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Zhang Jian-guo – One of the best experts on this subject based on the ideXlab platform.

  • Therapy of Male Infertility Patients with Asthenospermia by Eighteen Traditional Chinese Medicine Compound
    Chinese Journal of General Practice, 2010
    Co-Authors: Zhang Jian-guo

    Abstract:

    Objective To investigate the therapeutic regimen of male infertility patients with Asthenospermia and the mechanisms of eighteen traditional Chinese medicine compound.Methods Patients were randomly divided into treatment group and control group.The conventional semen parameters,prostate specific antigen,acid phosphatase and reproductive hormone before and after treatment were measured and compared.The correlation between the above-mentioned variables and the quality of semen were observed.Results Eighteen traditional Chinese medicine compound promoted the production of LH,FSH,T,prostate specific antigen and acid phosphatase,and improved sperm quality.The total effective rate for Asthenospermia was 81.7%,and the difference between the two groups had statistical significance(P0.05).Conclusion The curative effect eighteen traditional Chinese medicine compound is obvious,which may react by regulating the function of endocrine system and optimizing the reproductive environment.

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Qianxing Wang – One of the best experts on this subject based on the ideXlab platform.

  • Establishment of a Mouse Asthenospermia Model through Triggering DGalactose Mediated Oxidative Stress Injury.
    Endocrine metabolic & immune disorders drug targets, 2020
    Co-Authors: Nanjun Liu, Qianxing Wang

    Abstract:

    Asthenospermia is defined as forward motility of sperm less than 32%.
    This study aimed to establish mouse model of Asthenospermia through triggering D-galactose mediated oxidative stress.
    Total of 40 Kunming male mice were randomly divided into control group, low-dose group (administrating D-galactose at 60 mg/kg), high-dose group (administrating D-galactose at 120 mg/kg) and high-dose+feed addition group (administrating D-galactose at 120 mg/kg together with oral D-galactose). The testicular weight, testicular organ coefficient, sperm viability, sperm concentration and survival rate of tail of epididymis were measured. Oxidative damage of D-galactose to reproductive system of mice was evaluated by measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in testicular homogenate of mice.
    The sperm motility, motility rate, concentration and survival rate of low-dose, high-dose and high-dose+feed addition group were decreased, compared to that in control group. However, there were significant difference between highdose group/high dose+feed group and control group (p<0.05). The forward motile sperm motility rate and total motility rate accorded with critical criteria of Asthenospermia. Comparing with the control group, activity of SOD of model group mice significantly decreased, and MDA concentration significantly increased (p<0.05), excepting for low-dose versus control group for SOD activity. This suggests that testicular tissues suffered from oxidative damage.
    This study successfully established a mouse Asthenospermia model through D-galactose mediated oxidative stress injury. The establishment of Asthenospermia model in this study would provide a new promising insight and act as a potential approach for studying Asthenospermia in vivo levels.
    Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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  • establishment of a mouse Asthenospermia model through triggering dgalactose mediated oxidative stress injury
    Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2020
    Co-Authors: Nanjun Liu, Qianxing Wang

    Abstract:

    BACKGROUND Asthenospermia is defined as forward motility of sperm less than 32%. AIM/OBJECTIVE This study aimed to establish mouse model of Asthenospermia through triggering D-galactose mediated oxidative stress. MATERIALS AND METHODS Total of 40 Kunming male mice were randomly divided into control group, low-dose group (administrating D-galactose at 60 mg/kg), high-dose group (administrating D-galactose at 120 mg/kg) and high-dose+feed addition group (administrating D-galactose at 120 mg/kg together with oral D-galactose). The testicular weight, testicular organ coefficient, sperm viability, sperm concentration and survival rate of tail of epididymis were measured. Oxidative damage of D-galactose to reproductive system of mice was evaluated by measuring superoxide dismutase (SOD) and malondialdehyde (MDA) in testicular homogenate of mice. FINDINGS The sperm motility, motility rate, concentration and survival rate of low-dose, high-dose and high-dose+feed addition group were decreased, compared to that in control group. However, there were significant difference between highdose group/high dose+feed group and control group (p<0.05). The forward motile sperm motility rate and total motility rate accorded with critical criteria of Asthenospermia. Comparing with the control group, activity of SOD of model group mice significantly decreased, and MDA concentration significantly increased (p<0.05), excepting for low-dose versus control group for SOD activity. This suggests that testicular tissues suffered from oxidative damage. CONCLUSIONS This study successfully established a mouse Asthenospermia model through D-galactose mediated oxidative stress injury. The establishment of Asthenospermia model in this study would provide a new promising insight and act as a potential approach for studying Asthenospermia in vivo levels.

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Alejandro Vicente-carrillo – One of the best experts on this subject based on the ideXlab platform.

  • A splice donor variant in CCDC189 is associated with Asthenospermia in Nordic Red dairy cattle
    BMC genomics, 2019
    Co-Authors: Terhi Iso-touru, Christine Wurmser, Heli Venhoranta, Maya Hiltpold, Tujia Savolainen, Anu Sironen, Konrad Fischer, Krzysztof Flisikowski, Ruedi Fries, Alejandro Vicente-carrillo

    Abstract:

    Background
    Cattle populations are highly amenable to the genetic mapping of male reproductive traits because longitudinal data on ejaculate quality and dense microarray-derived genotypes are available for thousands of artificial insemination bulls. Two young Nordic Red bulls delivered sperm with low progressive motility (i.e., Asthenospermia) during a semen collection period of more than four months. The bulls were related through a common ancestor on both their paternal and maternal ancestry. Thus, a recessive mode of inheritance of Asthenospermia was suspected.

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  • Additional file 8: of A splice donor variant in CCDC189 is associated with Asthenospermia in Nordic Red dairy cattle
    , 2019
    Co-Authors: Terhi Iso-touru, Christine Wurmser, Heli Venhoranta, Maya Hiltpold, Tujia Savolainen, Anu Sironen, Konrad Fischer, Krzysztof Flisikowski, Ruedi Fries, Alejandro Vicente-carrillo

    Abstract:

    Candidate causal variants compatible with recessive inheritance of Asthenospermia. Functional consequences of 126 candidate causal variants that were compatible with recessive inheritance of Asthenospermia, i.e., they were homozygous for the alternate allele in two asthenospermic bulls and either heterozygous or homozygous for the reference allele in 237 healthy control animals. Variants were annotated using the Variant Effect Predictor tool. The quality of the sequence variant genotypes for both asthenospermic bulls is shown in columns 7 and 8. The number of heterozygous control animals (out of 237) is shown in column 9. The last column indicates the genotype distribution of 126 candidate causal variants (homozygous for the reference allele | heterozygous | homozygous for the alternate allele) in 2669 animals of the 1000 bull genomes dataset. (TXT 51 kb

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  • A splice donor variant in CCDC189 is associated with Asthenospermia in Nordic Red dairy cattle
    BMC, 2019
    Co-Authors: Terhi Iso-touru, Christine Wurmser, Heli Venhoranta, Maya Hiltpold, Tujia Savolainen, Anu Sironen, Konrad Fischer, Krzysztof Flisikowski, Ruedi Fries, Alejandro Vicente-carrillo

    Abstract:

    Abstract Background Cattle populations are highly amenable to the genetic mapping of male reproductive traits because longitudinal data on ejaculate quality and dense microarray-derived genotypes are available for thousands of artificial insemination bulls. Two young Nordic Red bulls delivered sperm with low progressive motility (i.e., Asthenospermia) during a semen collection period of more than four months. The bulls were related through a common ancestor on both their paternal and maternal ancestry. Thus, a recessive mode of inheritance of Asthenospermia was suspected. Results Both bulls were genotyped at 54,001 SNPs using the Illumina BovineSNP50 Bead chip. A scan for autozygosity revealed that they were identical by descent for a 2.98 Mb segment located on bovine chromosome 25. This haplotype was not found in the homozygous state in 8557 fertile bulls although five homozygous haplotype carriers were expected (P = 0.018). Whole genome-sequencing uncovered that both asthenospermic bulls were homozygous for a mutation that disrupts a canonical 5′ splice donor site of CCDC189 encoding the coiled-coil domain containing protein 189. Transcription analysis showed that the derived allele activates a cryptic splice site resulting in a frameshift and premature termination of translation. The mutated CCDC189 protein is truncated by more than 40%, thus lacking the flagellar C1a complex subunit C1a-32 that is supposed to modulate the physiological movement of the sperm flagella. The mutant allele occurs at a frequency of 2.5% in Nordic Red cattle. Conclusions Our study in cattle uncovered that CCDC189 is required for physiological movement of sperm flagella thus enabling active progression of spermatozoa and fertilization. A direct gene test may be implemented to monitor the Asthenospermia-associated allele and prevent the birth of homozygous bulls that are infertile. Our results have been integrated in the Online Mendelian Inheritance in Animals (OMIA) database (https://omia.org/OMIA002167/9913/)

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