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James J Leyden - One of the best experts on this subject based on the ideXlab platform.
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semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner city school children
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:Objective. To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. Methods. All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). Results. Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures ; Microspomm canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade ; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (>150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months : 19 (42%) became culture-negative ; of these, 17 (90%) had a 1+ spore load. Conclusions. We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population. Pediatrics 1995 ;96 :265-267 ; tinea capitis, Asymptomatic Carrier state, Trichophyton tonsurans, school children, epidemiology.
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semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner city school children
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:OBJECTIVE: To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. METHODS: All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). RESULTS: Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures; Microsporum canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (> 150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months: 19 (42%) became culture-negative; of these, 17 (90%) had a 1+ spore load. CONCLUSIONS: We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population.
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Semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner-city school children.
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures; Microsporum canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (> 150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months: 19 (42%) became culture-negative; of these, 17 (90%) had a 1+ spore load. We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population.
Poren Hsueh - One of the best experts on this subject based on the ideXlab platform.
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Asymptomatic Carrier state acute respiratory disease and pneumonia due to severe acute respiratory syndrome coronavirus 2 sars cov 2 facts and myths
Journal of Microbiology Immunology and Infection, 2020Co-Authors: Chih Cheng Lai, Yen Hung Liu, Cheng Yi Wang, Yahui Wang, Shun Chung Hsueh, Muh Yen Yen, Poren HsuehAbstract:Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel coronavirus [2019-nCoV]) in Wuhan, China in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 75,000 cases have been reported in 32 countries/regions, resulting in more than 2000 deaths worldwide. Despite the fact that most COVID-19 cases and mortalities were reported in China, the WHO has declared this outbreak as the sixth public health emergency of international concern. The COVID-19 can present as an Asymptomatic Carrier state, acute respiratory disease, and pneumonia. Adults represent the population with the highest infection rate; however, neonates, children, and elderly patients can also be infected by SARS-CoV-2. In addition, nosocomial infection of hospitalized patients and healthcare workers, and viral transmission from Asymptomatic Carriers are possible. The most common finding on chest imaging among patients with pneumonia was ground-glass opacity with bilateral involvement. Severe cases are more likely to be older patients with underlying comorbidities compared to mild cases. Indeed, age and disease severity may be correlated with the outcomes of COVID-19. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. Currently, effective infection control intervention is the only way to prevent the spread of SARS-CoV-2.
Joon Kee Lee - One of the best experts on this subject based on the ideXlab platform.
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environmental surface testing for severe acute respiratory syndrome coronavirus 2 sars cov 2 during prolonged isolation of an Asymptomatic Carrier
Infection Control and Hospital Epidemiology, 2020Co-Authors: Kyeong Seob Shin, Hee Sue Park, Jisu Lee, Joon Kee LeeAbstract:Environmental surface testing was performed to search for evidence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) environmental contamination by an Asymptomatic SARS-CoV-2 Carrier with persistently high viral loads under isolation. No evidence of environmental contamination was found. Further studies are needed to measure environmental contamination by SARS-CoV-2 Carriers and to determine reasonable isolation periods.
Judith V Williams - One of the best experts on this subject based on the ideXlab platform.
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semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner city school children
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:Objective. To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. Methods. All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). Results. Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures ; Microspomm canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade ; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (>150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months : 19 (42%) became culture-negative ; of these, 17 (90%) had a 1+ spore load. Conclusions. We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population. Pediatrics 1995 ;96 :265-267 ; tinea capitis, Asymptomatic Carrier state, Trichophyton tonsurans, school children, epidemiology.
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semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner city school children
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:OBJECTIVE: To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. METHODS: All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). RESULTS: Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures; Microsporum canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (> 150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months: 19 (42%) became culture-negative; of these, 17 (90%) had a 1+ spore load. CONCLUSIONS: We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population.
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Semiquantitative study of tinea capitis and the Asymptomatic Carrier state in inner-city school children.
Pediatrics, 1995Co-Authors: Judith V Williams, Paul J Honig, Kenneth J Mcginley, James J LeydenAbstract:To quantify and characterize the Asymptomatic Carrier state of tinea capitis in school children from the inner city. All students attending a parochial school (kindergarten through seventh grade) in the city of Philadelphia were cultured for tinea capitis periodically over 16 months (1404 hemi-scalp cultures from 224 children). Our initial prevalence study of this all-black population (ages 5 to 13 years) found a 3% rate of index cases (symptomatic) and a 14% rate of Asymptomatic Carriers (without black-dot lesions, obvious hair loss, scaling, crusts, pustules, or erythema). Trichophyton tonsurans was the predominant dermatophyte (96% of 125 positive cultures; Microsporum canis was the only other isolate). Fifty percent of all positive cultures came from children in kindergarten and first grade; first grade had the highest rate of index cases. The overall prevalence of Asymptomatic Carriers was not higher in the classes containing index cases. Fifty-nine percent of Asymptomatic Carriers had a 1+ spore load (1 to 10 colonies isolated per scalp), while 74% of index cases had a 4+ spore load (> 150 total colonies). Forty-five untreated Asymptomatic Carriers were followed for 2 to 5 months: 19 (42%) became culture-negative; of these, 17 (90%) had a 1+ spore load. We found that inner-city black school children who are Asymptomatic Carriers of T tonsurans had lower spore loads than index cases. Index cases did not appear to be the primary mode of transmission within a classroom. More than half of untreated Asymptomatic Carriers remained culture-positive after 2 months and probably play a role in the transmission of tinea capitis within this population.
C. J. Gibbs - One of the best experts on this subject based on the ideXlab platform.
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Transmission of human T-cell leukemia virus type I from a patient with HTLV-I associated myelopathy/tropical spastic paraparesis and an Asymptomatic Carrier to rabbits
Archives of Virology, 1991Co-Authors: H. Minagawa, C. A. Mora, D. M. Asher, G. A. Stone, P. P. Liberski, C. J. GibbsAbstract:Rabbits were infected successfully with two strains of human T-cell leukemia virus type I (HTLV-I), one isolated from a Colombian patient with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and the other from an Asymptomatic Carrier. HTLV-I was repeatedly demonstrated in peripheral blood mononuclear cells (PBMNC) of infected rabbits, and the rabbits had elevated antibodies against the various structural proteins of HTLV-I. Four rabbits inoculated with HTLV-I-infected autologous lymphoid cells intravenously (i.v.) and intracerebrally (i.c.) had virus present in their PBMNC for more than 40 weeks, while those that were inoculated either with HTLV-I-infected human lymphoid cells or with autologous rabbit lymphoid cells intraperitoneally (i.p.) had episodes during which virus was not recovered from their PBMNC. The one rabbit inoculated i.p. developed antibodies to viral envelope glycoproteins earlier than did those inoculated i.v. and i.c. Rabbit lymphoid cell lines persistently infected with HTLV-I were established by cocultivating the rabbit PBMNC with HTLV-I-infected human lymphoid cells that had been irradiated or by inoculation with cell-free supernatant fluids of HTLV-I infected non-irradiated lymphoid cell cultures. HTLV-I-infected rabbit cell lines were of T-cell origin and expressed HTLV-I antigens by immunofluorescence. Electron microscopy revealed type-C retrovirus particles.
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transmission of human t cell leukemia virus type i from a patient with htlv i associated myelopathy tropical spastic paraparesis and an Asymptomatic Carrier to rabbits
Archives of Virology, 1991Co-Authors: H. Minagawa, C. A. Mora, D. M. Asher, P. P. Liberski, Gary Stone, C. J. GibbsAbstract:Rabbits were infected successfully with two strains of human T-cell leukemia virus type I (HTLV-I), one isolated from a Colombian patient with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) and the other from an Asymptomatic Carrier. HTLV-I was repeatedly demonstrated in peripheral blood mononuclear cells (PBMNC) of infected rabbits, and the rabbits had elevated antibodies against the various structural proteins of HTLV-I. Four rabbits inoculated with HTLV-I-infected autologous lymphoid cells intravenously (i.v.) and intracerebrally (i.c.) had virus present in their PBMNC for more than 40 weeks, while those that were inoculated either with HTLV-I-infected human lymphoid cells or with autologous rabbit lymphoid cells intraperitoneally (i.p.) had episodes during which virus was not recovered from their PBMNC. The one rabbit inoculated i.p. developed antibodies to viral envelope glycoproteins earlier than did those inoculated i.v. and i.c. Rabbit lymphoid cell lines persistently infected with HTLV-I were established by cocultivating the rabbit PBMNC with HTLV-I-infected human lymphoid cells that had been irradiated or by inoculation with cell-free supernatant fluids of HTLV-I infected non-irradiated lymphoid cell cultures. HTLV-I-infected rabbit cell lines were of T-cell origin and expressed HTLV-I antigens by immunofluorescence. Electron microscopy revealed type-C retrovirus particles.
