The Experts below are selected from a list of 132 Experts worldwide ranked by ideXlab platform
Jason R Herr - One of the best experts on this subject based on the ideXlab platform.
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development of the large scale preparation of 2 methanesulfonyl Benzenesulfonyl Chloride
Organic Process Research & Development, 2012Co-Authors: Harold Meckler, Jason R HerrAbstract:A practical and scalable process is described for the preparation of 2-(methansulfonyl)Benzenesulfonyl Chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpensive 1,2-dichlorobenzene and methanethiol, and the process has been demonstrated on a multikilogram scale in 32% overall yield with a chemical purity of >98%.
Heinzjurgen Brauch - One of the best experts on this subject based on the ideXlab platform.
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analysis of primary and secondary aliphatic amines in waste water and surface water by gas chromatography mass spectrometry after derivatization with 2 4 dinitrofluorobenzene or Benzenesulfonyl Chloride
Journal of Chromatography A, 1997Co-Authors: Frank Sacher, Steffen Lenz, Heinzjurgen BrauchAbstract:Two methods for the determination of aliphatic amines such as methylamine, dimethylamine, ethylamine, diethylamine, piperidine, pyrrolidine or morpholine in waste water and surface water at the sub-ppb level are presented. The methods are based on a derivatization of the amines within the aqueous medium with 2,4-dinitrofluorobenzene and Benzenesulfonyl Chloride, respectively. In both cases the derivatives are extracted with dichloromethane and measured by GC-MS. The performance data of the two methods are compared and the method which is based on the derivatization with Benzenesulfonyl Chloride is finally applied to industrial waste waters and surface waters in order to determine the rate of occurrence of aliphatic amines in the aquatic environment.
Harold Meckler - One of the best experts on this subject based on the ideXlab platform.
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development of the large scale preparation of 2 methanesulfonyl Benzenesulfonyl Chloride
Organic Process Research & Development, 2012Co-Authors: Harold Meckler, Jason R HerrAbstract:A practical and scalable process is described for the preparation of 2-(methansulfonyl)Benzenesulfonyl Chloride, a key building block used in the synthesis of several drug candidates. The material is prepared by an efficient four-step sequence from inexpensive 1,2-dichlorobenzene and methanethiol, and the process has been demonstrated on a multikilogram scale in 32% overall yield with a chemical purity of >98%.
Paul R Hanson - One of the best experts on this subject based on the ideXlab platform.
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development and application of a recyclable high load magnetic co c hybrid romp derived Benzenesulfonyl Chloride reagent and utility of corresponding analogues
Organic Letters, 2017Co-Authors: Saqib Faisal, Qin Zang, Pradip K Maity, Agnes Brandhofer, Patrick C Kearney, Oliver Reiser, Robert N Grass, Diana Stoianova, Paul R HansonAbstract:The development and application of high-load, recyclable magnetic Co/C hybrid ROMP-derived Benzenesulfonyl Chloride and analogues is reported. The regeneration and utility of these reagents in the methylation/alkylation of various carboxylic acids is demonstrated via efficient retrieval of the magnetic reagent with a neodymium magnet. Additional reactions employing the analogue sulfonic acid and in situ generated magnetic Benzenesulfonyl azide are also reported.
Vijay Ramani - One of the best experts on this subject based on the ideXlab platform.
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ring opening metathesis polymerization for the preparation of polynorbornene based proton exchange membranes with high proton conductivity
Journal of Membrane Science, 2017Co-Authors: Yang Zhao, Xiaofeng Xie, Zhiming Feng, Xincheng Xiang, Shubo Wang, Vijay RamaniAbstract:Abstract Novel proton exchange membranes based on polynorbornenes with different crosslinker contents were prepared using ring-opening metathesis polymerization (ROMP). The precursor polymers were prepared from norbornene functionalized with Benzenesulfonyl Chloride (NBSC), norbornene, and dicyclopentadiene (DCPD). DCPD was used as a crosslinker. The polynorbornene-based membranes were obtained by the solution casting method. The sulfonyl Chloride groups were transformed into sulfonic acid groups by treating the membrane with potassium hydroxide and hydrochloric acid. NBSC was introduced to replace the sulfonate monomer, which was insoluble in the nonpolar solvents used in ROMP. This approach allowed the preparation of membranes with high ion exchange capacity (IEC) and high proton conductivity. A series of membranes with the same theoretical IEC but with different crosslinker contents were prepared and their properties were measured. The results obtained showed that the proton conductivity, water uptake and swelling ratio of the membranes were all lowered as the crosslink density was enhanced. The proton conductivity of the non-crosslinked membrane at room temperature was 117±4mS/cm. When the ratio of NBSC to DCPD crosslinker was 1:0.406, the proton conductivity, water uptake, swelling ratio and methanol permeability at room temperature were 96±2 mS/cm, 31±2.5%, 10.5±2% and 1.0±0.2×10 −6 cm 2 /s, respectively.