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Judy E. Stern - One of the best experts on this subject based on the ideXlab platform.
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validation of birth outcomes from the society for Assisted Reproductive Technology clinic outcome reporting system sart cors population based analysis from the massachusetts outcome study of Assisted Reproductive Technology mosart
Fertility and Sterility, 2016Co-Authors: Judy E. Stern, Daksha Gopal, Rebecca F Liberman, Marlene Anderka, Milton Kotelchuck, Barbara LukeAbstract:Objective To assess the validity of outcome data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) compared with data from vital records and the birth defects registry in Massachusetts. Design Longitudinal cohort. Setting Not applicable. Participant(s) A total of 342,035 live births and fetal deaths from Massachusetts mothers giving birth in the state from July 1, 2004, to December 31, 2008; 9,092 births and fetal deaths were from mothers who had conceived with the use of Assisted Reproductive Technology (ART) and whose cycle data had been reported to the SART CORS. Intervention(s) Not applicable. Main Outcome Measure(s) Percentage agreement between maternal race and ethnicity, delivery outcome (live birth or fetal death), plurality (singleton, twin, or triplet+), delivery date, and singleton birth weight reported in the SART CORS versus vital records; sensitivity and specificity for birth defects among singletons as reported in the SART CORS versus the Massachusetts Birth Defects Monitoring Program (BDMP). Result(s) There was >95% agreement between the SART CORS and vital records for fields of maternal race/ethnicity, live birth/fetal death, and plurality; birth outcome date was within 1 day with 94.9% agreement and birth weight was within 100 g with 89.6% agreement. In contrast, sensitivity for report of any birth defect was 38.6%, with a range of 18.4%–50.0%, for specific birth defect categories. Conclusion(s) Although most SART CORS outcome fields are accurately reported, birth defect variables showed poor sensitivity compared with the gold standard data from the BDMP. We suggest that reporting of birth defects be discontinued.
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accuracy of self reported survey data on Assisted Reproductive Technology treatment parameters and Reproductive history
American Journal of Obstetrics and Gynecology, 2016Co-Authors: Judy E. Stern, Barbara Luke, Alexander C Mclain, Germaine Buck M Louis, Edwina H YeungAbstract:Background It is unknown whether data obtained from maternal self-report for Assisted Reproductive Technology treatment parameters and Reproductive history are accurate for use in research studies. Objectives We evaluated the accuracy of self-reported in Assisted Reproductive Technology treatment and Reproductive history from the Upstate KIDS study in comparison with clinical data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Study Design Upstate KIDS maternal questionnaire data from deliveries between 2008 and 2010 were linked to data reported to Society for Assisted Reproductive Technology Clinic Outcome Reporting System. The 617 index deliveries were compared as to treatment type (frozen embryo transfer and donor egg or sperm) and use of intracytoplasmic sperm injection and Assisted hatching. Use of injectable medications, self-report for Assisted Reproductive Technology, or frozen embryo transfer prior to the index deliveries were also compared. We report agreement in which both sources had yes or both no and sensitivity of maternal report using Society for Assisted Reproductive Technology Clinic Outcome Reporting System as the gold standard. Significance was determined using χ 2 at P Results Universal agreement was not reached on any parameter but was best for treatment type of frozen embryo transfer (agreement, 96%; sensitivity, 93%) and use of donor eggs (agreement, 97%; sensitivity, 82%) or sperm (agreement, 98%; sensitivity, 82%). Use of intracytoplasmic sperm injection (agreement, 78%: sensitivity, 78%) and Assisted hatching (agreement, 57%; sensitivity, 38%) agreed less well with self-reported use ( P P Conclusion Women accurately report in vitro fertilization treatment but are less accurate about procedures handled in the laboratory (intracytoplasmic sperm injection or Assisted hatching). Clinics might better communicate with patients on the use of these procedures, and researchers should use caution when using self-reported treatment data.
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adverse pregnancy and birth outcomes associated with underlying diagnosis with and without Assisted Reproductive Technology treatment
Fertility and Sterility, 2015Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Michael Tobias, Hafsatou DiopAbstract:Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without Assisted Reproductive Technology (ART) treatment to non-ART pregnancies in fertile women. Design Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting Not applicable. Patient(s) Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and Reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospital discharges in women who had ART treatment (n = 3,689), women with no ART treatment in the current pregnancy (n = 4,098), and non-ART pregnancies in fertile women (n = 297,987). Intervention(s) None. Main Outcome Measure(s) Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios [AORs] and 95% confidence intervals [CIs]). Result(s) Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and Reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s) The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.
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using the society for Assisted Reproductive Technology clinic outcome system morphological measures to predict live birth after Assisted Reproductive Technology
Fertility and Sterility, 2014Co-Authors: Barbara Luke, Morton B. Brown, Judy E. Stern, Catherine Racowsky, Sangita K Jindal, David G BallAbstract:Objective To model morphological assessments of embryo quality that are predictive of live birth. Design Longitudinal cohort using cycles reported in the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System (SART CORS) between 2007 and 2011. Setting Clinic-based data. Patient(s) Fresh autologous Assisted Reproductive Technology (ART) cycles with ETs on day 3 or day 5 and morphological assessments reported (25,409 cycles with one embryo transferred and 96,093 cycles with two embryos transferred). Live-birth rates were modeled by morphological assessments using backward-stepping logistic regression for cycle 1 and over five cycles, separately for day 3 and day 5 transfers and number of embryos transferred (1 or 2). Additional models for each day of transfer also included the number of oocytes retrieved and the number of embryos cryopreserved. Intervention(s) None. Main Outcome Measure(s) Live births. Result(s) Morphological assessments of grade, stage, fragmentation, and symmetry were significant for the day 3 models; grade, stage, and trophectoderm were significant in the day 5 model; inner-cell mass was significant in the models when two embryos were transferred. Number of oocytes retrieved and number of embryos cryopreserved were significant for both day 3 and day 5 models. Conclusion(s) These findings confirm the significant association between embryo quality parameters reported to SART CORS and live-birth rate after ART.
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the effect of father s age in fertile subfertile and Assisted Reproductive Technology pregnancies a population based cohort study
Journal of Assisted Reproduction and Genetics, 2014Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Hafsatou Diop, Howard Cabral, Milton KotelchuckAbstract:Purpose To compare ages of mothers and of fathers at delivery in couples who are fertile, subfertile, and subfertile treated with Assisted Reproductive Technology (ART) and to characterize birth outcomes in the ART population according to paternal age.
Barbara Luke - One of the best experts on this subject based on the ideXlab platform.
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pregnancy and birth outcomes in couples with infertility with and without Assisted Reproductive Technology with an emphasis on us population based studies
American Journal of Obstetrics and Gynecology, 2017Co-Authors: Barbara LukeAbstract:Infertility, defined as the inability to conceive within 1 year of unprotected intercourse, affects an estimated 80 million individuals worldwide, or 10-15% of couples of Reproductive age. Assisted Reproductive Technology includes all infertility treatments to achieve conception; in vitro fertilization is the process by which an oocyte is fertilized by semen outside the body; non-in vitro fertilization Assisted Reproductive Technology treatments include ovulation induction, artificial insemination, and intrauterine insemination. Use of Assisted Reproductive Technology has risen steadily in the United States during the past 2 decades due to several reasons, including childbearing at older maternal ages and increasing insurance coverage. The number of in vitro fertilization cycles in the United States has nearly doubled from 2000 through 2013 and currently 1.7% of all live births in the United States are the result of this Technology. Since the birth of the first child from in vitro fertilization >35 years ago, >5 million babies have been born from in vitro fertilization, half within the past 6 years. It is estimated that 1% of singletons, 19% of twins, and 25% of triplet or higher multiples are due to in vitro fertilization, and 4%, 21%, and 52%, respectively, are due to non-in vitro fertilization Assisted Reproductive Technology. Higher plurality at birth results in a >10-fold increase in the risks for prematurity and low birthweight in twins vs singletons (adjusted odds ratio, 11.84; 95% confidence interval, 10.56–13.27 and adjusted odds ratio, 10.68; 95% confidence interval, 9.45–12.08, respectively). The use of donor oocytes is associated with increased risks for pregnancy-induced hypertension (adjusted odds ratio, 1.43; 95% confidence interval, 1.14–1.78) and prematurity (adjusted odds ratio, 1.43; 95% confidence interval, 1.11–1.83). The use of thawed embryos is associated with higher risks for pregnancy-induced hypertension (adjusted odds ratio, 1.30; 95% confidence interval, 1.08–1.57) and large-for-gestation birthweight (adjusted odds ratio, 1.74; 95% confidence interval, 1.45–2.08). Among singletons, in vitro fertilization is associated with increased risk of severe maternal morbidity compared with fertile deliveries (vaginal: adjusted odds ratio, 2.27; 95% confidence interval, 1.78–2.88; cesarean: adjusted odds ratio, 1.67; 95% confidence interval, 1.40–1.98, respectively) and subfertile deliveries (vaginal: adjusted odds ratio, 1.97; 95% confidence interval, 1.30–3.00; cesarean: adjusted odds ratio, 1.75; 95% confidence interval, 1.30–2.35, respectively). Among twins, cesarean in vitro fertilization deliveries have significantly greater severe maternal morbidity compared to cesarean fertile deliveries (adjusted odds ratio, 1.48; 95% confidence interval, 1.14–1.93). Subfertility, with or without in vitro fertilization or non-in vitro fertilization infertility treatments to achieve a pregnancy, is associated with increased risks of adverse maternal and perinatal outcomes. The major risk from in vitro fertilization treatments of multiple births (and the associated excess of perinatal morbidity) has been reduced over time, with fewer and better-quality embryos being transferred.
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validation of birth outcomes from the society for Assisted Reproductive Technology clinic outcome reporting system sart cors population based analysis from the massachusetts outcome study of Assisted Reproductive Technology mosart
Fertility and Sterility, 2016Co-Authors: Judy E. Stern, Daksha Gopal, Rebecca F Liberman, Marlene Anderka, Milton Kotelchuck, Barbara LukeAbstract:Objective To assess the validity of outcome data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) compared with data from vital records and the birth defects registry in Massachusetts. Design Longitudinal cohort. Setting Not applicable. Participant(s) A total of 342,035 live births and fetal deaths from Massachusetts mothers giving birth in the state from July 1, 2004, to December 31, 2008; 9,092 births and fetal deaths were from mothers who had conceived with the use of Assisted Reproductive Technology (ART) and whose cycle data had been reported to the SART CORS. Intervention(s) Not applicable. Main Outcome Measure(s) Percentage agreement between maternal race and ethnicity, delivery outcome (live birth or fetal death), plurality (singleton, twin, or triplet+), delivery date, and singleton birth weight reported in the SART CORS versus vital records; sensitivity and specificity for birth defects among singletons as reported in the SART CORS versus the Massachusetts Birth Defects Monitoring Program (BDMP). Result(s) There was >95% agreement between the SART CORS and vital records for fields of maternal race/ethnicity, live birth/fetal death, and plurality; birth outcome date was within 1 day with 94.9% agreement and birth weight was within 100 g with 89.6% agreement. In contrast, sensitivity for report of any birth defect was 38.6%, with a range of 18.4%–50.0%, for specific birth defect categories. Conclusion(s) Although most SART CORS outcome fields are accurately reported, birth defect variables showed poor sensitivity compared with the gold standard data from the BDMP. We suggest that reporting of birth defects be discontinued.
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accuracy of self reported survey data on Assisted Reproductive Technology treatment parameters and Reproductive history
American Journal of Obstetrics and Gynecology, 2016Co-Authors: Judy E. Stern, Barbara Luke, Alexander C Mclain, Germaine Buck M Louis, Edwina H YeungAbstract:Background It is unknown whether data obtained from maternal self-report for Assisted Reproductive Technology treatment parameters and Reproductive history are accurate for use in research studies. Objectives We evaluated the accuracy of self-reported in Assisted Reproductive Technology treatment and Reproductive history from the Upstate KIDS study in comparison with clinical data reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Study Design Upstate KIDS maternal questionnaire data from deliveries between 2008 and 2010 were linked to data reported to Society for Assisted Reproductive Technology Clinic Outcome Reporting System. The 617 index deliveries were compared as to treatment type (frozen embryo transfer and donor egg or sperm) and use of intracytoplasmic sperm injection and Assisted hatching. Use of injectable medications, self-report for Assisted Reproductive Technology, or frozen embryo transfer prior to the index deliveries were also compared. We report agreement in which both sources had yes or both no and sensitivity of maternal report using Society for Assisted Reproductive Technology Clinic Outcome Reporting System as the gold standard. Significance was determined using χ 2 at P Results Universal agreement was not reached on any parameter but was best for treatment type of frozen embryo transfer (agreement, 96%; sensitivity, 93%) and use of donor eggs (agreement, 97%; sensitivity, 82%) or sperm (agreement, 98%; sensitivity, 82%). Use of intracytoplasmic sperm injection (agreement, 78%: sensitivity, 78%) and Assisted hatching (agreement, 57%; sensitivity, 38%) agreed less well with self-reported use ( P P Conclusion Women accurately report in vitro fertilization treatment but are less accurate about procedures handled in the laboratory (intracytoplasmic sperm injection or Assisted hatching). Clinics might better communicate with patients on the use of these procedures, and researchers should use caution when using self-reported treatment data.
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Society for Assisted Reproductive Technology and Assisted Reproductive Technology in the United States: a 2016 update
Fertility and Sterility, 2016Co-Authors: James P. Toner, Charles C. Coddington, Kevin J. Doody, Brad Van Voorhis, David B. Seifer, G. David Ball, Barbara Luke, Ethan WantmanAbstract:The Society for Assisted Reproductive Technology (SART) was established within a few years of Assisted Reproductive Technology (ART) in the United States, and has not only reported on the evolution of infertility care, but also guided it toward improved success and safety. Moving beyond its initial role as a registry, SART has expanded its role to include quality assurance, data validation, practice and advertising guidelines, research, patient education and advocacy, and membership support. The success of ART in this country has greatly benefited from SART's role, as highlighted by a series of graphs. SART continues to set the standard and lead the way.
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adverse pregnancy and birth outcomes associated with underlying diagnosis with and without Assisted Reproductive Technology treatment
Fertility and Sterility, 2015Co-Authors: Judy E. Stern, Barbara Luke, Mark D Hornstein, Daksha Gopal, Michael Tobias, Hafsatou DiopAbstract:Objective To compare the risks for adverse pregnancy and birth outcomes by diagnoses with and without Assisted Reproductive Technology (ART) treatment to non-ART pregnancies in fertile women. Design Historical cohort of Massachusetts vital records linked to ART clinic data from Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Setting Not applicable. Patient(s) Diagnoses included male factor (ART only), endometriosis, ovulation disorders, tubal (ART only), and Reproductive inflammatory disorders (non-ART only). Pregnancies resulting in singleton and twin live births from 2004 to 2008 were linked to hospital discharges in women who had ART treatment (n = 3,689), women with no ART treatment in the current pregnancy (n = 4,098), and non-ART pregnancies in fertile women (n = 297,987). Intervention(s) None. Main Outcome Measure(s) Risks of gestational diabetes, prenatal hospitalizations, prematurity, low birth weight, and small for gestational age were modeled using multivariate logistic regression with fertile deliveries as the reference group adjusted for maternal age, race/ethnicity, education, chronic hypertension, diabetes mellitus, and plurality (adjusted odds ratios [AORs] and 95% confidence intervals [CIs]). Result(s) Risk of prenatal hospital admissions was increased for endometriosis (ART: 1.97, 1.38–2.80; non-ART: 3.34, 2.59–4.31), ovulation disorders (ART: 2.31, 1.81–2.96; non-ART: 2.56, 2.05–3.21), tubal factor (ART: 1.51, 1.14–2.01), and Reproductive inflammation (non-ART: 2.79, 2.47–3.15). Gestational diabetes was increased for women with ovulation disorders (ART: 2.17, 1.72–2.73; non-ART: 1.94, 1.52–2.48). Preterm delivery (AORs, 1.24–1.93) and low birth weight (AORs, 1.27–1.60) were increased in all groups except in endometriosis with ART. Conclusion(s) The findings indicate substantial excess perinatal morbidities associated with underlying infertility-related diagnoses in both ART-treated and non-ART-treated women.
Dmitry M. Kissin - One of the best experts on this subject based on the ideXlab platform.
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disparities in Assisted Reproductive Technology utilization by race and ethnicity united states 2014 a commentary
Journal of Womens Health, 2017Co-Authors: Ada C Dieke, Dmitry M. Kissin, Wanda D. Barfield, Yujia Zhang, Sheree L. BouletAbstract:Abstract Disparities in infertility and access to infertility treatments, such as Assisted Reproductive Technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities. We used 2014 National ART Surveillance System (NASS) data to calculate rates of ART procedures per million women 15–44 years of age, a proxy measure of ART utilization, for Census-defined racial/ethnic groups in the United States; rates were further stratified by the presence of insurance mandates for IVF treatment. Missing race/ethnicity data (35.6% of cycles) were imputed. Asian/Pacific Islander (A/PI) women had the highest rates of ART utilization at...
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perinatal outcomes among singletons after Assisted Reproductive Technology with single embryo or double embryo transfer versus no Assisted Reproductive Technology
Fertility and Sterility, 2017Co-Authors: Sheree L. Boulet, Jennifer F. Kawwass, Angela S Martin, Yujia Zhang, Patricia Mckane, Jeani Chang, Dana Bernson, Dmitry M. KissinAbstract:Objective To examine outcomes of singleton pregnancies conceived without Assisted Reproductive Technology (non-ART) compared with singletons conceived with ART by elective single-embryo transfer (eSET), nonelective single-embryo transfer (non-eSET), and double-embryo transfer with the establishment of 1 (DET −1) or ≥2 (DET ≥2) early fetal heartbeats. Design Retrospective cohort using linked ART surveillance data and vital records from Florida, Massachusetts, Michigan, and Connecticut. Setting Not applicable. Patient(s) Singleton live-born infants. Intervention(s) None. Main Outcome Measure(s) Preterm birth (PTB Result(s) After controlling for maternal characteristics and employing a weighted propensity score approach, we found that singletons conceived after eSET were less likely to have a 5-minute Apgar Conclusion(s) Compared with non-ART singletons, singletons born after eSET and non-eSET did not have increased risks whereas DET −1 and DET ≥2 singletons were more likely to have adverse perinatal outcomes.
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Assisted Reproductive Technology surveillance united states 2014
Morbidity and mortality weekly report. Surveillance summaries (Washington D.C. : 2002), 2017Co-Authors: Saswati Sunderam, Dmitry M. Kissin, Denise J. Jamieson, Sara Crawford, Suzanne G Folger, Lee Warner, Wanda D. BarfieldAbstract:Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of ART and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which eggs or embryos are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Women who undergo ART procedures are more likely than women who conceive naturally to deliver multiple-birth infants. Multiple births pose substantial risks to both mothers and infants, including obstetric complications, preterm delivery, and low birthweight infants. This report provides state-specific information for the United States (including the District of Columbia and Puerto Rico) on ART procedures performed in 2014 and compares birth outcomes that occurred in 2014 (resulting from ART procedures performed in 2013 and 2014) with outcomes for all infants born in the United States in 2014.
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trends in severe maternal morbidity after Assisted Reproductive Technology in the united states 2008 2012
Obstetrics & Gynecology, 2016Co-Authors: Angela S Martin, Dmitry M. Kissin, Denise J. Jamieson, William M Callaghan, Michael Monsour, Sheree L. BouletAbstract:OBJECTIVE:To examine trends in severe maternal morbidity from 2008 to 2012 in delivery and postpartum hospitalizations among pregnancies conceived with or without Assisted Reproductive Technology (ART).METHODS:In this retrospective cohort study, deliveries were identified in the 2008–2012 Truven Hea
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Assisted Reproductive Technology and the risk of preterm birth among primiparas
Fertility and Sterility, 2015Co-Authors: Galit Levi Dunietz, Dmitry M. Kissin, Sheree L. Boulet, Patricia Mckane, Glenn Copeland, Dana Bernson, Claudia Holzman, David Todem, William M Sappenfield, Michael P DiamondAbstract:Objective To investigate the risk of preterm birth among liveborn singletons to primiparas who conceived with Assisted Reproductive Technology (ART) using four mutually exclusive categories of infertility (female infertility only, male infertility only, female and male infertility, and unexplained infertility) and to examine preterm birth risk along the gestational age continuum. Design Retrospective cohort study. Setting Not applicable. Patient(s) Singletons born to primiparas who conceived with or without ART. Intervention(s) None. Main Outcome Measure(s) Preterm ( Result(s) For the male infertility only, female infertility only, combined male and female infertility, and unexplained infertility groups, ART-conceived singletons were significantly more likely than non-ART singletons to be born preterm: adjusted odds ratio (aOR) 1.24 (95% CI, 1.13, 1.37), aOR 1.60 (95% CI, 1.50, 1.70), aOR 1.49 (95% CI, 1.35, 1.64), and aOR 1.26 (1.12, 1.43) respectively. Among infants whose mothers were diagnosed with infertility, the odds of preterm birth were highest between 28–30 weeks [female infertility only, aOR 1.95 (95% CI, 1.59, 2.39); male and female infertility: 2.21 (95% CI, 1.62, 3.00)] compared with infants in the general population. Within the ART population, singletons of couples with female infertility only were more likely to be born preterm than singletons born to couples with other infertility diagnoses. Conclusion(s) Among singleton births to primiparas, those conceived with ART had an increased risk for preterm birth, even when only the male partner had been diagnosed with infertility. The risk of preterm birth for ART-conceived infants whose mothers were diagnosed with infertility included the earliest deliveries.
Ethan Wantman - One of the best experts on this subject based on the ideXlab platform.
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status of racial disparities between black and white women undergoing Assisted Reproductive Technology in the us
Reproductive Biology and Endocrinology, 2020Co-Authors: David B. Seifer, Ethan Wantman, Burcin Simsek, Alexander KotlyarAbstract:Numerous studies have demonstrated substantial differences in Assisted Reproductive Technology outcomes between black non-Hispanic and white non-Hispanic women. We sought to determine if disparities in Assisted Reproductive Technology outcomes between cycles from black non-Hispanic and white non-Hispanic women have changed and to identify factors that may have influenced change and determine racial differences in cumulative live birth rates. This is a retrospective cohort study of the SARTCORS database outcomes for 2014–2016 compared with those previously reported in 2004–2006 and 1999/2000. Patient demographics, etiology of infertility, and cycle outcomes were compared between black non-hispanic and white non-hispanic patients. Categorical values were compared using Chi-squared testing. Continuous variables were compared using t-test. Multiple logistic regression was used to assess confounders. We analyzed 122,721 autologous, fresh, non-donor embryo cycles from 2014 to 2016 of which 13,717 cycles from black and 109,004 cycles from white women. The proportion of cycles from black women increased from 6.5 to 8.4%. Cycles from black women were almost 3 times more likely to have tubal and/or uterine factor and body mass index ≥30 kg/m2. Multivariate logistic regression demonstrated that black women had a lower live birth rate (OR 0.71;P < 0.001) and a lower cumulative live birth rate for their initial cycle (OR 0.64; P < 0.001) independent of age, parity, body mass index, etiology of infertility, ovarian reserve, cycle cancellation, past spontaneous abortions, use of intra-cytoplasmic sperm injection or number of embryos transferred. A lower proportion of cycles in black women were represented among non-mandated states (P < 0.001) and cycles in black women were associated with higher clinical live birth rates in mandated states (P = 0.006). Disparities in Assisted Reproductive Technology outcomes in the US have persisted for black women over the last 15 years. Limited access to state mandated insurance may be contributory. Race has continued to be an independent prognostic factor for live birth and cumulative live birth rate from Assisted Reproductive Technology in the US.
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Society for Assisted Reproductive Technology and Assisted Reproductive Technology in the United States: a 2016 update
Fertility and Sterility, 2016Co-Authors: James P. Toner, Charles C. Coddington, Kevin J. Doody, Brad Van Voorhis, David B. Seifer, G. David Ball, Barbara Luke, Ethan WantmanAbstract:The Society for Assisted Reproductive Technology (SART) was established within a few years of Assisted Reproductive Technology (ART) in the United States, and has not only reported on the evolution of infertility care, but also guided it toward improved success and safety. Moving beyond its initial role as a registry, SART has expanded its role to include quality assurance, data validation, practice and advertising guidelines, research, patient education and advocacy, and membership support. The success of ART in this country has greatly benefited from SART's role, as highlighted by a series of graphs. SART continues to set the standard and lead the way.
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a prediction model for live birth and multiple births within the first three cycles of Assisted Reproductive Technology
Fertility and Sterility, 2014Co-Authors: Barbara Luke, Charles C. Coddington, Ethan Wantman, Morton B. Brown, William E. Gibbons, Judy E. Stern, Eric Widra, Valerie L Baker, David G BallAbstract:Objective To develop a model predictive of live-birth rates (LBR) and multiple birth rates (MBR) for an individual considering Assisted reproduction Technology (ART) using linked cycles from Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) for 2004–2011. Design Longitudinal cohort. Setting Clinic-based data. Patient(s) 288,161 women with an initial autologous cycle, of whom 89,855 did not become pregnant and had a second autologous cycle and 39,334 did not become pregnant in the first and second cycles and had a third autologous cycle, with an additional 33,598 women who had a cycle using donor oocytes (first donor cycle). Intervention(s) None. Main Outcome Measure(s) LBRs and MBRs modeled by woman's age, body mass index, gravidity, prior full-term births, infertility diagnoses by oocyte source, fresh embryos transferred, and cycle, using backward-stepping logistic regression with results presented as adjusted odds ratios (AORs) and 95% confidence intervals. Result(s) The LBRs increased in all models with prior full-term births, number of embryos transferred; in autologous cycles also with gravidity, diagnoses of male factor, and ovulation disorders; and in donor cycles also with the diagnosis of diminished ovarian reserve. The MBR increased in all models with number of embryos transferred and in donor cycles also with prior full-term births. For both autologous and donor cycles, transferring two versus one embryo greatly increased the probability of a multiple birth (AOR 27.25 and 38.90, respectively). Conclusion(s) This validated predictive model will be implemented on the Society for Assisted Reproductive Technology Web site (www.sart.org) so that patients considering initiating a course of ART can input their data on the Web site to generate their expected outcomes.
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second try who returns for additional Assisted Reproductive Technology treatment and the effect of a prior Assisted Reproductive Technology birth
Fertility and Sterility, 2013Co-Authors: Barbara Luke, Ethan Wantman, Morton B. Brown, Valerie L Baker, Daniel Grow, Judy E. SternAbstract:Objective To evaluate the effect of a prior Assisted Reproductive Technology (ART) live birth on subsequent live-birth rates. Design Historical cohort study. Setting Clinic-based data. Patient(s) The study population included 297,635 women with 549,278 cycles from 2004 to 2010 from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Try 1 refers to ART cycles up to and including the first live birth, try 2 to ART cycles after a first live birth. Intervention(s) None. Main Outcome Measure(s) Live-birth rates by cycle number, try number, and oocyte source. Result(s) Younger women at try 1 are more likely to return for try 2. Women returning for try 2 were more likely to have had an ART singleton versus multiple birth (33.2% after a try 1 singleton versus 8.1% after twins and 4.9% after triplets) and were less likely to have a diagnosis of diminished ovarian reserve or tubal factors. Live-birth rates were significantly higher for try 2 compared with try 1 for autologous fresh cycles, averaging 7.7 percentage points higher over five cycles. Live-birth rates were not significantly different for try 2 versus try 1 with thawed autologous cycles or either fresh or thawed donor cycles. Conclusion(s) These results indicate that when fresh autologous oocytes can be used, live-birth rates per cycle are significantly greater after a prior history of an ART live birth.
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Cumulative birth rates with linked Assisted Reproductive Technology cycles
The New England Journal of Medicine, 2012Co-Authors: Barbara Luke, Ethan Wantman, Morton B. Brown, A. Lederman, William E. Gibbons, Glenn L. Schattman, Rogerio A. Lobo, Richard E. Leach, Judy E. SternAbstract:Background Live-birth rates after treatment with Assisted Reproductive Technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success rates are a more important measure. Methods We linked data from cycles of Assisted Reproductive Technology in the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for the period from 2004 through 2009 to individual women in order to estimate cumulative live-birth rates. Conservative estimates assumed that women who did not return for treatment would not have a live birth; optimal estimates assumed that these women would have live-birth rates similar to those for women continuing treatment. Results The data were from 246,740 women, with 471,208 cycles and 140,859 live births. Live-birth rates declined with increasing maternal age and increasing cycle number with autologous, but not donor, oocytes. By the third cycle, the conservative and optimal estimates of live-birth rates w...
Denise J. Jamieson - One of the best experts on this subject based on the ideXlab platform.
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Assisted Reproductive Technology surveillance united states 2014
Morbidity and mortality weekly report. Surveillance summaries (Washington D.C. : 2002), 2017Co-Authors: Saswati Sunderam, Dmitry M. Kissin, Denise J. Jamieson, Sara Crawford, Suzanne G Folger, Lee Warner, Wanda D. BarfieldAbstract:Since the first U.S. infant conceived with Assisted Reproductive Technology (ART) was born in 1981, both the use of ART and the number of fertility clinics providing ART services have increased steadily in the United States. ART includes fertility treatments in which eggs or embryos are handled in the laboratory (i.e., in vitro fertilization [IVF] and related procedures). Women who undergo ART procedures are more likely than women who conceive naturally to deliver multiple-birth infants. Multiple births pose substantial risks to both mothers and infants, including obstetric complications, preterm delivery, and low birthweight infants. This report provides state-specific information for the United States (including the District of Columbia and Puerto Rico) on ART procedures performed in 2014 and compares birth outcomes that occurred in 2014 (resulting from ART procedures performed in 2013 and 2014) with outcomes for all infants born in the United States in 2014.
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trends in severe maternal morbidity after Assisted Reproductive Technology in the united states 2008 2012
Obstetrics & Gynecology, 2016Co-Authors: Angela S Martin, Dmitry M. Kissin, Denise J. Jamieson, William M Callaghan, Michael Monsour, Sheree L. BouletAbstract:OBJECTIVE:To examine trends in severe maternal morbidity from 2008 to 2012 in delivery and postpartum hospitalizations among pregnancies conceived with or without Assisted Reproductive Technology (ART).METHODS:In this retrospective cohort study, deliveries were identified in the 2008–2012 Truven Hea
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safety of Assisted Reproductive Technology in the united states 2000 2011
JAMA, 2015Co-Authors: Jennifer F. Kawwass, Dmitry M. Kissin, Aniket D Kulkarni, Andreea A Creanga, Donna R Session, William M Callaghan, Denise J. JamiesonAbstract:Use of Assisted Reproductive Technology (ART) continues to increase in the United States and globally. In an effort to improve patient safety, stimulation protocols have become less aggressive, oocyte retrieval has transitioned from laparoscopic to transvaginal, and pregnancy rates have improved.1 However, limited data exist regarding the incidence of maternal complications.2 We explored incidence and trends in reported patient and donor complications in fresh ART cycles using the US Centers for Disease Control and Prevention National ART Surveillance System (NASS).
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risk of ectopic pregnancy associated with Assisted Reproductive Technology in the united states 2001 2011
Obstetrics & Gynecology, 2015Co-Authors: Kiran M Perkins, Dmitry M. Kissin, Sheree L. Boulet, Denise J. JamiesonAbstract:OBJECTIVE:To assess national trends in ectopic pregnancy incidence among Assisted Reproductive Technology users and identify risk factors associated with ectopic pregnancy.METHODS:We identified 553,577 pregnancies reported to the National ART Surveillance System between 2001 and 2011. Of those, 9,48
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Monitoring health outcomes of Assisted Reproductive Technology.
New England Journal of Medicine, 2014Co-Authors: Dmitry M. Kissin, Denise J. Jamieson, Wanda D. BarfieldAbstract:To the Editor: During the past 35 years, Assisted Reproductive Technology has been transformed from a miracle to a standard and common part of medical practice. Although this Technology is believed to be safe and has resulted in more than 5 million infants born globally, rapid technological progress leading to treatment modifications makes it important to continually monitor the safety of Assisted Reproductive Technology for the rapidly growing population of users of the Technology and infants conceived with its use. Although many countries have national registries to monitor the use and effectiveness of Assisted Reproductive Technology, they are typically not . . .
