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Berberis vulgaris

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M H Boskabadi – One of the best experts on this subject based on the ideXlab platform.

  • Effects of hydro-ethanolic extract of Berberis vulgaris fruit on rabbit isolated heart
    DARU, 2006
    Co-Authors: H Parsaee, M N Shafiei, M H Boskabadi

    Abstract:

    Several therapeutic effects including antimicrobial, antidiarrhea, hepatoprotection and cardiotonic for Berberis vulgaris have been described. In the present study, the effects of hydro-ethanolic extract of Berberis vulgaris on the rate and contractility of isolated heart were examined. The heart mounted on a modified Langendorff apparatus and circulation was perfused through aorta. Heart rate and contractility were determined in the presence of four concentrations of hydro-ethanolic extract (0.5, 1.0, 2.0 and 5.0 mg/100ml) and diltiazem, a calcium channel blocker (0.1, 1,10 and 100 µM) in comparison with baseline values in two different groups of experiments as follows: 1) Perfused heart with normal Krebs solution (group1 experiments, n=10). 2) Perfused heart with calcium free Krebs solution (group 2 experiments, n=9). In group 1 only 3 highest concentrations of diltiazem showed significant reduction in heart rate (p

  • effects of hydro ethanolic extract of Berberis vulgaris fruit on rabbit isolated heart
    DARU, 2006
    Co-Authors: H Parsaee, M N Shafiei, M H Boskabadi

    Abstract:

    Several therapeutic effects including antimicrobial, antidiarrhea, hepatoprotection and cardiotonic for Berberis vulgaris have been described. In the present study, the effects of hydro-ethanolic extract of Berberis vulgaris on the rate and contractility of isolated heart were examined. The heart mounted on a modified Langendorff apparatus and circulation was perfused through aorta. Heart rate and contractility were determined in the presence of four concentrations of hydro-ethanolic extract (0.5, 1.0, 2.0 and 5.0 mg/100ml) and diltiazem, a calcium channel blocker (0.1, 1,10 and 100 µM) in comparison with baseline values in two different groups of experiments as follows: 1) Perfused heart with normal Krebs solution (group1 experiments, n=10). 2) Perfused heart with calcium free Krebs solution (group 2 experiments, n=9). In group 1 only 3 highest concentrations of diltiazem showed significant reduction in heart rate (p<0.05 to P<0.001). However, 3 highest concentrations of diltiazem showed significant decrease and the last 2 concentrations of hydro-ethanolic extract increased heart contractility significantly (p<0.01 to P<0.001). In group 2 only the last concentration of diltiazem showed significant reduction in heart rate and contractility (p<0.05). The relationship between concentrations of hydro-ethanolic extract and heart rate in both group were negative (p<0.01 to p<0.001). However, there was positive correlation between concentrations of hydro-ethanolic extract and heart contractility. These results showed that of hydro-ethanolic extract of Berberis vulgaris has strong effect on heart contractility. The results of the present study may also indicate an activatoion of the calcium channel of isolated heart by the extract.

H Parsaee – One of the best experts on this subject based on the ideXlab platform.

  • Effects of hydro-ethanolic extract of Berberis vulgaris fruit on rabbit isolated heart
    DARU, 2006
    Co-Authors: H Parsaee, M N Shafiei, M H Boskabadi

    Abstract:

    Several therapeutic effects including antimicrobial, antidiarrhea, hepatoprotection and cardiotonic for Berberis vulgaris have been described. In the present study, the effects of hydro-ethanolic extract of Berberis vulgaris on the rate and contractility of isolated heart were examined. The heart mounted on a modified Langendorff apparatus and circulation was perfused through aorta. Heart rate and contractility were determined in the presence of four concentrations of hydro-ethanolic extract (0.5, 1.0, 2.0 and 5.0 mg/100ml) and diltiazem, a calcium channel blocker (0.1, 1,10 and 100 µM) in comparison with baseline values in two different groups of experiments as follows: 1) Perfused heart with normal Krebs solution (group1 experiments, n=10). 2) Perfused heart with calcium free Krebs solution (group 2 experiments, n=9). In group 1 only 3 highest concentrations of diltiazem showed significant reduction in heart rate (p

  • effects of hydro ethanolic extract of Berberis vulgaris fruit on rabbit isolated heart
    DARU, 2006
    Co-Authors: H Parsaee, M N Shafiei, M H Boskabadi

    Abstract:

    Several therapeutic effects including antimicrobial, antidiarrhea, hepatoprotection and cardiotonic for Berberis vulgaris have been described. In the present study, the effects of hydro-ethanolic extract of Berberis vulgaris on the rate and contractility of isolated heart were examined. The heart mounted on a modified Langendorff apparatus and circulation was perfused through aorta. Heart rate and contractility were determined in the presence of four concentrations of hydro-ethanolic extract (0.5, 1.0, 2.0 and 5.0 mg/100ml) and diltiazem, a calcium channel blocker (0.1, 1,10 and 100 µM) in comparison with baseline values in two different groups of experiments as follows: 1) Perfused heart with normal Krebs solution (group1 experiments, n=10). 2) Perfused heart with calcium free Krebs solution (group 2 experiments, n=9). In group 1 only 3 highest concentrations of diltiazem showed significant reduction in heart rate (p<0.05 to P<0.001). However, 3 highest concentrations of diltiazem showed significant decrease and the last 2 concentrations of hydro-ethanolic extract increased heart contractility significantly (p<0.01 to P<0.001). In group 2 only the last concentration of diltiazem showed significant reduction in heart rate and contractility (p<0.05). The relationship between concentrations of hydro-ethanolic extract and heart rate in both group were negative (p<0.01 to p<0.001). However, there was positive correlation between concentrations of hydro-ethanolic extract and heart contractility. These results showed that of hydro-ethanolic extract of Berberis vulgaris has strong effect on heart contractility. The results of the present study may also indicate an activatoion of the calcium channel of isolated heart by the extract.

Anca Dinischiotu – One of the best experts on this subject based on the ideXlab platform.

  • Hepatoprotective Effects of Berberis vulgaris L. Extract/β Cyclodextrin on Carbon Tetrachloride–Induced Acute Toxicity in Mice
    International Journal of Molecular Sciences, 2012
    Co-Authors: Anca Hermenean, Cristina Popescu, Aurel Ardelean, Miruna Silvia Stan, Nicoleta Hadaruga, Ciprian-valentin Mihali, Marieta Costache, Anca Dinischiotu

    Abstract:

    The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl4-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of apartate-amino-transferase (AST), alanine-amino-transferase (ALT) and malondialdehyde (MDA) was found and a significant decrease in superoxide-dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-peroxidase (GPx) levels could be detected. This was accompanied by extended centrilobular necrosis, steatosis, fibrosis and an altered ultrastructure of hepatocytes. Pre-treatment with formulated or non-formulated extract suppressed the increase in ALT, AST and MDA levels and restored the level of antioxidant enzymes at normal values. Histopathological and electron-microscopic examination showed milder liver damage in both pre-treated groups and the protective effect was more pronounced after the formulated extract was administered. Internucleosomal DNA fragmentation induced by CCl4 was reduced in the group which received non-formulated extract and absent in the group which received formulated extract. Taken together, our results suggest that Berberis vulgaris/β-cyclodextrin treatment prevents hepatic injury induced by CCl4 and can be considered for further nutraceutical studies.

  • hepatoprotective effects of Berberis vulgaris l extract β cyclodextrin on carbon tetrachloride induced acute toxicity in mice
    International Journal of Molecular Sciences, 2012
    Co-Authors: Anca Hermenean, Cristina Popescu, Aurel Ardelean, Miruna Silvia Stan, Nicoleta Hadaruga, Ciprian-valentin Mihali, Marieta Costache, Anca Dinischiotu

    Abstract:

    The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl4-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of apartate-amino-transferase (AST), alanine-amino-transferase (ALT) and malondialdehyde (MDA) was found and a significant decrease in superoxide-dismutase (SOD), catalase (CAT), glutathione (GSH) and glutathione-peroxidase (GPx) levels could be detected. This was accompanied by extended centrilobular necrosis, steatosis, fibrosis and an altered ultrastructure of hepatocytes. Pre-treatment with formulated or non-formulated extract suppressed the increase in ALT, AST and MDA levels and restored the level of antioxidant enzymes at normal values. Histopathological and electron-microscopic examination showed milder liver damage in both pre-treated groups and the protective effect was more pronounced after the formulated extract was administered. Internucleosomal DNA fragmentation induced by CCl4 was reduced in the group which received non-formulated extract and absent in the group which received formulated extract. Taken together, our results suggest that Berberis vulgaris/β-cyclodextrin treatment prevents hepatic injury induced by CCl4 and can be considered for further nutraceutical studies.