The Experts below are selected from a list of 488223 Experts worldwide ranked by ideXlab platform
Artur Zembowicz - One of the best experts on this subject based on the ideXlab platform.
-
Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
Archives of pathology & laboratory medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
-
expression of soluble adenylyl cyclase in lentigo maligna use of immunohistochemistry with anti soluble adenylyl cyclase antibody r21 in diagnosis of lentigo maligna and Assessment of margins
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
Cynthia M. Magro - One of the best experts on this subject based on the ideXlab platform.
-
Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
Archives of pathology & laboratory medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
-
expression of soluble adenylyl cyclase in lentigo maligna use of immunohistochemistry with anti soluble adenylyl cyclase antibody r21 in diagnosis of lentigo maligna and Assessment of margins
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
Ghazi M. Rayan - One of the best experts on this subject based on the ideXlab platform.
-
Outcome following nonoperative treatment of displaced distal radius fractures in low-demand patients older than 60 years.
The Journal of hand surgery, 2000Co-Authors: Burt T. Young, Ghazi M. RayanAbstract:Twenty-five sedentary, low-demand patients older than 60 years were retrospectively evaluated for function and radiographic results following nonoperative treatment of displaced distal radius fractures. The mean age was 72 years and the average follow-up period was 34 months. All patients had radiographic and functional evaluations. The radiographic Assessment included a scoring system based on measurements of the final dorsal angle, loss of radial length, and the final radial inclination. The development of radiocarpal and distal radioulnar joint arthrosis was also investigated. The functional Assessment included subjective and Objective criteria. Overall satisfaction, ability to return to previous activity level or occupation, concern over wrist appearance, and a functional task questionnaire were part of the subjective Assessment. Objective Assessment included neuromuscular evaluation and measurements of range of motion and grip strength. The final radiographic scores revealed that 6 patients (24%) had excellent results, 11 (44%) had good results, 2 (8%) had fair results, and 6 (24%) had poor results. Six of 10 patients with intra-articular fractures developed progressive wrist arthrosis. Two of 6 patients with radiographic arthrosis had unsatisfactory functional outcome. Five of 8 patients with intra-articular fractures that healed with a residual stepoff >/=2 mm had satisfactory functional outcome; 3 of these 8 patients had unsatisfactory functional outcome. The functional Assessment revealed that 22 patients (88%) had excellent or good results and 3 (12%) had fair or poor results. The radiographic outcome did not correlate with the functional outcome. Twenty-three of 25 patients (92%) were satisfied with the overall outcome of the treatment and 22 (88%) were able to return to their previous activity level or occupation. Despite an obvious clinical deformity in over half of the patients, none were unhappy with the clinical appearance of the wrist. According to the functional task questionnaire, jar opening was by far the most difficult task to perform after fracture healing. Functional outcome was satisfactory in most cases; a high level of personal satisfaction and return to previous activity level was observed, regardless of the radiographic result. Nonoperative treatment of distal radius fractures yields satisfactory outcome, especially in those with low functional demands. It also is indicated in poor operative candidates. (J Hand Surg 2000; 25A:19-28.
-
outcome following nonoperative treatment of displaced distal radius fractures in low demand patients older than 60 years
Journal of Hand Surgery (European Volume), 2000Co-Authors: Burt T. Young, Ghazi M. RayanAbstract:Abstract Twenty-five sedentary, low-demand patients older than 60 years were retrospectively evaluated for function and radiographic results following nonoperative treatment of displaced distal radius fractures. The mean age was 72 years and the average follow-up period was 34 months. All patients had radiographic and functional evaluations. The radiographic Assessment included a scoring system based on measurements of the final dorsal angle, loss of radial length, and the final radial inclination. The development of radiocarpal and distal radioulnar joint arthrosis was also investigated. The functional Assessment included subjective and Objective criteria. Overall satisfaction, ability to return to previous activity level or occupation, concern over wrist appearance, and a functional task questionnaire were part of the subjective Assessment. Objective Assessment included neuromuscular evaluation and measurements of range of motion and grip strength. The final radiographic scores revealed that 6 patients (24%) had excellent results, 11 (44%) had good results, 2 (8%) had fair results, and 6 (24%) had poor results. Six of 10 patients with intra-articular fractures developed progressive wrist arthrosis. Two of 6 patients with radiographic arthrosis had unsatisfactory functional outcome. Five of 8 patients with intra-articular fractures that healed with a residual stepoff ≥2 mm had satisfactory functional outcome; 3 of these 8 patients had unsatisfactory functional outcome. The functional Assessment revealed that 22 patients (88%) had excellent or good results and 3 (12%) had fair or poor results. The radiographic outcome did not correlate with the functional outcome. Twenty-three of 25 patients (92%) were satisfied with the overall outcome of the treatment and 22 (88%) were able to return to their previous activity level or occupation. Despite an obvious clinical deformity in over half of the patients, none were unhappy with the clinical appearance of the wrist. According to the functional task questionnaire, jar opening was by far the most difficult task to perform after fracture healing. Functional outcome was satisfactory in most cases; a high level of personal satisfaction and return to previous activity level was observed, regardless of the radiographic result. Nonoperative treatment of distal radius fractures yields satisfactory outcome, especially in those with low functional demands. It also is indicated in poor operative candidates. (J Hand Surg 2000;25A:19–28. Copyright © 2000 by the American Society for Surgery of the Hand.)
Kwang-tsao Shao - One of the best experts on this subject based on the ideXlab platform.
-
Time series dataset of fish assemblages near thermal discharges at nuclear power plants in northern Taiwan
Scientific Data, 2018Co-Authors: Hungyen Chen, Ching-yi Chen, Kwang-tsao ShaoAbstract:Long-term time series datasets with consistent sampling methods are rather rare, especially the ones of non-target coastal fishes. Here we described a long-term time series dataset of fish collected by trammel net fish sampling and observed by an underwater diving visual census near the thermal discharges at two nuclear power plants on the northern coast of Taiwan. Both experimental and control stations of these two investigations were monitored four times per year in the surrounding seas at both plants from 2000 to 2017. The underwater visual census mainly monitored reef fish assemblages and trammel net samples monitored pelagic or demersal fishes above the muddy/sandy bottom. In total, 508 samples containing 203,863 individuals from 347 taxa were recorded in both investigations at both plants. These data can be used by ecologists and fishery biologists interested in the elucidation of the temporal patterns of species abundance and composition. Design Type(s) observation design • time series design • biodiversity Assessment Objective • species comparison design Measurement Type(s) species identification Technology Type(s) visual observation method Factor Type(s) temporal_interval Sample Characteristic(s) Gnathostomata • Taiwan • ocean biome Machine-accessible metadata file describing the reported data (ISA-Tab format)
-
Long-term monitoring dataset of fish assemblages impinged at nuclear power plants in northern Taiwan
Scientific Data, 2015Co-Authors: Hungyen Chen, Ching-yi Chen, Yun-chih Liao, Jeng-i Tsai, Lee-sea Chen, Kwang-tsao ShaoAbstract:The long-term species diversity patterns in marine fish communities are garnering increasing attention from ecologists and conservation biologists. However, current databases on quantitative abundance information lack consistent long-term time series, which are particularly important in exploring the possible underlying mechanism of community changes and evaluating the effectiveness of biodiversity conservation measures. Here we describe an impinged fish assemblage dataset containing 1, 283, 707 individuals from 439 taxa. Once a month over 19 years (1987–1990 and 2000–2014), we systematically collected the fish killed by impingement upon cooling water intake screens at two nuclear power plants on the northern coast of Taiwan. Because impingement surveys have low sampling errors and can be carried out over many years, they serve as an ideal sampling tool for monitoring how fish diversity and community structure vary over an extended period of time. Design Type(s) time series design • observation design • species comparison design • biodiversity Assessment Objective Measurement Type(s) species identification Technology Type(s) impinged animal monitoring Factor Type(s) Sample Characteristic(s) Gnathostomata • Taiwan • ocean biome Machine-accessible metadata file describing the reported data (ISA-Tab format)
Sung-eun Yang - One of the best experts on this subject based on the ideXlab platform.
-
Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
Archives of pathology & laboratory medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
-
expression of soluble adenylyl cyclase in lentigo maligna use of immunohistochemistry with anti soluble adenylyl cyclase antibody r21 in diagnosis of lentigo maligna and Assessment of margins
Archives of Pathology & Laboratory Medicine, 2012Co-Authors: Cynthia M. Magro, Sung-eun Yang, Jonathan H. Zippin, Artur ZembowiczAbstract:Context.—Soluble adenylyl cyclase (sAC) is an enzyme that generates cyclic adenosine monophosphate, a signaling molecule involved in regulating melanocyte functions. R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin Assessment. Objective.—To evaluate R21 in the diagnosis and evaluation of margins in lentigo maligna. Design.—Thirty one re-excision specimens for lentigo maligna were evaluated for R21 expression using previously published protocol. In addition, 153 cases including 41 lentigo malignas, 30 non–lentigo maligna-type melanomas, 38 lentigos, and 44 nevi were evaluated using a modified stringent protocol to eliminate all nonmelanocyte staining. Results.—The sensitivity of nuclear staining with R21 in lentigo maligna was 87.8%. Nuclear expression of sAC was observed in 40% of other melanomas and 2.3% of benign nevi. R21 did not stain nuclei of resting melanocytes but was observed in 28.9% of me...
