The Experts below are selected from a list of 260691 Experts worldwide ranked by ideXlab platform
Yehuda Shoenfeld - One of the best experts on this subject based on the ideXlab platform.
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Vitamin D and Autoimmune Diseases
Extraskeletal Effects of Vitamin D, 2018Co-Authors: Shir Azrielant, Yehuda ShoenfeldAbstract:Vitamin D has a crucial role in preserving musculoskeletal health and modulating the immune system; the latter has been a subject of great interest in recent years. Vitamin D deficiency is common in the general population and even more so among patients with various Autoimmune Diseases. Vitamin D deficiency has been previously linked to various Autoimmune Diseases, including multiple sclerosis, type 1 diabetes, inflammatory bowel Diseases, and rheumatoid arthritis. In this chapter, the association between vitamin D deficiency and various Autoimmune Diseases will be discussed, as well as the possible therapeutic implications derived from this relationship.
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THE ENVIRONMENT AND Autoimmune Diseases
Harefuah, 2015Co-Authors: Abdulla Watad, Howard Amital, Yehuda ShoenfeldAbstract:The immune system carefully distinguishes between self and non-self-components. Therefore, any small deviation of this balanced function may result in an Autoimmune activity and harm against self-antigens (autoantigens). The link between Autoimmune Diseases and various heredity and environmental factors has been discussed in numerous studies. The infectious factor is still considered to be the most important environmental factor leading to the development of Autoimmune disease. Recent studies associated new environmental factors to autoimmunity, such as excessive salt consumption. In this paper, we summarize the relationship between environmental factors and Autoimmune Diseases covering innovations in this field.
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Thymoma and Autoimmune Diseases
Cancer and Autoimmunity, 2007Co-Authors: Yaniv Sherer, Yehuda ShoenfeldAbstract:Publisher Summary Numerous Autoimmune phenomena are reported in malignancies. These Autoimmune conditions are regarded as paraneoplastic syndromes or syndromes that cannot be explained by the local effects of the tumor or its metastases. The most common neoplasm associated with Autoimmune Diseases is thymoma. Thymoma is an epithelial tumor that constitutes approximately 15% of all mediastinal masses. It usually arises in the anterior or anterior-superior mediastinum. The chapter describes the various Autoimmune Diseases that occur in patients with thymoma: myasthenia gravis (MG), pemphigus, systemic lupus erythematosus (SLE), and pure red cell aplasia (PRCA). Malignant thymomas, as opposed to benign thymomas, constitute a minority of all epithelial tumors of the thymus. The chapter discusses about the Autoimmune Diseases in malignant thymomas and the benign thymomas, and the differences. Bone-marrow transplantation is an optional treatment for severe Autoimmune Diseases. As there is a strong association between thymic pathology and autoimmunity, thymectomy has a beneficial effect on the course of Autoimmune Diseases.
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Vascular Endothelial Growth Factor (VEGF) in Autoimmune Diseases
Journal of Clinical Immunology, 2007Co-Authors: JozÉlio Freire Carvalho, Miri Blank, Yehuda ShoenfeldAbstract:Vascular endothelial growth factor (VEGF) is a potent stimulating factor for angiogenesis and vascular permeability. There are eight isoforms with different and sometimes overlapping functions. The mechanisms of action are under investigation with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins, which were not previously associated to angiogenesis. VEGF has important physiological actions on embryonic development, healing, and menstrual cycle. It also has a great role in pathological conditions that are associated to Autoimmune Diseases. There is considerable evidence in various Autoimmune Diseases such as in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis of an interrelationship between the VEGF system and theses disorders. Serum levels of VEGF correlate with disease activity in a large number of Autoimmune Diseases and fall with the use of standard therapy. We raised the possible future therapeutic strategies in Autoimmune Diseases with the anti-VEGF or anti-VEGFR (receptor). So far, this therapy has been used in cancer and macular ocular degeneration in diabetes. This review outlines the evidence for VEGF participation in various Autoimmune Diseases and proposes lines for future research in this field.
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Ferritin in Autoimmune Diseases.
Autoimmunity Reviews, 2007Co-Authors: Gisele Zandman-goddard, Yehuda ShoenfeldAbstract:Iron, an essential element for many important cellular functions in all living organisms, can catalyze the formation of potentially toxic free radicals. Excessive iron is sequestered by ferritin in a nontoxic and readily available form in a cell. Ferritin is composed of 24 subunits of different proportions of two functionally distinct subunits: ferritin H and L. The expression of ferritin is under delicate control and is regulated at both the transcriptional and post-transcriptional levels by iron, cytokines, hormones, and oxidative stress. Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy. Hyperferritinemia is associated with inflammation, infections, and malignancies. While elevated levels of ferritin are characteristic of adult-onset Still's disease and hemophagocytic syndrome, both associated with inflammation, it has scantly been evaluated in other Autoimmune Diseases. In this review, we describe ferritin structure and function, hyperferritinemia in disease states and in Autoimmune Diseases.
Huizhong Zhang - One of the best experts on this subject based on the ideXlab platform.
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The roles of adenosine deaminase in Autoimmune Diseases.
Autoimmunity reviews, 2020Co-Authors: Zhao-wei Gao, Huizhong Zhang, Xi Wang, Fang Lin, Chong Liu, Ke DongAbstract:Abstract Autoimmune Diseases patients are characterized by the Autoimmune disorders, whose immune system can't distinguish between auto- and foreign- antigens. Thus, Immune homeostasis disorder is the key factor for Autoimmune Diseases development. Adenosine deaminase (ADA) is the degrading enzyme for an immunosuppressive signal - adenosine, and play an important role in immune homeostasis regulation. Increasing evidences have shown that ADA is involved in various Autoimmune Diseases. ADA activity were changed in multiple Autoimmune Diseases patients and could be served as a biomarker for clinical diagnosis. In this study, we analyze the change of ADA activity in patients with Autoimmune Diseases, and we underline its potential diagnostic value for Autoimmune Diseases patients.
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the role of adenosinergic pathway in human Autoimmune Diseases
Immunologic Research, 2016Co-Authors: Ke Dong, Huizhong ZhangAbstract:Autoimmune Diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state of appropriate immune response to nonself-antigen and unresponsiveness to self-antigens. In normal situation, immune homeostasis is regulated by immunosuppressive signal and immunostimulating signal together. Accumulating data have demonstrated that the adenosinergic pathway played key roles in immune suppression and shield body from an excessive inflammatory response. The deficiency of adenosinergic pathway results in the imbalance between the pro- and anti-inflammatory activities. Thus, researchers pay much attention to the role of adenosinergic pathway in Autoimmune Diseases development. To date, accumulating data have suggested an important role of adenosinergic pathway-related molecules (i.e., CD39, CD73, ADA, adenosine receptors, etc.) in many types of human Autoimmune Diseases. More importantly, these findings have presented potential value of adenosinergic pathway analysis to be used for Autoimmune Diseases diagnosis, monitoring and treatment. In this review, we will provide a comprehensive description of the role of adenosinergic pathway in human Autoimmune Diseases.
Ke Dong - One of the best experts on this subject based on the ideXlab platform.
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The roles of adenosine deaminase in Autoimmune Diseases.
Autoimmunity reviews, 2020Co-Authors: Zhao-wei Gao, Huizhong Zhang, Xi Wang, Fang Lin, Chong Liu, Ke DongAbstract:Abstract Autoimmune Diseases patients are characterized by the Autoimmune disorders, whose immune system can't distinguish between auto- and foreign- antigens. Thus, Immune homeostasis disorder is the key factor for Autoimmune Diseases development. Adenosine deaminase (ADA) is the degrading enzyme for an immunosuppressive signal - adenosine, and play an important role in immune homeostasis regulation. Increasing evidences have shown that ADA is involved in various Autoimmune Diseases. ADA activity were changed in multiple Autoimmune Diseases patients and could be served as a biomarker for clinical diagnosis. In this study, we analyze the change of ADA activity in patients with Autoimmune Diseases, and we underline its potential diagnostic value for Autoimmune Diseases patients.
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the role of adenosinergic pathway in human Autoimmune Diseases
Immunologic Research, 2016Co-Authors: Ke Dong, Huizhong ZhangAbstract:Autoimmune Diseases are characterized by the abnormal immune response against self-tissue, which are caused by the failure of nature immune homeostasis. Nature immune homeostasis represents the normal state of appropriate immune response to nonself-antigen and unresponsiveness to self-antigens. In normal situation, immune homeostasis is regulated by immunosuppressive signal and immunostimulating signal together. Accumulating data have demonstrated that the adenosinergic pathway played key roles in immune suppression and shield body from an excessive inflammatory response. The deficiency of adenosinergic pathway results in the imbalance between the pro- and anti-inflammatory activities. Thus, researchers pay much attention to the role of adenosinergic pathway in Autoimmune Diseases development. To date, accumulating data have suggested an important role of adenosinergic pathway-related molecules (i.e., CD39, CD73, ADA, adenosine receptors, etc.) in many types of human Autoimmune Diseases. More importantly, these findings have presented potential value of adenosinergic pathway analysis to be used for Autoimmune Diseases diagnosis, monitoring and treatment. In this review, we will provide a comprehensive description of the role of adenosinergic pathway in human Autoimmune Diseases.
Mariana J. Kaplan - One of the best experts on this subject based on the ideXlab platform.
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Role of neutrophils in systemic Autoimmune Diseases
Arthritis Research & Therapy, 2013Co-Authors: Mariana J. KaplanAbstract:Neutrophils have emerged as important regulators of innate and adaptive immune responses. Recent evidence indicates that neutrophils display marked abnormalities in phenotype and function in various systemic Autoimmune Diseases, and may play a central role in initiation and perpetuation of aberrant immune responses and organ damage in these conditions. This review discusses the putative roles that neutrophils and aberrant neutrophil cell death play in the pathogenesis of various systemic Autoimmune Diseases, including systemic lupus erythematosus, small vessel vasculitis and rheumatoid arthritis.
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Endothelial damage and Autoimmune Diseases
Autoimmunity, 2009Co-Authors: Mariana J. KaplanAbstract:This issue of Autoimmunity reviews the mechanisms that lead to vascular damage in systemic Autoimmune Diseases. In addition, this issue explores recent advances in the understanding of how abnormalities in angiogenesis present in Autoimmune Diseases may lead to tissue damage and/or to premature vascular disease.
Michael Schirmer - One of the best experts on this subject based on the ideXlab platform.
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Imbalance of regulatory T cells in human Autoimmune Diseases
Immunology, 2006Co-Authors: Christian Dejaco, Christina Duftner, Beatrix Grubeck-loebenstein, Michael SchirmerAbstract:The breakdown of mechanisms assuring the recognition of self and non-self is a hallmark feature of Autoimmune Diseases. In the past 10 years, there has been a steadily increasing interest in a subpopulation of regulatory T cells, which exert their suppressive function in vitro in a contact-dependent manner and preferentially express high levels of CD25 and forkhead and winged-helix family transcription factor forkhead box P3 (FOXP3) (TREGs). Recent findings of changed prevalences and functional efficiencies indicate that these TREGs play a unique role in Autoimmune Diseases. Clinical findings in patients with mutated FOXP3 genes and a specific polymorphism in the promotor region of FOXP3 also support the role of FOXP3 as a 'master control gene' in the development and functioning of TREGs. Both altered generation of TREGs and insufficient suppression of inflammation in Autoimmune Diseases are considered to be crucial for the initiation and perpetuation of disease. TREG-related somatic cell therapy is considered as an intriguing new intervention to approach Autoimmune Diseases.
