Dai, Lixin Zhang, Xuekui Xia, Cuihua Liu, Fuhang SongAbstract:Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guerin. Compounds 1–4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.
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One new xanthenone from the marine-derived fungus Aspergillus versicolor MF160003.
Natural product research, 2019Co-Authors: Zhijun Song, Jieyu Gao, Pei Huang, Lixin Zhang, Fuhang SongAbstract:A new xanthenone derivative, 3-hydroxy pinselin (1), together with five known analogues (2–6) were isolated from the marine-derived fungus Aspergillus versicolor MF160003. Their structures were ide...
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One new xanthenone from the marine-derived fungus Aspergillus versicolor MF160003
2019Co-Authors: Zhijun Song, Jieyu Gao, Pei Huang, Lixin Zhang, Fuhang SongAbstract:A new xanthenone derivative, 3-hydroxy pinselin (1), together with five known analogues (2–6) were isolated from the marine-derived fungus Aspergillus versicolor MF160003. Their structures were identified by extensive 1D- and 2D-NMR, and high-resolution mass spectrometry data. Compounds 5 and 6 showed moderate bioactivities against BCG with MIC values of 40 and 20 μg/mL, respectively.
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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151
MDPI AG, 2019Co-Authors: Jieyu Gao, Huanqin Dai, Lixin Zhang, Xuekui Xia, Cuihua Liu, Fuhang SongAbstract:Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds 1−4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus
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Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359
Applied microbiology and biotechnology, 2014Co-Authors: Fuhang Song, Biao Ren, Caixia Chen, Xinru Liu, Yuhan Zhang, Na Yang, Xueting Liu, Huanqin DaiAbstract:During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 μg/mL, respectively.
Weiming Zhu - One of the best experts on this subject based on the ideXlab platform.
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cyclopeptides and polyketides from coral associated fungus Aspergillus versicolor lcj 5 4
Tetrahedron, 2011Co-Authors: Yibin Zhuang, Xiancun Teng, Yi Wang, Peipei Liu, Hui Wang, Weiming ZhuAbstract:Abstract Three new cyclopentapeptides, versicoloritides A–C (1–3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1–4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM.
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new quinazolinone alkaloids within rare amino acid residue from coral associated fungus Aspergillus versicolor lcj 5 4
Organic Letters, 2011Co-Authors: Yibin Zhuang, Xiancun Teng, Yi Wang, Peipei Liu, Weiming ZhuAbstract:Cottoquinazoline D (3), a new alkaloid with a 1-aminocyclopropane-1-carboxylic acid residue rarely discovered in nature, was isolated and identified together with two new quinazolinone alkaloids, cottoquinazolines B (1) and C (2), from coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures including absolute configurations were elucidated based on spectroscopic methods, X-ray single crystal diffraction analysis, and chemical methods. A possible biogenetic pathway for them was proposed.
Yonghong Liu - One of the best experts on this subject based on the ideXlab platform.
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structurally diverse diketopiperazine alkaloids from the marine derived fungus Aspergillus versicolor scsio 41016
Organic chemistry frontiers, 2019Co-Authors: Xiaowei Luo, Chunmei Chen, Huaming Tao, Xiuping Lin, Bin Yang, Xuefeng Zhou, Yonghong LiuAbstract:Ten new diketopiperazine alkaloids (DAs, 1–10) along with two known congeners (11–12) were characterized from the marine sponge-derived fungus Aspergillus versicolor SCSIO 41016. Their structures including absolute configurations were determined by spectroscopic analyses, quantum chemical calculations, and X-ray diffraction analysis. Pyranamides A–D (1–4) were obtained as rare 1-oxa-8,10-diazaspiro[5.5]undecane containing diketopiperazine alkaloids, while secopyranamide C (5) was obtained as a tetrahydropyran-ring cleavage derivative. Plausible biosynthetic pathways of 1–12 were postulated. Compounds 7 and 12 exhibited weak cytotoxic activities against ACHN, OS-RC-2, and 786-O cells.
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versispiroketal a an unusual tetracyclic bridged spiroketal from the sponge associated fungus Aspergillus versicolor scsio 41013
Organic and Biomolecular Chemistry, 2019Co-Authors: Limbadri Salendra, Xiaowei Luo, Xiuping Lin, Bin Yang, Xuefeng Zhou, Junfeng Wang, Yonghong LiuAbstract:Versispiroketal A (1), an unprecedented 6/5/5/6 tetracyclic polyketide featuring a rarely encountered bridge-fused spiroketal skeleton, was isolated from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. The structure and absolute configuration of 1 were unequivocally determined by comprehensive spectroscopic analysis, single-crystal X-ray diffraction analysis and quantum chemical ECD calculations. Compound 1 showed weak cytotoxicity against four cancer cell lines. A plausible biosynthetic pathway for 1 was also postulated.
Jee-h. Jung - One of the best experts on this subject based on the ideXlab platform.
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A Cytotoxic Fellutamide Analogue from the Sponge-Derived Fungus Aspergillus versicolor.
Bulletin of the Korean Chemical Society, 2011Co-Authors: Yoon-mi Lee, Jongki Hong, Chong-o. Lee, Ping Zhang, Jee-h. JungAbstract:Korea Research Institute of Chemical Technology, Daejon 305-343, Korea Received August 11, 2011, Accepted August 30, 2011Key Words : Cytotoxicity, Aspergillus versicolor, Sponge-derived fungus, FellutamideRecently, a series of linear lipopeptides containing unusualamino acid residues have been reported from marine fungi,and these serve as a valuable source of potential drug leads.These lipopeptides were found to have interesting bio-activities, including, anti-inflammatory, antimalarial proper-ties, antimicrobial, antileishmanial, cytotoxic and neuro-toxic activities.
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A New Antioxidant from the Marine Sponge-derived Fungus Aspergillus versicolor
Natural product sciences, 2011Co-Authors: Yoon-mi Lee, Jongki Hong, Kyung-sook Bae, Jae-soo Choi, Jee-h. JungAbstract:A chemical investigation of the marine-derived fungi Aspergillus versicolor led to the isolation of a new aromatic polyketide (1), The structure was elucidated by spectroscopic analysis, and its radical-scavenging activity, reducing power, and inhibitory activity to lipid oxidation were investigated. Those activities of compound 1 were compared with standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), tertiarybutylhydroquinone (TBHQ), and ascorbic acid (VC). Compound 1 showed antioxidant activity comparable to that of BHA, and siginificantly higher than that of BHT.
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Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor
Archives of pharmacal research, 2010Co-Authors: Yoon Lee, Jongki Hong, Kyung-sook Bae, Hee Young Cho, Mi Ae Kim, Dong-kyoo Kim, Jee-h. JungAbstract:As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4–8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41–4.61 μg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78–6.25 μg/mL.
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Polyketides from a Sponge-Derived Fungus, Aspergillus versicolor
Natural product sciences, 2007Co-Authors: Yoon-mi Lee, Tayyab A. Mansoor, Jongki Hong, Chong-o. Lee, Kyung-sook Bae, Jee-h. JungAbstract:Bioactivity guided fractionation of the cultured filtrates of Aspergillus versicolor, which was derived from a marine sponge Petrosia sp., yielded three polyketides: decumbenones A (1),B (2), and versiol (3). These compounds were identified on the basis of 1D and 2D NMR spectroscopic and MS analysis. The absolute configuration was defined by the modified Mosher's method. The isolated compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and antibacterial activity against twenty clinically isolated methicillin-resistant strains. This is the first report on the isolation of these compounds from a marine source.
Yibin Zhuang - One of the best experts on this subject based on the ideXlab platform.
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cyclopeptides and polyketides from coral associated fungus Aspergillus versicolor lcj 5 4
Tetrahedron, 2011Co-Authors: Yibin Zhuang, Xiancun Teng, Yi Wang, Peipei Liu, Hui Wang, Weiming ZhuAbstract:Abstract Three new cyclopentapeptides, versicoloritides A–C (1–3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1–4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM.
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new quinazolinone alkaloids within rare amino acid residue from coral associated fungus Aspergillus versicolor lcj 5 4
Organic Letters, 2011Co-Authors: Yibin Zhuang, Xiancun Teng, Yi Wang, Peipei Liu, Weiming ZhuAbstract:Cottoquinazoline D (3), a new alkaloid with a 1-aminocyclopropane-1-carboxylic acid residue rarely discovered in nature, was isolated and identified together with two new quinazolinone alkaloids, cottoquinazolines B (1) and C (2), from coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures including absolute configurations were elucidated based on spectroscopic methods, X-ray single crystal diffraction analysis, and chemical methods. A possible biogenetic pathway for them was proposed.
